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On 15 May, **BioOrbit** launched its compact **Box‑E** payload aboard a **SpaceX** rocket, beginning a six‑week orbital trial to grow ultra‑pure protein crystals for self‑injectable cancer therapies. Box‑E’s Orbital Test: Microgravity Enables Ultra‑Pure Protein Crystals The microwave‑sized unit will float aboard the International Space Station, where microgravity eliminates the disruptive effects of Earth’s gravity on crystal formation. The resulting crystals are more stable, allowing drug formulations that are impossible to achieve on the ground. Mission duration: ~6 weeks in orbit Target output: thousands of litres of fluid per box per year Goal: Produce cancer‑drug crystals that can be stored in a fridge and self‑injected £9.8 Million Funding Round and UK Space Agency Contract Last month **BioOrbit** closed a **£9.8 million** Series A round led by **LocalGlobe** and **Breega**, earmarked for the orbital test and scaling of the hardware. Earlier in March the company secured a **£250,000** contract from the UK Space Agency to manufacture drugs in microgravity. Potential Disruption of Cancer Treatment Delivery Current immunotherapies such as Merck’s **Keytruda** require lengthy IV infusions in hospitals. By crystallising the active protein, **Box‑E** could enable high‑concentration, low‑viscosity formulations suitable for pen‑injectors, reducing treatment time from hours to minutes and extending shelf‑life. Roadmap to Commercialisation and Market Size **BioOrbit** projects that, if orbital tests succeed, multiple **Box‑E** units could be stacked to meet the demand of a blockbuster drug within a handful of boxes. The company estimates a market of **$22.7 trillion** for in‑space manufacturing across sectors, with pharmaceuticals a key segment. Clinical trials and regulatory approval are expected to take at least five years before the new formulations reach patients. Future Outlook for Space‑Based Pharma Beyond cancer, the crystallisation platform could be applied to the roughly 70 % of top‑selling drugs that are currently administered intravenously. Partnerships with major pharma groups are already being explored, and competitors such as **Varda Space Industries** are also pursuing in‑orbit drug processing, signaling a burgeoning industry.

The Plight of Taxpayers Waiting for Rebates Multiple individuals have faced substantial delays in receiving tax rebates from HMRC, with some waiting up to a year or more for their refunds. These delays have caused significant financial strain, forcing some to use their savings or sell assets to cover costs they believed they owed. Case of a Year-Long Wait for a £153,500 Rebate A father, aged 86, applied for a rebate a year ago after overpaying inheritance tax. Despite HMRC confirming he was owed £153,500 eight months later, he waited another two months without hearing back. His situation worsened as he had to use his savings and sell a field to pay the tax he thought he owed, leaving him short of money. 13-Month Wait for a £5,094 Refund CK, living in Spain, faced a 13-month delay for a refund of £5,094 due to an HMRC error. She had initially paid £8,000 for class 3 national insurance contributions, only to discover she was eligible for the much cheaper class 2. Despite alerting HMRC and receiving a calculation, she waited months for her refund. Efforts to Address the Delays HMRC has acknowledged the issues, citing 'handling errors' and a surge in applications. The government has urged HMRC to improve its response times, and the agency has recruited additional staff. In some cases, intervention led to immediate resolution, with refunds being processed and paid out quickly. A Happy Ending for Some In a positive note, some individuals have seen swift resolutions after their cases were raised with HMRC. For instance, JI, 83, received £63,872 in overpaid tax after a five-month wait, following intervention. The Data Analysis: Financial Impact of Delays £153,500: The amount owed to a father in inheritance tax rebate. £5,094: The refund owed to CK for an overpayment in national insurance contributions. £63,872: The amount of overpaid tax returned to JI. The Impact Analysis: Why Taxpayers Are Affected The delays in tax rebates have significant implications for taxpayers, particularly the elderly and those with limited financial resources. These delays force individuals to use their savings or take on debt, exacerbating financial difficulties. The Prediction: Future Outlook for HMRC's Tax Rebate Process With HMRC's efforts to recruit more staff and address handling errors, there is hope for improvement in the tax rebate process. Enhanced efficiency and communication are crucial to preventing future delays and ensuring taxpayers receive their refunds in a timely manner.

The Shift in BHP's Climate Strategy BHP, the world's largest miner, has been a significant player in the global mining industry. However, recent internal documents leaked to the Guardian and the ABC's Four Corners program have revealed that the company is backtracking on its climate action plans. The Leaked Documents The leaked documents, dubbed the BHP files, show that the company has halted or delayed several key projects aimed at reducing emissions. These projects include: A 50-megawatt solar farm and 20MW battery at its Jimblebar mine, which was effectively shelved soon after being approved and funded by the board in mid-2023. A huge system of almost 500MW solar, wind and battery that could power a small city, which has been significantly delayed and will not progress in its current form until 2031 at the earliest. An iron ore processing plant that could have prevented 1.7m tonnes of emissions a year, which was dumped despite being described as 'well-aligned' with its climate transition action plan. The Impact on Climate Goals BHP's decision to backtrack on its climate action plans has raised concerns among experts and environmental groups. The company's failure to urgently decarbonize could put national climate targets, including a 43% cut below 2005 levels by 2030, in doubt. The Future Outlook BHP has stated that it is still focused on its emissions reductions goals and has reduced emissions by 36% on 2020 levels. However, experts argue that the company's actions are not in line with its public commitments, and it needs to take more drastic measures to achieve its climate goals.

The Star Player: Khadija ShawKhadija 'Bunny' Shaw has been named the best player in the WSL 2025-26 season. The Jamaica international scored 21 goals in 22 games, becoming the first player in WSL history to score more than 20 goals in three different seasons. Her impressive performance earned her the Golden Boot for a third consecutive year.The Mastermind: Andrée JeglertzManchester City's manager, Andrée Jeglertz, has been named the best manager of the season. He led the team to their first WSL title since 2016, transforming the squad's mentality and creating unity. Jeglertz's tactics and ability to manage ambitious individuals were key to the team's success.Best Goal of the SeasonThe best goal of the season was a subject of debate among writers, with Oona Siren's long-range volley and Jess Park's swerving strike being mentioned as top contenders.

The Lead: NAACP's Strategic Boycott CallSix years after the nation underwent a so-called "racial reckoning", Black America is under comprehensive assault from the country's highest elected, judicial, and legislative branches. In response, the National Association for the Advancement of Colored People (NAACP) has turned to sports, calling for Black athletes to boycott public universities in the Southeastern Conference (SEC), arguably the most powerful football conference in the country and certainly its greatest incubator of Black athletic talent.The Political Landscape: Assault on Black AmericaThe assault comes from multiple fronts: the president has codified into policy the belief that white people are the true victims of racial discrimination; the supreme court has gutted the Voting Rights Act of 1965; and state and federal legislative branches are implementing massive southern redistricting efforts that threaten to erase much of the Black political representation won over the past 60 years. These moves mirror historical patterns of segregation and disenfranchisement.The Athletic Response: Leveraging Cultural InfluenceThe NAACP is betting that Black Americans will recognize the urgency of the moment and realize their power. Black people represent 14% of the population but are more than 14% of American culture, with Black athletes being the most successful, influential, and visible Black employees in the country. A sustained, coordinated movement of Black athletes against hostile states could have profound effects on both sports and politics.The Historical Context: Athletes as Change AgentsBlack athletes have a history of effecting change. In 2015, University of Missouri football players' boycott threat led to the resignation of the school's president and system chancellor. In the 1960s, the exodus of Black high school talent from the south forced southern universities to integrate. Today's athletes have even more power through NIL (name, image, and likeness) deals and the transfer portal, which allows them to change schools without sitting out a year.The Media Silence: Suppressing Black VoicesOver the last half-decade, sports media has willingly eliminated the Black political voice, reducing athletes to "neutered laborers" who entertain predominantly white audiences. While there are Black faces on sports television addressing "representation," they often lack depth and reportage on major national stories. ESPN's minimal coverage of the NAACP boycott exemplifies this pattern of silencing Black perspectives.The Power Dynamics: Economic Influence and ResponsibilityThe NAACP action reminds Black athletes of their power and their connection to the future of Black America. As an economic bloc, they can shift the fortunes of institutions they inhabit. After largely being silent politically since the 2020 Floyd protests, a new generation is being asked to recognize their place in the Black athletic and civil rights heritage that "laid down its life for the comforts that are now being erased." The question remains whether they will choose to use their influence beyond the playing field.

The Contrast of Public Persona and Private RealityFatiha El-Ghorri, a British-Moroccan Muslim comedian from Hackney, delivers a raw and unfiltered performance in her new show 'Cockney Stacking Doll.' The central thesis of the performance lies in the stark contrast between her public persona and her private self. El-Ghorri describes this as the gap between 'what comes out of here'—her mouth—and 'this'—how she presents to the world. This dichotomy, characterized by a kindly-seeming woman in a hijab peddling gobby East End standup, forms the core of her comic power.An Unstructured Journey Through HackneyThe show offers a tour of El-Ghorri's world, navigating the complexities of her upbringing in Hackney, where she learned to handle herself after being mugged three times a day. The performance lacks a rigid structure, functioning more as an hour of assorted, relatable jokes than a cohesive narrative. Key elements include her observations on the gentrification of Broadway Market—described as now being filled with 'kefir, lidos and polyamory'—and her experiences with online dating and family dynamics. The show culminates in a unique 'Ted Talk' section where she addresses her audience directly, filling the final minutes with jokes about her nieces and the local McDonald's.Resilience in the Face of AdversityA significant portion of the show's impact is driven by El-Ghorri's recent health struggles. The review highlights that she recently underwent a forced menopause after cancer surgery. This personal adversity is woven into the performance, with scenes recreating her visits to the gynaecologist. Despite occasional memory lapses and a reliance on 'brutal punchlines,' her ability to transform vulnerability into comedy—using excuses like 'I was mortified by my heckler'—demonstrates a robust sense of her own ridiculousness.The Future of British Stand-upEl-Ghorri is confirmed as an 'earthy and endearing voice of the (clearly) not yet wholly gentrified East End.' Her authenticity and refusal to shy away from difficult topics position her as a rising star in the British comedy circuit. As she continues her tour, her ability to balance sharp social commentary with personal resilience suggests a promising trajectory for her career in the entertainment industry.

The Explicit RoleNot many actors are relieved when they have to film an eye-poppingly explicit sex scene, but that was the case with Jamie Bell on Half Man. His role involved chemsex in saunas, dogging in car parks and illicit quickies in library loos. "Honestly, I was so grateful to be shooting that stuff and not fucking 16-page dialogue scenes, where you're emoting and it's so intense," says Bell. "On days when my character had to have sex with random people, I'd think: 'Thank God!' Frankly, it came as a welcome reprieve."The Creative PartnershipRichard Gadd's first TV show since the Emmy-gobbling global Netflix hit Baby Reindeer, Half Man chronicles the combustible, codependent relationship between two "brothers from another lover". Niall (Bell) is bookish, bullied and closeted. Ruben (Gadd) is the swaggeringly violent ex-con son of his mother's girlfriend. The six-part drama – which reaches its devastating finale next week – traces the inseparable duo's toxic relationship across three decades.The role of Niall was written specifically for Bell. "I didn't realise that when I initially read the scripts," says Bell. "But later, when I met Richard in Los Angeles to discuss it, he said he wrote it with me in mind. I was incredibly flattered … It's a sensory experience reading Richard's material. He truly takes you to those places in your own life. It probes experiences you've kept hidden away somewhere and chosen to forget."Character ComplexityHe was drawn to his Half Man character's complexity. "I thought: 'Woah, this man is on such a destructive downward spiral …' He's got everything he wanted in life but still can't accept who he is. Niall is living as several different people and he's not comfortable with any of them."Bell really empathised with gentle Niall being drawn to such an aggressive alpha male. "Ruben is this disaster of a man. A bull in a china shop, destroying everything and everyone in his wake. Why doesn't Niall step away? Partly self-preservation. Niall feels vulnerable whereas Ruben is intimidatingly powerful. He can be Niall's protector. People fear him. Because of that, Niall latches on to him almost parasitically. Ruben becomes his life support system. I understood that 100%."I grew up in an all-female household and did ballet, so I used to attach myself to tough, troubled guys too. Not my kind of crowd at all but I'd rather have them on my team than not."Themes of Toxic MasculinityNiall struggles with his sexuality to the extent that he undergoes conversion therapy. As a straight man, Bell felt an acute sense of responsibility portraying that. "It's the centre of the character," he says. "The basis of all his issues. I took that very seriously. Niall's self-hate goes beyond shame or societal pressure. Somehow, his own sexuality doesn't sit right within his worldview. That, to me, is beyond sad. 'Be yourself' is the simplest advice yet at times, the hardest to adhere to." As a result of his turmoil, Niall goes to some dark places sexually. "Because of his repression, everything is guarded and hidden. That becomes the excitement. It's an addiction. He gets a kick from dangerous sex."With its portrayal of male rage and damaged antiheroes, Half Man taps into debates about toxic masculinity. Does Bell believe his gender is in crisis? "Look at who are the majority transgressors in this world," he says. "It's men, on all fronts – not just misogyny but conflict, crime, everything. It's important to shine a light on that. The conversation is ongoing. Hopefully this show adds something."The ImpactIt's no-holds-barred TV, full of sex, violence and gut-punch plot twists. "It's a brutal, beastly thing that Richard has created," says Bell. "I'd be lying if I said it was easy or fun to make." Yet the show represents a significant moment in television, pushing boundaries in its depiction of complex male relationships and sexuality. Bell's performance as Niall, combined with Gadd's writing and performance as Ruben, creates a character study that resonates with contemporary discussions about identity, self-acceptance, and the destructive patterns that can emerge from unresolved trauma.

The University of Southern California's Involvement The University of Southern California has been selling bodies donated for scientific research and education to the United States Navy. The Use of Donor Bodies for Military Training Some of these bodies are being used to train Israeli military surgical teams in Los Angeles – all without the donors’ consent. Investigative Reporting and Documentary Watch the AJ+ documentary here and read students’ reporting here. Episode Credits and Contributors Dena Takruri (@denatakruri), AJ+ senior presenter This episode was produced by Chloe K. Li with Spencer Cline, Catherine Nouhan, and our host, Malika Bilal. It was edited by Tamara Khandaker. Our sound designer is Alex Roldan. Our video editors are Hisham Abu Salah and Mohannad al-Melhem. Alexandra Locke is The Take’s executive producer.

The Comeback from the BrinkJames Tedesco delivered a performance that transcended mere athleticism, delivering a last-minute try that secured a famous State of Origin victory for New South Wales. The match narrative was defined by a stunning reversal of fortune, where a team trailing by two converted tries at halftime mounted a relentless comeback to snatch victory from the jaws of defeat. The 33-year-old fullback, often written off as a fading star following a coaching change at his club, stepped up when the pressure was greatest, rising above the physical exhaustion of the drizzling night to plant the ball over the line.Statistical Shifts in MomentumThe game was a study in statistical volatility, characterized by a pivotal turning point that altered the trajectory of the series. The match data highlights the dramatic shift in momentum:Halftime Deficit: New South Wales entered the break trailing 20-6, seemingly outplayed by a young, electric Queensland side.The Turning Point: The contest was fundamentally altered when Kalyn Ponga was sent off in the 57th minute for a high tackle on Tolu Koula, becoming only the seventh player in Origin history to receive a red card.Crowd Impact: The near-80,000-strong crowd witnessed a full spectrum of emotions, from early silence to a roaring finale as the Blues capitalized on the man advantage.Redefining the "Evergreen" FullbackThis victory serves as a powerful rebuttal to the narrative that Tedesco’s era had passed. Despite losing his club job last year and being viewed as a peripheral figure in the initial squad selection, the veteran fullback demonstrated an uncanny ability to perform on the biggest stage. His duel with young gun Hamiso Tabuai-Fidow encapsulated the match; it was a test of technique and willpower where the experience of the veteran prevailed over the raw speed of the rookie. Tedesco’s ability to regather the ball after a collision and elude defenders highlights a football IQ that remains elite.Series Trajectory and LegacyThe implications of this win extend beyond a single game; it signals a potential shift in the balance of power for the remainder of the series. For New South Wales, the psychological boost of overcoming a 14-point deficit with a man down cannot be overstated. For Tedesco, this performance cements his legacy as a clutch player capable of delivering monuments to the game when his team needs him most. The Blues have momentum, and their veteran leader has proven he still has plenty to give.