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The Lead: A High-Stakes Diplomatic Encounter Chinese President Xi Jinping is expected to seek concessions on Taiwan and US tariffs when he meets United States President Donald Trump for a critical summit taking place in the shadow of the war on Iran. Trump's arrival in China marks the first trip by a US leader to the country since 2017, setting the stage for what could be a pivotal moment in US-China relations. The Taiwan Confrontation: Core Interest and Red Lines Unlike Trump's mercurial policymaking approach, Xi is widely seen as predictable in his goals for the summit, particularly concerning Beijing's "core interests" related to national security and territorial integrity. At the top of that list is Taiwan, which Beijing views as an inalienable part of its territory despite Taiwan's self-governing status. China has named Taiwan as the first of "four red lines" that "must not be challenged." In a call with US Secretary of State Marco Rubio last month, Chinese Foreign Minister Wang Yi described Taiwan as "the biggest risk in the China-US relationship." While analysts say it's unlikely the US will change its position on Taiwan due to Chinese pressure, Trump has indicated the summit will include discussions about the $14bn arms package approved by Congress for Taiwan. The Trade War Dynamics: Economic Uncertainty and Strategic Maneuvering Xi is also eager to smooth over US-China relations after a tumultuous 18 months that saw Trump launch a second trade war with the world's second-largest economy. The standoff saw both countries implement escalating tariffs and punitive measures, including export controls, before hitting pause in May. During their last meeting in South Korea in October, Xi and Trump agreed to a one-year reprieve in their trade war, though some trade measures remain in place. China is likely to agree to increase purchases of US agricultural exports and Boeing planes during the summit, but is unlikely to make concessions on rare earths—a sector it dominates—without major political trade-offs from the US. The Geopolitical Chessboard: Iran Conflict and Global Implications The US-Israel war on Iran will loom large over the summit. Although not a direct participant, China has been significantly impacted by the economic fallout of the conflict and the shutdown of the Strait of Hormuz, through which one-fifth of global oil and natural gas supplies typically pass. Beijing has consistently called for negotiations and a comprehensive ceasefire since the conflict began, a message Xi is likely to reiterate. Despite Trump stating he doesn't need China's "help" resolving the war, the White House has pressured Beijing to influence Iran to reopen the strait. China has maintained a "comprehensive strategic partnership" with Iran since 2016 and purchases more than 80% of its oil, though Xi is expected to limit China's role to mediation, consistent with its non-intervention foreign policy principle. The Future of US-China Relations: Strategic Adjustments and Long-term Planning For Beijing, the stakes are particularly high as its view of Trump has shifted from a "predictable transactional counterpart" to a "more action-oriented and harder-to-restrain opponent." Rather than securing immediate concessions, China's priority is "trying to adjust the current strategic position and negotiating pace that are unfavorable to it, and bring US-China interactions back into a framework that it can better control." Xi may also support Trump's plan to create a "Board of Trade" and "Board of Investment" to oversee US-China economic ties, as Beijing seeks predictability and certainty for the remainder of Trump's term through January 2029. This stability would allow China to plan its own economic policies with greater confidence, particularly regarding tariff levels and trade relationships.

The Cultural Phenomenon Returns On a chilly morning at a Silvertown studio behind London City airport, the sunburst intro to Jimmy Cliff's The Harder They Come is on repeat. Dancers run through a routine studded with reggae and dancehall moves. "Get high," commands associate choreographer Neisha-yen Jones with a smile. "Get low!" The ensemble rise and dip. They do the bogle and whine around each other as their watchful director Matthew Xia nods along. They circle Natey Jones who breaks out the opening line: "Well, they tell me of a pie up in the sky." In the distance, a plane leaves the ground. From Film to Theatrical Celebration It's eight months since The Harder They Come's full-throttle takeoff at Stratford East, where the musical was so popular that it is now returning for a second run which will also serve as a eulogy for Cliff who died in November. Playwright Suzan-Lori Parks' adaptation of Perry Henzell's 1972 Jamaican film is bolstered by a handful of her own songs as well as classics including Israelites and Wonderful World, Beautiful People – plus every number on the film's monumental soundtrack. Jones is reprising the role of Ivan (played on screen by Cliff and inspired by real-life outlaw Rhyging), who arrives in Kingston from the country and is dismissed and exploited, before becoming both a hit singer and a fugitive. The Evolution of a Cultural Narrative The original was akin to cinéma vérité, directly evoked spaghetti westerns and veered into blaxploitation territory; Ivan's tale has gained greater warmth, humour and protest spirit on stage. It was the best musical I saw in 2025. "The story is a tragedy but the theatrical event is a celebration," says Xia of his production. Twenty years ago, the film was adapted as a musical with a book by Henzell, also at Stratford East. "It all started at Ivan's Nine Night," Xia recalls. "There was a massive poster of Ivan on the wall, with everyone coming, and it was told in retrospect with vignettes." Choreography and Cultural Connection Shelley Maxwell, recently arrived from Jamaica, was watching the musical in the audience one night and has since become the choreographer of the new production. She has fused the folk dance forms of revivalism and pocomania, learned in her childhood, with reggae, dancehall and moves that today's teenagers can recognise. "I wanted to tap into the youth market," she says. It's brought some enthusiastic feedback from audience members who may not know the film. "Like: 'Oh my God, they did that step I always do at a party!' It allows them to form a connection." Authenticity and Cultural Representation Xia, wearing trainers in the Jamaican flag's colours, and Maxwell, whose tracksuit has the same black, green and gold trim, were intent on instantly transporting their audience to Kingston. The opening, says the director, is an "establishing shot" with characters coming and going on Simon Kenny's magnificent multi-level set, accompanied by Toots and the Maytals' hit Funky Kingston. To borrow from its lyrics, you really can believe everything they do. Even each move in the dominoes game we see is scripted, explains Maxwell, who mapped out the market scene with precision: "Where are you going to? How heavy is the item that you're holding? This is the swing of the hips." Social Commentary Through Performance Xia, whose father came to England from Jamaica in the 1970s, praises the freewheeling realism of the film. "Lots of the background performers are just whoever happened to be in the market that day, or walking through the shantytown. Lots of the actors were people that Perry knew, they had no training." Henzell, says Xia, showed "the part of Jamaica that had always been hidden, people living hand to mouth". The musical depicts a "quartet of oppression" against Ivan, as he takes a stand against individuals representing hypocrisies of the church, law, drugs trade and music industry. Universal Themes and Contemporary Relevance The Harder They Come was both a pioneering example of independent film-making for Jamaicans and a portrait of a newly independent country. Maxwell, who grew up glued to Hollywood musicals, says it was empowering to discover a film full of the Jamaican songs she loved. "I was probably way too young when I saw it. But what I saw was the world around me." She traces how different forms of music played a pivotal part in the country establishing its identity, moving from African forms and American R&B; to mento, ska, rocksteady, reggae and the rise of Bob Marley and Jimmy Cliff. Maxwell captures that chain reaction with a tantalizing question: "What's this groove becoming?" Transforming the Narrative for Modern Audiences The musical also makes its hero's actions more understandable. "In the film, Ivan becomes a kind of wanton murderer," says Xia. In the musical, "he accidentally shoots a police officer when he's under threat, is remorseful, yet also knows that if he gives himself in then that's the end of his journey". Another significant change is the depth given to the principal women – Ivan's mother Daisy and Elsa, with whom he falls in love under the eye of her authoritarian guardian, the preacher. "The moral heart of the piece now resides in those two women," says Xia. Maxwell transforms a brief sequence from the film, in which Ivan imagines a tryst with the devout Elsa, into a floor-trembling set piece when the preacher's congregation lose their robes to indulge in lustful fantasy. The male gaze of the original scene is duly excised: "it had to be like it was both of them in partnership in that fantasy world," says Maxwell, who adds that the nature of dancehall – "grinding, gyrating on another body" required her to use her skillset as an intimacy director.

A new large‑scale randomized trial presented at the European Congress on Obesity in Istanbul indicates that the oral GLP‑1 antagonist orforglipron can help patients retain the majority of weight lost with injectable therapies such as tirzepatide (Mounjaro) and semaglutide (Wegovy).Trial Shows Oral Orforglipron Preserves Most Weight After Switching from InjectablesThe study, funded by Eli Lilly, followed 376 US patients who had been on tirzepatide or semaglutide injections for 72 weeks and then randomized them to a daily orforglipron tablet or placebo for an additional year.Participants were previously on weekly GLP‑1 jabs that typically produce 15‑20% body‑weight loss.After the injection phase, subjects were switched to oral therapy or placebo for 12 months.Primary endpoint: proportion of weight loss retained at 12 months.Quantitative Outcomes: 75% vs 49% Retention for Tirzepatide Users, 80% vs 38% for Semaglutide UsersWeight‑loss maintenance differed markedly between the pill and placebo groups:Tirzepatide cohort: 75% of lost weight retained with orforglipron vs 49% with placebo.Semaglutide cohort: 80% retained with the pill vs 38% with placebo.Secondary benefits—blood pressure, cholesterol, and glycaemic control—were also sustained in the pill arm.Implications for Obesity Management and Healthcare CostsExperts highlighted the broader significance:Dr Louis Aronne (Weill Cornell Medicine) emphasized that treating obesity directly can simultaneously improve glucose, lipid, and blood‑pressure metrics.Dr Marie Spreckley (University of Cambridge) noted patient preference for oral therapy due to convenience, storage, and lower cost.Dr Simon Cork (Anglia Ruskin University) warned that injectable GLP‑1 drugs, while highly effective, are expensive and limit long‑term accessibility for both private payers and the NHS.The findings suggest a potential shift toward oral agents that maintain efficacy while reducing financial and logistical burdens.Future Outlook: Oral GLP‑1 Therapies Could Redefine Chronic Obesity CareIf further trials confirm these results, orforglipron could become a cornerstone of chronic obesity management, enabling earlier intervention (BMI 25‑27) and possibly preventing progression to severe obesity.Regulators and payers will likely scrutinize cost‑effectiveness models, but the prospect of a cheap, daily tablet that sustains weight loss may reshape treatment algorithms worldwide.

Lead: Massive Street Demonstrations Across ArgentinaTens of thousands of Argentines converged in major cities on Tuesday to denounce the Javier Milei administration’s cuts to the public university system, a cornerstone of the nation’s tuition‑free higher‑education model.Thousands Take to Streets as Milei’s Cuts Target Tuition‑Free UniversitiesProtesters marched from central Buenos Aires toward the presidential palace, chanting against budget shortfalls that they claim undermine the foundations of higher education. The public university system has been tuition‑free since 1949 and has produced five Nobel laureates.Estimated protest size: tens of thousands nationwide.Key locations: Buenos Aires, Córdoba, Rosario.Government stance: Alejandro Alvarez, undersecretary for university policy, called the march “completely political”.Budget Shortfalls and Salary Declines Highlight Fiscal StrainCongress approved a law last year to finance operating costs and raise academic salaries in line with soaring inflation, but the Milei government has refused implementation and is challenging the legislation in court.University operating‑cost financing law: passed 2025.Real‑term professor salaries have fallen by about one‑third since Milei took office in late 2023.Unemployment and real wages are also declining, contributing to sliding approval ratings for Milei.Erosion of Higher‑Education Foundations Threatens Social MobilityThe cuts strike at a system that has historically enabled social mobility and scientific achievement. Public anger is amplified by corruption allegations surrounding Manuel Adorni, Milei’s cabinet chief, whose alleged lavish spending contrasts sharply with his official salary.Public universities: tuition‑free, historically elite‑producing.Corruption probe: media reports on extravagant expenses by Adorni.Political climate: protests include a broad cross‑section of ages and political leanings.Future Trajectory: Potential Escalation and Policy Reversal ScenariosIf the government continues to block the financing law, protests may intensify, potentially forcing a legislative or judicial reversal. Conversely, a negotiated settlement could restore funding, stabilizing university salaries and tempering social unrest.

Study Shows Fetal Exposure to Vegetable Flavours Influences Post‑Birth PreferencesThe research team gave pregnant volunteers powdered kale or carrot capsules during the third trimester and later measured their children’s facial reactions to the same smells. Reactions were recorded via ultrasound before birth, repeated at three weeks, and again when the children were about three years old.Methodology: Kale and Carrot Powder Capsules Administered to Expectant MothersParticipants were asked to swallow a capsule each day containing either kale or carrot powder. The study avoided large volumes of juice, which many volunteers found unpalatable, opting for a low‑cost capsule format.Capsules administered in late pregnancy (around 32 weeks gestation).Initial chemosensory response captured with ultrasound imaging.Follow‑up assessments at 3 weeks and 3 years post‑birth.Sample Size and Observed Reactions Reveal Early Flavor MemoryAlthough the cohort was modest, the findings were consistent:12 children were observed at age three.Infants exposed to carrot powder smiled when presented with a carrot scent and grimaced at kale, and vice‑versa for the kale group.The same preference pattern was evident in the ultrasound scans before birth.These results suggest that flavour exposure in utero can create a durable chemosensory memory.Potential Public‑Health Benefits of Early Dietary ConditioningIf replicated on a larger scale, the approach could offer a low‑cost strategy for improving population nutrition:Reducing childhood resistance to vegetables may lower long‑term risks of obesity and diet‑related diseases.Capsules are inexpensive and could be integrated into routine prenatal supplements.The concept is adaptable to different cultural diets, as noted by the researchers’ interest in fish‑rich Japanese diets.Next Steps: Larger Trials and Cross‑Cultural ApplicationsThe authors acknowledge the need for a bigger, funded study to confirm the effect across diverse populations. Future research aims to:Expand the sample size to hundreds of mother‑child pairs.Test additional flavours and odourants, including artificial sweeteners.Explore policy pathways for incorporating flavour‑exposure capsules into prenatal care guidelines.Published in Developmental Psychobiology, the paper titled “Do Human Fetuses Form Long‑Lasting Chemosensory Memories?” opens a new avenue for early nutritional interventions.

Roberto Sanchez, the left‑leaning presidential candidate of Juntos por el Peru, has been formally accused of financial crimes, with prosecutors seeking a five‑year‑four‑month prison term and a permanent ban from holding the presidency.Undisclosed Campaign Contributions Trigger Criminal ChargesProsecutors allege that Sanchez and his brother William Sanchez received more than 280,000 Peruvian soles (≈ $81,720) in contributions and membership fees between 2018 and 2020, which were omitted from the party’s financial disclosures to the National Office of Electoral Processes.Financial Scope of the AllegationsUndisclosed amount: 280,000 solesPeriod covered: 2018‑2020Proposed sentence: 5 years 4 months imprisonmentAdditional penalty: permanent disqualification from the presidencyPotential Ripple Effects on Peru’s Run‑off ElectionThe charges emerge just after electoral authorities confirmed Sanchez’s place in the June 7 run‑off against conservative rival Keiko Fujimori. A conviction could bar him from office, reshaping the dynamics of a contest that currently shows Fujimori leading with 17.17 % of the vote and Sanchez at 12 %.Judicial Timeline and What It Means for VotersA judge is slated to rule on May 27 whether the case proceeds to trial. If the case moves forward, Sanchez may be unable to campaign effectively, potentially boosting Fujimori’s chances or opening space for other candidates.

ACCESS: Medicare’s First AI‑Enabled Outcome‑Based Payment Model Pair Team was announced on April 30 as one of 150 organizations accepted into ACCESS (Advancing Chronic Care with Effective, Scalable Solutions), a CMS initiative that launches on July 5. The program shifts reimbursement from traditional time‑based fees to payments tied to measurable health outcomes such as lower blood pressure or reduced pain, covering conditions like diabetes, hypertension, chronic kidney disease, obesity, depression, and anxiety. Revenue Scale and Funding Behind Pair Team Staff: roughly 850 clinical professionals, the largest community‑health workforce in California. Revenue: exceeds nine figures (>$100 million) annually. Capital raised: about $30 million from investors including Kleiner Perkins, Kraft Ventures, and Next Ventures. Patient reach: partnerships give access to ~500,000 potential patients, with a goal of 1 million within three years. Industry context: digital‑health funding hit its highest Q1 total since the pandemic, with AI firms capturing the bulk of new capital. How Outcome‑Based Payments Could Redefine Chronic Care Delivery The ACCESS model creates the first federal mechanism to pay for AI agents that monitor patients between visits, coordinate social services, and ensure medication adherence. Flora, Pair Team’s voice‑AI assistant, now handles 24/7 intake, referrals, and check‑ins, delivering hour‑long conversations that act as both clinical touchpoints and companionship for high‑needs patients. Peer‑reviewed research in the Journal of General Internal Medicine shows Pair Team’s community‑integrated approach cuts avoidable emergency and inpatient utilization, with one‑in‑four hospital visits and one‑in‑two ER visits averted for its members. Risks remain: the program funnels highly sensitive data into a federal system with a history of breaches, and past CMS innovation pilots have drawn criticism for increasing federal spending without delivering projected savings. What’s Next for AI‑First Health Providers Under ACCESS Batlivala argues that lower per‑patient reimbursement rates are intentional, forcing providers to adopt lean, AI‑driven operations. As the program scales, success will hinge on: Automating patient interactions to keep costs below payment thresholds. Demonstrating measurable outcome improvements across the covered chronic conditions. Managing data‑privacy concerns to maintain trust among vulnerable populations. Attracting additional capital as investors watch the first AI‑centric Medicare payment model unfold. If Pair Team and its peers can prove the model’s efficacy, ACCESS could become a template for nationwide AI‑enabled, outcome‑based reimbursement, reshaping how Medicare incentivizes technology in health care.

The Lead A recent study has provided evidence that crickets may experience pain in a similar way to humans and other animals. Researchers at the University of Sydney have found that crickets exhibit behaviors that resemble pain responses when injured, such as stroking and grooming a sore antenna. Cricket Pain Response Study Associate Professor Thomas White, an entomologist from the University of Sydney, led the study, which was published in Proceedings of the Royal Society. The researchers applied a heated soldering iron to the antennae of dozens of crickets, causing a temporary but unpleasant sensation. The crickets that received the hot probe 'overwhelmingly' directed their attention to the affected antenna, grooming it more frequently and for a longer period than those that did not receive the treatment. The Data Analysis The study found that: Crickets that received the hot probe directed their attention to the affected antenna. They groomed the antenna more frequently and for a longer period. The soldering iron was set to 65C, hot enough to be unpleasant but not causing lasting harm. The Impact Analysis This research has significant implications for our understanding of insect cognition and pain. The study's findings suggest that insects may be capable of experiencing pain, which challenges traditional views of their cognitive abilities. This has important implications for animal welfare, particularly for insects that are farmed for food, feed, and research. The Prediction As science continues to reveal more about insect brains, behavior, and experiences, it is likely that our understanding of their capacity for pain and consciousness will evolve. This may lead to changes in animal welfare laws and our treatment of insects in various industries. Ultimately, this research encourages us to reevaluate our relationship with insects and consider their well-being.

A Sudden Tragedy Shocks the GrizzliesBrandon Clarke, the 29‑year‑old forward for the Memphis Grizzlies, was found dead at a home in California’s San Fernando Valley, the team announced on Tuesday. No cause of death has been released.Details of Clarke’s Passing and Career HighlightsClarke was born in Vancouver, Canada, and entered the NBA as the 21st overall pick in the 2019 draft, originally selected by the Oklahoma City Thunder before his rights were traded to Memphis on draft night. He spent his entire career with the Grizzlies, earning a spot on the NBA All‑Rookie First Team in 2020 after averaging 12.1 points and 5.9 rebounds in his debut season.Injuries—including knee, calf, Achilles issues—limited his availability; he appeared in only two games during the 2025‑26 season and has missed 174 of a possible 246 games over the past three seasons.Career Statistics and Recent Playing TimeAverage career: 10.2 points and 5.5 rebounds per game over seven seasons2025‑26 season: 2 games playedContract: multiyear extension signed in October 2022Ramifications for Memphis Grizzlies and the NBA CommunityThe Grizzlies issued a statement describing Clarke as “an outstanding teammate and an even better person,” while NBA Commissioner Adam Silver called him “a beloved teammate and leader.” The loss affects not only the roster but also the broader Memphis community, where Clarke was active in outreach.What Lies Ahead for the Grizzlies Without ClarkeWith Clarke’s contract still in effect, the team will need to address the roster spot and salary cap implications while seeking to fill the leadership void. The Grizzlies may look to develop younger forwards or explore trade options to maintain competitiveness in the Western Conference.