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The U.S. Food and Drug Administration announced on Wednesday that it has granted expedited approval to Eli Lilly’s oral weight‑loss medication, orforglipron—marketed under the brand name Foundayo. This makes Foundayo the second GLP‑1 pill to reach U.S. consumers, following Novo Nordisk’s Wegovy tablet approved in December. Orforglipron works by mimicking a natural hormone that regulates appetite and satiety, offering a non‑injectable alternative to existing GLP‑1 injectables. David A. Ricks, Eli Lilly’s chair and CEO, highlighted that fewer than one in ten eligible patients are currently using GLP‑1 therapies, citing barriers such as cost, stigma, and perceived complexity. Unlike Wegovy, which must be taken on an empty stomach each morning, Foundayo can be taken anytime of day regardless of meals, simplifying dosing schedules. Patients will start on a low dose that is gradually increased to mitigate side‑effects. Pricing is projected at $149 per month for the initial dose, with higher‑strength formulations potentially reaching $349 monthly. While private‑insurance coverage remains uncertain, a Trump‑administration proposal could allow Medicare to cover certain patients as early as this summer, with copayments as low as $50 per month. Distribution will commence on Monday through LillyDirect’s direct‑to‑consumer channel, with broader availability in pharmacies and telehealth platforms expected shortly thereafter. The convenience of a once‑daily pill is anticipated to improve adherence, especially for individuals who avoid injectables due to needle aversion or rigid dosing requirements. The approval follows a fast‑track submission submitted only months ago, positioning Foundayo to enter the market roughly three months after Wegovy. This rapid rollout is set to intensify competition in the burgeoning GLP‑1 space, where new agents are continually emerging with claims of better efficacy and lower costs.

The UK has been identified as the most vulnerable country in Europe to potential jet fuel shortages as the Iran war disrupts supplies from the Gulf, according to Ryanair CEO Michael O'Leary. O'Leary stated that Britain's reliance on Kuwait for approximately 25% of its jet fuel supply makes it particularly exposed to shortages. He emphasized that even if there is a surplus of jet fuel in the Middle East, the logistics of shipping it to Europe remain uncertain.Jet fuel prices have surged, averaging $195 a barrel last week, more than double the average from the previous year. This increase is largely attributed to the effective closure of the Strait of Hormuz, a critical passage through which over a fifth of the world's oil normally passes.While oil prices eased slightly after US President Donald Trump expressed hope for an end to the Iran war within two to three weeks, the situation remains precarious for airlines. Ryanair has hedged 80% of its fuel costs until next March at $67 a barrel, but O'Leary highlighted that supply disruptions, rather than prices, pose the greater risk.The airline industry faces potential flight cancellations and capacity reductions if fuel supply issues persist. O'Leary also mentioned that higher fares could be a possibility, although there are currently no plans to increase prices. Additionally, he called for the UK government to abolish air passenger duty (APD), a tax that recently increased, further impacting the competitiveness of UK air travel.

The recent waiving of Jaden Ivey by the Chicago Bulls following his anti-LGBTQ+ and religiously charged comments on social media was presented as a response to 'conduct detrimental to the team.' However, this situation exposes a more nuanced reality about player expendability and the league's priorities.On the surface, it appears to be a straightforward case of a player making controversial statements and facing consequences. Yet, there's an alternative scenario where Ivey, with the help of his publicist, issues a swift apology, participates in inclusion education, and possibly pays a fine or makes a donation. In this scenario, he could have potentially continued his career in the NBA, a league that has been pro-LGBTQ+ for over a decade.Ivey's comments revealed his beliefs, and the subsequent actions of the Bulls shed light on how NBA teams decide which voices to protect and which to discard. The situation raises questions about the league's commitment to inclusion and how it handles controversial player behavior.As a former NFL player, the author notes that locker room discussions often avoid sensitive topics like queer acceptance and religious beliefs. However, when such topics are broached, they usually involve players sharing how their faith has positively impacted their lives. The author suggests that Ivey's comments were not surprising and might have been shared by some of his teammates.The key difference in Ivey's case was that his comments were made outside the locker room, making them public and subject to scrutiny. The author recalls instances of ignorant comments in locker rooms but notes that peer conversations and diverse perspectives can lead to growth and learning.The swift release of Ivey was likely due to his lack of star power and a career marked by injuries and unremarkable performances. In contrast, superstars like Anthony Edwards, Rajon Rondo, and the late Kobe Bryant faced fewer consequences for similar behavior, with the league giving them time to apologize and make amends.The NBA's response to Ivey's comments does not necessarily indicate a solution to homophobia in locker rooms. Instead, it shows that teams know how to react when a player's behavior becomes visible and when that player is expendable enough to be made an example of. The culture within locker rooms won't shift simply because one voice is removed, especially when the underlying beliefs are not isolated.Ultimately, the NBA manages tensions rather than eliminating them. The gap between public statements and private actions will continue to exist, and incidents like Ivey's will keep surfacing in new ways until this gap closes.

The latest production of Romeo and Juliet brings a modern twist to Shakespeare's timeless tale, with Sadie Sink and Noah Jupe stepping into the iconic roles of Juliet and Romeo, respectively. This adaptation, directed by Robert Icke, presents a hipsterishly modern-dress interpretation that sometimes feels overburdened by its directorial flourishes. Sink, known for her role as Max Mayfield in Stranger Things, makes her West End debut as Juliet, bringing an intense and quirky neurotic energy to the character. Her performance is complemented by Jupe's portrayal of Romeo, showcasing a sweet and pure chemistry that captures the essence of first love. Their on-stage presence is undeniable, making their characters' tragic fate all the more poignant. The production features a range of inventive elements, including a digital clock that ticks down the hours leading to the tragic conclusion and alternative scenes that explore a universe where the couple's fate is averted. While these choices are ambitious, they sometimes feel like overthinking. Nonetheless, the central performances by Sink and Jupe anchor the production, elevating it above its directorial excesses. Supporting performances, including Clare Perkins as the cocky and endearing Nurse and Kasper Hilton-Hille as the mischievous Mercutio, add depth and humor to the production. The stage design, featuring a central bed and minimalist set, effectively underscores the themes of passion and tragedy. Despite some missteps, the production ultimately succeeds due to the compelling performances of its leads. With its blend of traditional and modern elements, this Romeo and Juliet offers a fresh perspective on a classic tale, making it a must-see for both Shakespeare enthusiasts and newcomers alike.

For theatre enthusiasts, April brings a range of exciting productions and performances. Patrick Stewart is set to read all 154 of Shakespeare's sonnets on Audible, a project that began as a pandemic hobby where he recited one sonnet each day on social media. This comprehensive collection, which includes his personal commentaries, will be available from April 7 and lasts almost four hours. In another notable production, Complicité presents 'I Don't Do Innocents', a radio play by Anne Carson directed by Simon McBurney, featuring a cast that includes Emma Corrin and Carson herself reading the stage directions. On the BBC, Sam Ryder gives a sneak preview of his Jesus Christ Superstar, which is set to appear at the London Palladium this summer, as part of the musical-theatre jamboree on iPlayer. Hosted by Jason Manford in Manchester, the event also features Victoria Hamilton-Barritt singing from Paddington: The Musical. Additionally, James Ijames' historical satire 'The Most Spectacularly Lamentable Trial of Miz Martha Washington' is set to run from April 9 to May 3. This play, which explores the life of the inaugural first lady of the US, could pair interestingly with 'Oh, Mary!' in the West End. The BBC is also celebrating the 120th anniversary of Henrik Ibsen's death with a comprehensive iPlayer season featuring various adaptations of his works, including two renditions of 'Hedda Gabler' and 'The Master Builder'. Other highlights include Rosie Sheehy's performance in 'King John' on Marquee TV and 'End' at the National Theatre, part of a trilogy by David Eldridge, which makes a compelling double bill with Stephen Poliakoff's 'Close My Eyes'. Finally, 'Back to the Future: The Musical' is set to embark on a UK tour after its run in London, with an Amazon Prime documentary offering a 'making of' insight into the show.

Coordinated strikes by United States and Israeli forces hit Tehran, Isfahan and several other Iranian cities on Tuesday, prompting widespread power outages and extensive damage to civilian sites. The Ministry of Energy confirmed that shrapnel from the raids ruptured a primary power‑transfer line, but the outage was restored within a few hours. Among the most critical targets was the Tofigh Darou pharmaceutical complex in the Karaj industrial zone. The facility, which supplies over 90% of Iran’s domestically produced medicines—including cancer and multiple‑sclerosis treatments—sustained heavy damage from multiple projectiles. In central Iran, Isfahan endured a barrage of heavy bunker‑buster bombs over a nearby mountainous area, likely aimed at military installations. The explosions triggered secondary blasts that illuminated the night sky and produced reverberating shockwaves across the city. North‑west of Tehran, in Zanjan, a building identified as the administrative department of the Hosseinieh Azam religious centre was struck, resulting in at least four fatalities and several injuries. Iranian authorities now claim that more than 2,000 people have been killed by US‑Israeli attacks since the conflict erupted on 28 February, with residential blocks, schools, hospitals and historic sites also affected. Additional targets this week included civilian nuclear facilities, major steel producers, petrochemical plants, and the Iran University of Science and Technology, where an imaging satellite was developed. A professor linked to Iran’s missile programme and his two children were assassinated at their home in northern Tehran. U.S. President Donald Trump reiterated threats to strike Iran’s oil and gas infrastructure, power plants and water‑desalination facilities. Despite the onslaught, the Islamic Revolutionary Guard Corps (IRGC) continues to project defiance. A spokesperson for the Khatam al‑Anbiya Central Headquarters declared that Tehran’s adversaries are “humiliated and on the path of destruction,” while senior commander Ali Fadavi warned that American warships are vulnerable and allegedly transmit false transponder signals. The IRGC also released footage of ballistic missiles aimed at Israel and surrounding nations, and claimed to have downed two U.S. MQ‑9 Reaper drones, promising retaliatory strikes against technology firms linked to the United States and Israel. Domestically, the judiciary announced the execution of two members of the foreign‑based Mojahedin‑e‑Khalq (MEK) group, labeling them terrorists. This follows a series of recent executions tied to the January protests and broader dissent. Authorities also issued new indictments against roughly 200 individuals accused of assisting the U.S. and Israel, including alleged “mercenaries” who disseminated strike footage abroad. Penalties for national‑security offenses now encompass asset confiscation and capital punishment. President Masoud Pezeshkian convened his first cabinet meeting since the war’s onset in a makeshift, blue‑covered space, emphasizing that any peace negotiations will safeguard Iran’s “dignity, security and national interests.” Israel’s Channel 14 reported that Pezeshkian sought greater negotiating leverage with the United States, a request allegedly rebuffed by IRGC chief Ahmad Vahidi.

The question of whether a peaceful settlement is possible in Iran remains a pressing concern for the international community. Diplomatic efforts have been underway to find a resolution to the country's complex situation, but a lasting solution has yet to be achieved.The country's strategic location in the Middle East makes its stability crucial for regional and global security. However, Iran's nuclear program and its stance on various international issues have been major points of contention.Despite these challenges, there are ongoing efforts to engage in dialogue and find a peaceful resolution. The international community continues to seek a negotiated settlement that addresses the concerns of all parties involved.

On a surprisingly quiet evening at Wembley, England’s 1-0 defeat to Japan unfolded in a half‑hour that was more ceremonial than competitive. The opening thirty minutes were fluffy and formless, offering little in the way of decisive play but plenty of clues about the team’s underlying issues.For manager Thomas Tuchel, the concession of the opening goal will likely linger in post‑match analysis sessions. The loss adds another chapter to what critics describe as the “never‑ending story of England footballdom,” where each friendly serves as a diagnostic test rather than a showcase of progress.Injuries and omissions forced Tuchel to field a makeshift side featuring Phil Foden, Morgan Rogers, Cole Palmer and Kobbie Mainoo. The line‑up lacked traditional power runners and aerial threats, resembling a “false nine” formation that felt experimental but ultimately failed to generate a clear tactical identity.Japan’s solitary goal came after Palmer lost possession in an attacking area, leaving a void that England’s midfield could not fill. The Japanese attack exploited the space, threading a pass through the centre of England’s formation and scoring with ease. The goal underscored England’s lack of pressure and positional awareness in the defensive third.Despite the disappointment, the match offered a glimpse of individual talent. Harry Maguire and Dan Burn were deployed on set‑pieces, and Jude Bellingham remained an unused asset, highlighting the depth of options available for the upcoming World Cup.Atmospherically, the match resembled a village fête more than a high‑stakes international fixture. Pre‑match entertainment featured a medley of music, fireworks and quirky performances, creating a backdrop that contrasted sharply with the on‑field performance.Analysts noted that England’s approach felt like an attempt to dress up “borrowed tactical clothes” rather than a coherent game plan. The lack of a defined structure left the side vulnerable to Japan’s disciplined, technically sound play.Looking ahead, Tuchel now faces the task of reconciling his experimental selections with the need for a pragmatic, battle‑ready squad. The friendly serves as a reminder that, while England possesses individual brilliance, the team must resolve its tactical ambiguities if it hopes to contend seriously for the 2026 World Cup.

England's World Cup preparations took a hit with a dismal 1-0 defeat to Japan, with Harry Kane's absence from the squad being keenly felt. Coach Thomas Tuchel experimented with various formations and players in Kane's absence, but the team struggled to create scoring opportunities.Tuchel deployed a fluid front four consisting of Phil Foden, Cole Palmer, Morgan Rogers, and Anthony Gordon against Japan, but the system failed to yield the desired results. The lack of creativity and goal-scoring threat without Kane was evident, raising concerns about England's reliance on their captain for goals this summer.“Why would Argentina not rely on Messi or Portugal on Ronaldo?” Tuchel said, highlighting the importance of key players to top teams and nations. He emphasized that Bayern Munich and no other team in the world have the same threat without Kane, underscoring his influence on the team.Tuchel, who was also without several key players including Jude Bellingham, Declan Rice, John Stones, Reece James, and Bukayo Saka, tried different approaches in recent matches. Despite the challenges, he expressed confidence that England can win games without Kane, but acknowledged that having him makes it “easier to win matches.”The coach reiterated that he is not looking for a second Harry Kane, as there is no replacing the influential striker. Tuchel stated that Kane's absence disrupts not only the team's on-field performance but also the squad's dynamics, given his role as captain and a key personality.Tuchel's comments suggest that England's World Cup prospects are heavily dependent on Kane's form and availability. The team's performance in their final camp before the World Cup has given Tuchel “more clarity” over his 26-man squad selection, but the absence of Kane and other key players has raised concerns about their readiness for the tournament.