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Recent CDC data reveal a dramatic 1,200% increase in kratom‑related poisonings across the United States over the last ten years, with the most pronounced surge recorded in 2025. Researchers link this rise to the growing presence of 7‑hydroxymitragynine (7‑OH), a synthetically produced compound that mimics kratom’s effects but carries opioid‑like risks. Walter Prozialeck, pharmacology professor at Midwestern University, said the trend was expected, noting that the synthetic alkaloid has entered the market through energy drinks and other products since 2024. Christopher McCurdy of the University of Florida warned that marketing 7‑OH as “enhanced kratom” blurs the line for consumers, turning poison‑control calls into a conflated metric for both natural and synthetic products. By contrast, natural kratom (Mitragyna speciosa)—a Southeast Asian plant used for centuries as a pain reliever—has demonstrated a relatively favorable safety profile in animal and human studies. A 2018 statement from then‑HHS Secretary Brett Giroir rejected the DEA’s push to schedule kratom as a Schedule I substance, citing insufficient evidence of harm. Despite the scientific distinction, several states have moved to implement or propose blanket bans on all kratom products, prompting concern from clinicians and patient advocates. A recent user survey indicated that about 50% of respondents rely on kratom for chronic pain, while roughly 40% use it during addiction recovery. Personal testimonies underscore the plant’s therapeutic role. Jeff Maslan, a 68‑year‑old Californian with severe osteoarthritis, credits kratom with easing opioid withdrawal after multiple surgeries. Similarly, “Steven,” a disabled California resident, describes how kratom eliminated unbearable oxycodone withdrawal symptoms without producing the euphoric “warm fuzzy” feeling typical of opioids. Researchers emphasize that 7‑OH carries genuine opioid hazards, including addiction, severe withdrawal, and respiratory depression that can lead to fatal overdose. In animal models, 7‑OH demonstrated the same respiratory‑depression risk as classic opioids, whereas kratom’s primary alkaloid did not. Prozialeck and colleagues explain that kratom’s pharmacology is more nuanced: it partially activates opioid receptors while also engaging adrenergic and serotonin pathways, resembling a hybrid of a weak opioid and an SNRI‑type antidepressant. This multimodal action likely accounts for its lower euphoric potential and the reported boost in energy among users. Nevertheless, experts caution that kratom is not without risk. Fatal poisonings often involve co‑ingestion of potent opioids such as fentanyl, suggesting that some users may cycle between kratom and stronger substances, raising overdose danger due to reduced opioid tolerance. Additionally, heavy‑metal contamination has been detected in certain kratom batches, though the source—soil, processing, or storage—remains unclear. Given these complexities, the consensus among scholars like Austin Zamarripa (Johns Hopkins) is that natural kratom should remain accessible, while concentrated 7‑OH products merit stricter regulation. “These products may offer meaningful benefits to some individuals, and those benefits could be lost if access is restricted too broadly,” Zamarripa said, urging a differentiated policy approach. As the debate unfolds, patients like Steven worry that a sweeping ban would ignore the nuanced safety profile of the plant. “There’s corn on the cob, there’s high‑fructose corn syrup, there’s whiskey— all derived from corn but fundamentally different,” he remarked, highlighting the need for targeted, evidence‑based regulation rather than a one‑size‑fits‑all prohibition.

Experts are closely monitoring climate patterns in the Pacific Ocean, which indicate a high chance of El Niño developing this summer. A strong El Niño event could lead to severe weather conditions, including super-charged rainstorms and droughts, depending on the region. A 'super El Niño' could push 2027 to break global heat records, according to climate scientists. This phenomenon occurs when ocean surface temperatures in the central and eastern tropical Pacific Ocean warm up, leading to significant impacts on global weather patterns. El Niño is characterized by warming of the ocean surface in the central and eastern tropical Pacific Ocean. It's one of three states scientists observe: La Niña, conversely, happens when sea surface temperatures are below average, and neutral conditions are defined when neither El Niño or La Niña are present and surface temperatures are about average. The 'El Niño-southern oscillation' (Enso) tends to develop during spring in the northern hemisphere and shifts every three to seven years. Warming and cooling at sea surface during El Niño and La Niña can range from 1C to 3C, and have enormous effects on precipitation, drought, heat, and climate disasters in different regions. Conditions are currently shifting from La Niña to a neutral pattern, according to the latest outlook from the US Climate Prediction Center. Models show a 62% chance El Niño will emerge this summer and linger until at least the end of the year. A super El Niño that occurred in 2015 brought severe drought in Ethiopia, water supply shortages in Puerto Rico, and smashed records after unleashing a vicious hurricane season in the central North Pacific. A 'super' El Niño means one that is stronger, typically defined by sea surface temperatures spiking up to at least 2C. Noaa scientists have given a 1 in 4 chance that this could happen by fall or winter, with the caveat that spring forecasts are sometimes muddled. Transitions in conditions that happen in the spring can make outcomes a bit harder to predict. Experts warn that a strong or super El Niño could lead to drought and heat across Australia, southern and central Africa, India, and parts of South America. Heavy precipitation, meanwhile, could hit the southern tier of the US, parts of the Middle East, and south-central Asia.

Scientists at London's Institute of Cancer Research and the RCSI University of Medicine and Health Sciences in Dublin have announced a new AI-driven approach to identify how patients with advanced bowel cancer will respond to bevacizumab, a drug recently introduced by the NHS. The method uses PhenMap, an AI tool that integrates complex data on the genetic makeup of tumors, allowing researchers to track patterns of how different patients react to the drug. This development aims to spare potentially thousands of patients from being given drugs that would be ineffective in fighting their cancers. In the UK alone, nearly 10,000 cases of advanced bowel cancer are identified every year, with young adults seeing a particular rise in diagnoses. Bowel cancer has the second-highest mortality rate of any cancer, behind only lung cancer. While survival rates can be as high as 98% when caught early, the five-year survival rate for advanced bowel cancer can be as low as 10%. The study tracked 117 European bowel cancer patients who had been treated with chemotherapy and bevacizumab. Researchers identified a group of patients who all had the same gene mutation and were at a high risk of having negative reactions. The scientists behind the tests now hope to expand the number of patient samples and see if the results can be used in treatments for other types of cancer. Anguraj Sadanandam, a professor in stratification and precision medicine at the ICR, said: “Once bowel cancer spreads to other parts of the body, there are very few treatment options available for patients. It is therefore positive that patients can now access the targeted drug bevacizumab on the NHS. However, we know that the majority of patients won’t benefit from the drug, meaning thousands of people in England could be facing unpleasant side effects unnecessarily.” Sadanandam added that while the findings were encouraging, the tool would need to be tested on a larger cohort to be validated. “In future, I hope this approach will lead to a test that can be used by clinicians, to ensure patients receive personalised care that has the highest chance of working against their cancer.”

Rory McIlroy faced a daunting challenge on the 12th hole at Augusta National Golf Club during the Masters Tournament. The hole, known as Golden Bell, had a pin positioned precariously on the far right edge, making it one of the most difficult holes in tournament golf. McIlroy decided to ignore Jack Nicklaus's advice to play for the middle of the green and instead went for the pin, a decision that could have easily backfired.Nicklaus, a legendary golfer and course designer, had previously advised McIlroy to avoid going for the pin if it's on the right side of the green, suggesting that players should prioritize making par over attempting a challenging shot. However, McIlroy chose to take a different approach, hitting his shot over the water and onto the green, where it bounded towards the cup.The crowd held its collective breath as McIlroy lined up his birdie putt, which was approximately seven feet left of the hole. With the wind whipping through the trees and the pressure mounting, McIlroy remained focused and sank the putt with ease, securing a crucial birdie that helped him stay in contention.This moment proved pivotal in McIlroy's victory, as he managed to navigate the challenging 12th hole successfully and maintain his position at the top of the leaderboard. McIlroy's win marked his continued dominance in the golf world, showcasing his skill and mental toughness under pressure.

Joz Norris' latest show, 'You Wait. Time Passes', is a thought-provoking exploration of artistic character and the choices that define a creative life. In this maverick confection of a show, Norris takes on the role of an unhinged, self-absorbed guru figure, imparting life lessons with a healthy dose of silliness.The show delves into Norris's career as a comedian, actor, and magician, as well as his bid to become Google's number one Joz. Through snippets of his career and interactions with his erratic AI girlfriend, Norris presents a picture of himself as a complex, multifaceted artist.At its core, the show poses big questions about the futility of the niche creative's life and whether weird artists are truly weird or just trying to express themselves in a different way. While some moments feel a bit strenuous or for-its-own-sake, the show's extreme dottiness is backed up by good jokes, twisty philosophy, and a highly energetic performance.Ultimately, 'You Wait. Time Passes' constitutes a curiously rousing defence of experimental art-making in a conformist, capitalist world. The show is a must-see for fans of comedy and experimental art, and it will be touring after its run at the Lowry in Salford.

Manchester City delivered a commanding 3‑0 win at Stamford Bridge on April 12, 2026, a result that brings them within a single game’s reach of the league leaders, Arsenal. The victory, part of City’s impressive April record of 19 wins and 4 draws from 23 matches, underscores Pep Guardiola’s reputation as a spring‑time title avenger. The opening goal arrived in the 10th minute when Nico O’Reilly headed a close‑range effort past the Chelsea keeper, a moment described as a “free header” that ignited the Etihad‑like atmosphere among the travelling fans. Within the next 17 minutes, Marc Guéhi and Jérémy Doku added their names to the scoresheet, exposing a Chelsea defence that resembled a “shop‑worn bead curtain”. Guardiola’s side now sits six points behind Arsenal with a game in hand. A win at the Etihad next Sunday would reduce the deficit to three points, and a subsequent victory at Burnley could see the two clubs level on points, with City holding the superior goal difference. Arsenal, meanwhile, are grappling with a dramatic slump. After a nine‑point lead that seemed unassailable, the Gunners suffered a home defeat to Bournemouth, leaving them vulnerable to a potential “quadruple collapse” over the next sixteen days. City’s recent form has been nothing short of dominant: in their last three fixtures they have beaten the league leaders, the title‑holders, and the Club World Champions, scoring nine goals while keeping a clean sheet. The squad’s depth is evident, with five different scorers contributing to the tally. In contrast, Chelsea’s performance highlighted the widening gulf at the top of the table. Manager Liam Rosenior, still finding his footing after a mid‑season appointment, has yet to secure a win against the league’s elite, having lost to Guardiola, Luis Enrique and Mikel Arteta. Guardiola, ever the seasoned tactician, appeared composed even when Chelsea showed brief bursts of energy. His sideline attire—a practical anorak and brown shoes—mirrored his methodical approach, while midfield dynamo Bernardo Silva moved with the poise of a “captive prince” amid the chaos. As the season edges toward its climax, City’s blend of experience, tactical flexibility, and spring‑time confidence positions them as genuine title contenders. The next few weeks will determine whether Guardiola’s “alpha‑dog” energy can finally translate into the Premier League crown, or if Arsenal can rally to retain their lead.

The new academic term began in Gaza in late March, but the usual bustle of students catching buses to campus has been replaced by the stark reality of displacement.Israel’s relentless campaign has turned most university buildings into rubble and shelters, forcing a shift to online learning that many students in tents cannot access due to lack of electricity, water, food and reliable internet.Against this backdrop, a glimmer of hope has emerged. In the overcrowded al‑Mawasi district of Khan Younis, the US‑based NGO Scholars Without Borders has erected a makeshift “University City,” a wooden and metal structure designed to bring students back into a real lecture hall."Our mission is to bring education closer to students in a better environment," said Hamza Abu Daqqa, the organisation’s Gaza representative.The facility houses six halls that can accommodate up to 600 students each day. Powered by solar panels, it offers internet access, improvised green spaces and even a small business incubator to help students explore entrepreneurial ideas.University City operates on a rotating weekly schedule, allocating each day to a different institution so that multiple universities can share the limited space. Priority is given to courses that require hands‑on instruction, such as practical labs and discussion‑based classes.Prominent Gaza institutions—including the Islamic University, Al‑Azhar University and the Palestine College of Nursing—have already begun using the site.For many students, this is the first time in years they have set foot in a space that feels like a real university. "When I saw this place, I was amazed," said 20‑year‑old nursing student Mariam Nasr, who fled Rafah and now travels four kilometres on foot to attend classes.Another first‑year student, Amr Muhammad, echoed the sentiment: "Being here with other students, discussing and engaging in class makes a huge difference."The broader picture remains grim. UN experts have labeled Israel’s systematic targeting of Gaza’s academic sector as “scholasticide.” More than 7,000 university students and staff have been killed or injured, and over 60 university buildings have been completely demolished, according to the Euro‑Med Human Rights Monitor.Materials for University City were sourced entirely within Gaza, a testament to the community’s resilience amid soaring costs and scarce resources. Yet the initiative is hampered by the same blockade that restricts reconstruction supplies, fuel and safe transport.Students still face daily hurdles: damaged roads, limited cash, and unreliable transport—often relying on worn‑out vehicles, donkey carts or long walks. "My father could only give me eight shekels (about $2.64) for a ride," Mariam explained, highlighting the economic strain.Even once inside the halls, challenges persist. Power outages and unstable internet make it difficult to print materials or follow online lectures, forcing many to rely on old phones and intermittent connections.Nevertheless, the atmosphere inside University City is one of determination. "For medical education, in‑person learning is essential," said Dr Essam Mughari of the Palestine College of Nursing. "Seeing students gather again restores something vital."For students like Mariam, the drive to continue studying is deeply personal. "My cousin, a nurse, was killed when an airstrike destroyed her family’s house. I study to heal others and honor her memory," she said.While University City now serves hundreds daily, thousands of Gaza’s students remain without comparable facilities. Abu Daqqa stresses that the project is only the beginning: "We have built dozens of makeshift schools, but the need is far greater. Imagine what could be done if the needed resources were allowed through."

Sabrina Carpenter took the stage at Coachella, fulfilling a promise she made two years prior to headline the festival. Her set, dubbed 'Sabchella' by fans, was a maximalist production that rivaled Lady Gaga's iconic 2025 performance. The show featured a Hollywood Hills-style set, complete with big block letters in 4K vision, and a dizzying array of costume changes and performance elements. Carpenter's setlist included hits like 'Espresso' and 'Taste,' as well as new material, all delivered with her signature blend of humor and relentless energy. The production incorporated pre-filmed chapter breaks, complex choreography, and guest appearances by Will Ferrell, Susan Sarandon, and Samuel L. Jackson. While the show was sometimes overwhelming, Carpenter's live vocals shone, and her ability to slip into different characters and personas was on full display. Despite some technical issues and a few moments of overkill, Carpenter's performance was a triumph, showcasing her growth as a performer and entertainer. Her set was a testament to her dedication and creativity, with seven months of work reportedly going into the production. As she drove offstage in a vintage car, Carpenter had gloriously kept her promises to deliver a memorable Coachella performance.

The Final Window for Disrupt 2026 RegistrationThe clock is ticking on the most significant opportunity for tech professionals to attend TechCrunch Disrupt 2026. With savings of up to $500 expiring at 11:59 p.m. PT tonight, the window to secure a pass is closing rapidly. This is the last chance to lock in a discounted rate for an event that promises to define the trajectory of the tech industry in 2026.San Francisco’s Moscone West: The Epicenter of InnovationTaking over San Francisco’s Moscone West from October 13–15, Disrupt 2026 is set to be a three-day powerhouse of industry activity. It is not merely a conference but a curated ecosystem designed for those actively building the future. The venue will host a tightly focused experience where the noise of the market is filtered out, leaving only the signal of genuine innovation.Why 10,000 Attendees and 300 Startups MatterThe scale of the event is a key differentiator. With 10,000 founders, VCs, and operators expected, the density of opportunity is unmatched. Furthermore, 300+ startups will showcase their innovations across the venue, while the Startup Battlefield 200 pitch competition offers a high-stakes environment for emerging unicorns. This concentration of talent creates a unique market dynamic where deals are not just discussed—they are executed.Curated Connections Over Passive AttendanceThe value proposition lies in the quality of interaction. Unlike generic trade shows, Disrupt focuses on intentional connections—facilitating direct dialogue between founders seeking capital and VCs hunting for the next big idea. It is a venue where operators exchange real-world lessons on scaling and shipping what’s next. For aspiring innovators, it provides a front-row seat to tomorrow’s technology.The Strategic Value of Early AccessAs the deadline approaches, the opportunity cost of missing this event increases. Securing a pass now ensures access to the same high-profile speakers and networking pool, but at a significantly reduced cost. For any professional looking to align their 2026 strategy with industry leaders, this is the critical moment to act and step into the conversations that move the business forward.