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A new large‑scale randomized trial presented at the European Congress on Obesity in Istanbul indicates that the oral GLP‑1 antagonist orforglipron can help patients retain the majority of weight lost with injectable therapies such as tirzepatide (Mounjaro) and semaglutide (Wegovy).Trial Shows Oral Orforglipron Preserves Most Weight After Switching from InjectablesThe study, funded by Eli Lilly, followed 376 US patients who had been on tirzepatide or semaglutide injections for 72 weeks and then randomized them to a daily orforglipron tablet or placebo for an additional year.Participants were previously on weekly GLP‑1 jabs that typically produce 15‑20% body‑weight loss.After the injection phase, subjects were switched to oral therapy or placebo for 12 months.Primary endpoint: proportion of weight loss retained at 12 months.Quantitative Outcomes: 75% vs 49% Retention for Tirzepatide Users, 80% vs 38% for Semaglutide UsersWeight‑loss maintenance differed markedly between the pill and placebo groups:Tirzepatide cohort: 75% of lost weight retained with orforglipron vs 49% with placebo.Semaglutide cohort: 80% retained with the pill vs 38% with placebo.Secondary benefits—blood pressure, cholesterol, and glycaemic control—were also sustained in the pill arm.Implications for Obesity Management and Healthcare CostsExperts highlighted the broader significance:Dr Louis Aronne (Weill Cornell Medicine) emphasized that treating obesity directly can simultaneously improve glucose, lipid, and blood‑pressure metrics.Dr Marie Spreckley (University of Cambridge) noted patient preference for oral therapy due to convenience, storage, and lower cost.Dr Simon Cork (Anglia Ruskin University) warned that injectable GLP‑1 drugs, while highly effective, are expensive and limit long‑term accessibility for both private payers and the NHS.The findings suggest a potential shift toward oral agents that maintain efficacy while reducing financial and logistical burdens.Future Outlook: Oral GLP‑1 Therapies Could Redefine Chronic Obesity CareIf further trials confirm these results, orforglipron could become a cornerstone of chronic obesity management, enabling earlier intervention (BMI 25‑27) and possibly preventing progression to severe obesity.Regulators and payers will likely scrutinize cost‑effectiveness models, but the prospect of a cheap, daily tablet that sustains weight loss may reshape treatment algorithms worldwide.

Trump's Beijing Visit Marks First U.S. Leader in a DecadePresident Donald Trump departed for Beijing ahead of a two‑day summit with President Xi Jinping, the first U.S. head of state to set foot in China since 2017. The high‑stakes meeting comes after weeks of stalled U.S. attempts to enlist Beijing’s help in reviving Iran negotiations and easing tensions in the Strait of Hormuz.Trade, Technology and Taiwan: Core Bargaining ChipsThe agenda is expected to centre on four pillars: trade (especially U.S. agricultural exports and Boeing sales), advanced semiconductor and rare‑earth restrictions, the Taiwan question, and the Iran war. Washington will press China for higher purchases of U.S. goods, while Beijing will seek relief from U.S. export controls on chip‑making equipment and a loosening of rare‑earth export curbs.Economic Stakes: Tariffs, Rare Earths and Energy FlowsChina controls roughly 90 % of global rare‑earth refining, a critical input for chips, EVs and military hardware.The United States has imposed tariffs on some Chinese goods that have risen to above 100 % in the past year.China buys more than 80 % of Iran’s shipped crude, giving it leverage over Tehran’s oil revenue.U.S. officials hope to secure new Chinese purchases of American beef, soybeans and aircraft.Geopolitical Ripple Effects: Iran, the Strait of Hormuz and Global OrderAnalysts see the Iran conflict as a rare area of overlapping interest: both Washington and Beijing benefit from stable energy flows through the Gulf. However, Beijing is unlikely to fully align with U.S. pressure on Tehran, preferring to protect its own oil‑buyer relationship. The summit also tests the durability of the “strategic rivalry‑dependency paradox” that binds the two economies.What the Summit Could Signal for Future U.S.–China RelationsA “successful” outcome for Trump would be visible trade wins—new Chinese purchase commitments, limited tariff pauses, or a framework for rare‑earth cooperation—that can be sold to domestic voters ahead of the 2026 midterms. For Xi, success means preserving China’s strategic autonomy while extracting economic predictability without appearing to concede to U.S. demands. Most experts expect a limited, issue‑by‑issue agreement rather than a comprehensive deal, leaving the deeper structural rivalry largely intact but temporarily managed.

A Novel of Female Defiance"Yes, you will leave this place," the chorus of child protagonists in a community of sex workers say at the start of Tahmima Anam's incantatory and fiery new novel of female defiance, Uprising. "This story will save your life," we were told three times in Deepa Anappara's 2020 debut, also featuring precarious children dwelling in the margins. What is the distance between imagination and action, lived realities and dreams? How can solidarities be forged in such circumstances? Uprising holds within its pages some answers and a deep conviction – for a better life, a more just world – and then reaches out and fights for it.The Island Community and Its OppressionAs a journalist, Anam visited the infamous "floating brothel" Banishanta in Bangladesh; her new novel, set on an isolated island "at the end of the country, in the middle of a river that emptied into the sea", fictionalises the island's community and ecological precarity. Here, a generation of daughters grow up watching their mothers trapped in sex work – "we knew that the work was something that was paid for in money, and also in bodies" – and wish a different life for themselves. The women are controlled by the cruel Amma, who was once herself sold into sex trafficking. The victim becomes the perpetrator – and the children are discerning enough to know that their mothers are "not here because they had done something bad, but because something bad had been done to them". The first lesson of the island? No one is coming to save you – and living here changes you, as inexorably as the rising tides.The island is a prison. The mothers are ghosts of their former selves. The children, witnessing the "sexing", are all too grown up, stripped of their innocence. By the time they are born, their mothers' memories have faded "like paint in the sun"; they live on the island "tied to" their daughters. What, or who, will it take to break free from these chains?Feminism and Climate Crisis in LiteratureWhen the waters rise, customers stay away. The mothers speculate: "the swirling river was keeping the smaller boats from making the journey"; "the land was cursed". In a last-ditch attempt to lure men back for business, Amma sends for a new girl. Little does she know that Kusum Khan's arrival will signal the beginning of the end. A girl from the city with a history of participating in protests against the Dictator, she doesn't acquiesce to the island's rules, as the others have been conditioned to; instead, she sows the seeds for what will grow into a life-altering act of resistance. The children start to believe that she is their saviour – maybe even Bon Bibi, a legendary guardian of the forest. A different life seems graspable, just beyond the island's shore. When the titular uprising at last arrives, it summons an all-consuming storm, washing over the island. And the reader, too, is ready to join the revolution – their fist in the open air.Uprising is a feminist novel ("here they were: a wall of women") and a protest novel ("The moment Kusum entered the protest, she felt as if she was becoming a small organ in a living, breathing thing"). It is a coming-of-age novel, and a response to the climate crisis; a story of sisterhood protecting, and failing to protect; of structural inequality and the rotten core of patriarchal corruption; of unlucky women in an unfair world. "When the men came to reclaim the island, we stood rooted in place with our eyes closed, unable to watch. We stood rooted in place with our eyes open, unable to stop watching." While the mothers and daughters in Anam's fictional world are victims of specific generational violence, this observation can be applied to humanity at large: we are all watching – frozen, complicit – as injustices rise the world over.The Power of Rage and Radical HopeThrough her unwaveringly political and unflinchingly forthright novel, Anam shows the power of rage and radical hope. A new world can burn bright from the fires of injustice – and here, it's the mothers that hold the match.

Demi Moore warned at a Cannes press conference that the film industry “cannot fight” the rise of artificial intelligence, describing resistance as a losing battle and calling for collaborative approaches.The Cannes Jury’s Candid Take on AI’s Inevitable RoleDuring a Tuesday press conference, the actress – a member of the Cannes Film Festival jury – answered questions about AI’s impact on cinema. She said, “AI is here. To fight it is a battle we will lose,” and suggested that filmmakers should explore ways to work with the technology rather than oppose it.Absence of Quantitative Data Highlights Qualitative ConcernsThe discussion contained no specific financial figures or usage statistics, underscoring that the debate is currently driven by ethical and creative considerations rather than measurable market impacts.Implications for Filmmakers and the Regulatory LandscapeMoore expressed doubt that the industry is doing enough to protect creators, hinting at a need for stronger regulation.Fellow juror Park Chan-wook reinforced the idea that art and politics should not be divided, linking the AI conversation to broader questions of creative freedom.Screenwriter Paul Laverty warned of potential “blacklisting” in Hollywood, suggesting that AI‑driven content controls could exacerbate existing censorship pressures.Future Outlook: Collaboration Over ConflictMoore concluded that the “beautiful aspects” of AI can enhance filmmaking, but the “true art” will always come from the human soul. The prevailing view among the jury is that embracing AI as a tool, while safeguarding artistic integrity, will shape the next era of cinema.

Trump’s Beijing Arrival Sets Stage for a High‑Stakes SummitDonald Trump is scheduled to land in Beijing on Wednesday evening, marking the first visit by a U.S. president to China in nearly ten years. The two‑day meeting with President Xi Jinping is framed as a chance to restore U.S. prestige after the protracted war in Iran.Diplomatic and Business Agenda of the VisitThe delegation will include more than a dozen American business leaders, notably Elon Musk of Tesla and Tim Cook of Apple. Trump has promised a “big, fat hug” from Xi and expects headline‑grabbing deals, including a new board of trade to coordinate bilateral purchases.Economic Stakes: 500 Boeing Jets and a Fragile Trade Truce500 Boeing 737 Max jets are slated for sale – one of the largest orders in the aircraft maker’s history.The U.S. and China remain under a “fragile tariff truce” established last autumn.China’s economy is under pressure from sluggish domestic demand and a prolonged property crisis.Geopolitical Ripple: Iran War, Taiwan, and Global EnergyThe Iran‑Israel conflict has entered its third month, with Tehran tightening control of the Strait of Hormuz, a route that carries roughly a fifth of the world’s oil supply.Washington has sanctioned several Chinese firms for allegedly supporting Iranian oil shipments.Trump’s willingness to discuss U.S. arms sales to Taiwan could signal a shift in the long‑standing U.S. policy of not consulting Beijing on Taiwan matters.Looking Ahead: Scenarios for the Trump‑Xi DialogueAnalysts see three possible outcomes: a breakthrough that eases sanctions on China and secures Iranian de‑escalation; a stalemate that leaves the tariff truce intact but no substantive progress on Iran; or a deterioration that could reignite trade tensions and complicate U.S. commitments to Taiwan.

President Vladimir Putin announced on May 13, 2026 that Russia’s new Sarmat ICBM test was successful, branding it the most powerful missile ever built and signalling a major step in Moscow’s nuclear modernisation.Putin Announces Successful Sarmat Test LaunchState TV showed Sergei Karakayev, commander of Russia’s strategic missile forces, briefing the president on the test conducted on Tuesday. The Sarmat, dubbed “Satan II” in the West, is slated to enter combat service before the end of the year.Technical Specs and Performance ClaimsRange: exceeds 35,000 km (about 21,750 miles) via sub‑orbital flight.Warhead yield: claimed to be more than four times that of any current Western ICBM.Replacement goal: to supplant roughly 40 aging Soviet‑era Voyevoda missiles with higher precision.Development timeline: program started in 2011; prior to this test only one successful launch and a 2024 catastrophic failure were recorded.Strategic Implications for Global Arms ControlThe test occurs against the backdrop of the New START treaty’s expiration in February 2026, leaving the United States and Russia without a binding cap on strategic warheads. Both sides accuse each other of non‑compliance, and no successor agreement is in sight, raising concerns about a new arms‑control vacuum.U.S. officials, including former President Donald Trump, have floated the idea of a trilateral treaty that would also involve China, whose nuclear arsenal, while smaller, is expanding.Potential Trajectory of Russia’s Nuclear ModernisationRecent additions: Avangard hypersonic glide vehicle (already in service), Oreshnik IRBM (used in Ukraine), Poseidon underwater drone (final development stage), Burevestnik nuclear‑powered cruise missile.Strategic rationale: counter perceived U.S. missile‑defence shield and ensure second‑strike capability.Putin framed these developments as a response to a “new reality” where maintaining strategic parity is essential for Russia’s security.Outlook: Risks and Possible Diplomatic PathsAnalysts warn that the Sarmat’s deployment could accelerate a new arms race, especially if the United States expands its own missile‑defence and offensive capabilities. However, the urgency of re‑engaging in arms‑control talks may grow, as the lack of a treaty increases the risk of miscalculation.Future scenarios range from renewed high‑level dialogue leading to a multilateral framework that includes China, to a continued escalation where each side expands its nuclear arsenal to offset perceived vulnerabilities.

On 2026-05-13, a Chinese robotics firm introduced a manned robot capable of changing its configuration, drawing visual inspiration from the famed “Transformer” series. The prototype marks a notable blend of human‑operated control and modular design. Breakthrough Unveiling: A Transformer‑Style Manned Robot The robot is designed for a human operator to occupy the central cockpit. Its exterior can reconfigure, allowing it to shift between compact and extended forms. The demonstration highlighted the mechanical articulation that enables the transformation. Absence of Financial Data Leaves Valuation Open No pricing, production cost, or projected sales figures were disclosed during the event. The firm did not release any immediate investment or partnership announcements. Potential Ripple Effects Across Robotics and Automation Sectors Combining manned operation with modular form factors could broaden applications in construction, disaster response, and entertainment. The visual appeal may accelerate public interest and investment in advanced robotics. Competitors may explore similar hybrid designs to stay competitive. What the Next Steps Might Look Like for the Firm and the Industry Further testing will likely focus on safety, reliability, and control integration. Regulatory approvals for manned robotic platforms will be a critical hurdle. Successful commercialization could set a precedent for future shape‑shifting, human‑centric robots.

The Lead In a United States court, OpenAI chief executive Sam Altman has rejected claims from fellow tech mogul Elon Musk that he betrayed the artificial intelligence company’s original vision. Altman's Testimony On the witness stand on Tuesday, Altman instead framed Musk as a competitor obsessed with exercising control over OpenAI. “It does not fit with my conception of the words ‘stealing a charity’ to look at what has actually happened here,” Altman told the court. The Dispute Over OpenAI's Equity “An early number that Mr Musk threw out was that he should have 90 percent of the equity to start,” Altman told the jury. “It then softened, but it always was a majority.” The Impact on OpenAI's Future The outcome of the trial could determine the future of OpenAI, its leadership, and products like ChatGPT. As part of his lawsuit, Musk is pushing for the removal of Altman and Brockman. The Trial's Implications The trial comes as OpenAI prepares for a potential initial public offering that could see it valued at $1 trillion, a historically large sum. The AI industry has become a driver of eye-watering investment in recent years, with the United Nations estimating that the global market could be worth $4.8 trillion by 2033.

The President’s Departure and Upcoming Beijing SummitDonald Trump left the White House on May 12, 2026 aboard Marine One, bound for Beijing where he will meet Xi Jinping on Thursday and Friday. The trip marks his second visit to China as president and the first since his second term began on January 20, 2025.Contrasting Messages on Iran Amidst Trade FocusTrump gave mixed signals about the Iran‑Israel war, first saying a “long talk” will be held, then claiming Iran is “under control” and that the U.S. “won’t need any help.” Meanwhile, U.S. officials are downplaying the war’s prominence in the agenda.Trade Figures and Tariff Threats Highlight Economic StakesAbout 20 percent of global oil passes through the Strait of Hormuz, a route threatened by the conflict.Trump previously imposed tariffs of up to 145 percent on Chinese goods.In May 2026 he threatened a 50 percent tariff on China over a reported air‑defence shipment to Iran.Both sides aim to avoid a renewed tariff war and discuss new business deals, with CEOs Elon Musk and Tim Cook accompanying the U.S. delegation.Geopolitical Ripple Effects for US‑China‑Iran RelationsThe meetings are the first face‑to‑face exchange since the APEC summit in Busan (October 2025). China’s backing of Iran’s ballistic and nuclear programmes, and its alleged delivery of weapons, remain friction points. Xi is also expected to press on U.S. arms sales to Taiwan.What the Next Weeks May Hold for Bilateral TiesAnalysts expect the agenda to centre on trade, energy security, and mechanisms to keep the Strait of Hormuz open. A successful outcome could stabilize markets and temper Iran‑related tensions, while any stalemate may reignite tariff threats and deepen strategic mistrust.