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A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Oil and gas markets rallied on Thursday as investors grappled with the shaky outlook for the two‑week Iran‑Israel ceasefire. Brent crude rose more than 2% to $96.77 a barrel, while New York light crude climbed nearly 3% to $97.23, still shy of the $100 threshold that many traders watch. The previous session had seen Brent plunge 13.29% to a four‑week low of $94.75. In the gas sector, the UK month‑ahead contract rebounded 1% to 115.35p per therm after a 15% drop the day before. European natural‑gas futures also recovered, edging toward €46/MWh from a five‑week trough of €45.30. The price uptick reflects growing scepticism about the durability of the ceasefire announced a day earlier by the United States and Iran, which included a pledge to reopen the Strait of Hormuz. UAE and Kuwait reported intercepting Iranian drones, and Iran’s parliamentary speaker accused the United States and Israel of breaching several agreement points. Iran’s Revolutionary Guards warned of a “regret‑inducing response” if Israeli strikes on Lebanon continue. The latest Israeli barrage killed at least 254 people and wounded 837, prompting the Fars news agency to note that oil‑tanker traffic through the strait had been halted. Former President Donald Trump used his Truth Social platform to threaten that U.S. forces would remain in the region until a “real agreement” is fully honoured, warning that any non‑compliance would trigger “stronger than anyone has ever seen before” military action. Asian equity markets reacted negatively: Japan’s Nikkei slipped 0.7%, South Korea’s Kospi fell 1.7%, and Hong Kong’s Hang Seng edged down 0.4%. In Europe, the FTSE 100 dipped 0.1%, Germany’s DAX fell 0.6%, France’s CAC 40 dropped 0.3%, and Italy’s FTSE MIB slipped 0.2%. The pan‑European Stoxx 600 trimmed 0.1% after a near‑4% rally the day before, while U.S. futures pointed to a lower opening on Wall Street. Deutsche Bank strategist Jim Reid noted that market stress has eased compared with 24 hours earlier, as the ceasefire news generated renewed optimism and reduced fears of a stagflationary shock. On the diplomatic front, White House press secretary Karoline Leavitt announced that Vice‑President JD Vance will lead a delegation to Islamabad, with initial talks slated for Saturday morning. Jefferies chief European economist Mohit Kumar argued that, despite its fragility, the truce is likely to hold because of the “mutually assured destruction” calculus. He added that both sides now see a ceasefire as the lesser‑evil, given the escalating costs of continued conflict and the strategic challenges of securing cheap drone interceptors and a reliable Hormuz passage.

Cheng Li-wun, chairwoman of Taiwan’s main opposition party the Kuomintang (KMT), used a high‑profile trip to mainland China to advocate for renewed dialogue with Beijing. On Wednesday she laid a wreath at Sun Yat‑sen’s mausoleum in Nanjing, invoking the revolutionary’s legacy of “equality, inclusiveness and unity” as a moral foundation for cross‑strait reconciliation. Her visit marks the first time a KMT leader has set foot in China in ten years. Cheng said the core values of Sun’s ideal—"all under heaven are equal"—should guide efforts to promote reconciliation and regional prosperity across the Taiwan Strait. During the trip Cheng also expressed hopes to meet Chinese President Xi Jinping, framing the potential encounter as a diplomatic test that could demonstrate the effectiveness of dialogue over deterrence. The timing of the trip is notable. It comes amid heightened friction between Taipei and Beijing, with China continuing to assert sovereignty over Taiwan while refusing to engage with President William Lai Ching‑te, whom it labels a “separatist”. Amid concerns that a distracted United States may be less able to guarantee Taiwan’s security, some Taiwanese voters view a thaw in relations as attractive. Wen‑ti Sung, a non‑resident fellow at the Atlantic Council’s Global China Hub, told Al Jazeera that a cordial photo‑op between Cheng and Xi could bolster the KMT’s argument that dialogue is more effective than military deterrence. Domestically, Cheng’s outreach occurs as Taiwan’s opposition‑controlled parliament has stalled a proposed $40 billion increase in defence spending. She acknowledged Taiwan’s democratic evolution, referencing the legacy of the “White Terror” period, while also praising China’s recent development achievements. The governing Democratic Progressive Party (DPP) sharply criticized the trip, accusing the KMT of undermining national security. Party spokesperson Wu Cheng argued that if the opposition truly seeks stability, it should stop blocking the defence budget increase. Neither Beijing nor Taipei formally recognises the other’s government, leaving any dialogue fragile and heavily politicised. Cheng’s visit therefore represents both a symbolic gesture toward historic ties and a contested move within Taiwan’s polarized political landscape.

The administration has confirmed a two‑week suspension of any imminent strikes on Iran, signaling a short‑term pause in hostilities. This move reflects a tentative step toward reducing immediate tensions, though officials did not elaborate on the conditions that would trigger a resumption of operations.

The fragile ceasefire between Iran and Israel faced a serious crisis on Wednesday as both sides presented conflicting accounts of the agreement. The development raised concerns about the potential collapse of the truce.Israel escalated its military operations in Lebanon, launching its heaviest attack yet on over 100 targets, resulting in at least 254 fatalities. This move directly contradicts the claims of Iran and Pakistan, who brokered the 11th-hour truce and asserted that the ceasefire included Lebanon.In response, Iran halted the passage of oil tankers through the Strait of Hormuz, citing an alleged Israeli breach of the ceasefire. The Fars news agency reported that oil prices had dropped sharply below $100 a barrel following the truce announcement, leading to a global stock market surge.The White House disputed Iran's claims about the closure of the Strait of Hormuz, calling the reports 'false' and stating that US President Donald Trump expected it to reopen 'immediately, quickly and safely.' The US signaled its continued adherence to the ceasefire, even as it threatened to unravel.Iran and the US have different interpretations of the agreement. Trump conveyed a version suggesting a 15-point proposal from the US, which included no enrichment of uranium and the destruction of Iran's highly enriched uranium stockpile. In contrast, Iran's 10-point plan, which Trump initially referred to as a 'workable basis for negotiation,' included the right to enrich uranium and the full lifting of sanctions.The US and Iran are set to engage in talks in Islamabad, Pakistan, this weekend, with a US negotiating team led by Vice-President JD Vance. The talks aim to cement the ceasefire into a more durable peace agreement, but significant gaps remain to be bridged.The situation in the Gulf remains fragile, with the US and Israel claiming to have destroyed Iran's industrial base and significant military assets. Iran, on the other hand, portrays the truce as a victory, with senior politician Ali Akbar Velayati stating that 'America was forced to accept a ceasefire.'

British computer scientist Adam Back has vehemently denied claims that he is the elusive creator of Bitcoin, known as Satoshi Nakamoto. A recent report in the New York Times had suggested that Back was Nakamoto, but he quickly took to social media to refute the claims. In a thread on X, Back stated, 'I also don’t know who satoshi is, and I think it is good for bitcoin that this is the case, as it helps bitcoin be viewed [as] a new asset class, the mathematically scarce digital commodity.' This denial comes after a years-long effort to unmask Nakamoto, the mysterious author of the bitcoin white paper which laid the theoretical foundations for modern digital currencies. The speculation surrounding Nakamoto's identity has been ongoing for years, with previous attempts pointing to Nick Szabo, Hal Finney, and an 'unknown Australian genius' who was later revealed to be a fraud. The latest trail led to Back, a London-born computer scientist and entrepreneur, who was a member of an online anarchist cryptography community called the cypherpunks in the early 1990s. Journalist John Carreyrou claimed to have found similarities between Back and Nakamoto by analyzing decades of old internet postings and shared niche interests. However, Back attributed the similarities to 'a combination of coincidence and similar phrases from people with similar experience and interests.' Not everyone is convinced by Back's denial, with some speculating that he may still be Nakamoto. Stephen Murdoch, a professor of computer science at University College London, noted that while there are indications that it could be Back, 'there’s no smoking gun.' Meanwhile, Dr. Jacky Mallett, an assistant professor of computer science at Reykjavík University, suggested that Satoshi was 'almost certainly more than one person,' citing updates to the bitcoin code that suggest multiple contributors. Back is the owner of a bitcoin treasury firm that is merging with a publicly traded company. If he were indeed Nakamoto and the owner of 1.1m coins worth tens of billions of pounds, he would have to disclose this to the Securities and Exchange Commission, as it could materially affect the bitcoin market.

Arthur Rosenfeld, 73, and Meryl Tankard, 70, open the performance by introducing themselves as “sprightly old geezers,” setting a tone of candid humor that runs through the evening. The production, ‘Kontakthof – Echoes of 78,’ is a fresh staging of Pina Bausch’s iconic 1978 work, now re‑imagined by Australian choreographer Meryl Tankard. Unlike the 2010 London run that split the piece between teenagers and senior amateurs, this rendition features the eight surviving members of the original cast—all now in their late sixties to early eighties—performing the very roles they created half a century ago. A ninth dancer was absent due to illness. Their live movements are mirrored on a large screen by the black‑and‑white film of the 1978 performance, creating a visual palimpsest where past and present dance together. The choreography, set to 1930s dance‑hall songs, remains a wry commentary on courtship, power dynamics and consent. Tankard’s direction emphasizes the passage of time, allowing audiences to witness the same steps executed by bodies that have aged, yet retain a striking vitality. Dancers such as Josephine Ann Endicott, now in her seventies, glide across the stage in silk dresses, their frames more fragile but their confidence undiminished. Moments of poignancy arise when the film shows cast members who have since passed away. Onstage, John Giffin reaches for his late partner’s face, only to grasp empty air—a visual metaphor for loss that resonated deeply with the audience. Personal revelations punctuate the performance: Beatrice Libonati, 71, describes herself as “paranoid and a misanthrope,” while Tankard admits, “I wish I’d had children; I miss my mother every day,” underscoring the undercurrent of longing that runs through the piece. Beyond its narrative, the production offers a meditation on continuity. Bausch’s signature walking patterns—slow circles and linear traverses—are repeated, suggesting that despite changing bodies, the human species continues to tread familiar social routes. The music, unchanged from the original, carries on until the final dancer pauses, symbolising the inevitable end of the dance of life. The show runs at Sadler’s Wells, London through 11 April, offering a rare glimpse into how art can bridge generations and celebrate the endurance of the human spirit.

Bruce Miller returns as showrunner to bring Margaret Atwood’s 2019 novel The Testaments to the screen, positioning it as a direct sequel to the acclaimed series The Handmaid’s Tale. The new eight‑part drama, now streaming on Disney+, shifts the narrative focus to the next generation of women living under Gilead’s regime. While the series adopts a lighter, almost YA‑ish tone compared with its predecessor, the underlying brutality remains unmistakable. Viewers are confronted with “bloody punishments, rotting corpses on gibbets and relentless indoctrination,” now filtered through the eyes of teenage protagonists. The visual palette expands beyond the iconic red, white and green of the original. Young girls of privileged status appear in pink dresses and cloaks, older students—dubbed “Plums”—wear purple headpieces that are more stylish than the oppressive bonnets of the handmaids, and menstruating women are marked by a teal hue, signaling a grim rite of passage. Central to the story is Agnes (Chase Infiniti), the adopted daughter of Commander MacKenzie and the secret first child of June/Offred. Her journey intertwines with that of Daisy (Lucy Halliday), a “Pearl Girl” recruited from outside Gilead, whose mysterious background fuels the series’ central mystery. Ann Dowd reprises Aunt Lydia, now presiding over an elite preparatory school where she tasks Agnes with mentoring Daisy. Their evolving relationship, alongside flashbacks that flesh out Aunt Lydia’s own history, anchors the ten‑episode arc. Beyond the personal dramas, the series continues to examine groupthink, systemic corruption and the subjugation of women. Scenes such as Agnes kneeling before her father in newly‑colored robes starkly echo real‑world teenage experiences of power dynamics, albeit in a far more visceral setting. Occasional moments of dark humour provide brief relief, but the overarching message remains clear: the mechanisms of oppression are timeless, and the fight for autonomy persists across generations. The Testaments is now available on Disney+, offering both fans of the original series and newcomers a stark reminder of how dystopian fiction mirrors historical and contemporary tyrannies.

The White House has firmly denied that it has any plans to use nuclear weapons against Iran, amid escalating tensions and a looming deadline imposed by President Donald Trump. Trump has warned that if Iran does not capitulate to his demands, a 'whole civilisation will die tonight'.The denial from Washington came as Trump employed apocalyptic language, insisting that Iran must make a deal or face a massive onslaught. The original ultimatum was made by Trump on Saturday, demanding that Iran open the Strait of Hormuz, through which about a fifth of global energy exports pass, or face an assault on key infrastructure.The deadline falls at 8pm Eastern time (00:00 GMT), and legal experts warn that targeting civilian infrastructure could amount to a war crime. Texas Democratic Congressman Joaquin Castro called on Trump to immediately clarify that he is not considering using nuclear weapons.Vice President JD Vance later stated that US forces could employ tools they 'so far haven't decided to use', sparking concerns. The Iranian response has been defiant, with the Islamic Revolutionary Guards Corps (IRGC) vowing to respond in kind if the US attacks civilian facilities.Iran has proposed a 10-point peace plan to end the war, which Trump called a 'significant step' but 'not good enough'. The situation remains volatile, with Israel-US strikes on Iran and Iranian attacks across the region and Israel intensifying.