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Recent CDC data reveal a dramatic 1,200% increase in kratom‑related poisonings across the United States over the last ten years, with the most pronounced surge recorded in 2025. Researchers link this rise to the growing presence of 7‑hydroxymitragynine (7‑OH), a synthetically produced compound that mimics kratom’s effects but carries opioid‑like risks. Walter Prozialeck, pharmacology professor at Midwestern University, said the trend was expected, noting that the synthetic alkaloid has entered the market through energy drinks and other products since 2024. Christopher McCurdy of the University of Florida warned that marketing 7‑OH as “enhanced kratom” blurs the line for consumers, turning poison‑control calls into a conflated metric for both natural and synthetic products. By contrast, natural kratom (Mitragyna speciosa)—a Southeast Asian plant used for centuries as a pain reliever—has demonstrated a relatively favorable safety profile in animal and human studies. A 2018 statement from then‑HHS Secretary Brett Giroir rejected the DEA’s push to schedule kratom as a Schedule I substance, citing insufficient evidence of harm. Despite the scientific distinction, several states have moved to implement or propose blanket bans on all kratom products, prompting concern from clinicians and patient advocates. A recent user survey indicated that about 50% of respondents rely on kratom for chronic pain, while roughly 40% use it during addiction recovery. Personal testimonies underscore the plant’s therapeutic role. Jeff Maslan, a 68‑year‑old Californian with severe osteoarthritis, credits kratom with easing opioid withdrawal after multiple surgeries. Similarly, “Steven,” a disabled California resident, describes how kratom eliminated unbearable oxycodone withdrawal symptoms without producing the euphoric “warm fuzzy” feeling typical of opioids. Researchers emphasize that 7‑OH carries genuine opioid hazards, including addiction, severe withdrawal, and respiratory depression that can lead to fatal overdose. In animal models, 7‑OH demonstrated the same respiratory‑depression risk as classic opioids, whereas kratom’s primary alkaloid did not. Prozialeck and colleagues explain that kratom’s pharmacology is more nuanced: it partially activates opioid receptors while also engaging adrenergic and serotonin pathways, resembling a hybrid of a weak opioid and an SNRI‑type antidepressant. This multimodal action likely accounts for its lower euphoric potential and the reported boost in energy among users. Nevertheless, experts caution that kratom is not without risk. Fatal poisonings often involve co‑ingestion of potent opioids such as fentanyl, suggesting that some users may cycle between kratom and stronger substances, raising overdose danger due to reduced opioid tolerance. Additionally, heavy‑metal contamination has been detected in certain kratom batches, though the source—soil, processing, or storage—remains unclear. Given these complexities, the consensus among scholars like Austin Zamarripa (Johns Hopkins) is that natural kratom should remain accessible, while concentrated 7‑OH products merit stricter regulation. “These products may offer meaningful benefits to some individuals, and those benefits could be lost if access is restricted too broadly,” Zamarripa said, urging a differentiated policy approach. As the debate unfolds, patients like Steven worry that a sweeping ban would ignore the nuanced safety profile of the plant. “There’s corn on the cob, there’s high‑fructose corn syrup, there’s whiskey— all derived from corn but fundamentally different,” he remarked, highlighting the need for targeted, evidence‑based regulation rather than a one‑size‑fits‑all prohibition.

Oil prices experienced a significant surge, rising more than $5, after President Donald Trump stated that the United States would continue its military operations against Iran. This development has heightened investor concerns about potential sustained disruptions to global oil supplies.Brent crude futures saw a notable increase, rising $6.33, or 6.3%, to $107.49 per barrel early on Thursday. Similarly, US West Texas Intermediate crude futures were up $5.28, or 5.3%, to $105.40 per barrel. These gains followed an earlier decline of more than $1 in both benchmarks prior to Trump's televised address to the nation.The recent escalation in tensions between the US and Iran has led to the closure of the Strait of Hormuz by Iran, in retaliation for the US-Israeli attacks. This strategic move has disrupted approximately one-fifth of global oil and liquefied natural gas (LNG) supplies, precipitating the world's most significant energy crisis in decades.Trump emphasized that the US military is nearing its objectives in the conflict, which he expects to conclude within two to three weeks. His remarks have contributed to increased uncertainty in financial markets.Asian stocks were severely impacted following Trump's speech. Most Southeast Asian countries, which heavily rely on oil imports, are particularly vulnerable to the sharp rise in oil prices triggered by the Middle East conflict. The MSCI gauge of EM Asia equities experienced a 2.3% decline, while regional currencies weakened by 0.2%.Notably, South Korea's main stock market, the Korea Composite Stock Price Index (KOSPI), plummeted by 4.2% after initially gaining nearly 2%. South Korean President Lee Jae Myung urged parliament to promptly pass a 26.2 trillion won ($17.3bn) supplementary budget to bolster the economy during what he described as the worst energy security threat caused by the Middle East crisis.Other Asian markets also saw significant declines, with Singapore's main stock market, the Singapore Exchange (SGX), slipping 0.8%, and Malaysia's benchmark index falling 1%. Markets in Indonesia and Taiwan declined by about 1% and 1.4%, respectively. Stocks in China and Hong Kong also fell, with the benchmark Shanghai Composite index dropping 0.53% and China's blue-chip CSI300 Index losing 0.74%.

Jeepney driver Arturo Modelo of Manila says his daily earnings have collapsed to roughly one‑third of the usual 600 pesos after fuel costs surged, leaving him unable even to afford his child’s lunch money.Modelo joined a two‑day transport strike on Thursday and Friday, hoping to make a “deaf government” listen to the plight of drivers who can no longer earn a living on the road.The iconic jeepney, born from repurposed U.S. military vehicles after World War II, remains the most affordable commuter option in the Philippines, yet its operators are now bearing the brunt of a global oil shock.Last week, jeepney owners walked out, and this week the protest expanded to include bus, taxi, minibus and motorcycle‑taxi drivers. Nearly a dozen national transport groups marched to the Presidential Palace demanding price caps on petrol and diesel, the removal of fuel taxes, and stricter regulation of the oil sector.Organised under the No to Oil Price Hike Coalition, the demonstrators also blamed “American aggression” against Iran for the domestic economic distress, with union chair Jerome Adonis likening the impact to “a bomb dropped on us”.In response, President Ferdinand Marcos Jr declared a national energy emergency on Tuesday night – the first such declaration in the country’s history. The emergency, set to last one year, grants the government powers to accelerate fuel procurement, curb hoarding and curb profiteering.Fuel prices remain among the highest in Southeast Asia: diesel is now about $2.3 per litre and petrol close to $2 per litre in the Philippines, versus $2.7 and $2.35 respectively in Singapore, while Malaysia, Vietnam and Thailand report roughly half those prices.To alleviate the burden, the administration has introduced a 5,000‑peso ($83) subsidy for motorcycle‑taxi drivers and other public‑transport workers, and disbursed 2.5 billion pesos (≈$414 million) in fuel subsidies to roughly 300,000 transport employees. Unions claim the sector employs about two million people, leaving many without aid.During the strike, picket lines appeared at 85 commuter terminals, and jeepneys were scarce on Manila’s usually congested streets. Authorities, however, argued that the action did not cripple the city’s transport network.Union leader Mody Floranda of the Piston group accused President Marcos of favouring oil companies, saying the president could issue an executive order to cap prices but has yet to act decisively.Energy officials note that 98 % of the Philippines’ crude oil is imported and that the country’s high 12 % value‑added tax, excise duties and a deregulated market – shaped by the Oil Industry Deregulation Law of 1998 – amplify price volatility. Professor Krista Yu of De La Salle University highlighted the nation’s limited refining capacity as a structural weakness.Chief economist Emmanuel Leyco warned that the law allowing industry‑driven price adjustments “is the main culprit”, especially as “half the population is poor”.Amid mounting pressure, Marcos signed legislation permitting the temporary suspension of fuel excise taxes when crude oil prices exceed a set threshold. Opposition lawmaker Renee Co urged that the 12 % VAT also be removed, calling both taxes “regressive” burdens on ordinary Filipinos.Co and other lawmakers have also filed a resolution demanding an immediate end to the U.S.‑Israel‑Iran conflict, linking regional geopolitics to the domestic fuel crisis.

Muslim communities around the globe observed Eid al-Fitr on Friday, signifying the conclusion of the sacred month of Ramadan, during which devotees abstain from food and drink from dawn till dusk. The culmination of Ramadan is marked by the sighting of the new moon, heralding the onset of Shawwal. However, variations in moon sighting practices lead to discrepancies in the timing of Eid celebrations across different countries. In several nations, including Mali, Niger, and Afghanistan, Eid al-Fitr was observed on Thursday, whereas in the Middle East, Africa, and Southeast Asia, it was celebrated on Friday. This joyous occasion, which extends over two days, is distinct from Eid al-Adha, which occurs during the Hajj pilgrimage. Traditionally, Eid al-Fitr commences with congregational prayers in open spaces, providing an opportunity for families and friends to unite for collective prayers and festivities. The celebrations this year are overshadowed by conflicts and instability in numerous Muslim-majority countries. In Iran, the ongoing war has resulted in widespread disruptions, while regions in the Gulf have experienced repercussions from escalating tensions. The United Nations reported that over one million people have been displaced in Lebanon due to Israeli attacks. Furthermore, Sudan has evolved into the world's largest humanitarian crisis as the conflict enters its third year.

The US Department of Justice has charged three people, including a co-founder of Super Micro Computer, with helping to smuggle at least $2.5 billion worth of US AI technology to China. The indictment alleges a complex scheme to send US-made servers through Taiwan to other countries in Southeast Asia, where they were swapped into unmarked boxes and sent on to China.The defendants, Yih-Shyan Liaw, Ruei-Tsang Chang, and Ting-Wei Sun, are accused of using fabricated documents and staged bogus equipment to pass audit inventories, and a pass-through company to conceal their misconduct and true clientele list.The US has had export restrictions on China for advanced AI chips since 2022. Nvidia, which dominates the market for AI chips, has stated that strict compliance with export laws is a top priority.Liaw, 71, was arrested in California and released on bail, while Sun, 44, a company contractor, was held for a bail hearing. Chang remains a fugitive. Super Micro's shares fell 8 percent in after-hours trading following the news.