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What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

Palantir Accuses Mayor of Prioritising Politics Over SafetyPalantir says London mayor Sadiq Khan is “politicising procurement” by blocking a two‑year, £50 million AI contract for the Metropolitan Police, arguing the move jeopardises public safety.Mayor Blocks £50m AI Procurement Deal with Met PoliceKhan’s office cited a “clear and serious breach” of procurement rules and rejected the plan for the Met to use Palantir’s AI to process intelligence in criminal investigations. The decision was first reported by the Guardian on 21 May 2026.Financial Stakes: £50m Contract and Wider Government Deals£50 million – value of the blocked Met Police contract.£330 million – NHS England deal with Palantir.£240 million – Ministry of Defence agreement.Less than £500,000 – earlier separate AI pilot with the Met to detect rogue officers.Political Fallout and Policing Implications in LondonThe move has split Labour MPs: Rosena Allin‑Khan and Clive Lewis praised the block, while Stella Creasy condemned Palantir’s CEO for “using sexual‑abuse allegations to attack the mayor”. The Metropolitan Police Federation called the AI system “big brother”. Business Secretary Peter Kyle defended Palantir’s capabilities and urged Khan to explain his decision.Future of AI Procurement and Domestic Tech AlternativesKhan’s stance may encourage a shift toward British‑owned AI solutions, echoing Kyle’s call for more investment in domestic firms. Ongoing debates about foreign AI providers could reshape how UK public services adopt advanced technology, with potential impacts on policing effectiveness and public trust.

The Disco Legend Returns to the SpotlightLost in Music, He's the Greatest Dancer, Thinking of You and We Are Family – many artists would long for just one of these songs at any time in their career, but for Sister Sledge they all appeared on a single side of one of their albums. As she brings these and the rest of the disco group's still-sensational catalogue to the Electric Paradise festival this summer, Kathy Sledge will be joining us to answer your questions.The Rise of Sister SledgeKathy is one of four Sledge sisters along with Debbie, Joni and Kim, who formed the group as children in the mid-1960s, picking up gigs at churches and local events in their home city of Philadelphia as the Sledge Sisters. After flipping the name around, they got a record deal and their first chart success came in the UK in 1973, with the Top 20 hit Mama Never Told Me.The Chic Collaboration That Defined an EraFurther commercial success eluded them for a few years – though that's no reflection on the quality of early disco material such as Pain Reliever – until their label paired them with Chic's Nile Rodgers and Bernard Edwards. Sister Sledge's poise and charisma shone from the aforementioned hits the pair wrote for them, collected on the album We Are Family. The title track reached No 2 in the US and it, along with the others, endure as pinnacles of the disco era.Chart Success Through the DecadesRemixed versions of those songs came back around in 1984 and 1993, each to great success particularly in the UK, though the group's only UK No 1 single was in a very different style in 1985, with the swaying neo-60s pop of Frankie.A Solo Career and Continued PerformancesKathy took the lead vocal on some of their biggest hits, and after Sister Sledge went on hiatus in 1987, she had a solo career interspersed with occasional Sister Sledge reunions, and later – amid some legal wrangles with her sisters – solo tours of Sister Sledge material. Next up she'll perform at Electric Paradise in Milton Keynes, on 8 August, alongside other legends of the era such as Grace Jones, Candi Staton, Kool and the Gang and more.Your Questions for the Disco IconNow 67, Kathy has been in countless nightclubs and recording studios around the world across her multi-decade career, so there's plenty to ask her. Post your questions in the comments below before 6pm GMT on Wednesday, and we'll publish her answers later in the week.

Lead: Guardiola’s Transformative Tenure at Manchester CityWhen Pep Guardiola took charge in February 2016, he inherited a squad in transition. Over the next four seasons the club evolved into a dominant force, redefining Premier League standards and setting new statistical benchmarks.2016‑17: Building the Blueprint – A Trophy‑Free InceptionThe inaugural season was a learning curve. City finished third in the league and exited the Champions League in the last‑16 to Monaco. The campaign highlighted the emerging influence of Kevin De Bruyne in midfield, laying the tactical foundations for future success.2017‑18: The 100‑Point Milestone and Domestic SupremacyGuardiola’s second season delivered historic numbers:100 points – a Premier League record at the time106 goals scoredLeague title secured with a 19‑point margin over Manchester UnitedLeague Cup triumph over ArsenalDespite a 5‑0 victory over Liverpool early on, City were eliminated by the same opponents in the Champions League quarter‑finals.2018‑19: Securing the Domestic Treble Amidst European FrustrationCity’s third campaign saw a slight dip in points (98) and goals (95), but the season culminated in a historic domestic treble:Premier League championsLeague Cup winnersFA Cup winnersEuropean ambitions were thwarted when Tottenham knocked City out on away‑goals in the Champions League quarter‑finals.2019‑20: Covid‑Era Setback and Cup ConsolationThe pandemic‑disrupted season saw City finish second, 18 points behind Liverpool. A memorable 4‑2 aggregate win over Real Madrid hinted at European progress, but a one‑off quarter‑final loss to Lyon ended the run. The club salvaged silverware with a League Cup victory over Aston Villa.Financial and Brand Impact of City’s SuccessGuardiola’s trophy haul has driven commercial growth:Global sponsorship deals expanded, boosting revenue by an estimated £200 million annually.Matchday attendances consistently topped 55,000, reinforcing the Etihad’s status as a premier venue.Merchandise sales surged, with the 2017‑18 season alone generating record shirt sales worldwide.Strategic Implications for English Football and EuropeCity’s dominance has forced rivals to rethink recruitment, tactical flexibility and financial investment. The club’s emphasis on possession‑based, high‑pressing football has become a benchmark for Premier League aspirants, while the continued European shortfall underscores the tactical gap between English and continental powerhouses.Future Outlook: What Lies Ahead for Guardiola and CityLooking forward, Guardiola aims to convert domestic supremacy into Champions League success, likely by further strengthening the squad’s depth and adapting to evolving European tactics. With a solid financial base and a clear footballing philosophy, Manchester City is positioned to remain at the forefront of both English and European competition for years to come.

The Lead: Russia's Escalation and Ukraine's Counteroffensive Russia's attempts at escalation via Belarus, where it has delivered more nuclear weapons and held highly publicized joint war games, come as its ground war falters in Ukraine. Ukrainian commander-in-chief Oleksandr Syrskii reports that Ukraine has seized the tactical initiative, with Ukrainian offensive assaults now outnumbering Russian assaults on Ukrainian positions. Russia's Soldier Shortage and Recruitment Crisis Ukraine's forces have gained the upper hand because Russian forces are running out of soldiers to conduct offensive operations. According to Syrskii, "Since the beginning of 2026, the total losses of the enemy have already exceeded 141,500 people, of which more than 83,000 are irreversible." Ukraine's Foreign Intelligence Service believes Russia is unable to replenish these losses of more than 1,000 people a day, and this year is recruiting at a rate of 800-930 a day, suffering a net decrease of battlefield strength. In response, 40 Russian regions have increased sign-up bonuses by between 30 and 100 percent. Putin has also simplified citizenship procedures for Russian speakers in the Transnistrian region of Moldova, which Ukrainian President Volodymyr Zelenskyy described as "Russia looking for new soldiers." Economic Impact: Ukraine's War on Russian Oil Infrastructure Russia's economy is fraying, having run up a $78.4bn deficit in the first four months of 2026 after budgeting for a $50.5bn deficit for the entire year. "Oil dealt the main blow. Revenues from hydrocarbons fell by 38.3 percent," according to Ukraine's Foreign Intelligence Service. Ukraine has scaled up its long-range campaign against Russian refineries and oil export terminals, depriving Moscow of windfall profits from high oil prices. International Energy Agency (IEA) data shows Russia has curtailed production by 460,000 barrels per day (bpd) in April 2026 compared with April 2025. Reuters estimates that Ukrainian drone attacks knocked out about 700,000 bpd of refining capacity between January and May across 16 refineries, accounting for a quarter of Russia's refining capacity. Shift to Asymmetric Warfare: Ukraine's Strategy Evolution "Given our limited resources, to effectively resist a much larger enemy, we are trying to shift from a 'war of attrition' to an asymmetric strategy," Syrskii told the European Union Military Committee. "Our main tasks are to stop the enemy's advance and effectively counterattack, strike at the Russians' rear, including deep within their territory." Ukraine has attacked military-industrial targets in a 100km radius around Moscow, including the Angstrem semiconductor plant, the Solnechnogorsk oil pumping station, and the Moscow Refinery. Ukraine has also targeted refineries in Ryazan, Yaroslavl, Kstovo, and Sizran, as well as military hardware including helicopter gunships, amphibious craft, and anti-aircraft missile systems. Belarus Front: Russia's Nuclear Escalation and Ukraine's Warning Russia has put pressure on Belarus President Alexander Lukashenko to open a new front in the war against Ukraine. Zelenskyy stated that Russia would launch a simultaneous attack from its neighboring region of Bryansk against Chernihiv. "We know that there have been additional contacts between the Russians and Alexander Lukashenko aimed at persuading him to join new Russian aggressive operations," Zelenskyy said. Russia involved Belarus in a joint nuclear exercise with 64,000 personnel, more than 200 missile launchers, 140 aircraft, 73 surface ships and 13 submarines. Russian President Vladimir Putin confirmed that the two countries would launch ballistic and cruise missiles as part of the exercise. Russia has parked its new Oreshnik tactical nuclear missile in Belarus since last year and has threatened to attack European arms manufacturing and military sites with it.

The Sequel Announcement The studio behind hit Michael Jackson biopic 'Michael' has revealed plans for a sequel despite the controversy that surrounded the original. Production Details Speaking in a quarterly earnings call, Lionsgate motion picture chair Adam Fogelson said that preparations for a projected sequel “continue to go exceptionally well”. Fogelson added that there is a lot of entertaining Michael Jackson story that was not touched upon in the first film. The Financial Impact The original film delivered record-breaking box office figures in both the US and UK, with its current revenue standing at $715.8m worldwide. Fogelson suggested that some of the previously shot footage could be utilised for the sequel, which would help lower the sequel’s production costs. Addressing Controversy The production of 'Michael' was dogged by issues surrounding allegations of child sex abuse against Jackson. It is not clear how or even if a sequel will deal with these allegations. However, Fogelson suggested that the sequel may not follow chronologically. The Future Outlook Lionsgate believes that they have 25 to 30% of a second movie already shot from the prior production activity. The studio is confident that the sequel will appeal once again to a global audience.

The Shift in India's Oil Imports Venezuela has emerged as India’s third-largest crude oil supplier this month, as the war on Iran and the closure of the Strait of Hormuz force countries to scramble for alternative energy sources. Shipments from Venezuela to India are nearly 50 percent higher than they were in April, according to energy tracking data. The Impact of the Strait of Hormuz Crisis Nearly half of India’s crude oil imports are normally shipped from Gulf producers through the Strait of Hormuz, along with large volumes of liquefied natural gas and petroleum gas. But the narrow Gulf shipping route has become inaccessible as the conflict around Iran intensifies. The Data Analysis Venezuela has supplied India with about 417,000bpd so far this month, up from 283,000bpd in April. India's total crude imports have risen this month to about 4.9 million bpd amid the global oil supply crisis. The Impact Analysis Analysts say Washington is attempting to reshape global energy supply chains – reducing Iran’s leverage in any peace talks – while simultaneously tightening its grip over Venezuela’s oil sector. Critics say Washington’s campaign against Maduro was never simply about democracy or human rights, but about restoring US influence over one of the world’s largest oil reserves and replacing Iranian crude with Venezuelan supplies – opening the door to a conflict with Tehran. The Prediction Experts say the parallel visits by Rubio and Rodriguez to India demonstrate how energy diplomacy is increasingly being shaped by the geopolitical fallout from the wars involving Iran and Venezuela. Rodriguez and Rubio will now be hoping to secure a deal that could pave the way for this surge in oil exports to continue.

The Nuclear Buildup in Eastern Europe Earlier this week, Belarusian President Alexander Lukashenko for the first time took part in the "rehearsal" of Russia's use of tactical and strategic nuclear weapons. Between Tuesday and Thursday, he and Russian President Vladimir Putin presided over joint military drills covering the area from Eastern Europe to the Pacific, involving hundreds of Russian missile launchers, warplanes, warships and nuclear submarines. "We threaten absolutely no one," said Lukashenko, who has helmed Belarus since 1994. "But we have such weapons, and we're ready in every possible way to defend our common fatherland from [the western Belarusian city of] Brest to [Russia's Pacific port of] Vladivostok." Russia's Nuclear Drills and Capabilities "It's important to further boost the level of readiness of strategic and tactical nuclear forces," Putin stated during the exercises. Both leaders ordered the launch of the intercontinental, hypersonic Yars missile capable of carrying three independently targetable nuclear missiles, which flew 5,750km (3,573 miles) from the Plesetsk Cosmodrome in northwestern Russia to the Pacific Kamchatka Peninsula in less than 20 minutes. As part of the drills, Moscow supplied Minsk with modified Su-25 fighter jets and Iskander-M ballistic missiles with a range of up to 500km (310 miles). Nuclear weapons are reportedly stored at the Asipovichi military range, less than 200km (124 miles) north of the Ukrainian border. Geopolitical Implications The drills come amid heightened tensions between Russia and NATO. NATO Secretary-General Mark Rutte warned that if Moscow uses nuclear weapons against Ukraine, the alliance's response would be "devastating." The exercises are clearly timed to a summit of NATO foreign ministers in Sweden's Helsingborg, a venue symbolic as Sweden joined the alliance after Russia's full-scale invasion of Ukraine. "The events develop suddenly, seemingly without any external reasons," noted Nikolay Mitrokhin, a researcher with Germany's Bremen University. "Something big is taking place, something that will be significant for international politics in general, and for mass media, including the very supply of nuclear arms." Belarus's Calculus While Belarus enjoys economic preferences and cheap hydrocarbons from Russia, Lukashenko has resisted Putin's attempts to merge Belarus with Russia as part of "union state" deals dating back to the 1990s. In recent months, ties between Belarus and the United States have also warmed, with Lukashenko joining United States President Donald Trump's Board of Peace. "We're not going to get sucked into the war in Ukraine. There's no need for it, neither civil nor military," Lukashenko stated, signaling his readiness to meet with Ukrainian President Zelenskyy. "If [Zelenskyy] wants to discuss something, seek advice, or anything else, he's welcome. I'm ready to meet him anywhere in Ukraine or Belarus." Future Scenarios Ukrainian President Zelenskyy has warned that the drills may be part of Moscow's preparations to launch a new offensive against northern Ukraine and Kyiv after Russian troops failed to capture sizeable areas in eastern and southern Ukraine this year. However, the current concentration of Russian forces in Belarus is "insufficient" for a new offensive, according to the head of the Kyiv-based Penta think tank. "Attacking Ukraine with Belarusian forces alone may end very badly for Lukashenko," said Volodymyr Fesenko. "For him, involving Belarus in the war is too big a risk." Despite this, analysts acknowledge that "unfortunately, there is such a risk" of Belarus becoming more directly involved in the conflict, though most believe Lukashenko will avoid such a development.

The Departure of a Legend Manchester City have confirmed that Pep Guardiola is leaving at the end of the season. The manager is to step away after Sunday’s match at home to Aston Villa with one year on his contract, and City have lined up Enzo Maresca to replace him. Guardiola's Legacy at Manchester City Guardiola has been City’s manager for 10 years, winning 17 major trophies, including this season’s Carabao Cup and FA Cup. Hopes of a domestic treble ended on Tuesday when City’s 1-1 draw at Bournemouth made Arsenal the Premier League champions. The Appointment of Enzo Maresca Maresca has agreed in principle a three-year deal to succeed Guardiola, who he assisted at City in the 2022-23 season. Maresca has been out of work since leaving Chelsea on New Year’s Day. Chelsea are in line for sizeable compensation for the Italian, who departed with three and a half years on his deal, plus the club option of an extra year. Guardiola's Parting Words Guardiola said with a nod to Manchester’s history: “This is a city built from work. From graft. You see it in the colour of the bricks. From people who clocked in early, stayed late. The factories. The Pankhursts. The unions. The music. Simply the industrial revolution and how this changed the world. And I think I grew to understand that, and my teams did too. We worked. We suffered. We fought. And we did things our own way. Our way.”