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A new large‑scale randomized trial presented at the European Congress on Obesity in Istanbul indicates that the oral GLP‑1 antagonist orforglipron can help patients retain the majority of weight lost with injectable therapies such as tirzepatide (Mounjaro) and semaglutide (Wegovy).Trial Shows Oral Orforglipron Preserves Most Weight After Switching from InjectablesThe study, funded by Eli Lilly, followed 376 US patients who had been on tirzepatide or semaglutide injections for 72 weeks and then randomized them to a daily orforglipron tablet or placebo for an additional year.Participants were previously on weekly GLP‑1 jabs that typically produce 15‑20% body‑weight loss.After the injection phase, subjects were switched to oral therapy or placebo for 12 months.Primary endpoint: proportion of weight loss retained at 12 months.Quantitative Outcomes: 75% vs 49% Retention for Tirzepatide Users, 80% vs 38% for Semaglutide UsersWeight‑loss maintenance differed markedly between the pill and placebo groups:Tirzepatide cohort: 75% of lost weight retained with orforglipron vs 49% with placebo.Semaglutide cohort: 80% retained with the pill vs 38% with placebo.Secondary benefits—blood pressure, cholesterol, and glycaemic control—were also sustained in the pill arm.Implications for Obesity Management and Healthcare CostsExperts highlighted the broader significance:Dr Louis Aronne (Weill Cornell Medicine) emphasized that treating obesity directly can simultaneously improve glucose, lipid, and blood‑pressure metrics.Dr Marie Spreckley (University of Cambridge) noted patient preference for oral therapy due to convenience, storage, and lower cost.Dr Simon Cork (Anglia Ruskin University) warned that injectable GLP‑1 drugs, while highly effective, are expensive and limit long‑term accessibility for both private payers and the NHS.The findings suggest a potential shift toward oral agents that maintain efficacy while reducing financial and logistical burdens.Future Outlook: Oral GLP‑1 Therapies Could Redefine Chronic Obesity CareIf further trials confirm these results, orforglipron could become a cornerstone of chronic obesity management, enabling earlier intervention (BMI 25‑27) and possibly preventing progression to severe obesity.Regulators and payers will likely scrutinize cost‑effectiveness models, but the prospect of a cheap, daily tablet that sustains weight loss may reshape treatment algorithms worldwide.

Canvas Reaches Agreement with Hackers to Purge Stolen Data Instructure, the parent company of the Canvas learning platform, announced that it has “reached an agreement with the unauthorized actor involved in this incident” to delete the data stolen in last week’s cyberattack that disrupted finals for students worldwide. Scope of the Breach: 9,000 Schools and 275 Million Records Affected 9,000 schools worldwide were threatened with data exposure. 275 million individuals’ personal information, including student IDs, email addresses, names and messages, were compromised. The hacking group ShinyHunters demanded a ransom by 6 May, later extending the deadline. Implications for U.S. Higher‑Education Operations and Cyber‑Risk Management The breach forced many U.S. colleges to lock out users, delay final exams and temporarily take Canvas offline, highlighting the platform’s central role in grading, coursework distribution and communication. Instructure’s chief information security officer Steve Proud confirmed that passwords, dates of birth, government IDs and financial data were not found in the stolen set, but the incident raised concerns about potential future publication of the data. What This Means for Future EdTech Security Strategies Instructure plans to work with “expert vendors” for forensic analysis, system hardening and a comprehensive review of the data involved. The company also received “digital confirmation” in the form of “shred logs” that the hackers destroyed remaining copies, though it acknowledged no absolute certainty of total erasure. Analysts suggest that the episode will push educational institutions to reassess vendor security contracts, invest in multi‑factor authentication and develop incident‑response playbooks tailored to large‑scale data breaches.

Executive Overview: Syringe‑Smuggled Ants in NairobiThe Guardian article reveals that Nairobi is emerging as a nexus for the illegal trade of giant harvester ants, which are being hidden inside medical syringes to evade detection. This unconventional smuggling method highlights a growing challenge at the intersection of wildlife trafficking and public‑health safety.How Syringes Enable the Giant Harvester Ant TradeAccording to the report, traffickers exploit the small, sealed nature of syringes to conceal live ants during transport. The method allows large numbers of insects to be moved discreetly through customs and local markets, bypassing traditional inspection procedures.Scale of the Illicit Ant MarketWhile precise figures are not disclosed, the article notes a noticeable increase in seizures and police investigations related to ant smuggling in Nairobi.Local markets are reportedly offering the insects for purposes ranging from traditional medicine to exotic pet trade.Implications for Public Health and BiodiversityThe practice poses dual risks: the potential spread of ant‑borne pathogens to humans, and the ecological impact of removing a keystone species from its native habitats. Kenyan authorities are urged to strengthen bio‑security protocols to mitigate these threats.Future Outlook: Regulation and EnforcementExperts cited in the Guardian piece suggest that tighter customs inspections, public awareness campaigns, and regional cooperation will be essential to curb the syringe‑based trafficking network. Ongoing monitoring will determine whether Nairobi can shift from a trafficking hub to a model for effective wildlife‑trade enforcement.

Charities Call for a New Clean Air Act Before the King's Speech More than 60 charities representing over 230,000 members have urged the incoming Labour government to introduce a Clean Air Act that would ban wood‑burning, remove diesel vehicles from roads and compel local councils to cut pollution. Details of the Lobbying Push and Proposed Measures The letter, signed by groups such as Mums for Lungs and led by founder Jemima Hartshorn, repeats Labour’s 2023 opposition promise to make clean air a human right. It calls for an outright ban on non‑essential wood‑burning stoves, a phase‑out of existing units, and support for rural households to switch to low‑carbon heating such as heat pumps. Financial and Complaint Data Highlight the Scale of the Problem Air‑pollution costs the UK economy about £27bn a year, linked to asthma, cancer and dementia. From August 2024 to August 2025, there were 15,195 wood‑burning complaints in England, yet only 24 fines were issued. Recent data show a surge in wood‑burner sales in urban areas, despite evidence that particles from wood are as toxic as coal‑derived emissions. Implications for UK Air Quality Policy and Rural Economies Experts such as Stephen Holgate, special adviser to the Royal College of Physicians, describe the lack of enforcement as a “disgrace”. The Stove Industry Association (SIA) has lobbied both the Scottish and UK governments, influencing the Future Homes Standard that currently permits wood‑burning installations in new builds. Industry spokespeople argue that a ban would “negatively impact the UK’s manufacturing and rural economies”, while charities stress the public‑health imperative. What the Next Parliamentary Session May Hold for Clean‑Air Legislation With the King’s Speech imminent, the pressure is on Labour to reverse the omission of a Clean Air Act from its manifesto. If the government adopts the charities’ recommendations, we could see the first statutory ban on wood‑burning and stricter diesel restrictions within the next year; otherwise, the status quo of voluntary guidance is likely to persist.

The Trump-Xi Summit: A Pivotal Moment in US-China Relations Donald Trump's state visit to China this week – the first by the US president in nearly a decade – comes amid a time of geopolitical upheaval, a new and intractable conflict in the Middle East, and a sometimes rocky relationship between the world's two major superpowers. There is much for Trump and Xi Jinping to discuss, but a few key issues are likely to dominate the agenda. Five Critical Issues on the Summit Agenda The high-stakes meeting between the two leaders addresses several pressing matters that could reshape the global landscape: The Iran Conflict and Hormuz Strait Crisis Trump is eager for China to lean on Tehran to advance peace talks and reopen the strait of Hormuz. To now, Beijing has sat back and watched the US struggle against Iran, at least publicly. But with about half of China's crude oil imports passing through the strait, Xi does want the waterway unblocked. China knows its exports will suffer if a global recession results from an oil supply crisis. Complicating the picture, the US this week put sanctions on several Chinese firms accused of assisting Iranian oil shipments and supplying satellite imagery allegedly used in Iranian military operations, claims that Beijing denied. Trump's arrival comes after Iran's foreign minister, Abbas Araghchi, visited Beijing last week. Taiwan: The Flashpoint in US-China Relations Beijing is keen to push the US on Taiwan, with Trump saying he is prepared to raise the issue of arms sales to the island, which China claims as a breakaway territory despite never having ruled it. In December, Trump authorised an $11bn arms package for Taiwan, the largest weapons sale ever to the island, but no shipments have been made yet. Xi may seek changes in how the US refers to Taiwan. Ideally, from the perspective of Beijing, this would be a statement from Washington "opposing" Taiwan's independence rather than "not supporting" it. Taiwan will be watching closely. Just two weeks ago, China's foreign minister in a phone call with Marco Rubio urged the US to "make the right choices" on Taiwan. With Trump known to veer off script, John Kirby, a former US state department and Pentagon spokesperson cautioned: "They just have to be so extraordinarily precise when you're talking about Taiwan because, quite frankly, the stakes are enormously high." The AI Cold War: Technological Supremacy at Stake China and the US are locked into a race on artificial intelligence that is becoming something of a technological cold war. In April, the White House accused China of stealing US AI labs' intellectual property on an industrial scale, claims Beijing denied. Meanwhile, Beijing has been frustrated by Washington's reluctance to allow Nvidia to export its most powerful processing chips to China. In January, the White House said Nvidia could export its second most powerful chip, the H200, but no shipments have been sent yet. Analysts and ethics leaders hope Trump and Xi will discuss non-binding AI guidelines, including sharing information about AI misuse and safety, which are seen as critical guardrails amid the advent of AI weaponry and military adoption. Trade War: Rare Earth Minerals and Economic Leverage Trump has repeatedly threatened China over trade, imposing tariffs above 140% last year. But Xi held some cards of his own and did not fold. Instead, China blocked exports of its rare earth minerals and magnets to the US. Trump, finally, backed down. The US has depleted notable levels of its weapons arsenal in the war against Iran, with many weaponry components requiring critical minerals that are linked to supply chains dominated by China. China is expected to announce purchases related to Boeing airplanes, American agriculture and energy, US officials have said. In turn, Beijing wants the US to ease curbs on exports of advanced semiconductors. Beijing also wants to reduce barriers to investment in the US, and hopes to establish a Board of Investment to match the Trump-back Board of Trade. Fentanyl: The Drug War and Political Posturing Fentanyl is a key item on Trump's agenda this week, Politico reported, citing an administration official granted anonymity to preview the closed-door sessions. The US has long accused Chinese businesses of knowingly supplying the chemical precursors to Mexican cartels who use them to make the drug. Trump knows that being seen to press China hard over fentanyl and precursors plays well with his Maga base. But Trump lost important leverage on the fentanyl front when China defied his tariffs threats. In March, the US and China clashed over fentanyl and trade at a UN drugs meeting. China wants to be removed from the state department's annual list of "major drug transit or illicit drug producing countries", due to be updated in September.

The Unparalleled Experience of CannesNothing prepares you for the shock that is the Cannes film festival: the adrenaline, the fatigue, the elation and the emotion, but also the hunger, the anger, the magic and the ridicule. For young cinephiles, and for almost everybody who works in the film industry, it is the mecca of cinema and has been so for nearly eight decades. Anyone going for the first time this week, as I did 25 years ago, should not listen to the old grognards – Cannes' battle-worn veterans – who will lament that the festival has become an abominable circus and swear this year will be their last. It is a circus, and you can bet they will be back for as long as their knees can take it. For there is nothing quite like it.From Resistance to Global Cinema HubBorn to counteract Benito Mussolini's Venice film festival, its first edition was planned for September 1939, but Adolf Hitler had other plans. The previous year, under pressure from Berlin and Rome, the Venice film festival's top prize, the Coppa Mussolini, was handed to Leni Riefenstahl's propaganda film Olympia, prompting the French, British and American delegates to walk out. Hence Cannes, conceived as the festival of the "free world". More than 80 years later, for all its sins, it has remained faithful to that founding promise.The Expansive Scale of Modern CannesOver the decades, Cannes has mutated into an ever-hungrier mammoth, needing more space, and more venues, as it attracts an increasing number of journalists and professionals. A purpose-built Palais des Festivals had to be erected in the 1980s. "The bunker", as we have come to call it, is not exactly beautiful but brutally efficient at managing Cannes' mind-boggling crowds. This year, about 40,000 accredited festival-goers are descending on the French Riviera from 140 different countries, with dozens of films selected across all sidebars. At the same time, the Marché du Film, running alongside the festival since the late 1960s, is gathering about 16,000 participants, with thousands of films and projects up for sale. Cannes is both a summit for the cinema elite and a giant film bazaar.Three Worlds Colliding at La CroisetteFor 11 days in May, three different worlds lead parallel lives – critics, deal-makers and red-carpet royalty – colliding almost by accident on the seafront boulevard known as La Croisette. Hundreds of critics watch multiple films a day with monastic discipline. When they give in to parties, they bitterly regret it the next morning. You can spot some of us sleeping through entire screenings; how some colleagues manage to review films is a mystery. I remember a well-known French critic who had such vivid dreams in the darkness that he became convinced they were scenes in the films. His reviews were full of brilliant analysis of moments that did not exist.We critics rush between screenings, press conferences, interviews, our desks and the bunker's free espresso machines, often forgetting to eat or even pee. Downstairs, in the bunker's basement, and in hotel suites and rented apartments, the film market runs day and night: buyers juggle numbers, producers charm, directors and screenwriters fight for their vision. Above them floats Cannes' top layer – stars and "talent" spending hours in hair and makeup before climbing the 24 steps of the red carpet in borrowed couture and jewellery. When people in the industry groan, "oh God, it's Cannes again", it is this collision of financial anxiety, choreographed glamour and sheer exhaustion they are bracing themselves for.The Magic and Meaning Behind the GlamourThese worlds sometimes collide in the most poetic or grotesque ways. One morning, rushing to my first screening at 7.30am, I was walking along the Croisette when I saw, coming towards me, slightly dishevelled in a tuxedo, Jack Nicholson on his way back to his hotel after a long night. I smiled, he smiled back. He was alone, no bodyguards, no chaperones. Those were the days. I also shared a lift with Takeshi Kitano in full samurai attire, and I will never forget turning into a hotel corridor and finding myself nose to nose with Max von Sydow – Ingmar Bergman's medieval knight from The Seventh Seal. My cinephile heart skipped a beat.One of my favourite sidebars in Cannes, alongside the competition where you watch the year's best crop of films, is Cannes Classics, showing restored world masterpieces and documentaries about cinema. I always start the festival there: it is the best way to reset and begin afresh. Then I am ready for the 10-day onslaught of motion pictures, and for the magic moment that precedes each Cannes screening – the festival's own jingle, a palm ascending the red carpet from underwater and then into the sky, lifted by the ethereal arpeggios of Camille Saint-Saëns's Carnival of the Animals.Cannes: Enduring Symbol of Cinematic ResistanceIn 1955, Cannes gave its first official Palme d'Or to Delbert Mann's Marty; half a century later I found myself befriending its wonderful star, Betsy Blair, on the Croisette. I had the joy of seeing Ken Loach twice climbing those steps to collect the Palme, escorted by police outriders from Nice airport as if he were a head of state. I watched Iranian directors Jafar Panahi and Mohammad Rasoulof showing films at peril to their lives. For all the craziness of the red carpet and the samurai outfits, Cannes never forgets that it was founded as a gesture of resistance. That, as much as the glamour and the exhaustion, is why we keep going back.

Study Shows Fetal Exposure to Vegetable Flavours Influences Post‑Birth PreferencesThe research team gave pregnant volunteers powdered kale or carrot capsules during the third trimester and later measured their children’s facial reactions to the same smells. Reactions were recorded via ultrasound before birth, repeated at three weeks, and again when the children were about three years old.Methodology: Kale and Carrot Powder Capsules Administered to Expectant MothersParticipants were asked to swallow a capsule each day containing either kale or carrot powder. The study avoided large volumes of juice, which many volunteers found unpalatable, opting for a low‑cost capsule format.Capsules administered in late pregnancy (around 32 weeks gestation).Initial chemosensory response captured with ultrasound imaging.Follow‑up assessments at 3 weeks and 3 years post‑birth.Sample Size and Observed Reactions Reveal Early Flavor MemoryAlthough the cohort was modest, the findings were consistent:12 children were observed at age three.Infants exposed to carrot powder smiled when presented with a carrot scent and grimaced at kale, and vice‑versa for the kale group.The same preference pattern was evident in the ultrasound scans before birth.These results suggest that flavour exposure in utero can create a durable chemosensory memory.Potential Public‑Health Benefits of Early Dietary ConditioningIf replicated on a larger scale, the approach could offer a low‑cost strategy for improving population nutrition:Reducing childhood resistance to vegetables may lower long‑term risks of obesity and diet‑related diseases.Capsules are inexpensive and could be integrated into routine prenatal supplements.The concept is adaptable to different cultural diets, as noted by the researchers’ interest in fish‑rich Japanese diets.Next Steps: Larger Trials and Cross‑Cultural ApplicationsThe authors acknowledge the need for a bigger, funded study to confirm the effect across diverse populations. Future research aims to:Expand the sample size to hundreds of mother‑child pairs.Test additional flavours and odourants, including artificial sweeteners.Explore policy pathways for incorporating flavour‑exposure capsules into prenatal care guidelines.Published in Developmental Psychobiology, the paper titled “Do Human Fetuses Form Long‑Lasting Chemosensory Memories?” opens a new avenue for early nutritional interventions.

ACCESS: Medicare’s First AI‑Enabled Outcome‑Based Payment Model Pair Team was announced on April 30 as one of 150 organizations accepted into ACCESS (Advancing Chronic Care with Effective, Scalable Solutions), a CMS initiative that launches on July 5. The program shifts reimbursement from traditional time‑based fees to payments tied to measurable health outcomes such as lower blood pressure or reduced pain, covering conditions like diabetes, hypertension, chronic kidney disease, obesity, depression, and anxiety. Revenue Scale and Funding Behind Pair Team Staff: roughly 850 clinical professionals, the largest community‑health workforce in California. Revenue: exceeds nine figures (>$100 million) annually. Capital raised: about $30 million from investors including Kleiner Perkins, Kraft Ventures, and Next Ventures. Patient reach: partnerships give access to ~500,000 potential patients, with a goal of 1 million within three years. Industry context: digital‑health funding hit its highest Q1 total since the pandemic, with AI firms capturing the bulk of new capital. How Outcome‑Based Payments Could Redefine Chronic Care Delivery The ACCESS model creates the first federal mechanism to pay for AI agents that monitor patients between visits, coordinate social services, and ensure medication adherence. Flora, Pair Team’s voice‑AI assistant, now handles 24/7 intake, referrals, and check‑ins, delivering hour‑long conversations that act as both clinical touchpoints and companionship for high‑needs patients. Peer‑reviewed research in the Journal of General Internal Medicine shows Pair Team’s community‑integrated approach cuts avoidable emergency and inpatient utilization, with one‑in‑four hospital visits and one‑in‑two ER visits averted for its members. Risks remain: the program funnels highly sensitive data into a federal system with a history of breaches, and past CMS innovation pilots have drawn criticism for increasing federal spending without delivering projected savings. What’s Next for AI‑First Health Providers Under ACCESS Batlivala argues that lower per‑patient reimbursement rates are intentional, forcing providers to adopt lean, AI‑driven operations. As the program scales, success will hinge on: Automating patient interactions to keep costs below payment thresholds. Demonstrating measurable outcome improvements across the covered chronic conditions. Managing data‑privacy concerns to maintain trust among vulnerable populations. Attracting additional capital as investors watch the first AI‑centric Medicare payment model unfold. If Pair Team and its peers can prove the model’s efficacy, ACCESS could become a template for nationwide AI‑enabled, outcome‑based reimbursement, reshaping how Medicare incentivizes technology in health care.

The Media Revolution The news industry is once again experiencing a revolution, one that is reshaping news for a new generation of consumers. This disruption transcends all news brands, impacting all journalists and all journalism, everywhere. The Shift in Consumer Behavior We're witnessing a significant shift in how consumers access news. TV news audiences have declined by nearly 4 million people in the past five years, while YouTube has seen a trebling of its news audience and TikTok a 10-fold increase. This shift is not just about platforms; it's about the rise of independent journalists and personalities. The Rise of Creator Journalism Independent journalists like Joe Rogan, Piers Morgan, and Emily Maitlis have built massive audiences on platforms like YouTube and Substack. Joe Rogan has 20.9m subscribers on YouTube, while Piers Morgan's Uncensored YouTube channel has gained significant traction. This creator journalism is not a sideshow; it's becoming the main event. The Data Analysis The global podcast market is projected to grow from $32bn to $114bn by 2030. The UK is Substack's second-largest and fastest-growing market, with over half a million people paying subscriptions directly to writers. The Impact Analysis This revolution matters because it's driven by commentary and conversation, and the established media has yet to break into this new world at scale. The challenge is clear: will we wake up to the existential nature of this great shift in our industry, or will we be left behind? The Prediction The established news media has everything it needs to succeed in this new world, including talented journalists, experienced experts, and brands that have meaning for audiences. However, success is conditional on whether the established media is willing to deploy those assets to win and not be left behind. The priorities are clear: restore trust, reconnect through authenticity, and reinvent the newsroom.