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A new large‑scale randomized trial presented at the European Congress on Obesity in Istanbul indicates that the oral GLP‑1 antagonist orforglipron can help patients retain the majority of weight lost with injectable therapies such as tirzepatide (Mounjaro) and semaglutide (Wegovy).Trial Shows Oral Orforglipron Preserves Most Weight After Switching from InjectablesThe study, funded by Eli Lilly, followed 376 US patients who had been on tirzepatide or semaglutide injections for 72 weeks and then randomized them to a daily orforglipron tablet or placebo for an additional year.Participants were previously on weekly GLP‑1 jabs that typically produce 15‑20% body‑weight loss.After the injection phase, subjects were switched to oral therapy or placebo for 12 months.Primary endpoint: proportion of weight loss retained at 12 months.Quantitative Outcomes: 75% vs 49% Retention for Tirzepatide Users, 80% vs 38% for Semaglutide UsersWeight‑loss maintenance differed markedly between the pill and placebo groups:Tirzepatide cohort: 75% of lost weight retained with orforglipron vs 49% with placebo.Semaglutide cohort: 80% retained with the pill vs 38% with placebo.Secondary benefits—blood pressure, cholesterol, and glycaemic control—were also sustained in the pill arm.Implications for Obesity Management and Healthcare CostsExperts highlighted the broader significance:Dr Louis Aronne (Weill Cornell Medicine) emphasized that treating obesity directly can simultaneously improve glucose, lipid, and blood‑pressure metrics.Dr Marie Spreckley (University of Cambridge) noted patient preference for oral therapy due to convenience, storage, and lower cost.Dr Simon Cork (Anglia Ruskin University) warned that injectable GLP‑1 drugs, while highly effective, are expensive and limit long‑term accessibility for both private payers and the NHS.The findings suggest a potential shift toward oral agents that maintain efficacy while reducing financial and logistical burdens.Future Outlook: Oral GLP‑1 Therapies Could Redefine Chronic Obesity CareIf further trials confirm these results, orforglipron could become a cornerstone of chronic obesity management, enabling earlier intervention (BMI 25‑27) and possibly preventing progression to severe obesity.Regulators and payers will likely scrutinize cost‑effectiveness models, but the prospect of a cheap, daily tablet that sustains weight loss may reshape treatment algorithms worldwide.

A Novel of Female Defiance"Yes, you will leave this place," the chorus of child protagonists in a community of sex workers say at the start of Tahmima Anam's incantatory and fiery new novel of female defiance, Uprising. "This story will save your life," we were told three times in Deepa Anappara's 2020 debut, also featuring precarious children dwelling in the margins. What is the distance between imagination and action, lived realities and dreams? How can solidarities be forged in such circumstances? Uprising holds within its pages some answers and a deep conviction – for a better life, a more just world – and then reaches out and fights for it.The Island Community and Its OppressionAs a journalist, Anam visited the infamous "floating brothel" Banishanta in Bangladesh; her new novel, set on an isolated island "at the end of the country, in the middle of a river that emptied into the sea", fictionalises the island's community and ecological precarity. Here, a generation of daughters grow up watching their mothers trapped in sex work – "we knew that the work was something that was paid for in money, and also in bodies" – and wish a different life for themselves. The women are controlled by the cruel Amma, who was once herself sold into sex trafficking. The victim becomes the perpetrator – and the children are discerning enough to know that their mothers are "not here because they had done something bad, but because something bad had been done to them". The first lesson of the island? No one is coming to save you – and living here changes you, as inexorably as the rising tides.The island is a prison. The mothers are ghosts of their former selves. The children, witnessing the "sexing", are all too grown up, stripped of their innocence. By the time they are born, their mothers' memories have faded "like paint in the sun"; they live on the island "tied to" their daughters. What, or who, will it take to break free from these chains?Feminism and Climate Crisis in LiteratureWhen the waters rise, customers stay away. The mothers speculate: "the swirling river was keeping the smaller boats from making the journey"; "the land was cursed". In a last-ditch attempt to lure men back for business, Amma sends for a new girl. Little does she know that Kusum Khan's arrival will signal the beginning of the end. A girl from the city with a history of participating in protests against the Dictator, she doesn't acquiesce to the island's rules, as the others have been conditioned to; instead, she sows the seeds for what will grow into a life-altering act of resistance. The children start to believe that she is their saviour – maybe even Bon Bibi, a legendary guardian of the forest. A different life seems graspable, just beyond the island's shore. When the titular uprising at last arrives, it summons an all-consuming storm, washing over the island. And the reader, too, is ready to join the revolution – their fist in the open air.Uprising is a feminist novel ("here they were: a wall of women") and a protest novel ("The moment Kusum entered the protest, she felt as if she was becoming a small organ in a living, breathing thing"). It is a coming-of-age novel, and a response to the climate crisis; a story of sisterhood protecting, and failing to protect; of structural inequality and the rotten core of patriarchal corruption; of unlucky women in an unfair world. "When the men came to reclaim the island, we stood rooted in place with our eyes closed, unable to watch. We stood rooted in place with our eyes open, unable to stop watching." While the mothers and daughters in Anam's fictional world are victims of specific generational violence, this observation can be applied to humanity at large: we are all watching – frozen, complicit – as injustices rise the world over.The Power of Rage and Radical HopeThrough her unwaveringly political and unflinchingly forthright novel, Anam shows the power of rage and radical hope. A new world can burn bright from the fires of injustice – and here, it's the mothers that hold the match.

Conan O’Brien has been officially announced as the host for the 99th Academy Awards, scheduled for 14 March 2027, extending his run as the ceremony’s comedic anchor for a third year in a row.Academy Confirms O’Brien as Host for the 99th AwardsThe Academy’s leaders, Bill Kramer and Lynette Howell Taylor, praised the “incredible team” behind the past two shows and highlighted O’Brien’s “brilliance and humor” as central to the celebration. Executive producers Raj Kapoor and Katy Mullan will return, ensuring continuity in the production’s tone and style.Viewership Trends and Social Engagement Under O’Brien’s Tenure2025 inaugural year: 19.7 million TV viewers tuned in.2026 ceremony: traditional broadcast ratings dipped (exact figure not disclosed), but social‑media interaction rose 42% compared to the previous year.2027 broadcast will air live on ABC from the Dolby Theatre in Los Angeles.What O’Brien’s Return Means for the Oscars’ Brand and Broadcast FutureIndustry analysts note that O’Brien’s comedic style has revitalized audience perception, offsetting the ratings slump with heightened online buzz. Craig Erwich, president of the Disney Television Group, emphasized that O’Brien “makes Hollywood’s biggest night one of the most entertaining celebrations of the year.” The continuity also buys the Academy time as it prepares for a major platform shift slated for 2029.Looking Ahead: Potential Shifts in Hosting and Platform StrategyThe 99th ceremony will be the penultimate event held at the Hollywood Dolby Theatre and the last on traditional broadcast TV. By 2029, the Oscars are set to move to YouTube and relocate to downtown Los Angeles for the 101st awards, suggesting a long‑term pivot toward digital distribution. O’Brien’s presence in 2027 serves as a bridge between the legacy broadcast era and the forthcoming streaming‑first model.

The LeadA man arrested for stealing hard drives containing unreleased Beyoncé music has pleaded guilty in an Atlanta court and been sentenced to two years in prison.The Theft DetailsKelvin Evans was arrested in September 2025 in connection to a July 2025 car robbery where two suitcases containing Beyoncé music and tour plans were stolen from a rental car. In an Atlanta court, Evans accepted a five-year sentence of which he will serve two years in custody. He was ordered to avoid the location of the theft in Atlanta and refrain from contact with the victim as part of his probation terms.The Music Industry ImpactThe stolen hard drives contained "watermarked music, some unreleased music, footage plans for the show and past and future set list," according to a police report. The theft occurred before Beyoncé's Cowboy Carter tour dates in Atlanta, which was later the highest-grossing tour of 2025, earning the performer over $407m across 32 shows.The Legal ConsequencesEvans initially pleaded not guilty and reportedly declined to take a deal in April, but changed his plea in court. He was arrested several weeks after the victims filed a report and was released on a $20,000 bond a month later. At the time of his arrest, Atlanta police confirmed that the stolen property had not been recovered, and it remains unclear whether it has since been found.The Beyoncé ContextBeyoncé's Cowboy Carter won the 2025 album of the year Grammy and was praised as "a thrilling 27-track journey through and beyond America's roots music." Earlier this month, Beyoncé co-chaired the Met Gala alongside Nicole Kidman, Venus Williams and Anna Wintour. Rumors have been swirling that Beyoncé will drop her new album this summer, speculatively titled Act III with a possible rock direction.

Study Shows Fetal Exposure to Vegetable Flavours Influences Post‑Birth PreferencesThe research team gave pregnant volunteers powdered kale or carrot capsules during the third trimester and later measured their children’s facial reactions to the same smells. Reactions were recorded via ultrasound before birth, repeated at three weeks, and again when the children were about three years old.Methodology: Kale and Carrot Powder Capsules Administered to Expectant MothersParticipants were asked to swallow a capsule each day containing either kale or carrot powder. The study avoided large volumes of juice, which many volunteers found unpalatable, opting for a low‑cost capsule format.Capsules administered in late pregnancy (around 32 weeks gestation).Initial chemosensory response captured with ultrasound imaging.Follow‑up assessments at 3 weeks and 3 years post‑birth.Sample Size and Observed Reactions Reveal Early Flavor MemoryAlthough the cohort was modest, the findings were consistent:12 children were observed at age three.Infants exposed to carrot powder smiled when presented with a carrot scent and grimaced at kale, and vice‑versa for the kale group.The same preference pattern was evident in the ultrasound scans before birth.These results suggest that flavour exposure in utero can create a durable chemosensory memory.Potential Public‑Health Benefits of Early Dietary ConditioningIf replicated on a larger scale, the approach could offer a low‑cost strategy for improving population nutrition:Reducing childhood resistance to vegetables may lower long‑term risks of obesity and diet‑related diseases.Capsules are inexpensive and could be integrated into routine prenatal supplements.The concept is adaptable to different cultural diets, as noted by the researchers’ interest in fish‑rich Japanese diets.Next Steps: Larger Trials and Cross‑Cultural ApplicationsThe authors acknowledge the need for a bigger, funded study to confirm the effect across diverse populations. Future research aims to:Expand the sample size to hundreds of mother‑child pairs.Test additional flavours and odourants, including artificial sweeteners.Explore policy pathways for incorporating flavour‑exposure capsules into prenatal care guidelines.Published in Developmental Psychobiology, the paper titled “Do Human Fetuses Form Long‑Lasting Chemosensory Memories?” opens a new avenue for early nutritional interventions.

The Cooking Gas Crisis in AsiaIn the ramshackle lanes of a south Delhi slum, Afshana Khatoon crouched wearily on her haunches and began lighting a small pile of firewood. She had just returned from six hours spent trudging through the urban forests and dry parks of India's capital looking for kindling to turn into a makeshift stove. As the unforgiving summer heat soared above 40C, she had walked for miles, piling the sticks and fallen branches into a bundle on her head while sweat ran down her face.Just a few weeks ago, the 35-year-old had been preparing meals for her four children on a small gas stove with little fuss. But as the crisis in the Middle East has choked India's vital supplies of imported liquefied petroleum gas (LPG) – used by more than 60% of the country's population for cooking – refills have been scarce and prices have risen far beyond what is widely affordable.Return to Traditional FuelsKhatoon, like growing numbers of people in India and more widely across Asia, has been forced to cook with crude, dirty fuels such as firewood and coal in order to survive. "It already feels like hell," she said, as she bustled about, filling a pot with water. "I'm not eating properly, and I have to work much more than before. My whole day now is about collecting firewood and cooking."The return to fuels such as firewood and coal is not only deepening the economic strain of the war on ordinary civilians in countries across Asia, but raising concerns about public health, air pollution and the fragility of the energy transition.Supply Chain Disruption and Price SurgeIndia imports about 60% of its LPG needs, of which about 90% usually comes through the strait of Hormuz, the critical shipping route still blockaded amid the ongoing conflict between Iran and the US. Official data shows India's LPG consumption fell by 2.2m tonnes in April, the sharpest decline in years.As the war has dragged on, cooking gas prices in informal markets have surged. In Khatoon's dimly lit shanty, her 5kg gas canister sat empty and forlorn in the corner. She said LPG had become prohibitively expensive for her family, rising to more than four times what she used to pay. "My husband earns 400 to 500 rupees a day. We can't spend 1,000 rupees just on gas for a week," she said.While the Indian government insists there is no shortage, in a speech this week the prime minister, Narendra Modi, called on people to adopt austerity measures including limiting their use of fuel and petrol. According to the defence minister, India has petroleum gas reserves to last just 45 days.Health and Environmental ConsequencesOnce Khatoon's fire stove is lit, thick smoke rises from the flames. It stings the eyes and throat but she has no option but to breathe it in as she cooks. She put her head in her hands, admitting she felt utterly exhausted. "We just want to cook as quickly as possible," she said.The return to biomass is raising alarms about air quality in cities across the region. Solid fuels such as wood and charcoal come with a range of health and environmental risks. They emit a dangerous set of pollutants that have been linked to respiratory problems, such as chronic obstructive pulmonary disease and lung cancer, strokes and heart disease.The combined effects of ambient air pollution and household air pollution are associated with 6.7 million premature deaths annually, according to the World Health Organization. Women and children, widely responsible for household chores such as cooking or collecting firewood, are the most vulnerable.Reversal of Environmental ProgressDelhi already ranks among the world's most polluted cities, and years of policy have focused on promoting cleaner fuels such as LPG and compressed natural gas to reduce emissions.Environmental activists fear years of progress toward widespread use of cleaner fuels is being reversed as the war in the Middle East drags on. With shortages deepening, authorities in Delhi have temporarily relaxed restrictions on the use of coal and firewood."When prices rise, it's the poorest who are forced to switch back to biomass," said Harjeet Singh, a climate activist and the founding director of the Satat Sampada Climate Foundation. "Biomass burning is a major source of fine particulate pollution."Future OutlookAs the conflict in the Middle East continues to disrupt global energy supplies, the health implications of reverting to traditional cooking methods across Asia are likely to worsen. Without immediate intervention to either increase LPG supplies or provide affordable alternatives, public health crises in major urban centers could escalate, potentially reversing years of progress in air quality improvement.The situation highlights the vulnerability of energy-dependent nations to geopolitical conflicts and underscores the urgent need for diversified energy sources and more resilient supply chains in the region.

Roberto Sanchez, the left‑leaning presidential candidate of Juntos por el Peru, has been formally accused of financial crimes, with prosecutors seeking a five‑year‑four‑month prison term and a permanent ban from holding the presidency.Undisclosed Campaign Contributions Trigger Criminal ChargesProsecutors allege that Sanchez and his brother William Sanchez received more than 280,000 Peruvian soles (≈ $81,720) in contributions and membership fees between 2018 and 2020, which were omitted from the party’s financial disclosures to the National Office of Electoral Processes.Financial Scope of the AllegationsUndisclosed amount: 280,000 solesPeriod covered: 2018‑2020Proposed sentence: 5 years 4 months imprisonmentAdditional penalty: permanent disqualification from the presidencyPotential Ripple Effects on Peru’s Run‑off ElectionThe charges emerge just after electoral authorities confirmed Sanchez’s place in the June 7 run‑off against conservative rival Keiko Fujimori. A conviction could bar him from office, reshaping the dynamics of a contest that currently shows Fujimori leading with 17.17 % of the vote and Sanchez at 12 %.Judicial Timeline and What It Means for VotersA judge is slated to rule on May 27 whether the case proceeds to trial. If the case moves forward, Sanchez may be unable to campaign effectively, potentially boosting Fujimori’s chances or opening space for other candidates.

ACCESS: Medicare’s First AI‑Enabled Outcome‑Based Payment Model Pair Team was announced on April 30 as one of 150 organizations accepted into ACCESS (Advancing Chronic Care with Effective, Scalable Solutions), a CMS initiative that launches on July 5. The program shifts reimbursement from traditional time‑based fees to payments tied to measurable health outcomes such as lower blood pressure or reduced pain, covering conditions like diabetes, hypertension, chronic kidney disease, obesity, depression, and anxiety. Revenue Scale and Funding Behind Pair Team Staff: roughly 850 clinical professionals, the largest community‑health workforce in California. Revenue: exceeds nine figures (>$100 million) annually. Capital raised: about $30 million from investors including Kleiner Perkins, Kraft Ventures, and Next Ventures. Patient reach: partnerships give access to ~500,000 potential patients, with a goal of 1 million within three years. Industry context: digital‑health funding hit its highest Q1 total since the pandemic, with AI firms capturing the bulk of new capital. How Outcome‑Based Payments Could Redefine Chronic Care Delivery The ACCESS model creates the first federal mechanism to pay for AI agents that monitor patients between visits, coordinate social services, and ensure medication adherence. Flora, Pair Team’s voice‑AI assistant, now handles 24/7 intake, referrals, and check‑ins, delivering hour‑long conversations that act as both clinical touchpoints and companionship for high‑needs patients. Peer‑reviewed research in the Journal of General Internal Medicine shows Pair Team’s community‑integrated approach cuts avoidable emergency and inpatient utilization, with one‑in‑four hospital visits and one‑in‑two ER visits averted for its members. Risks remain: the program funnels highly sensitive data into a federal system with a history of breaches, and past CMS innovation pilots have drawn criticism for increasing federal spending without delivering projected savings. What’s Next for AI‑First Health Providers Under ACCESS Batlivala argues that lower per‑patient reimbursement rates are intentional, forcing providers to adopt lean, AI‑driven operations. As the program scales, success will hinge on: Automating patient interactions to keep costs below payment thresholds. Demonstrating measurable outcome improvements across the covered chronic conditions. Managing data‑privacy concerns to maintain trust among vulnerable populations. Attracting additional capital as investors watch the first AI‑centric Medicare payment model unfold. If Pair Team and its peers can prove the model’s efficacy, ACCESS could become a template for nationwide AI‑enabled, outcome‑based reimbursement, reshaping how Medicare incentivizes technology in health care.

Survey Reveals Strong Patriotic Sentiment Among UK Millionaires The research, commissioned by Patriotic Millionaires UK and carried out by Survation, asked 501 individuals with assets over £1 million (excluding their homes) about their attachment to the United Kingdom and their willingness to fund public services through higher taxation. Key Numbers: Pride, Concern, and Tax‑Paying Willingness 88% of respondents agreed with the statement “I am proud to live in the UK”. 75% said they would be willing to pay more tax to ensure social, cultural, and economic assets are properly funded. 64% support increasing taxes on capital and assets of the wealthiest to reduce the overall tax burden. 43% identified doctors and other qualified health staff as the group whose departure would hurt the country most. 9% were most worried about other millionaires leaving the UK. Other concerns included young people and business owners, each cited by 19% of respondents as potential losses to the nation. Implications for UK Fiscal Policy and Political Landscape The findings arrive as the Labour Party grapples with internal leadership questions following disappointing local election results. Proposals from candidates such as Andy Burnham and Wes Streeting include raising capital gains tax to fund a 2p cut in national insurance. The willingness of a sizable share of the ultra‑wealthy to back higher taxes could provide political cover for such measures. Critics have pointed to reports of a “millionaire exodus”, but the survey notes that the alleged 16,500‑person outflow cited by Henley & Partners represents only 0.5% of the UK’s three‑million millionaires. What This Means for Future Tax Debates and Migration Trends If policymakers take the survey at face value, future tax reforms may encounter less resistance from the very demographic they target. Moreover, the emphasis on retaining medical professionals—highlighted by the departure of over 4,000 doctors in 2024—suggests that addressing sector‑specific retention could become a fiscal priority alongside broader tax policy. Analysts will watch whether the Labour leadership leverages this data to counter narratives of a fleeing elite and to justify progressive tax proposals ahead of the next general election.