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Lead: Sleep Deprivation Emerges as a Possible Driver of Early-Onset CancerResearch presented at the American Society of Clinical Oncology’s annual meeting in Chicago suggests that irregular sleeping patterns could be a significant, yet modifiable, risk factor for cancers diagnosed before age 50.The Study Linking Sleep Disruption to Early-Onset CancerTwo investigations led by MD Anderson Cancer Center analysed health records of over 18 million U.S. adults aged 18‑50. Participants with chronic insomnia showed a markedly higher incidence of bowel, breast, uterine, and ovarian cancers compared with well‑rested peers.Key Numbers Highlight the Scale of the IssueGlobal early‑onset cancer cases rose from 1.82 million (1990) to 3.26 million (2019), an 80% increase in three decades.Cancer deaths among people in their 30s, 40s, or younger climbed 27% over the same period.In the MD Anderson cohorts, insomnia was associated with up to three‑fold higher cancer risk within five years.Why This Matters for Public Health and Clinical PracticeThe data position sleep quality alongside genetics and lifestyle as a potential lever for curbing the surge in early‑onset cancers. Experts caution that the studies show association, not causation, but note that sleep deprivation can impair immune function and promote behaviours (smoking, poor diet, reduced exercise) that are already linked to cancer.Looking Ahead: Research, Screening, and Prevention StrategiesStakeholders anticipate a wave of longitudinal studies to test whether improving sleep can lower cancer incidence. In the meantime, clinicians are likely to incorporate sleep assessments into risk‑stratification tools, while public‑health campaigns may emphasise sleep hygiene alongside anti‑smoking and sun‑safety messages.

The Lead Bordeaux-Bègles' second successive Champions Cup title has solidified France's grip on European club rugby. Their 41-19 victory over Leinster in the final was a testament to their strength, with a blend of youthful talent and seasoned players proving too potent for their Irish opponents. Bordeaux's Dominant Performance Bordeaux's performance was characterized by their exceptional pace and skill. Louis Bielle-Biarrey, just 22, scored two tries, while fly-half Matthieu Jalibert, 27, controlled the game with precision. The team's captain, Maxime Lucu, 33, continues to defy expectations with his outstanding play. The Data Analysis Bordeaux's victory marked their second successive Champions Cup title. The final score was 41-19, with Bordeaux dominating the game. Leinster have now lost five Champions Cup finals in the last eight years. The Impact Analysis This victory cements France's dominance in European club rugby, with no other nation winning the Champions Cup since 2018. The Top 14's financial clout and ability to attract premium foreign talent have given French clubs a significant advantage. Leinster's coach, Leo Cullen, acknowledged that his team needs to adapt to the increasing speed of the modern game. The Prediction With a talented young squad and experienced players, Bordeaux are well-placed to continue their dominance. Leinster, on the other hand, face a significant challenge to regain their former glory. The gap between French clubs and their European rivals appears to be growing, and it may take significant changes for teams like Leinster to bridge this gap.

The Revolutionary GeneticistCraig Venter, the pioneering geneticist who revolutionized genome sequencing and challenged traditional scientific approaches, has died at age 79. His announcement at the 2001 BioVision conference that humans possess only about 30,000 genes—far fewer than the previously estimated 100,000—shattered scientific assumptions about genetic determinism. "We simply do not have enough genes for this idea of biological determinism to be right," Venter declared, emphasizing that human diversity is shaped primarily by environmental influences rather than hard-wired genetic code.The Breakthrough in Genome SequencingVenter's most significant contribution was developing the revolutionary whole genome shotgun sequencing technique, which allowed for faster, more efficient genome mapping. In 1995, his team achieved the remarkable feat of sequencing the first genome of a living organism, the bacterium Haemophilus influenzae. This breakthrough led to the founding of Celera Genomics in 1998, which aimed to sequence the entire human genome using Venter's innovative methods.The competition between Venter's privately funded Celera and the publicly funded Human Genome Project, spearheaded by the US government and UK's Wellcome Trust, created what scientists described as "testosterone-driven" rivalry. Despite tensions, this competition dramatically accelerated progress in genomics research, culminating in the announcement of the first draft human genome sequence at a White House ceremony in June 2000.The Scientific MaverickVenter was as famous for his bold personality as for his scientific achievements. A brilliant entrepreneur and unapologetic self-promoter, he enjoyed showcasing his success, private plane, yacht, and luxury watches. This flamboyant approach made him both admired and controversial. James Watson, co-discoverer of DNA's double-helix structure, compared Venter to Hitler for attempting to patent human genes, while others nicknamed him "Darth" Venter after the Star Wars villain.His tendency to break scientific protocols became evident when he revealed that much of the DNA used in Celera's human genome sequencing came from his own cells—a decision that annoyed scientists who felt he had subverted standard processes. "I've been accused of that so many times, I've got over it," Venter responded, noting that the analysis revealed he had an abnormal fat metabolism and elevated risk of Alzheimer's disease.A Life Shaped by Science and WarBorn in Salt Lake City, Utah, Venter had an unconventional path to scientific greatness. Growing up in California, he had a poor academic record and initially pursued "pursuits that involved drink, girls and bodysurfing" rather than education. His life took a dramatic turn during the Vietnam War, where he served as a senior corpsman in a naval hospital's intensive care unit in Da Nang."I witnessed several hundred soldiers die, more often than not while I was massaging their hearts – at times with my bare hand – or attempting to breathe life into them," Venter recalled. "Vietnam would teach me more than I ever wanted to know about the fragility of life." This experience sparked his interest in life sciences, leading him to study at the University of California, San Diego, where he earned a PhD in physiology and pharmacology in 1975.The Legacy of a Scientific PioneerAfter being dismissed as head of Celera in 2002, Venter used his substantial payoff to endow the J. Craig Venter Institute with $100 million. There, he pursued ambitious projects including designing energy-producing microbes and synthesizing bacterial genomes. He later founded Human Longevity and Diploid Genomics, companies that aim to combine artificial intelligence with advances in aging research and gene sequencing to extend human lifespans and improve disease diagnosis.While some of Venter's claims about the primacy of environmental influences over genetics have been questioned, his impact on genomics research remains undeniable. His revolutionary sequencing techniques transformed the field, and his competitive approach accelerated what would have otherwise been a much slower process of mapping the human genome. As the scientific community remembers Craig Venter, it acknowledges a complex figure who was simultaneously a brilliant innovator, a controversial competitor, and a transformative force in our understanding of life's fundamental building blocks.

The British Solving Championship: An Opportunity for Chess Enthusiasts This week’s puzzle is a chance to enter an annual national competition in which Guardian readers ­traditionally perform well and in ­considerable numbers. White in the diagram, ­playing as usual up the board, is to play and checkmate in two moves, against any black defence. The Event Details The puzzle is the first stage of the annual Winton British Solving Championship, organised by the British Chess Problem Society and sponsored by the investment ­managers ­Winton. This competition is only open to ­British ­residents and entry is free. To take part, simply send White’s first move by post to Nigel Dennis, Boundary House, 230 Greys Road, Henley-on-Thames, Oxon RG9 1QY, or by email to [email protected]. Entry Requirements and Deadline All entries must be postmarked or emailed no later than 31 July 2026. Entrants must provide their name and home address. Juniors under 18 on 31 August 2025 must also give their date of birth. The Competition Structure The best 15-20 players from the postal round, plus the best juniors, will be invited to the final at Harrow school on Saturday 13 February 2027, where the prize money is expected to be at least £1,600. The winner of the final will have the right to represent Great Britain at the 2027 world ­solving championships, an event where GB are often medal contenders. A Note on Chess and Professionals Back in the 1950s most top English players were amateurs, often civil servants or teachers, who competed in tournaments during their vacations. After the 1970s Fischer boom and English successes brought an influx of sponsors, chess professionals could earn a decent living, but the tide turned again during the 1990s. The breakup of the Soviet Union brought harder international competition, while Nigel Short’s world title defeat and the move to screen rather than print marketing drove sponsors away. A New Grandmaster: Harry Grieve Harry Grieve became England’s latest grandmaster on Tuesday when the 25-year-old, who was British champion in 2022 and helped CSC/Kingston finish second in this season’s UK 4NCL League, won first prize in Budapest with a 7/9 total.

The Inevitable Relegation West Ham's relegation to the Championship has been confirmed, a bitter pill to swallow for the London club. Despite a convincing 3-0 victory over Leeds, the team's fate was sealed by Tottenham's win over Everton. This marks a disappointing end to the season, with the club's struggles on the pitch reflecting a deeper malaise. The Executive Failure The root cause of West Ham's downfall lies in its executive leadership. The club's ownership, led by David Sullivan, has been criticized for its complacency and lack of vision. The team's failure to adapt to changing circumstances and improve its performance has led to this point. The Financial Implications The financial implications of relegation are significant, with estimated losses of £100m in the first season alone. This will likely lead to job losses and a reduction in staff, as well as a decrease in the club's overall value. The Way Forward As West Ham looks to the future, it is clear that changes are needed. The club will likely undergo a period of restructuring, with potential changes to its management and playing staff. The appointment of a new manager and the departure of key players, such as Jarrod Bowen and Mateus Fernandes, are already on the cards. A New Era for West Ham? The relegation of West Ham presents an opportunity for the club to rebuild and rebrand itself. With a new approach and a renewed focus on developing young talent, the club may be able to recover and return to its former glory. However, this will require a fundamental shift in its approach to the game and its relationship with its fans.

The Unconventional Auction Artists Hilary Powell and Dan Edelstyn are auctioning off their work from the past decade and a half to help fund a community-led renewable power station in Nigel Farage's Clacton constituency. The big-ticket item going under the hammer will be the remnants of a gold Ford Transit van containing £1.2m in fake banknotes that the pair blew up in London's Docklands in 2019. The Blown-Up Van The van wreckage and charred banknotes were gathered up and reconstituted as an Alexander Calder-like mobile that, for a while, hung in Cambridge's Fitzwilliam Museum. Now, for perhaps £100,000, this sculpture could be the centrepiece of your living room. Powell hopes that the exploded van will be bought by a public institution. The Fundraising Goal The pair hope to raise at least £250,000 for the project. Alongside the in-person auction, they are hosting an online iteration that will run until 31 May. They currently have £750 and need about 250 times that to fund the project. The Purpose Behind the Project The pair call what they do Method Art. They aim to build a community-owned renewable power station in Reform's first seat as a response to the party's donations from oil and gas interests, highly polluting industries, and climate science deniers. The Future of Community-Owned Renewable Energy The proceeds from the auction will bankroll the work the pair are doing to set up in Clacton and to make a film about the project. If they sell the blown-up van, the proceeds will be core funding for their not-for-profit production company. The funding for the power station will come from issuing shares and other fund-raising to create a community benefit society.

The Escalating Cost of Russia's War in UkraineEvidence of Russia's poor performance in its war in Ukraine, both militarily and economically, has been mounting over the past week. The US Defence Intelligence Agency (DIA) has confirmed earlier assessments that Russia has lost territory it previously occupied in Ukraine, while Ukraine has managed to reclaim approximately 400 square kilometers in and around Dnipropetrovsk – more territory than at any time since late 2022.Russia's Military Setbacks and Economic StrainRussia has still made a net territorial gain in 2026, but its advance is slowing down dramatically. According to the Institute for the Study of War (ISW), a Washington-based think tank, Russia advanced by a net 104 sq km between January 1 and May 26, 2026, compared to its seizure of 1,619 sq km during the same period last year.Ukrainian President Volodymyr Zelenskyy reported that Russian casualties had increased to 145,000 this year, of which 86,000 were killed and 59,000 troops seriously wounded. Ukraine's Defence Minister, Mykhailo Fedorov, highlighted that this meant 179 Russian losses per square kilometre of advance, compared to 67 last year – a rate higher than what Russia is currently able to replace through recruitment.Russia's war is also becoming increasingly difficult to finance. Having exceeded its entire 2026 budget deficit allowance by April, and depleted its foreign exchange reserves, Russia has been drawing down gold reserves at an unprecedented pace. According to its Central Bank, Russia has sold 27.9 tonnes of its gold reserves this year, worth more than $4bn, leaving reserves at their lowest since the beginning of the full-scale invasion in February 2022.Shifting Battlefield Dynamics and StrategiesThe DIA attributed Ukraine's territorial gains to Russia losing access to Starlink satellite services used for targeting and counter-battery fire. Ukraine attributes its success to its strategy of interdicting Russian logistics through mid-range drone and artillery strikes, which Fedorov described as a programme called "Logistical Lockdown" designed "to scale up middle-strike and systematically destroy Russian capabilities at the operational depth."This Ukrainian tactic has prevented reinforcements of men and equipment from reaching the frontlines, diminishing Russia's superiority in depth of resources and mass. The effectiveness of this strategy was demonstrated when Kherson occupation governor Vladimir Saldo restricted movement along the M-14 highway connecting Mariupol, Berdyansk and Melitopol, due to the number of vehicles being struck there.On the defensive front, Ukraine received a significant boost when Sweden announced it would donate 16 Gripen warplanes to Ukraine, which would also purchase an additional 20 through the EU's Ukraine Support Loan in a deal worth $2.9bn. Zelenskyy noted that "Gripen fighters with appropriate weapons, in particular Meteor missiles, which destroy targets at a distance of more than 200 kilometres, will help us push back Russian aircraft" against the approximately 3,000 Russian glide bombs dropped weekly.Simultaneously, Ukraine continued its long-range strikes on the Russian oil economy, which funds the war. On May 23-24, Ukraine struck oil depots and terminals at Novorossiysk and Tamanneftegaz on the Black Sea, as well as military and industrial sites including the Metafrax Chemicals plant in Perm and the Taganrog Airbase in Rostov.Russia's Response and Escalation TacticsIn response to Ukrainian advances, Russia pursued its own aerial tactic of striking Kyiv through massive combined attacks of drones and missiles. On May 24, Russia launched 600 long-range drones and 90 missiles against Kyiv and surrounding areas, including 36 ballistic missiles. Ukraine managed to shoot down 91 percent of the drones and 81 percent of the cruise missiles, though those that hit damaged government buildings, museums, and a market, injuring at least 87 people and killing two.Russia framed these attacks as retaliation for what it described as a terror attack on a college in occupied Luhansk, which it claimed killed six students and injured 39. Ukraine's General Staff countered that it was a strike on a centre for Advanced Unmanned Technologies run by Rubikon, Russia's unmanned systems force.Russian Foreign Minister Sergei Lavrov informed his US counterpart, Marco Rubio, that Russia would begin striking "military sites" in Kyiv in retaliation, warning foreign citizens, including diplomats, to leave. Moscow specifically mentioned using its newest Oreshnik intermediate range missile in the attacks, which it has also forward-positioned in Belarus.Future Outlook of the ConflictThe current trajectory suggests that Ukraine's strategy of targeted strikes on Russian logistics and supply lines, combined with enhanced air defense capabilities from international partners, will continue to challenge Russia's military advances. However, Russia's demonstrated willingness to escalate attacks on urban centers and its deployment of advanced weaponry indicate that the conflict may enter a more intense phase.As Russia depletes its financial resources and struggles to replace casualties, its ability to sustain current operations may diminish. Conversely, Ukraine's increasing success in securing international military support and refining its asymmetric tactics could shift the balance further in its favor, though the long-term outcome remains uncertain as both sides adapt their strategies.

The Lead: Arsenal's Quest for European GloryMikel Arteta has dismissed suggestions the pressure is off Arsenal in Saturday's Champions League final after their first Premier League title for 22 years and insists he and his players are hungry for more trophies. The manager has declared that their ambition is bigger as they seek to add European success to their domestic triumph.The Event Details: Arsenal vs PSG in the Final ShowdownParis Saint-Germain, who defeated Arsenal in the semi-finals last year before being crowned European champions for the first time, saw off Chelsea, Liverpool and Bayern Munich in the knockout stages and are strongly fancied to retain their crown. Jurriën Timber looks likely to start after Arteta confirmed the Netherlands defender had recovered from a groin injury, although he has not featured since the win over Everton on 14 March.The Data Analysis: A Season of Record MatchesSaturday's game will be Arsenal's 63rd of the season, more than any other team from the top five European leagues. It will be PSG's 56th but Saka insisted fatigue would not play a part. "We've had a week to recover and we're ready to go again and a game like this is not going to be decided on minutes," he said. "It will be decided on moments and which team can produce a bit of quality and be well organised."The Impact Analysis: Writing a New Chapter in Arsenal HistoryArsenal have yet to win the Champions League and reached the final on one previous occasion, in 2006, when they were defeated by Barcelona. Arteta is determined Arsenal seize their opportunity on the biggest stage in club football after finally ending their long wait for the league title. "We have the opportunity to write a new chapter in the history of this football club," the manager said. "And in order to do that, we have to play with such clarity, a lot of courage, and a relentless desire to win."The Prediction: A Team Driven by DesireArteta, asked whether he had noticed something different when he looks in the eyes of his players, said: "That they want more. Going through those moments brings you a different kind of desire. Because you lift it, you know exactly how it feels. You want to reproduce that feeling as many times as possible." Bukayo Saka, who scored Arsenal's goal in last season's 3-1 aggregate defeat by PSG, revealed that Thierry Henry – part of the team that lost to Barcelona 20 years ago – had been in touch this week to offer encouragement. "It feels like this last week it's all become a reality and tomorrow is another exciting opportunity to create more history and win another for the club that I love," Saka said.

The Lead: Israel's Gaza Expansion Beyond Agreed TermsAfter two years of relentless bombardment and ground invasions, Israel's future in Gaza had appeared to be settled with the signing of United States President Donald Trump's 20-point peace plan on October 9, 2025. Under the terms of that agreement, Israeli forces were meant to withdraw behind what planners called the "Yellow Line", maintaining control of 58 percent of the territory, with their full withdrawal to be set at a date to be determined.The Event Details: Military Expansion and Territorial ChangesThat withdrawal hasn't happened. In fact, in the months since, as well as killing at least 922 people in near-daily strikes on the enclave during the "ceasefire", Israel has expanded its territory by about 11 percent. According to satellite data gathered in March, it has also established at least 32 military outposts, a ground barrier and infrastructure along what was supposed to be a temporary line.The Data Analysis: Humanitarian Crisis and Casualty FiguresSince October last year, numerous humanitarian agencies, including Oxfam, have accused Israel of compounding the humanitarian crisis in Gaza by restricting deliveries of aid and other essential goods. To date, since the onset of its war on Gaza in October 2023, Israeli forces have killed at least 72,819 men, women and children in Gaza, with many thousands more missing and presumed dead under the rubble. By 2025, Israel had caused a confirmed famine in the enclave and has now decimated nearly all infrastructure needed to support life.The Impact Analysis: International Response and Legal Implications"If Israel's ultimate plan is to exercise permanent effective control over the entirety of the Gaza Strip, we are talking about unlawful annexation," Michael Becker, a professor of international human rights law at Trinity College in Dublin, told Al Jazeera. "As the International Court of Justice reaffirmed in a 2024 advisory opinion, annexation constitutes a violation of the bedrock prohibition of the acquisition of territory by force."Hopes that the US might enforce its own conditions on Israel also appear ill-founded. Since announcing a ceasefire in the enclave in October last year, the US has failed to react as Israel has expanded and entrenched its presence in Gaza, choking off access to about two-thirds of the enclave for its inhabitants by April 2026.The Future Outlook: Population Displacement and Regional StabilityIsrael's answer to how Gaza's population can survive in such a reduced territory is what they call "voluntary emigration." "The plan for voluntary emigration from Gaza will also be implemented, all at the proper time and in the proper manner," Defence Minister Israel Katz wrote in a statement. Observers typically acknowledge that this means the ethnic cleansing of the enclave."The idea of permanently removing Palestinians from Gaza smacks of forced displacement and would also violate the fundamental right to self-determination of the Palestinian people," Becker said. However, he noted that the spotlight of international attention has now shifted from the crisis in Gaza to the US and Israel's war on Iran, as well as Israel's actions in Lebanon, where it has occupied large swaths of the south of the country.