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What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

The Sudden Loss of a Racing Legend Longtime teammates, former rivals and others around the sports world have joined the wave of condolences over the sudden death of Nascar driver Kyle Busch on Thursday. Busch, a two-time Cup Series champion who was the winningest driver across the sport's three series in history, died at 41 after being hospitalized earlier Thursday with a severe illness. No cause of death has been announced. Tributes from the Racing Community "Absolutely cannot comprehend this news," Denny Hamlin, a 22-year Nascar veteran and Busch's former teammate, said on social media. "We just need to think of his family during this time. We love you KB." "There aren't really words for today. I've raced against Kyle for a long time, and anyone who's lined up next to him knows exactly what made him special, he gave you everything he had, every single lap, and he made all of us better for it," driver Ricky Stenhouse Jr said in a post. "But more than the wins and the records, I keep thinking about Samantha, Brexton, and Lennix, and the entire Busch family right now. That's where my heart is. Rest easy, Rowdy. The sport won't be the same without you." A Legendary Career Busch was in his fourth season at Richard Childress Racing. He ranked 24th in the Cup Series standings, with two top-10 finishes in 12 races this season, and had been the Cup Series champion in 2015 and 2019 with Joe Gibbs Racing. He won a Nascar Truck Series race at Dover International Speedway last week and was slated to compete in this weekend's Coca-Cola 600 in Charlotte, North Carolina, before his family announced on Thursday he had been hospitalized. The Impact on the Racing World Dale Earnhardt Jr, an on-track rival after he took over Busch's car after he departed Hendrick Motorsports in 2007 who later became a friend, called Busch one of the "greatest drivers in Nascar history". "Kyle and I had a really challenging existence for many years. But we luckily took the time to figure out our differences and that was something he instigated with a conversation in his bus around how we each managed our racing teams. I was super eager for us to get on better terms. But it was he who made the effort for that to be possible," Earnhardt said. "I will never be able to make sense of this loss but I am thankful that we had found a way to become friends."

Palantir Accuses Mayor of Prioritising Politics Over SafetyPalantir says London mayor Sadiq Khan is “politicising procurement” by blocking a two‑year, £50 million AI contract for the Metropolitan Police, arguing the move jeopardises public safety.Mayor Blocks £50m AI Procurement Deal with Met PoliceKhan’s office cited a “clear and serious breach” of procurement rules and rejected the plan for the Met to use Palantir’s AI to process intelligence in criminal investigations. The decision was first reported by the Guardian on 21 May 2026.Financial Stakes: £50m Contract and Wider Government Deals£50 million – value of the blocked Met Police contract.£330 million – NHS England deal with Palantir.£240 million – Ministry of Defence agreement.Less than £500,000 – earlier separate AI pilot with the Met to detect rogue officers.Political Fallout and Policing Implications in LondonThe move has split Labour MPs: Rosena Allin‑Khan and Clive Lewis praised the block, while Stella Creasy condemned Palantir’s CEO for “using sexual‑abuse allegations to attack the mayor”. The Metropolitan Police Federation called the AI system “big brother”. Business Secretary Peter Kyle defended Palantir’s capabilities and urged Khan to explain his decision.Future of AI Procurement and Domestic Tech AlternativesKhan’s stance may encourage a shift toward British‑owned AI solutions, echoing Kyle’s call for more investment in domestic firms. Ongoing debates about foreign AI providers could reshape how UK public services adopt advanced technology, with potential impacts on policing effectiveness and public trust.

The Disco Legend Returns to the SpotlightLost in Music, He's the Greatest Dancer, Thinking of You and We Are Family – many artists would long for just one of these songs at any time in their career, but for Sister Sledge they all appeared on a single side of one of their albums. As she brings these and the rest of the disco group's still-sensational catalogue to the Electric Paradise festival this summer, Kathy Sledge will be joining us to answer your questions.The Rise of Sister SledgeKathy is one of four Sledge sisters along with Debbie, Joni and Kim, who formed the group as children in the mid-1960s, picking up gigs at churches and local events in their home city of Philadelphia as the Sledge Sisters. After flipping the name around, they got a record deal and their first chart success came in the UK in 1973, with the Top 20 hit Mama Never Told Me.The Chic Collaboration That Defined an EraFurther commercial success eluded them for a few years – though that's no reflection on the quality of early disco material such as Pain Reliever – until their label paired them with Chic's Nile Rodgers and Bernard Edwards. Sister Sledge's poise and charisma shone from the aforementioned hits the pair wrote for them, collected on the album We Are Family. The title track reached No 2 in the US and it, along with the others, endure as pinnacles of the disco era.Chart Success Through the DecadesRemixed versions of those songs came back around in 1984 and 1993, each to great success particularly in the UK, though the group's only UK No 1 single was in a very different style in 1985, with the swaying neo-60s pop of Frankie.A Solo Career and Continued PerformancesKathy took the lead vocal on some of their biggest hits, and after Sister Sledge went on hiatus in 1987, she had a solo career interspersed with occasional Sister Sledge reunions, and later – amid some legal wrangles with her sisters – solo tours of Sister Sledge material. Next up she'll perform at Electric Paradise in Milton Keynes, on 8 August, alongside other legends of the era such as Grace Jones, Candi Staton, Kool and the Gang and more.Your Questions for the Disco IconNow 67, Kathy has been in countless nightclubs and recording studios around the world across her multi-decade career, so there's plenty to ask her. Post your questions in the comments below before 6pm GMT on Wednesday, and we'll publish her answers later in the week.

The Underwhelming Experience of Cannes 2026 The 2026 Cannes film festival has come to a close, leaving many with a sense of disappointment. This year's event was marked by a lack of standout films, with even seasoned veterans like László Nemes, Pedro Almodóvar, and Asghar Farhadi delivering average performances. The Absence of Hollywood Glamour One notable absence was the lack of big-budget Hollywood films in the official selection. Typically, films like Mission: Impossible or Elvis would add a touch of glamour to the festival, but their absence was felt this year. The Disappointing Auteurs Films from renowned directors like Ryusuke Hamaguchi's 'All of a Sudden' and Cristian Mungiu's 'Fjord' received mixed reviews, with some critics calling them contrived and lacking in substance. The Data Analysis: A Look at the Numbers While there aren't specific numbers to analyze, the overall sentiment among critics and attendees suggests that this year's festival was a letdown. The Impact Analysis: A Shift in the Film Festival Landscape The underwhelming experience of Cannes 2026 raises questions about the future of the film festival. Will it continue to be a premier event for filmmakers and industry professionals, or will it struggle to regain its momentum? The Prediction: What's Next for Cannes Based on this year's lineup, it's clear that Cannes needs to adapt and evolve to stay relevant. The festival may need to consider new ways to attract top talent and engage audiences. Standout Films and Awards Despite the overall disappointment, some films stood out, including Andrey Zvyagintsev's 'Minotaur,' Paweł Pawlikowski's 'Fatherland,' and Rodrigo Sorogoyen's 'The Beloved.' These films showcased exceptional direction, acting, and storytelling. Palme d'Or: Minotaur (dir. Andrey Zvyagintsev) Grand Prix: Fatherland (dir. Paweł Pawlikowski) Jury Prize: The Black Ball (dirs. Javier Calvo, Javier Ambrossi)

The LeadMajor US social media companies including Meta's Facebook and Instagram platforms have blocked the accounts of Saudi Arabian dissidents so they are no longer visible inside the kingdom, following orders by Saudi authorities. Those affected include Abdullah Alaoudh, a US-based activist and vocal critic of Saudi human rights violations, and Omar Abdulaziz, a Canada and UK-based activist who worked closely with Jamal Khashoggi before the journalist's murder by Saudi agents in 2018.The Platform Response to Government DemandsAt least seven accounts had been blocked by Meta at the end of April, including those of two American citizens and two individuals based in Europe, according to the advocacy group American Committee for Middle East Rights (ACMER). Meta did not respond to the "dirty work" claim, but provided a statement to the Guardian saying that when "something happens" on one of its platforms that is reported as violating local law but not the companies' own community standards, the company may restrict the content's availability in the country where it is alleged to be unlawful.Meta operates a public "transparency center," where it acknowledges that Saudi authorities contacted the company and sought restrictions on a total of 144 Instagram accounts, Facebook pages, and Facebook profiles during April. The site also shows that Meta restricted access to 108 "items".Inconsistent Approaches to Government RequestsInterviews with some of the dissidents targeted suggest the companies approached by Saudi authorities did not all respond in the same way. While Meta did alert users that their content was being blocked due to a "local legal requirement, or a request from a government," Snapchat appears to have slowed or removed accounts in Saudi Arabia – including one used by Abdulaziz – without alerting the account owners of the change. It is not clear how many Snapchat accounts were affected, and its owner, Snap Inc, declined to comment.At least two users of X, which is owned by Elon Musk, received letters informing them that the platform had received a request from the Saudi communications, space and technology commission claiming their accounts violated Saudi laws. X told users including Abdulaziz that it had not taken any action on the reported content yet, writing that the company "strongly believes in defending and respecting the voice of our users". It then urged addressees to seek legal advice if they wished, or to delete the relevant content voluntarily.Human Rights Concerns and ImplicationsAbdulaziz told the Guardian: "I think this is just the introduction to a massive crackdown by the Saudi government to mute opposition. It could go as far as committing atrocities, just like they did with the murder of Jamal Khashoggi." The Saudi government did not respond to a request for comment, sent through the Saudi embassy in Washington.Other accounts targeted include those of individuals linked to the London-based human rights organisation ALQST, including its founder, Yahya Assiri. Dr Maryam Aldossari, an ALQST board member, stated: "These [account holders] are not dangerous actors; they are people documenting abuses, challenging state propaganda and giving voice to Saudis inside the country who cannot speak freely. Blocking these accounts would not protect public safety, it would project authoritarian power from scrutiny."The Future of Digital DissentDr Aldossari further commented: "This is how authoritarian censorship travels: through legal notices, platform pressure and the attempted outsourcing of repression to global technology companies." As social media platforms continue to navigate the complex landscape of international laws and human rights standards, the case of Saudi dissidents highlights the growing challenge of maintaining free expression in an increasingly interconnected digital world where governments increasingly seek to control online discourse beyond their borders.

The Marine Heatwave's Persistence and ExpansionAn enormous marine heatwave off the US west coast is ringing alarm bells among ocean and atmospheric scientists as new data shows its ecological and environmental effects are intensifying. The unusual area of warm water has persisted since peaking in size during September 2025 and still stretches thousands of miles from the California coastline – more than halfway across the Pacific – affecting a vast triangle-shaped region of oceanic habitats from Hawaii to British Columbia and southward to Mexico.The Event DetailsAs recently as early April, marine scientists had hoped that the heatwave might diminish and the worst of its effects may be avoided. However, new projections released last week by the National Oceanic and Atmospheric Administration (Noaa) show it is now expected to expand and strengthen in the months to come.The Data AnalysisScientists say the effects may already be far reaching. A surge in the marine heatwave would accompany the formation of El Niño in the tropical Pacific – resulting in an atmospheric and oceanic mélange that could influence everything from record-breaking temperatures on land to disrupted marine food chains.The Impact AnalysisAdditional data acquired in recent weeks has left climate scientists gobsmacked and re-examining their assumptions of how the complex interplay between the ocean and the atmosphere could accelerate the effects of human-caused climate crisis. Climate scientists said the persistent marine heatwave has contributed to shockingly extreme temperatures downstream across most of the United States.The Prediction“There’s real concern right now that even if this marine heatwave didn’t persist, we’re heading into a bad wildfire season with poor water supply conditions,” said Larry O’Neill, an Oregon State University climatologist. “Our summer is going to be much warmer than normal.”

President Donald Trump and Supreme Leader Ayatollah Mojtaba Khamenei have issued opposing statements on Iran’s 60‑percent enriched uranium stockpile, intensifying a diplomatic deadlock that could shape the future of the nuclear talks between Washington and Tehran. Trump’s Stance and Khamenei’s Countermand on Iran’s Uranium Stockpile During a Thursday press briefing, Trump declared, “We will get it. We don’t need it, we don’t want it. We’ll probably destroy it after we get it, but we’re not going to let them have it.” The same day, Reuters reported that Khamenei issued a directive forbidding the removal of the uranium, emphasizing a consensus within Iran’s establishment that the material must stay inside the country. Quantifying the 60‑Percent Enriched Uranium Stockpile 440 kg (approximately 970 lb) of uranium enriched to 60 percent is believed to be held by Iran. Enrichment to 90 percent is required for weapons‑grade material; the current level shortens the time needed to reach that threshold. International Atomic Energy Agency chief Rafael Grossi warned that, if further enriched, the stockpile could produce more than 10 nuclear warheads. The material is stored primarily as uranium hexafluoride gas in small canisters, each comparable in size to a scuba tank. Geopolitical Stakes of the Uranium Dispute The stockpile sits at the heart of US‑Iran negotiations. The United States seeks its removal—potentially handing it over to the US or a third party—while Iran, backed by its supreme leader, resists any export. Israeli Prime Minister Benjamin Netanyahu has linked the end of the regional conflict to the removal of the uranium, the cessation of Iran’s proxy support, and the dismantling of its ballistic missile capabilities. Scenarios for the Future of Iran’s Enriched Uranium Recent diplomatic exchanges suggest several possible pathways: Deadlock: Iran’s top diplomat Abbas Araghchi described the issue as postponed, indicating a stalemate in current talks. Down‑blending: Unconfirmed reports claim Iran offered to irreversibly reduce the enrichment level from 60 percent to the 3.67 percent limit of the 2015 JCPOA. Third‑party custodianship: The United States has hinted at a clause ensuring the stockpile’s removal, while Iran has reportedly considered handing it only to a neutral third party. Safe transport protocols: The IAEA outlines the use of type 30B steel cylinders to move uranium hexafluoride, mitigating criticality and toxic‑chemical risks. Historical precedents include the US‑Canada medical‑isotope shipments of highly enriched uranium (mid‑1980s to 2021) and the 1994 “Project Sapphire” operation that safely relocated 600 kg of weapons‑grade uranium from Kazakhstan to the United States. Outlook: What Lies Ahead for the Negotiations? Given the entrenched positions of both Washington and Tehran, the uranium issue is likely to remain a bargaining chip in any future agreement. If Iran proceeds with down‑blending or agrees to third‑party oversight, the immediate proliferation risk could diminish, potentially unlocking broader diplomatic concessions. Conversely, a refusal to move the material may prolong sanctions and heighten regional tensions, especially with Israel emphasizing its removal as a precondition for peace.

The Deadliest Day in Recent Honduran HistoryGunmen have killed at least 25 people, including six police officers, in attacks across Honduras. The attacks marked Thursday as one of the most violent days the country has seen in recent years. They came despite ongoing efforts by the government to rein in organised crime and violence.Details of the Coordinated AttacksNineteen people were killed as gunmen raided a palm plantation in the municipality of Trujillo in the north of the country. A leader of one rural group told the AFP news agency that those killed were employees of an armed group controlling a plantation. However, local media indicated that armed suspects had fired indiscriminately on labourers. They reported that the oldest victim was 61.Meanwhile, in the west near the Guatemalan border, six police officers were killed in another shooting in the municipality of Omoa. Police report that the officers had travelled to the area as part of an operation to quash gang activity. However, they were ambushed.After the two attacks, the National Police issued a statement, saying it "will proceed immediately with a direct intervention in the affected areas." "The state will act firmly to capture those responsible, protect vulnerable communities and guarantee comprehensive justice for all affected victims," it added.The Human Cost of ViolencePhotos showed bodies, some wearing thick rubber boots for work, strewn on the ground outside the plantation in Trujillo. The attacks represent a significant loss of life in a single day, highlighting the extreme danger faced by ordinary citizens and security forces alike in Honduras.The National Police has vowed to respond forcefully to the attacks, but the scale of violence suggests that the security situation in Honduras remains precarious despite government efforts to address the problem.Honduras' Ongoing Security CrisisHonduras is struggling to crack down on gang violence. Until January, many parts of the country were under a state of emergency launched in 2022. That emergency decree ended, however, with the inauguration of right-wing President Nasry "Tito" Asfura, a close ally of United States President Donald Trump, who has prioritised a hardline approach to security in Latin America.The attacks will, therefore, raise concerns over security, but also civil liberties. Laws passed earlier this week will allow authorities to designate gangs and drug cartels as terrorist groups. A new anti-organised crime unit has also been created.Root Causes: Land Conflict and Organized CrimeThe Trujillo shooting occurred near the Aguan River Valley, where armed groups, involved in narcotrafficking and palm oil extraction, have been fighting over land for decades. Trujillo police chief Carlos Rojas told local media that the groups occupy and illegally exploit several large African palm plantations, using money from the crops to obtain weapons.Local farmer groups, however, accuse transnational agribusiness corporations of sponsoring the criminal groups to carry out land occupations and prevent residents from reclaiming disputed lands. According to Reuters, more than 150 people in the area have been killed or disappeared, with environmental and land rights activists a particular target.Honduras is one of the most dangerous countries in the world for such activists. Earlier this month, police arrested several individuals, including a mayor, for plotting the assassination of a prominent environmental campaigner in 2024.Future Outlook for Security in HondurasThe recent surge in violence suggests that Honduras' security challenges are far from resolved despite the new administration's hardline stance. The combination of organized crime, land disputes, and narcotrafficking creates a complex security environment that cannot be addressed through law enforcement measures alone.International attention and cooperation, particularly with the United States, may play a crucial role in addressing the root causes of violence. However, the immediate priority for the Honduran government will be to demonstrate its ability to protect citizens and restore a sense of security in the affected regions.