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A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Oil and gas markets rallied on Thursday as investors grappled with the shaky outlook for the two‑week Iran‑Israel ceasefire. Brent crude rose more than 2% to $96.77 a barrel, while New York light crude climbed nearly 3% to $97.23, still shy of the $100 threshold that many traders watch. The previous session had seen Brent plunge 13.29% to a four‑week low of $94.75. In the gas sector, the UK month‑ahead contract rebounded 1% to 115.35p per therm after a 15% drop the day before. European natural‑gas futures also recovered, edging toward €46/MWh from a five‑week trough of €45.30. The price uptick reflects growing scepticism about the durability of the ceasefire announced a day earlier by the United States and Iran, which included a pledge to reopen the Strait of Hormuz. UAE and Kuwait reported intercepting Iranian drones, and Iran’s parliamentary speaker accused the United States and Israel of breaching several agreement points. Iran’s Revolutionary Guards warned of a “regret‑inducing response” if Israeli strikes on Lebanon continue. The latest Israeli barrage killed at least 254 people and wounded 837, prompting the Fars news agency to note that oil‑tanker traffic through the strait had been halted. Former President Donald Trump used his Truth Social platform to threaten that U.S. forces would remain in the region until a “real agreement” is fully honoured, warning that any non‑compliance would trigger “stronger than anyone has ever seen before” military action. Asian equity markets reacted negatively: Japan’s Nikkei slipped 0.7%, South Korea’s Kospi fell 1.7%, and Hong Kong’s Hang Seng edged down 0.4%. In Europe, the FTSE 100 dipped 0.1%, Germany’s DAX fell 0.6%, France’s CAC 40 dropped 0.3%, and Italy’s FTSE MIB slipped 0.2%. The pan‑European Stoxx 600 trimmed 0.1% after a near‑4% rally the day before, while U.S. futures pointed to a lower opening on Wall Street. Deutsche Bank strategist Jim Reid noted that market stress has eased compared with 24 hours earlier, as the ceasefire news generated renewed optimism and reduced fears of a stagflationary shock. On the diplomatic front, White House press secretary Karoline Leavitt announced that Vice‑President JD Vance will lead a delegation to Islamabad, with initial talks slated for Saturday morning. Jefferies chief European economist Mohit Kumar argued that, despite its fragility, the truce is likely to hold because of the “mutually assured destruction” calculus. He added that both sides now see a ceasefire as the lesser‑evil, given the escalating costs of continued conflict and the strategic challenges of securing cheap drone interceptors and a reliable Hormuz passage.

Cheng Li-wun, chairwoman of Taiwan’s main opposition party the Kuomintang (KMT), used a high‑profile trip to mainland China to advocate for renewed dialogue with Beijing. On Wednesday she laid a wreath at Sun Yat‑sen’s mausoleum in Nanjing, invoking the revolutionary’s legacy of “equality, inclusiveness and unity” as a moral foundation for cross‑strait reconciliation. Her visit marks the first time a KMT leader has set foot in China in ten years. Cheng said the core values of Sun’s ideal—"all under heaven are equal"—should guide efforts to promote reconciliation and regional prosperity across the Taiwan Strait. During the trip Cheng also expressed hopes to meet Chinese President Xi Jinping, framing the potential encounter as a diplomatic test that could demonstrate the effectiveness of dialogue over deterrence. The timing of the trip is notable. It comes amid heightened friction between Taipei and Beijing, with China continuing to assert sovereignty over Taiwan while refusing to engage with President William Lai Ching‑te, whom it labels a “separatist”. Amid concerns that a distracted United States may be less able to guarantee Taiwan’s security, some Taiwanese voters view a thaw in relations as attractive. Wen‑ti Sung, a non‑resident fellow at the Atlantic Council’s Global China Hub, told Al Jazeera that a cordial photo‑op between Cheng and Xi could bolster the KMT’s argument that dialogue is more effective than military deterrence. Domestically, Cheng’s outreach occurs as Taiwan’s opposition‑controlled parliament has stalled a proposed $40 billion increase in defence spending. She acknowledged Taiwan’s democratic evolution, referencing the legacy of the “White Terror” period, while also praising China’s recent development achievements. The governing Democratic Progressive Party (DPP) sharply criticized the trip, accusing the KMT of undermining national security. Party spokesperson Wu Cheng argued that if the opposition truly seeks stability, it should stop blocking the defence budget increase. Neither Beijing nor Taipei formally recognises the other’s government, leaving any dialogue fragile and heavily politicised. Cheng’s visit therefore represents both a symbolic gesture toward historic ties and a contested move within Taiwan’s polarized political landscape.

Israel's conflict with Iran has ended in a strategic failure for Prime Minister Benjamin Netanyahu, with the war achieving none of its main goals and damaging Israel's global standing.Despite years of threats and diplomatic pressure, Israel's war with Iran has resulted in a fragile and vague ceasefire, with Iran's regime still intact and its military assets significant.The US intelligence community had deemed Israeli predictions of regime change and revolution in Iran as 'farcical', and Netanyahu's assessment that the war would be short-lived proved woefully wide of the mark.Netanyahu's insistence on continuing attacks in southern Lebanon appears hubristic, and Israel's actions have been criticized by opposition leaders, including Yair Lapid and Yair Golan, who have called the ceasefire a 'strategic failure'.The reality is that Netanyahu gambled everything on his war and failed to secure the fall of the Iranian regime, the seizure of Tehran's stockpile of highly enriched uranium, or meaningful state degradation.Instead, Israel's global standing has been damaged, and its role in pushing the US to war in Iran has been assailed by both progressives and the far right in America.The domestic fallout for Netanyahu in an election year in Israel will be significant, with many Israelis likely to question his ability to deliver on his promises of security and victory.

After Tehran announced a two‑week ceasefire in the Iran war, financial markets breathed a noticeable sigh of relief. Oil prices tumbled by more than 10% on Wednesday, stock indices rallied, and optimism about the global economic outlook resurfaced. However, the reprieve is far from complete.For six weeks the world’s economy has been under pressure as Iran effectively closed the Strait of Hormuz, a chokepoint that handles roughly one‑fifth of global oil and gas shipments. The closure sparked what analysts have called the worst energy crisis of the modern era, driving oil to historic highs.Any progress toward re‑opening Hormuz would ease fears of a supply crunch that could otherwise trigger a cascade of recession risks. Yet the situation remains volatile: Tehran and Washington continue to send mixed signals about the waterway’s status, and Israel’s ongoing strikes in Lebanon add further uncertainty.Consumers already feel the strain. Despite the recent price dip, Brent crude remains above $90 a barrel, a sharp contrast to the sub‑$73 levels recorded before the conflict began. While this is an improvement from the period when prices hovered above $100, it still represents a significant premium over pre‑war benchmarks.Most economists expect oil to stay above its pre‑war price throughout 2026. In its baseline forecast, consultancy Capital Economics projects Brent to settle around $80 per barrel by year‑end. Under that scenario, headline inflation in the United States and Europe would hover between 3% and 4% year‑on‑year, while GDP growth is likely to decelerate across major economies.The lingering uncertainty is amplified by the unpredictable stances of both Iran and the United States, as well as the broader geopolitical turbulence involving Israel. Prior to the conflict, few analysts believed Tehran would actually close Hormuz, a threat it has floated intermittently since the 1979 revolution.Given the strait’s pivotal role in the world economy, any prolonged disruption could add a costly premium to global business operations. The International Monetary Fund (IMF) warned in a recent report that wars since 1946 have left “economic scars” lasting more than a decade. The IMF cautioned that even after a ceasefire, persistent political and economic uncertainty can depress investment returns, fuel capital outflows, and constrain both investment and labor supply.In short, while the ceasefire has delivered a short‑term boost to markets, the underlying energy‑price pressures and geopolitical risks mean that the relief is far from absolute.

Pakistan's diplomatic efforts have yielded a significant breakthrough, securing a temporary ceasefire between the US and Iran. The development comes after intense negotiations led by Pakistan's Prime Minister Shehbaz Sharif and Army Chief Asim Munir.The crisis had escalated to a point where Pakistan's government and military were deeply concerned about the potential consequences for the country's economy, defense, national security, and sectarian harmony. A defense pact with Saudi Arabia meant that if Riyadh entered the war, Pakistan would be drawn into it as well.Behind the scenes, Munir and Asim Malik, the country's head of army intelligence and national security adviser, played a crucial role in mediating the ceasefire. Munir's strong personal rapport with US President Donald Trump and his longstanding relationship with Iran's Revolutionary Guards were instrumental in brokering the deal.China emerged as a key player in the negotiations, with Pakistani officials claiming that Beijing directly encouraged Iran to accept a ceasefire, promising to act as a guarantor of Iran's safety in any talks. This included assurances that Iranian leaders would not be assassinated if they traveled for negotiations.The ceasefire deal was secured by 4am in Islamabad, with both the US and Iran agreeing to a temporary and fragile truce. Michael Kugelman, south Asia fellow at the Atlantic council, described it as Pakistan's 'biggest diplomatic win in years'.Pakistani officials have expressed concerns that Israel and the United Arab Emirates could still try to sabotage the peace process. However, the successful brokering of the ceasefire has been hailed as a 'shining moment' in Pakistan's history and a 'first step' towards peace.

President Donald Trump issued a stark warning that the United States would eradicate Iran’s “civilisation” unless the regime reopens the Strait of Hormuz and complies with his demands. The statement, posted on his Truth Social account less than twelve hours before the self‑imposed deadline, declared that a whole civilisation could die “tonight, never to be brought back again.” Trump set the cutoff for compliance at 8 p.m. Washington time (00:00 GMT) on Tuesday, framing the moment as a decisive point in what he called a long‑standing struggle against Iranian extortion and corruption. For more than two weeks, the president has threatened to strike Iran’s civilian infrastructure—bridges, power stations, roads and other non‑military assets—if his terms are not met. Legal analysts have warned that such actions would constitute a war crime under international law. “It’s horrific. It’s pure evil. It’s disqualifying,” said Yasmine Taeb, legislative and political director of MPower Change Action Fund, condemning the president’s rhetoric as that of “a deranged, unstable madman.” She called for a stronger response from both U.S. lawmakers and the global community. Democratic leaders reacted forcefully. Senate Majority Leader Chuck Schumer labeled Trump “an extremely sick person,” while House Minority Leader Hakeem Jeffries urged Republican colleagues to “put patriotic duty over party and stop the madness,” warning that the conflict could spiral into a world war. Representative Rashida Tlaib suggested invoking the 25th Amendment to remove Trump, citing the recent bombing of a school in Minab that killed over 170 children. Congressional attempts to curb the president’s war powers have stalled; a recent resolution to limit his authority failed to pass, leaving the legal basis for the campaign in question. Critics argue that launching a military operation without congressional approval violates the U.S. Constitution, which reserves the declaration of war to Congress. Republican reactions were muted. Representative Mike Lawler downplayed the threat, stating that any strikes would target only Iran’s energy and civilian infrastructure to cripple the regime’s economy, and affirmed that Trump is acting within his constitutional authority as commander‑in‑chief. The conflict, which began on February 28 when the United States and Israel allegedly killed Iranian Supreme Leader Ali Khamenei and other senior officials, has already claimed more than 2,000 lives, including civilians in schools, residential blocks and medical facilities. Iran’s retaliatory rocket and drone attacks have hit Israeli and U.S. assets across the Middle East, while Iranian forces have blocked the Strait of Hormuz, driving global energy prices higher. Despite the heavy toll, Iran’s governing structure appears intact, bolstered by the Islamic Revolutionary Guard Corps, designated by the United States as a terrorist organization. No major defections or anti‑government protests have emerged, and Khamenei’s son, Mojtaba Khamenei, has assumed a leading role. Trump, while maintaining a hardline stance, left a narrow window for diplomacy, suggesting that “maybe something revolutionary wonderful can happen.” He framed the deadline as “one of the most important moments in the long and complex history of the world,” promising that “47 years of extortion, corruption, and death will finally end.” Vice President J.D. Vance echoed the president’s message, warning Iran that the United States possesses additional, undisclosed tools and will employ them if Tehran does not alter its conduct, emphasizing the U.S. desire for free flow of oil and gas.

The Sharif University of Technology in Tehran was bombed on Monday, destroying and damaging multiple buildings, including an artificial intelligence centre housing critical databases. The university's website and other online services went dark.University President Masoud Tajrishi stated that the attack was intended to hinder Iran's progress in AI technology, which the university had been working on for two years. He emphasized that the enemy does not want Iran to succeed or develop, but all Iranian universities are now united in response to these attacks.The US and Israel have not provided an official reason for targeting Iran's higher education hubs or cultural heritage sites, which are considered civilian infrastructure. Over 30 universities have been affected by US and Israeli attacks since the start of the war on February 28.The attacks have prompted the Islamic Revolutionary Guard Corps (IRGC) to declare US and Israeli-affiliated universities 'legitimate targets'. In response, university heads have urged the IRGC to refrain from attacking other universities, considering them 'human and global heritage' entities.The increasing systematic targeting of civilian infrastructure has caused deep concerns among many Iranians, especially since the country was already dealing with economic woes and an energy crisis. The attacks have also sparked debate among Iranians, with some supporting US and Israeli actions in the hope of toppling the governing establishment.

The White House has firmly denied that it has any plans to use nuclear weapons against Iran, amid escalating tensions and a looming deadline imposed by President Donald Trump. Trump has warned that if Iran does not capitulate to his demands, a 'whole civilisation will die tonight'.The denial from Washington came as Trump employed apocalyptic language, insisting that Iran must make a deal or face a massive onslaught. The original ultimatum was made by Trump on Saturday, demanding that Iran open the Strait of Hormuz, through which about a fifth of global energy exports pass, or face an assault on key infrastructure.The deadline falls at 8pm Eastern time (00:00 GMT), and legal experts warn that targeting civilian infrastructure could amount to a war crime. Texas Democratic Congressman Joaquin Castro called on Trump to immediately clarify that he is not considering using nuclear weapons.Vice President JD Vance later stated that US forces could employ tools they 'so far haven't decided to use', sparking concerns. The Iranian response has been defiant, with the Islamic Revolutionary Guards Corps (IRGC) vowing to respond in kind if the US attacks civilian facilities.Iran has proposed a 10-point peace plan to end the war, which Trump called a 'significant step' but 'not good enough'. The situation remains volatile, with Israel-US strikes on Iran and Iranian attacks across the region and Israel intensifying.