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Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

Stephen Fry opened his appearance on ITV’s The Assembly with a startling question: “You tried to kill yourself a couple of times. Are you happy to be alive now?” The boldness set the tone for a conversation that veered far from the usual celebrity‑friendly script.The programme distinguishes itself by placing a well‑known guest in front of a panel of young adults with neurodivergence or learning disabilities. Free from the conventional safeguards of mainstream talk shows, the panel asks questions that are simultaneously unconventional and deeply human, prompting guests to respond without the usual rehearsed veneer.For Fry, the format proved liberating. Known for translating complex ideas into accessible language, he used the platform to discuss suicidal ideation, likening the experience to the lingering memory of a broken limb—painful yet now distant. This candidness allowed him to reaffirm why he remains a cultural touchstone.One of the most memorable moments came when a participant asked, “I read that you are bipolar. One of my family has that. How can I help them?” Fry responded with a vivid analogy, describing bipolar disorder as a “rainstorm raging inside you—eventually the sun returns, and it’s the weather, not the person, that changes.” This explanation resonated as both compassionate and educational.The interview oscillated between gravitas and levity. Fry fielded whimsical queries such as “Can you help me meet Céline Dion?” and “How much have you spent on cocaine?” alongside the probing “Are you a top or a bottom?” The juxtaposition amplified the emotional weight of the serious topics.At one point, a young panelist named Luca chose not to ask a question, instead performing William Wordsworth’s poem “The World Is Too Much With Us” with theatrical flair—a rare blend of poetry and performance that underscored the show’s experimental spirit.Another highlight involved Jacob, a panel member who brandished a list of Fry’s past advertising gigs—Heineken, Twinings, Honda, and more—before delivering the punchline, “Is there anything you wouldn’t do for money?” The extended joke built a collective laugh that softened the subsequent, more probing inquiries.Critics have likened the show’s tone to a hybrid of Radio 4’s In the Psychiatrist’s Chair and the cheeky, irreverent style of classic British comedy interviews such as those with Dame Edna Everage or Mrs Merton, creating a unique space where vulnerability and humor coexist.The episode concluded with Nina Simone’s “I Wish I Knew How It Would Feel to Be Free” playing as Fry reflected on his experiences with antisemitism and bipolar disorder. Moved by the music, he rose and danced, offering a visual testament to the therapeutic power of the format.The Assembly aired on ITV1 and is now available for streaming on ITVX.

Copenhagen returns to the London stage under Michael Longhurst’s direction at Hampstead Theatre, a timing the reviewer calls “terrifyingly timely.” The three‑hander dramatizes the 1941 encounter between Danish physicist Niels Bohr (played by Richard Schiff) and German scientist Werner Heisenberg (Damien Molony), set against the looming threat of Hitler’s nuclear ambitions. The production draws unsettling parallels to contemporary politics, invoking Donald Trump’s recent threats toward Iran as a modern echo of the era’s extremist rhetoric. This resonance, the reviewer notes, amplifies the play’s relevance alongside the theatre’s downstairs offering, ROI (Return on Investment), which also interrogates the morality of scientific discovery. Visually, Joanna Scotcher’s set is a striking, non‑realist circle surrounded by water—a subtle nod to the “heavy water” used in Nazi nuclear research and a poignant reminder of the personal tragedy that befell one of Bohr’s sons. The second half’s dense scientific dialogue is rendered accessible, though the reviewer argues it sometimes falls short of fully unpacking the deeper metaphors embedded in the science. Performance-wise, the age gap between Bohr and Heisenberg (Bohr being sixteen years senior) hampers the on‑stage chemistry. Schiff’s portrayal of the seasoned Bohr occasionally stumbles over lines, while Molony’s Heisenberg comes across as a brooding, almost adolescent figure. In contrast, Alex Kingston’s turn as Bohr’s wife and editor, Margrethe, provides the emotional core, shouldering much of the play’s affective weight. Thematically, the drama wrestles with the question of whether scientists bear a moral duty beyond their research. Heisenberg’s famed uncertainty principle is employed as a metaphor for the psychological ambiguity surrounding their historic meeting. Yet the script conspicuously omits any direct reference to the bombings of Hiroshima and Nagasaki, focusing instead on the fear of a Nazi atomic weapon and sidestepping the United States’ own nuclear legacy. While the production boasts compelling aesthetics and a thought‑provoking premise, the reviewer finds moments of sluggish pacing and a missed opportunity to confront the irony of overlooking the U.S. bombings, especially as contemporary concerns about American military assertiveness rise. The show runs at Hampstead Theatre, London until 2 May.

Delta Air Lines chief executive Ed Bastian told investors that customers should expect higher airfares as oil prices climb in response to the ongoing US‑Israel conflict with Iran. The carrier has already absorbed an additional $330 million in fuel costs and anticipates a further $2 billion increase in fuel expenses for the current quarter. Despite the cost pressure, Delta forecasts a 10% rise in revenue, citing robust passenger demand that it describes as a "healthy" travel environment. Bastian noted that the surge in demand is especially strong among affluent travelers who continue to purchase premium‑class seats. Other U.S. airlines have begun raising baggage fees, attributing the move to volatile fuel markets. Bastian suggested that such fee hikes could become a permanent feature of airline pricing, adding that "at this level of fuel pricing, it’s hard to call anything temporary." Oil markets showed a brief reprieve after Iran announced the reopening of the Strait of Hormuz under a two‑week cease‑fire agreement with the United States. Brent crude fell from roughly $110 per barrel to just under $95 per barrel, yet prices remain about $20 per barrel above pre‑conflict levels. U.S. carriers have felt the ripple effects of the conflict. Since the start of the year, American Airlines shares have slipped about 25% and United Airlines about 13%. United’s CEO, Scott Kirby, warned that fares could climb as much as 20% if fuel costs stay elevated, even as airlines strive to keep demand strong. Delta’s stock, which surged 17% last year, has been flat so far in 2026, reflecting both consumer resilience and the headwinds from the conflict. The shares did gain 6% in early trading on Wednesday. To mitigate fuel consumption, Delta plans to trim capacity on lower‑load midweek and overnight routes, mirroring a similar capacity‑reduction announcement from United earlier in the month. Bastian also highlighted that Delta has benefited from a "K‑shaped" economic recovery, where wealthier consumers continue to spend on travel while lower‑income households curb discretionary spending. "Our customers at the top of the K are still investing in travel," he told CNBC, emphasizing that premium travel remains a priority for this segment.

The Masters gnome drama has taken another twist, with Augusta National chair Fred Ridley admitting he is in the dark about the future of the must-have items. Despite repeatedly asking about the gnomes' status, Ridley revealed that there is internal secrecy even towards him.At the annual Masters media address, Ridley responded to a question about the gnomes' future, saying, "I've been asking that question for several years and they won't tell me the answer. So I can't help you." This has sparked intrigue about who is behind the decision-making process and why Ridley is being excluded.The Masters gnomes, which typically sell out within one hour, have become a highly sought-after item, with a resale value significantly higher than their $49.50 price tag. This has raised concerns among officials about the spectator experience in merchandise outlets.On a more serious note, Ridley maintained Augusta's position on a potential rollback of the ball, which has met resistance from equipment manufacturers and several leading players. He emphasized that Augusta's stance is "grounded on much more than protecting the Augusta National golf course" and that the club will continue to make modifications to react to increasing driving distances.

In a thrilling Champions League matchup, Arsenal claimed a crucial victory in Lisbon, with Kai Havertz scoring the winning goal in injury time after Gabriel Martinelli drew the defense. This win comes after Arsenal lost their previous two matches, making it a significant turnaround for the team.Elsewhere, Bayern Munich secured a win at the Bernabéu, with Trent Alexander-Arnold's perfect ball setting up Kylian Mbappé's goal. This result keeps the tie very much alive, with both teams still in contention.The podcast also discusses a big Easter of Football League action and pays tribute to Aaron Ramsey. Listeners can find Football Weekly on various platforms, including Instagram, TikTok, and YouTube.

Ian Cheshire, a seasoned City veteran and former CEO of Kingfisher, has been appointed as the new chair of Ofcom, the UK's media regulator. Cheshire, who previously served as the chair of Channel 4 until last year, will lead Ofcom through a critical period marked by rapid growth in online content and rising concerns over politically partisan broadcasting.Cheshire's appointment comes at a time when Ofcom is tasked with overseeing the implementation of the Online Safety Act, legislation aimed at regulating social media in the UK. He will serve a four-year term, pending approval from a parliamentary hearing. The new chair has expressed his commitment to effective regulation, stating that he has 'seen first-hand how much effective regulation matters – for consumers, for businesses and for the wider economy.'The technology secretary, Liz Kendall, praised Cheshire's 'proven track record of leading complex organisations through periods of significant change,' highlighting his suitability for the role. Cheshire's extensive experience includes leadership positions at Landsec, Barclays, and Debenhams. He is expected to succeed Michael Grade, who will step down at the end of the month.As chair of Ofcom, Cheshire will be responsible for guiding the regulator's efforts to ensure online safety and maintain fair and impartial broadcasting standards. His appointment was chosen over other candidates, including Margaret Hodge and Jeremy Wright. The role of Ofcom chair comes with an annual salary of £120,000 for a commitment of three days a week.

The author's concerns about AI were previously localized to her household income and the job market, but after reading the alarming article, she now worries about the bigger picture. The investigation reveals that AI is a power story as much as a technology story, with Sam Altman at its center.The chatbot, ChatGPT, created by OpenAI, was asked to summarize the key findings of the article, but its response was deemed neutral and lacking in substance. A human-powered summary, on the other hand, describes Altman as a corporate grifter whose actions could have world-ending consequences.The article highlights the dangers of AI, including the alignment problem, where AI uses its superior intelligence to trick human engineers and outmaneuver them. This could lead to AI seizing control of critical infrastructure, such as the energy grid, stock market, or nuclear arsenal.Elon Musk's 2014 tweet about AI being potentially more dangerous than nukes is recalled, and Altman's own blog post from 2015 warning about the risks of superhuman machine intelligence is mentioned. However, since OpenAI became mainly a for-profit entity, Altman has stopped discussing these risks and now sells the technology as a portal to utopia.The author concludes that the greatest danger we face is from a failure of imagination in understanding the vast gap between personal AI use and its potential use by governments, military regimes, or rogue actors. The chatbot's response to the author's concern about entering the permanent underclass is seen as wholly witless and without threat, highlighting the need for greater awareness and oversight of AI.

Wayne Koestenbaum's latest novel, 'My Lover, the Rabbi', defies expectations with its unapologetically obsessive prose and exploration of desire. The story centers around a man who works as an antique furniture restorer and his overwhelming desire for a man who works in a synagogue. This central fact is accepted by all characters, and the writing treats realist conventions with a kind of exalted scorn.The book's 188 chapters are short and plunge the reader into a world of carnality, confusion, and bizarrely specific detail. The title of the book is reiterated throughout, becoming almost a mantra. This insistent and anxious formality is at the heart of the book's uncanny life, matching style to subject in a brilliant and unconventional way.As the plot emerges, it seems almost 19th century in its storyline, with themes of infidelity, illegitimacy, madness, shopping, coincidences, and death. The narrator's need to discover the secret of his rabbi's attractiveness drives the plot, much like Proust's Swann. The mystery of the rabbi's allure and the death of his three-year-old son become central to the narrative, revealing vistas of unknowability.The book's whirlwind invention culminates in a final, fugue-like recapitulation, where the narrator's obsessive desire morphs into a vision of the unknowability of any object of desire. This gloriously original evocation explores what it might feel like to admit to the inability of love to triumph over death. Koestenbaum's writing is like that of the best kind of angel, unafraid to come down to earth and explore the complexities of human desire.