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England's hopes of winning the Women's Six Nations title have been hit by a series of setbacks, including injuries and pregnancies. Prop Hannah Botterman has been ruled out of their opener against Ireland with an ankle injury, and her participation in the tournament is uncertain.The team is already dealing with several injuries, two retirements, and four pregnancies, including that of Rosie Galligan, whose partner is England teammate Marlie Packer. Coach John Mitchell said that Botterman's ankle is not yet mechanically sound, and they will have more information on her return timeline next week.England remain favorites for the grand slam, but Mitchell acknowledged that the team has been affected by the post-World Cup euphoria. Ellie Kildunne will start at full-back, with Claudia Moloney-MacDonald and Jess Breach on the wings. New captain Meg Jones, who took over from pregnant Zoe Stratford, will start at outside centre.Mitchell believes that the team has built a legacy and has the opportunity to create a dynasty. However, he also acknowledged that there will be challenges along the way, including a Lions tour in 2027 and the fact that several players are becoming mothers.

The crew of Artemis II is preparing to return to Earth on Friday, following their historic 10-day lunar flyby mission. Nasa leaders have outlined the critical steps needed to ensure a safe splashdown off the coast of San Diego. The Orion capsule will travel at nearly 24,000mph before making a final splashdown several miles off the coast of San Diego. The operation requires multiple teams and careful coordination to safely extract the crew from the spacecraft. Nasa's associate administrator Amit Kshatriya emphasized the importance of the mission, stating, "To every engineer, every technician that's touched this machine, tomorrow belongs to you. The crew has done their part. Now we have to do ours." Jeff Radigan, lead flight director of the mission, highlighted the precision required for re-entry, noting the team has "less than a degree of an angle" to hit the correct flight path. "Let's not beat around the bush. We have to hit that angle correctly – otherwise we're not going to have a successful re-entry," he said. The splashdown is expected to occur at 5:07pm PT, with the USS John P Murtha ready to assist with recovery operations. The crew will undergo post-mission medical evaluations before being flown to Nasa's Johnson Space Center in Houston, Texas. Pilot Victor Glover, the first Black man to travel beyond low Earth orbit, reflected on the journey, saying, "We have to get back. There's so much data that you've seen already, but all the good stuff is coming back with us. There are so many more pictures, so many more stories."

Max Verstappen's future in Formula One has been thrown into doubt after his long-time engineer, Gianpiero Lambiase, announced that he will be leaving Red Bull to join McLaren in 2028. Lambiase has been a crucial part of Verstappen's team since 2016, playing a key role in his four world championships.The news is a significant blow to Red Bull, as Lambiase's departure comes at a time when Verstappen has been expressing disenchantment with the current F1 regulations. The Dutch driver has been vocal about his frustration with the focus on energy management, which he believes has made the racing less enjoyable.Verstappen's contract with Red Bull runs until 2028, but performance-related escape clauses could allow him to exit before then. The team has been going through a period of change, with several key figures leaving, including Christian Horner as team principal, Adrian Newey as chief designer, and Jonathan Wheatley as sporting director.Lambiase's move to McLaren will see him take on a role supporting the team principal, Andrea Stella. The British-Italian engineer has been a close ally of Verstappen, and their partnership has been highly successful. Their radio interactions during races have been closely followed, showcasing a strong professional and personal bond.The departure of Lambiase and other key figures has raised questions about the future of Red Bull and Verstappen's commitment to the team. With the current regulations and the competitiveness of the Red Bull car, Verstappen's future in F1 is uncertain.

Virgil van Dijk drew a direct parallel between Liverpool’s current Champions League challenge against Paris Saint‑Germain and the club’s famous comeback against Barcelona in 2019, but warned that belief in the squad may be waning under new manager Arne Slot.Liverpool entered the quarter‑final with a 2‑0 deficit after a lackluster first‑leg loss at the Parc des Princes. Van Dijk, however, remains 100% convinced that a dramatic Anfield turnaround is still possible, citing the memory of overturning a 3‑0 first‑leg loss to Barcelona and winning 4‑0 at home.Reflecting on the 2019 semi‑final, the Dutch defender said, “We faced one of the best teams in Europe with the best player in the world, and we were injured. Now we face the European champions again, and on paper no one gives us a chance.” He stressed that success hinges on self‑belief, the manager’s game plan, and relentless intensity from the first minute to the last.Van Dijk also addressed Liverpool’s broader season, which has already produced 16 defeats across all competitions, including a penalty shoot‑out loss in the Community Shield and a recent FA Cup quarter‑final exit to Manchester City. “It’s unacceptable,” he said, describing the inconsistency as “disappointing” and acknowledging that the current squad does not match the standards set during the Klopp era.Despite the setbacks, the captain highlighted a positive sign: the team’s resilience in the previous Champions League rounds, notably the comeback against Galatasaray in the last‑16 and a strong showing against PSG at Anfield last season. He warned that “everything has to click” against a PSG side that excels in every department.Slot’s tactical shift to a three‑man central defence was only practiced for two days before the Paris match, adding to the challenges. Van Dijk admitted that recent league defeats, starting with a 2‑1 loss at Brighton, have tested the squad’s morale, but he remains hopeful that the experience gained in earlier European ties can fuel a decisive second‑leg performance.

Liverpool's struggles continued as they were thoroughly outplayed by Paris Saint-Germain in a 2-0 defeat. The Reds had a dismal 28% possession and failed to register a single shot on target. Manager Arne Slot acknowledged that his team had been 'ripped apart' at times and admitted to employing negative tactics to keep the tie alive for the second leg.PSG's dominance was evident throughout the match, with their midfielder Vitinha standing out. Despite their superior performance, PSG were unable to capitalize on their chances, allowing Liverpool to stay in the tie. Liverpool's Virgil van Dijk has called on fans to make a significant impact in the return leg at Anfield, but it remains to be seen if the team can mount a successful comeback.The defeat has raised questions about Slot's approach and the team's ability to compete with top-tier opponents. The return leg next Tuesday promises to be a crucial encounter, with Liverpool needing a significant turnaround to advance to the next round of the Champions League.

Meta announced the launch of Muse Spark, the debut artificial‑intelligence model from the company’s ambitious "superintelligence" squad that was assembled last year with a multi‑billion‑dollar budget. The team, spearheaded by former Scale AI chief Alex Wang—brought on board in a $14.3 bn acquisition—has been offered compensation packages running into the hundreds of millions to attract top talent. Muse Spark is the first installment of the internally codenamed "Avocado" series. For now, the model is accessible only through Meta’s AI app and website, but Meta says it will soon supplant the existing Llama models that power chatbots on WhatsApp, Instagram, Facebook and the firm’s smart‑glasses lineup. Unlike earlier open releases of Llama, Meta has kept Muse Spark’s architecture details under wraps, offering a private preview to a select group of unnamed partners. In a blog post, Meta described the system as "small and fast by design, yet capable enough to reason through complex questions in science, math and health," positioning it as a solid foundation for future, larger versions. Independent testing shows Muse Spark narrowing the gap with leading models from Google, OpenAI and Anthropic in language and visual comprehension, though it still trails in coding and abstract reasoning tasks. The model placed tied for fourth on a comprehensive AI benchmark compiled by Artificial Analysis. CEO Mark Zuckerberg had previously cautioned investors that early releases would be modest but would demonstrate a "rapid trajectory." Wang echoed this sentiment on social media, acknowledging "rough edges" that will be refined over time and confirming that bigger variants are already in development, with some slated for open release. Beyond performance metrics, Meta hinted at commercial ambitions, embedding shopping suggestions directly into its AI chatbot to guide users toward purchasable items. With over 3.5 billion active users across its platforms, the company hopes AI‑driven personal tasks will boost engagement and create a competitive edge over rivals with smaller user bases. Practical use‑cases highlighted include estimating meal calories from a photo, virtually placing a mug on a shelf via augmented reality, and a new "Contemplating Mode" that runs multiple agents simultaneously—mirroring advanced reasoning features seen in Google’s Gemini Deep Think and OpenAI’s GPT‑Pro. Meta says this mode could, for example, help a family plan a vacation by having one agent draft an itinerary while another scouts kid‑friendly activities.

From the world’s smallest footballing nation – a population of just 45,319 – the American Samoa women entered the 2026 World Cup qualifiers ranked 153rd, the lowest spot in the global rankings.Team captain Alma Mana’o describes the squad as a close‑knit family, noting that several sets of sisters play together and that the Mana’o family holds the record for the most relatives to appear at FIFA events.In November, the side faced Tonga, the tournament’s highest‑ranked opponent. 18‑year‑old Cassidy Drago etched her name into Samoan folklore by netting the nation’s first ever goal in women’s World Cup qualifying, followed quickly by a second, sealing a 3‑0 victory. The momentum continued with a win over the Cook Islands, cementing their reputation as genuine upset‑makers.The second round seemed to promise a return to reality when the Solomon Islands – 80 places above them in the rankings and 2025 Pacific Nations Cup champions – thrashed American Samoa 7‑1 in an Olympic qualifier. Yet, just 90 minutes later, the Samoans produced one of the competition’s most astonishing results: a 1‑0 win over the same opponents.That triumph was followed by another narrow victory, 1‑0 against neighbouring Samoa, securing a place in the final OFC qualifying round and completing the team’s evolution “from underdog to dark horse,” as Mana’o puts it.Looking ahead, American Samoa will meet Papua New Guinea in Auckland – the venue of their inaugural women’s international match 28 years ago. The squad now benefits from the guidance of Amanda Cromwell, the 1996 U.S. Olympic gold‑medal‑winning coach, who has overseen four wins in five games. Mana’o credits Cromwell with professionalising the program, from nutrition plans to dedicated training staff, and says the new standards will become the norm.Mana’o herself broke ground as the first “off‑island” player in 2011 at age 15, enduring an 8‑0 debut loss. Today she celebrates a new generation of teenagers, such as Mia Toeaina and Naiyah Ve’e, who are experiencing a vastly different, more positive football environment.

Northampton Saints' JJ van der Mescht is a force to be reckoned with on the rugby field. Standing at an impressive 6ft 7in and weighing 23st, he is the joint-heaviest player in the Premiership. His size and strength make him a major collision threat, and his skills have earned him a spot in South Africa's alignment squad.Van der Mescht, 26, has a unique playing style that has drawn comparisons to Australia's Will Skelton. He is too heavy to be lifted regularly in the lineout, but his ability to give his team vital post-contact metres makes him a valuable asset. His director of rugby, Phil Dowson, describes him as 'a fly-half trapped in a second-row's body.'The South African lock has a personal connection with Bath prop Thomas du Toit, with whom he played as a youngster at the Sharks in Durban. He is eager to bump into his old friend during the match, and he expects a fierce encounter. Van der Mescht has dropped seven kilos since joining Northampton and currently weighs 146kg. He credits the club with rekindling his love for rugby, saying that he now enjoys the game again and feels happy.Van der Mescht's impressive performance has put him back on the South African radar, and he may be considered for the Springboks in the future. For now, he is focused on helping Northampton overcome Bath in the Champions Cup quarter-final. The match could be a prelude to another battle between England's top two sides in the Premiership final.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.