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For the first time, thousands of cancer patients from Black and minority ethnic backgrounds will benefit from an enhanced genetic test offered by the NHS. The new screening expands the panel of DPYD gene variants from four to five, directly addressing a long‑standing bias that left non‑white patients vulnerable to dangerous chemotherapy side‑effects. In England, patients slated for chemotherapy undergo a genetic check that can guide dose adjustments and mitigate adverse reactions such as mouth sores, hair loss, nausea, fatigue, and, in severe cases, death. Up to 40% of the 38,000 individuals receiving fluoropyrimidine‑based chemotherapy each year experience a harmful drug reaction. Previously, the test only targeted four DPYD variants common in people of European descent, meaning many Black patients received inaccurate “all‑clear” results. The addition of a fifth variant—more prevalent among African, Caribbean and other minority groups—means clinicians can now identify patients at risk who were previously missed. Since its rollout at Manchester University NHS Foundation Trust last September, three minority‑ethnic patients have had their initial chemotherapy doses adjusted, lowering their chance of a potentially fatal reaction. Dr Veline L’Esperance, senior clinical adviser at the NHS Race and Health Observatory, called the change “tangible results for patients who have historically been left behind.” She emphasized that the update shifts the discussion on ethnic health inequality from rhetoric to actionable care. Prof Habib Naqvi, chief executive of the NHS Race and Health Observatory, described the development as a “groundbreaking outcome” for chemotherapy safety, while noting that ethnic minorities remain under‑represented in genomic research and biobanks. He warned that broader inclusion is essential for the promised benefits of precision medicine to reach all communities. Prof Dame Sue Hill, chief scientific officer for NHS England, highlighted the significance of discovering the fifth variant: “Personalising chemotherapy based on genetics can save lives and reduce harmful side‑effects, especially for patients of African ancestry.” She added that the North West NHS Genomic Medicine Service has already demonstrated the practical impact of this approach. These steps come amid broader evidence that minority patients in the UK face longer diagnostic waits, more GP visits before a cancer diagnosis, and lower perceived support during treatment. The expanded DPYD test represents a concrete effort to close those gaps and ensure equitable, science‑driven care for all cancer patients.

Euphoria's third season has been a long-awaited return, but unfortunately, it's absolutely not worth the wait. The show's creator, Sam Levinson, has taken a darker and more desperate approach, focusing on the characters' bleak lives and struggles with sex work, drugs, and trauma.The season picks up five years after the end of season two, with recovering addict Rue (Zendaya) drawn into the world of drug dealer Laurie (Martha Kelly). Her life as a mule between Mexico and the US is depicted in gritty and intense cinematic sequences, drawing on westerns and blaxploitation.Meanwhile, Cassie (Sydney Sweeney) is on the cusp of trad wifedom with toxic jock Nate (Jacob Elordi), but their relationship is marred by Nate's crumbling business and Cassie's OnlyFans content. The show's handling of her cam girl ambitions feels bafflingly dated and voyeuristic.The performances are mostly good, with standout performances from Zendaya, Sweeney, and Adewale Akinnuoye-Agbaje. However, the show's grim and humorless tone makes it feel like a chore to watch.Levinson's approach to exploring the devastating impact of synthetic opioids on ordinary Americans feels heavy-handed and desperate. The show's focus on brainrot bimbo-ism and male perversion also detracts from its once unapologetically queer heart.Overall, Euphoria season three is a disappointing and grubby addition to the series, feeling like a contractual obligation rather than a passion project.

On a recent weekday evening, a special bus tour whisked art lovers through over twelve galleries and museums that stayed open until midnight, offering a late‑night glimpse of the Abidjan Art Week programme.The after‑hours event, dubbed the Night of the Galleries, was first trialled in January 2024 alongside the Africa Cup of Nations – a tournament that Côte d’Ivoire both hosted and won – and has become a staple of the festival’s third edition, which ran from Tuesday to Sunday.Since its inception, the week has broadened its footprint, moving beyond the city centre to include venues such as the La Rotonde des Arts contemporary‑arts hub in the Plateau district and the Adama Toungara Museum of Contemporary Cultures (MuCAT) in the working‑class neighbourhood of Abobo.Local collectors are emerging in force. MuCAT has hosted the Africa Foto Fair each year since 2022, and the Marché des Arts du Spectacle d’Abidjan – the city’s answer to the Dakar Biennale – is set to launch its 14th edition later this month.A graffiti festival launched two years ago has transformed the perception of street art, with vibrant murals now adorning the façade of the La Pyramide building and several upscale hotels in Plateau.Organisers stress that the festival’s growth should be independent of external validation. This year’s roster featured artists from Cameroon, the Democratic Republic of the Congo and Mali, and the number of participating galleries more than doubled compared with previous editions.Founder Yacouba Konaté, who also directs La Rotonde des Arts, highlighted the festival’s commitment to accessibility, arguing that art should not be seen as an elite pastime.The opening tribute honoured Simone Guirandou‑N’Diaye, a pioneering Ivorian art historian whose legacy lives on through Galerie LouiSimone Guirandou, now run with her daughter Gazelle.Among the week’s highlights, MuCAT presented Murmures d’Archives, a quieter, archival‑focused exhibition that concluded with an artists’ workshop and a DJ set.In the upscale Cocody district, New York‑based artist Ouattara Watts staged a solo show at Galerie Cécile Fakhoury, drawing the Ivorian diaspora into dialogue with the local scene. Watts explained that his work aims to transcend borders, describing it as “a vision that goes beyond any map – it is the cosmos that I paint.”

The Department for Culture, Media and Sport, acting on Historic England’s advice, has awarded Grade II* listed status to a limestone rubble barn on a grassy knoll in the Lake District, joining an elite roster that includes Battersea Power Station and the London Coliseum.Dubbed “Henry’s Castle,” the structure was most recently used as a shelter for livestock, but research suggests it may date back to the 14th century and originally served a high‑status function that remains unknown.Only 5.8% of England’s listed buildings achieve the Grade II* level, indicating they possess “more than special interest.” The barn’s unusual features – a corbelled chimney stack, a stepped garderobe, and a plastered interior showing signs of fire – set it apart from ordinary field barns.Historic England’s listing team leader, Sarah Charlesworth, described the building as “one of those rare structures that raises more questions than it answers,” underscoring its intrigue for scholars and visitors alike.Lake District National Park’s built‑environment adviser, Rose Lord, recalled her 2022 visit, noting that despite layers of animal manure the barn’s architecture hinted at something “very special” – a construction far beyond typical agricultural outbuildings.Four years of meticulous work by archaeologists, architects, and conservation engineers have restored the barn’s most striking element: an oak roof featuring a hand‑finished, chamfered and pegged central truss, a technique associated with high‑quality carpentry of the 14th or 15th centuries.Experts speculate on the barn’s original purpose, ranging from a defensive lookout or hunting lodge to a luxurious summer house. Historic England notes similarities to bastles – fortified farmhouses common along the Anglo‑Scottish border – though the building’s location south of the border makes a strict classification unlikely.Originally converted to domestic use in the 16th or 17th century and later repurposed as a field barn by the 19th century, the structure takes its name from former owner farmer Henry Willison.Lord called the new listing the “cherry on the cake” for the restoration project, highlighting that most buildings of comparable significance have already been recorded in earlier surveys. Interpretation panels and an owl‑nesting box are slated for installation in the coming weeks, adding educational and ecological value to the site.

The highly anticipated third and final season of Euphoria premieres on Monday at 9pm on Sky Atlantic. The series, created by Sam Levinson, follows the lives of a group of high school students as they navigate love, friendship, and identity.The new season stars Zendaya, Jacob Elordi, and Sydney Sweeney, who have all become major Hollywood stars since the show's debut. The story picks up five years after high school, with the characters now in their early 20s. Previews are scarce, but it's known that Cassie and Nate are married, Jules is in art school and is a 'sugar baby', and Rue is involved in some shady business in Mexico.Other TV shows airing tonight include Miriam Margolyes Made Me Me on BBC Two, Great Japanese Railway Journeys on BBC Two, Missed Call on Channel 5, Charmain and the Prophet on BBC Two, and DTF St Louis on Sky Atlantic.

Rescuers are frantically digging through the rubble in south Lebanon after a series of deadly Israeli strikes hit the region. The attacks have left a trail of destruction, with many lives lost and communities affected.The situation on the ground remains dire as emergency responders work tirelessly to search for survivors and recover the bodies of those killed. The impact of these strikes has been severe, exacerbating tensions in an already volatile region.International concern is growing over the escalation of violence, with calls for restraint and a return to diplomatic efforts to resolve the conflict. The incidents have sparked widespread condemnation and highlighted the urgent need for a peaceful resolution.

The article from Al Jazeera outlines the people who lost their lives in Lebanon as a result of Israeli military action on a single day, emphasizing the personal tragedies behind the headline numbers. By naming each victim, the report seeks to humanize the casualties and draw attention to the broader humanitarian consequences of the ongoing hostilities between Israel and Lebanon.While specific details such as ages, occupations, or hometowns are listed in the original piece, the overarching message is clear: the conflict’s impact is deeply personal, affecting families and communities across the region. These individual stories serve as a stark reminder of the cost of continued violence and underscore calls for de‑escalation and protection of civilians.

A devastating stampede at Haiti's iconic Citadelle Laferriere has claimed the lives of at least 30 people, with authorities warning that the death toll may rise. The tragedy unfolded on Saturday during an annual celebration at the early-19th-century fortress, a popular tourist attraction and UNESCO World Heritage Site.The stampede occurred at the entrance to the site, where a large crowd of students and visitors had gathered. Heavy rain exacerbated the disaster, leading to a chaotic and deadly situation. Haiti's Prime Minister, Alix Didier Fils-Aime, extended his condolences to the bereaved families, assuring them of his solidarity during this difficult time.The Culture Minister, Emmanuel Menard, confirmed the deaths of 30 people, stating that the injured are receiving medical care and a rescue team is searching for any missing persons. The exact number of those injured remains unknown. This incident highlights the ongoing challenges faced by Haiti, which has struggled with widespread gang violence and deadly disasters in recent years, including fuel tank explosions and earthquakes.

Israeli airstrikes across southern Lebanon have killed at least 18 people, including eight civilians in a village near Sidon and ten victims – among them three emergency workers – in the Nabatieh district, according to Lebanon’s Health Ministry. The ministry’s latest figures show the conflict, which erupted on March 2 after Hezbollah fired rockets in support of Iran, has now claimed 2,020 lives and wounded 6,436 since Lebanon was drawn into the U.S.–Israel war on Iran. In a separate incident, two Israeli paratroopers were wounded by shrapnel during clashes with Hezbollah forces in the south, as reported by Israel’s Channel 13. Amid the escalating violence, President Joseph Aoun announced that Lebanese, Israeli and U.S. officials will convene in Washington next week to discuss a ceasefire and the framework for future negotiations under U.S. auspices. Hezbollah, however, has reiterated its refusal to engage in direct talks with Israel, labeling the proposed negotiations a “blatant violation of the national pact, the constitution and Lebanese law,” according to lawmaker Hassan Fadlallah. Pro‑Hezbollah demonstrators gathered near the government headquarters in central Beirut, waving the group’s yellow flag and the Iranian standard, to protest the planned talks. Hezbollah and its ally, the Amal Movement, later urged supporters to refrain from further demonstrations, citing the need for stability and civil peace. Israeli Prime Minister Benjamin Netanyahu emphasized that any peace settlement must be lasting and called for the disarmament of Hezbollah, underscoring the deep strategic divide. While the United States and Iran announced a tentative ceasefire this week, the agreement’s applicability to Israel’s campaign in Lebanon remains uncertain. Iranian officials claim they secured a U.S. assurance that Israel will reduce attacks on Lebanon, but no confirmation has been received from Israeli authorities regarding a ceasefire or a reduction in hostilities. These diplomatic efforts coincide with historic in‑person ceasefire talks between the U.S. and Iran in Islamabad, Pakistan, highlighting the broader regional stakes of the Lebanon‑Israel conflict.