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The Breakthrough in Addiction Treatment Results from a new clinical trial published in JAMA Network Open this month show that a single dose of psilocybin could be an effective treatment for cocaine addiction. The study found that 19 participants who received psilocybin were more likely to abstain from cocaine than 17 participants who received a placebo of diphenhydramine, a common antihistamine. Participants in both groups worked with therapists to process their experiences, highlighting the importance of the therapeutic context alongside the medication. The Urgent Need for Cocaine Addiction Treatments Dr. Peter Hendricks, a behavioral health professor at the University of Alabama at Birmingham and lead author of the study, emphasized the critical need for effective treatments. Currently, there are no FDA-approved medications for addiction to cocaine or other stimulants like methamphetamine. Overdoses involving stimulants are killing more Americans, and according to the latest UN global drug report, cocaine deaths are rising globally as cocaine production reaches an all-time high. Understanding the Mechanism Experts believe psilocybin works by increasing neuroplasticity and psychological plasticity – the ability to change thinking and behavior. Addictions inherently involve resistance to changing rigid, impulsive behaviors, which psychedelics may help overcome. Unlike traditional addiction medications that target the same neurochemical systems as the substance itself, psilocybin produces a profound altered state of consciousness within a structured psychotherapy context. It acts more like a catalyst within a therapeutic process rather than a maintenance medication. Addressing Cocaine Withdrawal Symptoms Cocaine withdrawal symptoms are primarily psychological rather than physically painful, including bad dreams, agitation, depression, and cravings. This psychological nature may make psilocybin particularly effective for cocaine addiction, as it can facilitate shifts in perspective and self-compassion that help people change their behavior. The therapeutic framework allows individuals to process their experiences and develop new insights about their addiction patterns, potentially breaking the cycle of craving and use. Diverse Clinical Trial Participation This study is notable as the first psychedelic clinical trial to include a majority of Black participants. While many spiritual rituals involving psychedelics originated in Indigenous societies in Latin America and Africa, US psychedelic culture today is often associated with Silicon Valley and elite, white personalities. Dr. Hendricks specifically recruited participants who were dependent on cocaine and wanted to stop, rather than advertising for psychedelic enthusiasts. This approach likely reduced the "expectation effect" and produced more generalizable results. Future Research Directions A critical commentary published alongside the study noted that the results might not be generally applicable because the study excluded people with comorbid depression and anxiety. However, experts point out that psilocybin shows promise for treating both conditions. The success of this trial is a clear indication that psilocybin for cocaine use disorder is a promising treatment that should proceed to larger-scale clinical trials. As research continues, the medical community may gain more insight into how psychedelics can be integrated into addiction treatment protocols.

Israeli Naval Action Near Cyprus: Immediate DevelopmentsOn May 18, 2026, Israeli forces deployed naval assets to intercept a civilian‑led aid flotilla sailing from Cyprus toward the Gaza Strip. The flotilla, organized by several NGOs, was halted in international waters, and Israeli authorities cited security concerns related to potential weapon smuggling.Legal and Diplomatic Context of the InterceptionThe interception occurs against a backdrop of ongoing disputes over the legality of blockades and humanitarian corridors in the region. While Israel argues the blockade is a lawful security measure, critics contend that stopping a civilian aid mission violates international maritime law and could be deemed an act of aggression.Regional Reactions and Stakeholder PositionsCyprus: Government officials expressed concern over the safety of vessels operating from its ports and called for a diplomatic dialogue.United Nations: The UN Office for the Coordination of Humanitarian Affairs (OCHA) urged all parties to respect humanitarian access.NGOs: Aid organizations condemned the interception, warning it could delay critical supplies to Gaza.Potential Shifts in Humanitarian LogisticsThe incident may prompt a reassessment of maritime routes for delivering aid to Gaza. Alternative pathways, such as overland corridors through Egypt or air drops, could gain prominence if naval interceptions become more frequent.Outlook: How This Could Influence Future Aid OperationsAnalysts anticipate heightened diplomatic negotiations between Israel, Cyprus, and international bodies to establish clear protocols for humanitarian shipments. Continued interceptions could lead to increased pressure on Israel to modify its blockade policy, while NGOs may seek new partnerships to circumvent maritime obstacles.

The Lead: A Mis‑Timed Pandemic ThrillerGuardian reviewer Erin Kellyman returns to the plague‑infested screen in Woken, a 2023‑made post‑apocalyptic thriller that aims to ride the post‑Covid zeitgeist but ultimately falters under its own ambitions.The Narrative Setup: Amnesiac Survival on a Plague‑Ravaged IslandKellyman plays Anna, an amnesiac, heavily pregnant woman who awakens in a rundown cottage on an isolated island, unaware that a pandemic is sweeping the region. Guided by the unsettling neighbour Helen (Maxine Peake) and a dubious husband James (Ivanno Jeremiah), Anna’s reality unravels when infected castaways arrive on a swan‑shaped pedalo, prompting a violent confrontation that reveals the island’s true horror.Visual and Thematic Influences: Echoes of Children of Men and Social‑Realist Brit Sci‑FiDirector Alan Friel frames the story against brooding shale cliffs, using muted interiors and seagrass‑fringed impressionism to highlight Anna’s fragility. The film nods to the social‑realist British sci‑fi lineage of Never Let Me Go and Children of Men, especially in its bleak world‑building and the later shift toward clandestine labs, ligament‑weaving surgery units, and fascistic hazmat squads.Critical Verdict: Strong Performances Undermined by a Disjointed PlotWhile Kellyman’s “wide‑eyed, floundering” performance and Peake’s authoritative presence earn praise, the narrative never fully gels. The first half feels like “tepid domestic parlour games” dressed in visual flair, and the second half’s sci‑fi revelations feel regurgitated, making the film’s climax feel like a “certifiable debt” to its inspirations.Future Outlook: Post‑Covid Horror Must Find Fresh GroundWoken will be available on digital platforms from 25 May 2026, but its mixed reception signals that the genre needs more originality than pandemic‑centric melodrama. For filmmakers, the lesson is clear: compelling visuals and strong acting cannot compensate for a story that fails to innovate within an increasingly saturated post‑pandemic horror market.

The Lead: US-Nigeria Joint Military Operation Against ISILThe United States military's Africa Command (AFRICOM) has conducted additional air strikes against ISIL (ISIS) fighters in northeastern Nigeria in coordination with the Nigerian government. These "additional kinetic" strikes, which took place on Sunday and were announced on Monday, represent the latest in a series of collaborative military operations between the two nations targeting terrorist groups in the region.The Event Details: Recent Strikes and Leadership DecapitationThe latest strikes occurred two days after both countries' presidents announced the killing of Abu-Bilal al-Minuki, described as the second in command of ISIL. Al-Minuki was targeted "along with several of his lieutenants" in a strike on his compound in the Lake Chad Basin, Nigerian President Bola Tinubu confirmed on Saturday. US President Donald Trump first made the announcement in a social media post on Friday without disclosing specific details about the operation.Before pledging allegiance to ISIL in 2015, al-Minuki was a prominent Boko Haram leader, according to the Nigerian army. He oversaw key ISIL operations in the Sahel and West African regions for the ISIL affiliate in West Africa Province (ISWAP).The Strategic Context: Expanding US Military Presence in NigeriaThis latest wave of US-Nigeria coordinated attacks comes as dozens of US soldiers have been deployed to Nigeria in recent months to help fight against armed groups, engage in intelligence sharing, and provide technical support. Nigeria's Defence Headquarters spokesman Samaila Uba clarified that US soldiers will not play a direct combat role but will share technical expertise under the full command authority of Nigerian forces."The removal of these terrorists diminishes the group's capacity to plan attacks that threaten the safety and security of the US and our partners," AFRICOM stated in its announcement. "AFRICOM remains committed to leveraging specialized US capabilities in support of our partners to defeat shared security threats."The Regional Impact: Power Vacuum and Shifting AlliancesDennis Amachree, former director of the US Department of State Services in Nigeria, told Al Jazeera that the killing of al-Minuki "is going to create a huge vacuum in the leadership and financing of ISWAP as many top officers were decimated with him." This assessment suggests that the targeted strikes may have a more significant impact than initially apparent, potentially disrupting the operational capabilities of ISWAP in the region.The Nigerian government has previously rejected Trump's accusation of mass killings of Christians in the country, with analysts noting that people across all faiths, not just Christians, are victims of armed groups. This context highlights the complex nature of the security challenges in Nigeria and the broader Sahel region.The Future Outlook: Escalating Counterterrorism OperationsLast Christmas, US forces launched air strikes on ISIL-affiliated fighters in northwestern Nigeria. When asked if this was part of a broader military campaign, Trump told The New York Times: "I'd love to make it a one-time strike. But if they continue to kill Christians, it will be a many-time strike." This statement suggests a potential escalation in US military involvement in the region, contingent on perceived threats.As the US continues to expand its counterterrorism operations in West Africa, the coordination with regional partners like Nigeria will be crucial. The success of these operations in degrading terrorist capabilities while maintaining local sovereignty will likely shape future security partnerships in the region.

The Wedding TragedyDrone strikes by Mali's army have killed at least 10 civilians as they prepared to celebrate a wedding in the central region of San, marking another escalation in the conflict since armed groups launched a widespread coordinated assault late last month. The strikes on Sunday occurred during a security crisis after attacks on the military government's positions last month by fighters from the al-Qaeda-linked Jama'at Nusrat al-Islam wal-Muslimin (JNIM) and Tuareg separatists known as the Azawad Liberation Front (FLA).A resident of the Tene locality, where the strikes took place, told the AFP news agency that "10 of our children" were killed. "What was supposed to be a moment of joy in the village turned into immense sorrow," he said, speaking on condition of anonymity. "The tragedy occurred as the villagers were preparing the second edition of this traditional collective wedding, a major cultural event for this community," a security source who requested anonymity for safety reasons told AFP.The Escalating ConflictMali has been in a critical security situation since JNIM teamed up with rebels in the FLA in April. A deadly offensive on April 25 and 26 targeted strategic towns and killed the country's influential defence minister. Kidal and other towns and villages in the north have been captured and are now controlled by the FLA and JNIM, who have since imposed a blockade on the capital, Bamako.Another wave of attacks by al-Qaeda-affiliated fighters was also reported on May 7, killing at least 30 people in central Mali. The villages of Korikori and Gomossogou in the Mopti region were targeted. Mali, which is rich in gold and other valuable minerals, has been dealing with unrest since 2012. It has faced a deepening security crisis driven by the FLA, JNIM and the Africa Corps, a Russian government-controlled paramilitary that replaced the private Wagner Group.International InvolvementMali's former colonial ruler, France, and the United Nations had deployed soldiers and peacekeepers to the country to try to control the violence by armed groups, but Bamako expelled their forces after military coups in 2020 and 2021 and is now using Russian fighters instead. Al Jazeera's Nicolas Haque, who has reported extensively from Mali, had said, according to military sources, "the fighters involved in this coordinated attack are targeting military armed compounds", adding that "there is an unprecedented level of panic" in the military ranks.Haque told Al Jazeera he learned from witnesses that Russian mercenaries were "fighting in Bamako, around the airport, where they have one of their headquarters". Alex Vines, Africa director at the European Council on Foreign Relations, told Al Jazeera that Malian authorities appear to have been caught off guard by the latest wave of attacks.

The Bread Crisis in Gaza Standing in a long queue under the beating sun, 14-year-old Muhammed al-Roubi was waiting to buy bread. But there was a strong chance that, despite his patience, he would not get any. A flour and fuel shortage in recent weeks, brought on by Israeli restrictions on imports into Gaza, means that bakeries cannot produce as much bread as Palestinians in Gaza need. Shortages and Struggles Palestinians, the vast majority of them living displaced as a result of Israel's genocidal war on the territory, are instead forced to wait for hours in queues outside of the few remaining bakeries to get subsidised bread packages. "My uncle's family and ours live in the same house, and we share food, so we need a large amount of bread every day," said al-Roubi, who had come to the bakery with his cousin before separating and joining different queues. "That is why my cousin and I each stand in a separate line," he explained. "Some days, we return empty-handed because the bread runs out and there are too many people." The Impact of Israeli Restrictions The growing queues at the few remaining distribution points reflect the current decline in production levels, while demand continues to rise, driving increased prices and the growth of a black market. Ismail al-Thawabta, the head of Gaza's Government Media Office, said last month that the territory needs about 450 tonnes of flour per day, but that only 200 tonnes were coming in. Recent shortages stem from Israel's decision to close the crossings into Gaza on February 28, when Israel launched a joint war with the United States on Iran. The crossings partially reopened after a few days, but traffic through them has been limited. Multiple Crises in Gaza Gaza is facing multiple crises alongside the bread shortage, including a sharp decrease in cooking gas supplies, which were already limited. The provision of cooking gas, overseen by Gaza's Ministry of Economy through gas distributors and stations, has slowed from once every six weeks to once every three months due to the limited quantities Israel allows into the enclave. The price of firewood, an alternative fuel for cooking and baking, has also risen. The Future Outlook Having hardly recovered from the famine last year, Palestinians in Gaza fear that the expansion of the humanitarian crisis could mean a return to the hunger, which only ended with the October "ceasefire". "During the last famine, people were dying from hunger and for a piece of bread," said Maysar. "Did the world not see that? This crisis must be solved before it becomes worse."

The Weekend's Football Action: Key Talking PointsThe latest round of Premier League matches and the FA Cup final provided plenty of talking points for football fans, from Manchester City's cup triumph to Liverpool's injury concerns and the ongoing VAR controversies that continue to divide opinion.Shaw's World Cup Hopes After Impressive SeasonLuke Shaw's first goal in over three years for Manchester United was a further reminder of the left-back's capabilities. This has been his best season at Old Trafford having featured in all 37 league games thus far, leaving his injury-prone past forgotten. Considering Shaw's experience and quality, he should be considered for a spot at the World Cup. Thomas Tuchel does not have a vast array of riches in the position and Shaw's consistency has been key to Michael Carrick's turnaround at Old Trafford. "He deserves to go," said Carrick after the win against Nottingham Forest. "His consistency, his performances, his experience, his qualities. He's an excellent full-back." Nico O'Reilly is the current first choice for England and he has a very different profile from Shaw, having converted from playing as a central midfielder under Pep Guardiola. Tuchel may want to take Shaw to provide variety and reliability, which would be a sensible approach.VAR Controversy Continues to Plague the GameAnother weekend of football brought another VAR controversy, this time at Old Trafford. Let's get this out of the way, it was handball. In a game with more on the line this latest VAR aberration would be hoisted up by abolitionists as another egregious example of why football is no better for the involvement of Stockley Park. "I think we need to have a meeting together to understand when it is a handball," said a measured Vítor Pereira post-match. We need a meeting to understand what good process is. Accidental handball was the final ruling; not sure that matters when it leads to a goal, but whatever. From the original incorrect decision to award the goal, it took the VAR three minutes to look at the ball clearly striking Bryan Mbeumo's hand, then another 60 seconds for the referee, Michael Salisbury, to go over to the screen and look at it again, only to ignore the referral and decide he was right the first time. That is far too long to make the wrong call. Pereira neatly summed it up with another damning understatement: "A lot of the time we don't understand the decisions."West Ham's Fight Against RelegationWhile it was hard to argue with Nuno Espírito Santo's assessment that West Ham had "a bad performance and a bad day" at St James' Park, his team are not Championship-bound just yet. Tottenham only need a point against Chelsea on Tuesday to effectively ensure their survival owing to their far superior goal difference, but they last took a point at Stamford Bridge four years ago. Their record against Chelsea is not reassuring: they have lost their past five meetings on the bounce by an aggregate scoreline of 12-4, with eight defeats from their last 10. Chelsea's players will have the added motivation of auditioning for the newly appointed Xabi Alonso, not that they need another reason to make their opponents' lives miserable. It could still easily come down to the final day, when Spurs face another difficult fixture against Everton. Nuno can only grit his teeth, hope Chelsea do his side a favour and, assuming Spurs's horrible run in west London continues, rally his troops for a desperate last stand against Leeds.Liverpool's Injury Woes ContinueAston Villa's season high represented another sobering low for Liverpool. Arne Slot's side failed to hurt Villa and were weak in defence, leaking two more goals at set pieces. Liverpool were without nine first-team players, including Alexander Isak, their £125m marquee signing who was not risked with a minor problem but could return against Brentford on the last day. Isak's season has been symptomatic of Liverpool's struggles. Is it just bad fortune or have Slot and his side simply underperformed? The truth is probably somewhere in the middle. "I don't think it could come to anyone as a surprise that if you miss your pre-season and then break your leg that minor injuries can occur if you then start into Premier League games in that intensity," Slot said. "Just a bit of bad luck for him that in a moment of time he comes back, then Hugo [Ekitiké] gets injured and we need him more."Guardiola's Warning Against ComplacencyAfter Saturday's FA Cup triumph over Chelsea, the 17th major trophy of Pep Guardiola's decade leading Manchester City, he reminded his players to never be complacent. "The most important thing is that [winning] trophies is good. Know what it takes to compete and win but don't take it for granted," the City manager said. "You start to believe that you are special, you will not win the FA Cup. Special we are not. The moment that we think [that], we will not be in these places. That is one of the things that through the years, we were OK with: knowing how difficult it is to win."Chelsea's Wembley Woes ContinueChelsea's dressing room and boardroom have been in a constant state of flux since Todd Boehly's BlueCo bought the club in 2022, but one thing has remained the same: they have a dire recent record in cup finals at Wembley. In the first decade after the stadium reopened in 2007, Chelsea won five of their six cup finals under the arch. Saturday's 1-0 defeat to Manchester City was their eighth loss in nine finals since 2017. Scoring goals at Wembley has also proven hard going, particularly since the departure of Didier Drogba (five goals in his five Wembley cup final starts). Christian Pulisic was the last Chelsea player to score in a domestic cup final, against Arsenal in front of empty stands in 2020. That's five finals in a row without a goal. It is a dry spell that can be tied to a young squad's relative lack of experience, but that argument does not stand up if you take into account the seven goals fired in against Paris Saint-Germain and Real Betis in the Club World Cup and Conference League finals just last year. Xabi Alonso is unlikely to have European football to play with next season, putting even more emphasis on Chelsea ending their Wembley drought and filling their silverware quota in domestic competitions.What's Next in the Premier League RaceWith the season drawing to a close, several key fixtures remain that could determine the final standings. Tottenham's survival hopes hinge on their match against Chelsea, while Liverpool will be hoping to end their injury-hit season on a positive note against Brentford. Manchester City, meanwhile, will be looking to build on their cup success as they continue their pursuit of more silverware in the final weeks of the season.

Legal Threats Emerge Over UK‑US Drug Pricing AgreementCampaigners Global Justice Now and Just Treatment have issued a nine‑page “letter before claim” stating they will pursue a judicial review if the Department of Health and Social Care (DHSC) does not repeal a statutory instrument that lets the health secretary overrule the independent judgment of NICE on NHS drug prices.Statutory Instrument Gives Ministers Power to Override NICEThe secondary legislation came into force last month, granting ministers authority to direct how much the NHS should pay for certain medicines.Both groups argue this constitutes an “unlawful power grab” that breaches the Health and Social Care Act 2012.Former health secretary Andrew Lansley has also labelled the instrument unlawful.Opaque Cost Data Undermines Parliamentary ScrutinyMPs from multiple parties have criticised the government’s refusal to publish an impact assessment of the decade‑long UK‑US deal.No concrete figures on the long‑term cost to the NHS have been released, limiting debate in the Commons.Potential Erosion of NICE Independence Risks NHS Price ControlsNICE is globally respected for its independent cost‑effectiveness assessments.Overriding its recommendations could lead to higher drug prices for the NHS, undermining the mechanism that keeps “big pharma’s overinflated prices” in check.Campaigners warn the move jeopardises patient safety and democratic oversight.Future Legal Battles May Shape UK Drug Policy LandscapeIf the judicial review proceeds, courts will examine whether the statutory instrument conflicts with existing health legislation.Continued parliamentary pressure may force the government to renegotiate aspects of the UK‑US tariff‑free drug export agreement.The outcome could set a precedent for how future health‑related secondary legislation is crafted and scrutinised.

The Celestial DisplayKeep an eye on the western sky after sunset this week to watch a beautiful sequence unfold over several evenings. A young crescent moon moves first past Venus and then Jupiter, creating a chance to track the moon's movement through its orbit around the Earth.The Lunar JourneyThe chart shows the view on May 18 looking west from London at 22:00. The moon will be just 2.4 days old, and just 6.2% of its visible surface will be illuminated. Close to this slim arc of light, Venus will be shining brightly, unmistakable even in twilight.Jupiter sits a little higher and dimmer, but is still prominent. Finally, dimmest of all are the stars of Gemini; the twins, Castor and Pollux. Over the next few nights, the moon moves eastward, towards Jupiter, growing in percentage illumination as the angle it makes to the sun changes night after night.Optimal Viewing ConditionsFor the best chance of seeing the alignment, choose a viewpoint with an unobstructed western horizon. The crescent moon and planets will be visible to the naked eye, but binoculars may enhance the viewing experience by revealing more details of the moon's surface and the surrounding stars.A Global PerspectiveFrom the southern hemisphere, the view will be a little easier to see. At this time of the year, the ecliptic, the path followed by the sun, moon and planets, is tilted upwards more steeply from the horizon. This will place the conjunction higher in the sky at sunset, making it more accessible for observers in southern latitudes.