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A phase‑3 trial of retatrutide, a once‑weekly triple‑hormone injection, showed patients with type 2 diabetes cut HbA1c by up to 1.9 percentage points and shed up to 15 % of body weight after 40 weeks.Triple‑Hormone Mechanism Sets Retatrutide ApartThe drug combines analogues of GLP‑1, GIP and glucagon, targeting appetite, glucose regulation and energy expenditure simultaneously. Unlike Ozempic or Wegovy (GLP‑1 only) and Mounjaro (GLP‑1 + GIP), the added glucagon activity aims to boost metabolic rate.Trial Numbers Reveal Double‑Digit HbA1c Cuts and 15% Weight Loss930 adults with type 2 diabetes, BMI ≥ 23, not on other diabetes meds.Randomised to 4 mg, 9 mg or 12 mg retatrutide or placebo for 40 weeks.HbA1c reduction: 1.7‑1.9 pp vs 0.8 pp placebo.Weight loss: 11.5‑15.3 % vs 2.6 % placebo.Improvements in cholesterol and blood pressure observed.Serious adverse events in 14 participants (including 2 on placebo); most side effects were mild gastrointestinal issues.Potential Shift in Diabetes‑Obesity Treatment LandscapeExperts say the dual impact on glycaemic control and weight could reshape management pathways. Dr Kath McCullough (Royal College of Physicians) called the results “life‑changing,” while Dr Marie Spreckley (University of Cambridge) cautioned that head‑to‑head data against existing agents are still needed.For health systems such as the NHS, a drug delivering both outcomes may reduce long‑term cardiovascular complications and associated costs, but pricing and safety profiles will drive adoption.Next Steps: Head‑to‑Head Comparisons and Long‑Term SafetyFurther phase‑3 studies are planned to compare retatrutide directly with semaglutide and tirzepatide. Regulators will scrutinise the balance of metabolic benefits against gastrointestinal adverse events before approval.

Pakistan's Diplomatic Mission to IranPakistan's Interior Minister Mohsin Naqvi has travelled to Iran to deliver a "special letter" to Iran's Supreme Leader Mojtaba Khamenei as part of diplomatic efforts to end the United States-Israeli war on Iran, which began 100 days ago.Naqvi arrived in the Iranian capital, Tehran, late on Saturday, and met his Iranian counterpart, Eskandar Momeni. The two discussed the "latest regional developments and matters related to internal security", among other issues, Naqvi said on social media. Before his arrival, Iranian media reported that the Pakistani official was carrying a letter from his country's army chief and prime minister for the supreme leader.Rising Tensions in the Gulf RegionHis visit comes amid renewed tensions in the Gulf region. On Sunday, the US Central Command (CENTCOM) said its forces had shot down two Iranian one-way attack drones "that threatened international maritime traffic in the Strait of Hormuz".On Friday, it said it intercepted seven ballistic missiles heading towards Kuwait and Bahrain hours after it had shot down four Iranian drones launched towards the strait, a key waterway through which about 20 percent of globally traded oil normally passes. United States forces said they "subsequently" struck Iranian coastal surveillance radar sites in Garuk and on Qeshm Island "to defend against further maritime attacks".The attacks drew the ire of Gulf nations that are bearing the brunt of a war they lobbied against. Bahrain denounced the latest attacks as "blatant aggression". The island nation hosts the headquarters of the US Fifth Fleet. Kuwait said the attacks "represent a dangerous escalation". Egypt, Jordan and Qatar joined the condemnation.Stalled Peace NegotiationsDespite tit-for-tat attacks and sporadic exchanges of fire, negotiations over a deal to end the war are continuing, but an agreement remains elusive.US President Donald Trump has alternated between threatening a renewed military campaign and expressing optimism about a diplomatic breakthrough. On Wednesday, he said an agreement could be finalised over the weekend.But Iranian officials have offered a more cautious tone. "The negotiations are at a deadlock, and Trump must break this deadlock," Mohsen Rezaei, military adviser to Iran's supreme leader, told US media outlet CNN on Saturday. He also called for the release of about $24bn in frozen Iranian assets.Key Obstacles to PeaceThe unfreezing of Iranian assets is one of the key sticking points in ongoing talks. On Wednesday, media reports said US Treasury Secretary Scott Bessent was considering using them to support rebuilding efforts in the Gulf caused by Iranian attacks."The Treasury will utilise all tools available to allow Iranian assets to be made available to our Gulf allies to support rebuilding and repairs for any future damage caused by Iran," a US official told several news agencies.Other sticking points include an end to hostilities across all fronts, including Lebanon; sanctions waivers on crude exports; the lifting of a US port blockade; and leverage over the Strait of Hormuz.Global Energy Security at RiskIran has blocked the narrow waterway since the US and Israel launched the war on February 28. Tehran responded by firing waves of drones and missiles at Israel, US targets in the region and neighbouring Gulf countries.It declared the Strait of Hormuz closed and threatened to attack vessels transiting through the narrow waterway without its permission. Its effective control of the trade chokepoint sent oil and gas prices to a multi-year high and threatened global supplies.Armed hostilities largely subsided after the temporary Pakistan-mediated ceasefire began on April 8. Direct talks in Islamabad broke down on April 12, and the two sides have exchanged a series of proposals to end the war via Pakistan since then. However, several flare-ups since have led to growing fears that full-scale fighting could resume.

The Final Curtain: A Pivotal Moment in Music HistoryThe Beatles' last official concert on August 29, 1966, at Candlestick Park in San Francisco marked more than just the end of a touring era—it symbolized a fundamental shift in how music would be created and experienced. As Jim Marshall's photographs capture, the band was already feeling nostalgic for what they were leaving behind, even as they stood on the precipice of their most innovative period.The Creative Divide: Studio Innovation vs. Live PerformanceTwo months before their final show, the Beatles had completed recording "Revolver," an album that would push the boundaries of popular music. Yet during their final tour, they performed none of these groundbreaking tracks. The complexity of songs like "Eleanor Rigby" and "Tomorrow Never Knows" simply couldn't be replicated in a live setting with their four-piece band configuration.This creative divide reveals a crucial moment in music history. Until the Beatles, recordings were essentially documentation of live performances. Their first album, "Please Please Me," captured songs honed on stages in Hamburg and Liverpool. By 1966, however, the Beatles had come to see the studio as a creative platform in its own right—a place where experimentation with sounds and techniques could create something entirely new.The Changing Landscape of Live MusicWhile the Beatles were pioneering studio techniques, other artists were revolutionizing the live concert experience. Bob Dylan and the Rolling Stones were developing what we now recognize as the modern rock gig—longer performances, more artistic expression, and a direct connection with audiences that extended beyond simple entertainment.The Beatles' live shows, by contrast, remained stuck in the past. Their 1966 concert format resembled a package-tour variety show, with five or six acts and the Beatles appearing last for a breathless half-hour set before saying goodnight. This disconnect between their recorded work and live performances became increasingly unsustainable as their studio work grew more ambitious.The Legacy of the Final TourThe Beatles' decision to stop touring wasn't merely a practical response to the challenges of performing complex music live—it reflected a deeper artistic evolution. By focusing on studio innovation, they paved the way for future artists who would similarly embrace recording technology as an integral part of the creative process.Ironically, this decision that seemed to separate them from their audience would ultimately transform how musicians connected with fans. The studio innovations pioneered by the Beatles during this period would influence generations of artists, creating new possibilities for musical expression that continue to resonate today.The End of an Era and the Birth of a New Musical LanguageThe Beatles' final tour marked not just the end of an era for the band, but a turning point for popular music as a whole. As they transitioned from live performers to studio innovators, they helped create a new musical language that would define the decades to come.The photographs from this period, capturing the band at this transitional moment, serve as a visual document of one of music history's most significant transformations. They show a group on the cusp of their most creative period, already looking back with nostalgia at the live performances that had made them global superstars, while simultaneously embracing the future possibilities that studio recording would unlock.

Lead: The United States Central Command reported shooting down a pair of Iranian drones threatening the Strait of Hormuz, a move that coincided with Tehran firing missiles at Bahrain and Kuwait and a flurry of diplomatic activity involving Pakistan’s interior minister. The latest exchanges underscore a volatile cease‑fire that was only agreed on April 8, while humanitarian and economic pressures mount across the Gulf. Escalation at the Strait of Hormuz: US Forces Down Two Iranian Drones The US military confirmed that two Iranian drones were intercepted and destroyed after they "threatened international maritime traffic" in the strategic waterway. Iran’s Ministry of Foreign Affairs condemned the action as a "flagrant" violation and accused Washington of "hostile and provocative behaviour". Pakistan’s Interior Minister Mohsin Naqvi arrived in Tehran on a diplomatic mission, carrying a "special letter" from Pakistan’s army chief and prime minister, according to ISNA. Missile Barrage Targets Bahrain and Kuwait Amid Fragile Ceasefire In retaliation, Iran launched a salvo of missiles aimed at US allies Bahrain and Kuwait, drawing condemnation from Gulf states. The attacks come as the cease‑fire, brokered on April 8, shows signs of unraveling under continued tit‑for‑tat threats. Financial Levers: $24 billion Frozen Assets and Asset‑Redirect Plans A US source told Reuters that Washington plans to redirect Iranian assets to Gulf states for reconstruction and repair of damage caused by Iran. Mohsen Rezaei, adviser to Iran’s supreme leader, told CNN that a peace deal hinges on the release of $24 billion in Iranian assets frozen by the US. The US also denied visas to 15 members of Iran’s World Cup delegation, citing security concerns. Regional Ripple Effects: Casualties in Lebanon and Gaza Two Lebanese army officers and a soldier were killed in an Israeli strike on a military vehicle in south Lebanon. Hezbollah claimed to have hit an Israeli command headquarters in Naqoura with Ababil drones. In Gaza, the death toll rose to 10 after a drone attack killed a man and his son in Gaza City. What the Next Hundred Days May Hold for the Gulf Flashpoint Analysts warn that the combination of military skirmishes, asset‑freeze negotiations and diplomatic overtures could either push the parties toward a negotiated settlement or trigger further escalation. Pakistan’s involvement may open a back‑channel for de‑escalation, but the parallel conflicts in Lebanon and Gaza add layers of complexity. Continued disruptions to the Strait of Hormuz would threaten global oil and gas shipments, pressuring international markets to seek alternative routing.

The Lead: Spain's Coaching Philosophy Finally Gains Recognition As Spain prepares for the World Cup, national team coach Luis de la Fuente reflects on the journey that took him from teaching in the Spanish federation's classrooms to leading his country to European Championship glory. The coach who never played for the senior national team has overseen a generation of Spanish football that has produced some of the world's most successful coaches and players. The Coaching Classroom: Where Spain's Football Leaders Are Born On the ground floor of the Spanish football federation's headquarters in Las Rozas are two classrooms covered with photos of everyone who has played for la selección. More than 800 men are there, but Luis de la Fuente's picture is missing—his international playing career only took him as far as the under-21s. This is where he taught; it is also, he says, where he learned, his pupils not alone in going on to big things. De la Fuente spent three years teaching at the federation from 2017, while also coaching Spain's under-19s and under-21s. He taught two subjects on the federation's Uefa pro licence coaching course: the evolution of football and team building. In his classes sat future coaching greats including Lionel Scaloni, Xabi Alonso, Xavi Hernández, and Raúl—names that would go on to shape football at the highest levels. The Global Impact of Spanish Coaches From Spain it was not only Fabián Ruiz, David Raya and Martín Zubimendi who were in Budapest recently but also the managers: Luis Enrique, De la Fuente's predecessor, and Mikel Arteta. The week before, Unai Emery lifted the Europa League. Pep Guardiola bade farewell as perhaps the most influential coach the Premier League has had. And Xabi Alonso has been appointed at Chelsea, Andoni Iraola at Liverpool. "This is a process that goes back a long time; at last it seems people are starting to appreciate it," De la Fuente says. "That appreciation should have happened ages ago. With trophies, it becomes more visible but the development, the way it is structured and conducted, the work done by coaching schools at regional and national federations, was always an example to everyone." The Philosophy of Teaching Football "It would be easy to now say Scaloni stood out but it is true that there were some who had something a bit different," De la Fuente reflects. "That restlessness, how they would challenge you: 'I don't see it.' Scaloni debated everything, argued. We're similar too, a parallel in our paths. He starts at the under-20s, then made his way into the senior squad and won it all. He had to, we both did: it was win, win, win, win, because if we hadn't..." Within six years teacher and pupil would be European and South American champions respectively. Those successes should have brought a class reunion at the Finalissima in Qatar but war forced postponement. "Two don't play if one doesn't want to; we were mad keen to play," De la Fuente says. "It was a pity. I don't think politics will be a problem this summer: football is something that can bring people together of all creeds, ideologies, races and religions." The Future: Spain's World Cup Ambitions "Who would have thought it?" De la Fuente asks, reflecting on his journey to the senior national team. His first big senior job came past 60, having worked in Spain's youth structure for a decade. Scaloni, 40 when thrust into the seniors, hadn't worked at a club. "Life provides these moments. And nothing was given to us for free. It's all through work, work and more work..." "In the end, sporting success is fleeting. But I remember my teachers... So when I had the chance to work at the RFEF [federation], I thought: it's my job to shape people." With Spain heading to the World Cup as one of the favorites, De la Fuente's philosophy of developing both players and coaches continues to bear fruit on the world stage.

The Appointment of Dr. Marnie Lovejoy Dr. Marnie Lovejoy, a criminal lawyer and passionate angler, has been appointed as the first female chair of the Grayling Society. This appointment marks a significant milestone for the organization, which has traditionally been male-dominated. The State of Grayling and Its Habitat The grayling, known as the 'lady of the stream' due to its iridescent pink scales and elegant dorsal fin, is a crucial indicator species for water quality. Dr. Lovejoy emphasized that grayling are highly reactive to changes in water quality and are often the first to suffer from pollution or chemical increases in rivers. Promoting Inclusivity in Fly-Fishing Dr. Lovejoy aims to promote fly-fishing among women and increase youth membership in the Grayling Society. She believes that by showcasing the sport's appeal and importance, more women can be inspired to join. Lovejoy also highlighted the historical role of women in fly-tying, a crucial aspect of fly-fishing. The Future of Grayling Conservation Dr. Lovejoy's first task as chair will be to set up a grayling map using catch-and-release data from members. This initiative will help identify areas where grayling are thriving and inform conservation efforts. With her leadership, the Grayling Society is poised to take a more proactive approach to protecting this iconic species and its habitat.

The LeadThe Tribeca Film Festival has found itself at the center of a controversy after screening a film containing a highly offensive joke about Palestinian 'dog rape.' The remark has sparked immediate backlash from audiences, critics, and advocacy groups, raising questions about the festival's selection process and the boundaries of acceptable content in artistic expression.The Controversial Film MomentThe joke in question appeared during a screening at the prestigious Tribeca Film Festival, which is known for showcasing independent films and fostering diverse voices in cinema. The specific remark referencing Palestinian 'dog rape' has been widely condemned as crossing ethical boundaries, with many questioning how such content made it through the festival's selection process.The Public ReactionSocial media has erupted with condemnation of the joke, with numerous hashtags trending including #TribecaControversy and #BoycottTribeca. Palestinian advocacy groups have issued strong statements condemning the remark as dehumanizing and inflammatory. Several celebrities who had planned to attend festival events have also expressed their disappointment and reconsidered their participation.The Festival's ResponseIn a statement released yesterday, Tribeca Film Festival organizers acknowledged the controversy but defended their decision to screen the film, citing their commitment to showcasing diverse perspectives. However, they also announced they would be hosting a panel discussion about the boundaries of free speech in artistic expression, attempting to turn the controversy into a meaningful dialogue about representation and sensitivity in media.Broader Implications for the Film IndustryThis incident comes at a time when the film industry is already grappling with issues of representation, cultural sensitivity, and the responsibilities of artists when addressing sensitive political topics. The controversy highlights the challenges festivals face in balancing artistic freedom with the potential harm certain content may cause, particularly when dealing with politically charged subjects involving marginalized communities.Future of the FestivalIndustry analysts suggest this controversy may prompt Tribeca to reevaluate its content guidelines and selection process. The festival has historically prided itself on being a platform for underrepresented voices, but this incident has raised questions about whether those voices are being properly represented or if harmful stereotypes are being perpetuated under the guise of artistic expression. The long-term impact on the festival's reputation and attendance remains to be seen.

The Lead: A War‑Year Timeline of Near‑Deal MomentsThe conflict that began with Operation Epic Fury on February 28 has seen several flashpoints where a US‑Iran settlement seemed possible, only to dissolve amid competing demands and renewed hostilities.April 8: Pakistan‑mediated ceasefire begins.April 11‑12: Direct talks in Islamabad.April 16‑17: Lebanon ceasefire and temporary Hormuz opening.June 1: Trump’s angry phone call with Netanyahu.Direct Talks in Islamabad: First Direct US‑Iran Negotiations Since 1979What happened: On April 11‑12, the US and Iran met in Islamabad, the first direct dialogue since the 1979 revolution. The US team was led by Vice President JD Vance with Special Envoy Steve Witkoff and Jared Kushner. Iran’s delegation included Foreign Minister Abbas Araghchi, Parliament Speaker Mohammad Bagher Ghalibaf, and senior security figure Ali Bagheri Kani.What went wrong: After 21 hours, Vance announced the talks would end without an agreement, citing Iran’s refusal to accept the US “final and best offer” and to provide a long‑term nuclear‑non‑proliferation commitment.Quantifying the Stakes: Ceasefire Dates, Naval Blockade, and Enriched Uranium StockpilesApril 8: Pakistan‑mediated ceasefire begins.April 12: US announces a naval blockade of Iranian ports.Iran holds an estimated 440 kg (970 lb) of uranium enriched to 60 %, short of the 90 % weapons‑grade threshold.20 % of the world’s oil and LNG pass through the Strait of Hormuz each day.During the war, transit fees for ships in the strait have reportedly reached $2 million per vessel.Lebanon casualties: >3,000 killed since March 2; >600 killed in the month after the April 16 ceasefire.Why Each Attempt Crumbled: Political Red Lines and Strategic MisalignmentsThe failures share common friction points:US demand for a definitive, long‑term nuclear commitment versus Iran’s insistence on deferring details.Israel’s continued strikes in Lebanon, violating the April 16 ceasefire and undermining Iran’s “red line” for peace.US‑imposed naval blockade that undercut any momentum from the Islamabad talks.Control of the Strait of Hormuz—Iran seeks leverage through tolls; the US pushes for pre‑war free navigation.Personal and diplomatic tensions, exemplified by Trump’s angry call to Benjamin Netanyahu, which did not translate into concrete de‑escalation.Looking Ahead: What the Pattern Suggests for Future US‑Iran DiplomacyRepeated near‑misses indicate that any viable settlement will likely require:A multilateral framework that addresses both the nuclear issue and regional security concerns, especially Israel‑Lebanon dynamics.Concrete, verifiable steps on nuclear enrichment limits, possibly linked to phased sanctions relief.Mechanisms to keep the Strait of Hormuz open without imposing punitive fees, restoring confidence in global energy markets.Continued third‑party mediation—Pakistan’s role proved useful but needs broader international backing.Without aligning these strategic interests, future talks may again stall at the “last five percent” of agreement.

The LeadThomas Tuchel was unhappy with England's "freestyle" performance in the first half of their 1-0 win over New Zealand but the head coach was pleased with Jude Bellingham's impact as a substitute in Tampa. Harry Kane's goal just before half-time was the difference in a forgettable encounter at Raymond James Stadium.Tuchel's Tactical Concerns"I'm OK with it," was the German's forthright assessment of England's display. "I'm not super-happy about it. I like the second half more than the first half. We played more from our positions and that's why we played with more speed and off the ball we played with a bit more bite. The first half we were out of positions and it was a bit too much freestyle."Tuchel explained that his "freestyling" comment mainly related to positional awareness. "We were lacking width so players were coming inside and narrowing ourselves down and slowing ourselves down and changing positions for too long," he said. "We were taking crosses, a lot of long-range shots, normally not our style of play. We played a lot of long balls, we played a lot of long passes. That was not part of training in the last four days."Match ChallengesThere were other factors behind England's lack of flow. They fielded different XIs in each half, the pitch was awkward and the heat was difficult to master. "We had one training in the sun and now this match felt really, really odd," Tuchel said. "But it's good that we're exposed because that's why we're here. We wanted it that way and we need to get used to it because it will come at some point."Bellingham's ImpactBellingham was handed the captain's armband after replacing Morgan Rogers at half-time and the Real Madrid midfielder pressed his case to start in the No 10 role when England open their campaign against Croatia on 17 June."Jude has the decisiveness and he has the bite," Tuchel said. "This is a key characteristic. You can see that he comes back from an injury and is full of energy and happy to be back on the pitch. He had his break, unfortunately, in a decisive part of the season. But you can see now that he is actually in a sweet spot. He comes back, he's fresh, he wants to play and he's in top shape."Kane's ImportanceKane's 79th goal for England, who head to Orlando to face Costa Rica in their final warm-up game on Wednesday, underlined the captain's importance to the side. "He's always there to score," Tuchel said. "It's a decisive goal. Harry is in top shape and I think that when the pressure comes and the tournament starts, that will bring the best out of all our players."