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The Childcare Crisis in BritainThe number of childminders in England has roughly halved over the past decade, with many citing rising costs, low pay and increasing paperwork as reasons for leaving the profession. Campaigners warn the decline is making it harder for families to find flexible and affordable childcare.Seeking Parent ExperiencesWe want to hear from parents and carers whose childminder has recently closed their business, stopped accepting certain age groups such those over three-year-olds or reduced the number of children they look after.Impact on FamiliesHow did it affect your family? Did you struggle to find alternative childcare? Have you been forced to move your child into a nursery setting despite feeling they were better suited to a smaller, home-from-home environment?Share Your StoryThe Guardian is collecting experiences from parents affected by the decline in childminding services. If you're 18 or over, you can share your story anonymously if you wish. Your responses are secure as the form is encrypted and only The Guardian has access to your contributions.Call for ActionAs the childcare landscape continues to change, it's crucial to understand how these changes are affecting families across the UK. By sharing your experiences, you can help highlight the challenges and potential solutions in the childcare sector.

Retatrutide Delivers Up to 28% Body‑Weight Reduction in Phase 3 StudyA new weight‑loss drug has helped participants in a sizable trial lose much more weight than other obesity drugs already on the market – up to an average of 28% of their body weight, Eli Lilly announced on Thursday. Phase 3 Trial Design and Dosing RegimenThe Indiana‑based company randomized 2,339 adults with obesity or overweight and at least one weight‑related comorbidity (no diabetes) to receive Retatrutide at 4 mg, 9 mg, 12 mg, or placebo for 80 weeks. The drug is a once‑weekly triple hormone receptor agonist targeting GLP‑1, GIP, and glucagon. Quantitative Outcomes and Safety ProfileAverage weight loss: 70.3 lb (28.3%) at the 12 mg dose.Average loss at 9 mg: 64.4 lb (25.9%).Average loss at 4 mg: 47.2 lb (19.0%).45.3% of 12 mg participants lost ≥30% of body weight.65.3% reduced BMI below 30; 37.5% of those starting with BMI ≥ 40 achieved this.Side‑effects increased with dose: nausea (28.6%‑42.4%), diarrhea (25.2%‑34.1%), vomiting (up to 25%).For comparison, Zepbound yields 15‑20% loss over 72 weeks and Wegovy 14‑19% over 64‑72 weeks. Implications for the Obesity‑Drug LandscapeThe magnitude of loss positions Retatrutide as the most effective pharmacologic option to date, potentially shifting prescriber preference away from existing GLP‑1 monotherapies. Its triple‑agonist mechanism adds glucagon, a hormone absent from current products, which may enhance metabolic control and appetite suppression. Future Outlook: Approval Path and Market PotentialAnalysts expect regulatory submissions within the next year, with a likely U.S. FDA review in 2027. If approved, Retatrutide could capture a sizable share of the rapidly expanding obesity‑treatment market, prompting competitors to explore multi‑agonist formulations.

The Lead The Royal Exchange's 50th anniversary season production, 'Even These Things', is a bold attempt to encapsulate the complex history of Manchester. The play explores themes of identity, community, and belonging through three seemingly unrelated scenes. MAPPING MANCHESTER'S HISTORY The play is built from three scenes, each set in a different time period. The first scene is set in 1846 and features a heavily pregnant Irish immigrant, Annie Donovan, who brushes shoulders with Friedrich Engels on her way to a fist fight. The second scene is set in 1996 and describes the city-centre life of an ordinary Saturday, with a community cast playing out whimsical vignettes. The final scene takes place after the IRA bomb outside the Arndale Centre and features a tender exchange between two strangers of Irish heritage. THE POWER OF COMMUNITY The play's cumulative meaning may be tricky to grasp, but as the scenes rub up against each other, what emerges is a thoughtful, rich and complex picture of home. The connections between the scenes are elliptical, but they ultimately reveal a city with a shared history and a strong sense of community. THE FUTURE OF MANCHESTER The play suggests that, however difficult, a future is possible. The final scene's chat about miscarriage and childbirth between two strangers of Irish heritage meeting in the park some months after the attack on an Ariana Grande concert brought the city together, implies that the city can heal and move forward. CONCLUSION 'Even These Things' is a bold and ambitious production that successfully maps Manchester's complex history. The play's themes of identity, community, and belonging are timely and thought-provoking, making it a must-see for anyone interested in theatre and the city of Manchester.

A candid kitchen conversation with Sir Derek Jacobi The Guardian’s interview captures a warm, unguarded moment as Jacobi and his husband, director Richard Clifford, share coffee and stories in their London home. Jacobi, 80, jokes about his looks, admits he never felt “movie‑star material,” and confides that he would love to reach his centenary. Career milestones and personal anecdotes 1970s breakthrough as the stammering Emperor in I, Claudius. Acclaimed stage work including Cyrano de Bergerac (Royal Shakespeare Company, 1980s) and Macbeth at the Barbican (1993). Recent TV roles in Vicious and Last Tango in Halifax. Early life in Leytonstone; rheumatic fever at nine sparked a shift from working‑class roots to a posh accent and ambition. No financial figures – cultural impact takes centre stage The piece contains no monetary data; its value lies in documenting the lived experience of a veteran actor whose voice and presence have shaped British drama for five decades. What Jacobi’s reflections mean for British theatre and aging performers Jacobi’s honesty about age, health (including his AIDS diagnosis) and self‑image highlights the often‑unspoken pressures on older actors. His partnership with Clifford, who directs and designs their home, underscores the importance of supportive creative collaborations in sustaining long‑term artistic careers. Looking ahead: the goal of hitting 100 Jacobi ends on a hopeful note, expressing a desire to “hit 100” and continue contributing to the arts. His story suggests that longevity in performance is as much about personal resilience and community as it is about talent.

Activists Dock in Turkiye and Share Their StoriesOn 21 May 2026, a flotilla of human‑rights activists reached the port of Turkiye after a contested voyage aimed at highlighting the situation in Gaza. Upon disembarkation, the participants gathered a press briefing to recount alleged incidents of violence perpetrated by Israeli forces during the journey.First‑Hand Accounts of Israeli ViolenceActivists described being intercepted by Israeli naval vessels in international waters.Witnesses reported the use of tear‑gas canisters and rubber‑bullet fire.Several participants claimed injuries requiring medical attention upon arrival.Regional Diplomatic RepercussionsThe arrival has prompted statements from both the Turkish government and the Israeli foreign ministry. Ankara condemned the alleged use of force, while Tel Aviv defended its actions as lawful enforcement of maritime security.Implications for Future Maritime ActivismHuman‑rights groups argue the testimonies could galvanize further flotilla initiatives, whereas security analysts warn of heightened naval confrontations in the Eastern Mediterranean.Looking Ahead: Potential DevelopmentsInternational observers anticipate increased diplomatic dialogue at upcoming UN forums, with the activists’ accounts likely influencing discussions on the legality of blockades and the protection of humanitarian missions.

Spotify and Universal Music Group announced a landmark licensing pact that will allow paid‑subscriber users to create AI‑generated song covers and remixes directly within the Spotify app. The move marks the streaming giant’s first foray into user‑driven AI content creation and is positioned as a way to boost earnings for artists and songwriters. Deal Overview: AI‑Powered Remixes for Subscribers Subscription model: A paid add‑on will be offered to Premium users. Scope: Participants can remix tracks from artists signed to Universal, though the specific roster was not disclosed. Key executives: Alex Norström, co‑CEO of Spotify, and Lucian Grainge, CEO of Universal Music, highlighted consent, credit, and compensation as core principles. Related initiatives: Spotify recently launched a “Verified by Spotify” badge to differentiate human artists from AI‑generated content. Financial Snapshot: Share Surge and Revenue Outlook Stock reaction: Spotify’s shares rose 16% on the announcement day. Revenue guidance: The company projects a “mid‑teens” annual growth rate. Profit outlook: Gross‑profit margins are expected to stay between 35%‑40% through 2030. Industry Ripple: How AI Remix Licensing Could Reshape Music Streaming New revenue channel: The tool promises additional income for artists and songwriters beyond traditional royalties. Artist concerns: The deal addresses longstanding worries about copyright and attribution in AI‑generated music. Competitive pressure: By integrating AI creation tools, Spotify aims to diversify beyond standard subscription revenue. Looking Ahead: Potential Paths for AI Integration in Audio Platforms Expansion of AI features: Spotify may roll out further AI‑driven experiences, such as personalized podcasts and content curation. Regulatory landscape: Ongoing debates over AI‑generated music rights could shape future licensing frameworks. Artist adoption: Success will depend on how many high‑profile Universal artists opt into the program.

Spotify‑UMG Deal Enables Fan‑Made AI Covers and Remixes Spotify announced a licensing agreement with Universal Music Group (UMG) that will let Premium subscribers use generative AI tools to create covers and remixes of catalog songs. The feature will be offered as a paid add‑on and will include a revenue‑share model for participating artists. Alex Norström, Spotify co‑CEO, said the initiative is “grounded in consent, credit, and compensation for the artists and songwriters that take part.” Sir Lucian Grainge, UMG Chairman and CEO, called it a way for artists to deepen fan relationships while opening new revenue streams. Revenue‑Sharing Model and Pricing Details Remain Vague Tool will be a paid add‑on for Spotify Premium users; exact price not disclosed. Participating artists receive a share of revenue generated from AI‑derived tracks, though the split percentage was not revealed. The agreement follows earlier Spotify teasers involving Sony, Warner, Merlin and Believe. Implications for Music Rights and AI Competition Spotify emphasizes “consent, credit, and compensation,” positioning itself against platforms like Suno that have faced lawsuits. Recent legal settlements: Suno settled a $500 million lawsuit with Warner Music Group; UMG settled its suit with Udio. The deal could set a precedent for label‑first AI licensing, potentially reducing litigation risk for AI music services. Future Outlook: More Label Partnerships and an Expanded AI Music Ecosystem UMG may be the first of several major‑label agreements; Spotify hinted at a broader roll‑out. Combined with other AI announcements (audiobook creation, podcaster tools, concert‑ticket reservations), Spotify is positioning AI as a core growth engine. Industry observers expect increased competition among streaming platforms to offer AI‑enhanced creator tools.

Google’s AI‑First Search Redesign at I/O 2026At the Google I/O 2026 keynote, Google unveiled a complete overhaul of its search product, introducing an optional AI mode and embedding an AI Overview chat box directly into results. Elizabeth Reid, head of Search, called it “the biggest upgrade to our iconic search box since its debut over 25 years ago.” The new experience aims to let users enlist AI agents for tasks such as automatic tour notifications for favorite bands.Pricing and Feature Shifts Highlight User ConcernsAI Overviews will appear even for non‑AI mode searches, adding a chat‑style interface.Google’s ad‑supported model remains unchanged, but the AI layer raises questions about data usage.Early feedback labels the change as “another AI‑forced adjustment,” recalling the controversial “stare into the sun” rollout.Why Users Are Turning to Alternative Search EnginesThe backlash stems from two main pain points: intrusive AI features and growing distrust of Google’s market dominance, reinforced by a 2024 U.S. District Court ruling on monopoly practices. Users seeking privacy, ad‑free experiences, or simple AI‑free results are exploring other options.Top Alternatives and Their Unique Value PropositionsKagi – Subscription‑based ($5/month or $10 for unlimited searches). Ad‑free, customizable “lenses” for academic or niche queries, and optional AI “Quick Answer” summaries.DuckDuckGo – Free, ad‑supported but privacy‑first; no tracking of search, browsing, or purchase history. AI answers can be disabled in settings.Startpage – Acts as a proxy to Google, stripping personal data before forwarding queries. Offers AI toggle and a more private Google experience.&udm;=14 – Open‑source script (available on GitHub) that appends a parameter to Google searches to suppress AI Overviews automatically.Brave – Chromium‑based browser with its own search engine; supports “Goggles” to filter results by source type and lets users enable or disable AI features.Ecosia – Chrome‑compatible, ad‑supported, and pledges ~80% of revenue to global reforestation projects, with transparent financial reporting.Looking Ahead: The Future Landscape of SearchIf Google’s AI integration continues to alienate a segment of its user base, the market share of privacy‑centric and subscription‑based engines could grow, pressuring Google to refine its approach or offer clearer opt‑out mechanisms. The competition may also accelerate innovation in AI‑free search experiences and sustainable monetization models.

The Play's Concept Imagine if One Day was set in Long Eaton. Now, take its sweeping, time-spanning love story, but make it platonic, and about two theatre-obsessed best mates. That’s the foundation for Jane Upton’s luminous, heart-exploding play, which catches Jess and Billy in a series of snapshots across their friendship. The Story Unfolds Beginning in the early 90s, during their school days, and then moving through their 20s, 30s and into their mid-40s, the play threads together teenage crushes, career decisions, breakups, marriages, births and children. Jess (Katie Redford) is an oversharer while Billy (Benedict Salter) has secrets. Their early years together pass through play rehearsals, parties, personal revelations and betrayals, but even in their lowest moments, the two are always pulled back to each other’s side. The Evolution of Friendship As their lives move in different directions, with Billy heading to London for drama school and later building a career as a high-flying agent, and Jess staying at home in a “suburban bubble” before eventually tiptoeing her way back into the creative scene as a playwright, they turn their noses up at the other’s choices. Still, in times of turmoil, they can’t help but pick up the phone or race across the country just to be there for their old friend. Their dialogue accurately captures people who know each other’s lives inside out. The Production Directed by Hannah Stone, the production shows friendship as something defining. Redford and Salter make their characters people we want to stay with across the decades. In fact, time here slips through our fingers. One moment they’re 15 in 1995, and Jess is getting advice from More! magazine; the next it is 2022, and a 42-year-old Billy is considering surrogacy for his next child. Abby Clarke’s design evokes nostalgia, with the back wall composed of white, Polaroid-inspired squares that shift from photographic outlines to mirrors. The Verdict With so much life to fit into 95 minutes, there are inevitable gaps in Billy and Jess’s stories. We could learn more about the structure of their families and the other relationships in their lives. But really, this is a play about the complicated, beautiful bond between two people. It leaves you desperate for more days with them. Where to Watch At Nottingham Playhouse until 12 June