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OpenAI has put on hold plans for a landmark UK investment, Stargate UK, citing high energy costs and regulation, in a blow to the government which has put AI at the centre of its growth strategy.The Stargate project was part of the UK-US AI deal announced last September, in which US companies appeared to commit £31bn to the UK’s tech sector. The project aimed to support Britain in building out “sovereign compute” – infrastructure that would allow the government and other UK institutions to run AI models on datacentres in the country.Victoria Collins MP, the Liberal Democrat spokesperson for science, innovation and technology, said: “This is a wake-up call for the government to manage energy costs in the UK and foundation infrastructure.”The Labour MP Clive Lewis said: “When a government has no economic strategy worthy of the name and no real industrial vision, it becomes vulnerable.”An OpenAI spokesperson said: “We see huge potential for the UK’s AI future, and we support the government’s ambition to be an AI leader. We continue to explore Stargate UK.”High energy costs, rising further because of the US-Israel war on Iran, are expected to delay or derail AI datacentre projects worldwide. The UK’s industrial electricity prices were already the highest in Europe before the start of the war.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

The UK government has pledged £380 million to accelerate the build‑out of a new battery factory in Somerset that will supply Jaguar Land Rover (JLR) with cells for its forthcoming electric Range Rover and Jaguar models. The plant, operated by Tata’s battery subsidiary Agratas, was highlighted during a site visit by Business Secretary Peter Kyle, who emphasized the grant’s role in safeguarding jobs and driving economic growth. When fully operational, the gigafactory is projected to employ 4,200 workers and deliver up to 40 GWh of battery capacity annually—enough for hundreds of thousands of electric vehicles. It will become the UK’s second high‑volume battery facility after the Chinese‑owned AESC plant in Sunderland. Construction remains in its early stages, with only a steel frame erected so far. Although the original timetable targeted production start‑up in 2026, delays have pushed the expected commencement to the end of 2027. Agratas has reduced the footprint of the first building but claims the change reflects more efficient process design rather than a cut‑back in output. JLR, the nation’s largest automotive employer, had planned to launch its electric Range Rover in 2025, but the debut has slipped to 2026 and the vehicle is still not on sale. The postponement follows a broader trend of EV manufacturers worldwide scaling back or postponing battery projects after over‑optimistic forecasts of rapid consumer migration from petrol. Recent spikes in petrol prices—spurred by geopolitical tensions linked to Donald Trump’s war in Iran—could make electric cars more appealing, potentially justifying the sizeable capital commitments required for a transition to EV production. Until the Somerset facility becomes operational, JLR will continue to source batteries from AESC. That arrangement was confirmed last year by investment bank Société Générale, though references to JLR have since been removed from public statements. In addition to the battery grant, Tata previously secured a £500 million pledge to modernise its Welsh steelworks with electric arc furnaces, underscoring the government’s broader push for greener industrial capacity. Peter Kyle said the investment, alongside other automotive research initiatives announced on the same day, would “boost economic growth, secure jobs and put more money in people’s pockets.” He added that the UK’s “modern industrial strategy” provides the stability needed for long‑term planning. Earl Wiggins, Agratas’s vice‑president for UK manufacturing, welcomed the funding, noting it will enable the company to “deliver net‑zero goals and strengthen the UK’s position as a global leader in battery manufacturing.” He projected that over 2,200 staff would be on‑site within the next year, with further growth thereafter.

As rising temperatures push snakes and humans into closer contact, the world faces an estimated 5.5 million snakebites each year, resulting in 138,000 deaths and 400,000 lasting disabilities. In response, a Wisconsin‑based amateur scientist has taken an extreme route to help solve the crisis.For almost 20 years, Tim Friede, a former window cleaner, allowed some of the planet’s most lethal snakes to bite him, accumulating over 200 intentional bites. His goal: to provoke his own immune system into producing antibodies that could be harvested for a near‑universal antivenom.The endeavor has been perilous. Friede survived a coma after being bitten by two cobras within an hour, endured anaphylactic shocks, lost tissue in a finger, and even had to cut necrotic muscle from his leg. Yet he persisted, eventually becoming immune to the inland taipan—the world’s most venomous snake, whose single bite can kill more than 100 people.In 2019, California biotech firm Centivax hired Friede to extract his antibodies. Early laboratory work showed that his serum can neutralise toxins from 19 elapid species, including cobras, mambas, taipans, coral snakes and kraits—roughly half of all venomous snakes worldwide.The next step is a veterinary trial in Australia, slated for later this year, before any human application. If successful, the antivenom could dramatically reduce the burden of snakebite in low‑income regions across Asia and Africa, where most victims live.Climate scientists warn that warming climates will expand snake habitats and increase human exposure, as illustrated by the recent surge of rattlesnake bites in California’s Ventura County. This amplifies the urgency for scalable, affordable antivenoms, especially as international aid budgets face cuts and manufacturing capacity remains insufficient.Friede’s unconventional path underscores a broader lesson: confronting emerging health threats may require bold, unconventional science, but the potential payoff—a life‑saving treatment for millions—could be transformative.

The little corella infestation on Kangaroo Island has reached critical levels, with the birds causing widespread destruction and disruption to daily life. Despite a recent culling effort that resulted in the death of 2,640 little corellas, authorities acknowledge that it won't be enough to mitigate the problem.The birds, which are not native to the island, have been covering a local school in faeces, tearing up infrastructure, damaging crops, and causing mental distress to residents with their screeching. They have also been spotted using the nesting hollows of the endangered glossy-black cockatoo, smashing their eggs and killing their nestlings.Past attempts to control populations by shooting, scaring, trapping, or gassing them have failed, with the highly intelligent birds learning how to survive or just moving to cause havoc somewhere else. The Kangaroo Island Landscape Board's general manager, Will Durack, says that night-time shooting was more efficient, with the roosting birds easier to kill in large numbers, but it is not clear how much of a dent they made in the population.The little corellas have created a perfect environment for themselves on the island, with a predictable water supply from stock troughs and dams, and food from grain crops. Residents have expressed concerns about the physical and mental health impacts of the infestation, including the spread of diseases such as ornithosis and the disruption to daily life caused by the birds' loud shrieks.Coordination with other agencies and more resources are needed if the trial is to be expanded, according to the landscape board. A resident, Rodney Bell, has four grandchildren at the school and says: “They poo all over the yard, then the kids are playing in it.” He also mentions that “near the school, they would drive anyone insane from the sheer noise.”

The temporary cease‑fire in the US‑Israel‑Iran war has given Iran and China a strategic opening to challenge the US dollar’s supremacy in global finance. Both nations share a common objective: to reduce reliance on the greenback, especially in the oil sector where, according to a 2023 JP Morgan estimate, roughly 80% of transactions are settled in dollars. In a practical step toward this goal, Iran’s de‑facto toll‑booth system in the Strait of Hormuz—a chokepoint that handles about one‑fifth of the world’s oil and LNG shipments—has started accepting transit fees in Chinese yuan. Lloyd’s List reported that at least two vessels had already paid in yuan by March 25, and China’s Ministry of Commerce later acknowledged the reports on social media. Iran’s embassy in Zimbabwe even called for the introduction of a “petroyuan” to the global oil market, underscoring the political symbolism of the move. While Tehran pledged to guarantee safe passage for two weeks under a US‑brokered cease‑fire, Beijing declined to comment. Harvard economist Kenneth Rogoff told Al Jazeera that Iran’s actions serve a dual purpose: they “poke a thumb in the United States’s eye” and provide a practical alternative to dollar‑based sanctions. Rogoff added that Iran’s shift to yuan aligns with China’s broader effort to redenominate trade among BRICS nations. For both countries, the yuan offers a way to sidestep US sanctions and lower transaction costs. Their trade relationship, cemented by a 25‑year strategic partnership signed in 2021, sees China buying over 80% of Iran’s oil—often at discounted rates—while Iran imports Chinese machinery, electronics, chemicals, and industrial components. Data from Kpler and TankerTrackers indicate that, despite the conflict, Iran’s oil exports to China have remained near pre‑war levels, ranging between 12 million and 13.7 million barrels in the first two weeks of hostilities. China’s ambition to elevate the yuan is long‑standing. President Xi Jinping, in a 2024 address, expressed hope that the yuan would become a global reserve currency. Yet significant hurdles remain: the yuan is not freely convertible due to strict capital controls, and the Chinese financial system is perceived as opaque, limiting broader adoption. According to the IMF, the dollar still dominated global foreign‑exchange reserves at 57% last year, far ahead of the euro’s 20% and the yuan’s modest 2%. Cross‑border trade settled in yuan rose to 3.7% in 2024, up from under 1% in 2012, per S&P; Global—an encouraging but limited shift. Natixis chief economist Alicia Garcia‑Herrero cautioned that the Strait of Hormuz experiment adds only “incremental pressure” and that a true “de‑dollarisation” would require Gulf states, which have priced oil in dollars since the 1970s in exchange for US security guarantees. European analyst Hosuk Lee‑Makiyama highlighted that China’s ability to supply Iran with essential goods makes the yuan a viable alternative, a dynamic not possible for Europe or Japan. He described China as the closest the world has seen to a “manufacturing one‑stop shop.” Consultancy founder Dan Steinbock echoed that while the dollar’s supremacy is unlikely to crumble overnight, the gradual increase in yuan usage could “chip away” at US dominance in specific sectors over time. Rogoff concluded that the long‑term impact hinges on the war’s outcome. If Iran and China emerge stronger, many countries may diversify away from the dollar to avoid US‑imposed financial constraints. Conversely, a decisive US victory could reinforce dollar hegemony for the foreseeable future.

The fragile ceasefire between Iran and Israel faced a serious crisis on Wednesday as both sides presented conflicting accounts of the agreement. The development raised concerns about the potential collapse of the truce.Israel escalated its military operations in Lebanon, launching its heaviest attack yet on over 100 targets, resulting in at least 254 fatalities. This move directly contradicts the claims of Iran and Pakistan, who brokered the 11th-hour truce and asserted that the ceasefire included Lebanon.In response, Iran halted the passage of oil tankers through the Strait of Hormuz, citing an alleged Israeli breach of the ceasefire. The Fars news agency reported that oil prices had dropped sharply below $100 a barrel following the truce announcement, leading to a global stock market surge.The White House disputed Iran's claims about the closure of the Strait of Hormuz, calling the reports 'false' and stating that US President Donald Trump expected it to reopen 'immediately, quickly and safely.' The US signaled its continued adherence to the ceasefire, even as it threatened to unravel.Iran and the US have different interpretations of the agreement. Trump conveyed a version suggesting a 15-point proposal from the US, which included no enrichment of uranium and the destruction of Iran's highly enriched uranium stockpile. In contrast, Iran's 10-point plan, which Trump initially referred to as a 'workable basis for negotiation,' included the right to enrich uranium and the full lifting of sanctions.The US and Iran are set to engage in talks in Islamabad, Pakistan, this weekend, with a US negotiating team led by Vice-President JD Vance. The talks aim to cement the ceasefire into a more durable peace agreement, but significant gaps remain to be bridged.The situation in the Gulf remains fragile, with the US and Israel claiming to have destroyed Iran's industrial base and significant military assets. Iran, on the other hand, portrays the truce as a victory, with senior politician Ali Akbar Velayati stating that 'America was forced to accept a ceasefire.'

Allianz, one of the world's largest insurance companies, is taking legal action against six individuals allegedly involved in Palestine Action protests against the company. The insurer is seeking damages of almost £300,000 for protests at its UK offices in October 2024 and March 2025.The protests, carried out by Palestine Action, targeted Allianz over its provision of insurance to Elbit Systems UK, a subsidiary of Israel's largest arms manufacturer. During the protests, red paint was daubed over Allianz's UK headquarters in Guildford, Surrey, and its City of London office.The six defendants, who have been charged with criminal offences and pleaded not guilty, are applying to the civil court to stay the case brought by Allianz until after their criminal trials. An Allianz spokesperson stated that the company respects the right to lawful protest but will not tolerate alleged intimidation of staff, threats, or behaviour that endangers the safety and security of its people, business, or property.The defendants, including Seren John-Wood, Anna Letts, and George Elliott, expressed concerns about the civil case, citing the lower burden of proof in civil courts and the significant financial burden of defending the case. The case is believed to be the first civil case brought against individuals accused of involvement in direct action with Palestine Action.

At a Pentagon briefing, Defense Secretary Pete Hegseth asserted that Iran’s request for a temporary cease‑fire was a direct result of the United States’ intensive air campaign, which he described as having reduced Iran’s weapons factories to rubble and rendered its military ineffective for years to come. Hegseth, standing beside Joint Chiefs Chairman Dan Caine, said the final wave of strikes before President Donald Trump announced a two‑week pause had completely destroyed Iran’s defense industrial base. While Iran can still fire from existing stockpiles, it can no longer replace lost munitions, according to the secretary. President Trump posted on Truth Social that he had agreed to suspend hostilities less than two hours before his self‑imposed deadline to “decimate the entirety of Iranian civilization.” The decision followed a last‑minute diplomatic push by Pakistan’s Prime Minister Shehbaz Sharif and army chief Gen Asim Munir. Iran’s foreign minister Abbas Araghchi confirmed Tehran’s acceptance of the pause, and the country’s supreme national security council announced it would send a delegation to Islamabad for formal talks starting Friday. Both sides claimed victory: Iran’s security council said it had achieved “nearly all the objectives of the war,” while the United States highlighted the crippling of Iran’s military capabilities. The cease‑fire ends a conflict that began on 28 February, when the U.S. and Israel launched nearly 900 strikes in a 12‑hour window against Iranian military infrastructure, missile sites, and leadership. The opening day saw the death of Supreme Leader Ali Khamenei, with his son Mojtaba Khamenei named successor on 8 March. Hegseth warned that the United States had prepared additional strikes on Iran’s power plants, bridges and energy infrastructure—targets he said Iran could not defend or rebuild for decades—if Tehran had refused the pause. According to Joint Chiefs Chairman Caine, 13 U.S. service members were killed during the fighting. Total casualties across the region exceed 5,000, including over 1,600 Iranian civilians and at least 1,497 deaths in Lebanon. By the sixth day of the war, U.S. military spending had reached roughly $12.7 billion, with a pending supplemental request of $200 billion before Congress. The future of a lasting settlement remains uncertain. Trump later announced that Iran would hand over its enriched uranium and cease all enrichment activities, while Iran’s supreme national security council released a 10‑point counter‑proposal that explicitly demands the right to continue enrichment. Disagreements also persist over the cease‑fire’s scope. Israel maintains that the pause does not apply to Lebanon, where ground and air campaigns are at their most intense since Israel’s northern invasion. Both Pakistan and Iran, however, have stated that Lebanon is included in the cease‑fire. Subsequent reports indicated Iranian missile and drone attacks on Kuwait and the United Arab Emirates, as well as strikes on Iran’s oil infrastructure on Lavan Island. Iran’s supreme national security council warned that its forces remain on high alert, stating, “our hands are on the trigger, and any mistake by the enemy will be met with full force.” When asked about the long‑term U.S. presence in the region, Hegseth replied unequivocally: “We’re not going anywhere.”