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The Lead: Biotech Barbie's Mission to Edit Human DNA Cathy Tie, a Canadian entrepreneur known as "Biotech Barbie," is pursuing a controversial mission to genetically modify embryos to prevent hereditary diseases, following in the footsteps of her ex-husband He Jiankui, who served prison time for creating the world's first gene-edited babies. Despite global bans on germline gene editing for reproductive purposes, Tie aims to conduct this work openly with regulatory approval and venture capital funding. The Technical Breakthrough: Gene Editing Made Accessible Since the invention of the Crispr-Cas9 gene editing tool in 2012, the technical process of altering DNA has become relatively straightforward. "The hardest thing about genetically engineering a baby is getting permission to do it; the technical part is not particularly complicated," the article explains. The process is compared to using "find, copy, cut and paste functions on a computer" and doesn't require extensive expertise in molecular biology. Germline gene editing—altering eggs, sperm, or early embryos—is particularly significant because changes are passed down to future generations, potentially altering human evolution permanently. This is why such procedures are banned in the UK, US, and China, with international agreement against research that could result in gene-edited babies. The Financial Landscape: Billionaires Investing in Genetic Engineering Money is flowing into human genetic engineering, with some of the world's richest men investing in companies pursuing similar goals. Preventive, a gene editing startup launched in October 2025 with the aim of "preventing disease before birth," has attracted investment from OpenAI's Sam Altman, his husband Oliver Mulherin, and Coinbase CEO Brian Armstrong. Armstrong has coined the term "the Gattaca stack"—referencing the dystopian film about a genetically engineered society—which includes technologies for "disease prevention, or enhancement" of babies. This suggests a growing interest not just in preventing diseases but in enhancing human traits. Preimplantation genetic testing (PGT), already common in the US fertility treatments, allows parents to "choose the embryo that best matches what you want," with companies like Nucleus Genomics advertising on subways with the tagline "Have your best baby." The Global Impact: A New Biological Arms Race? "There's a big geopolitical component to this," Tie states, referring to the growing interest in genetic engineering. China, where Tie was banned from entering, has already demonstrated what gene editing can do—Chinese researchers made the first edits to human embryos in 2015, and Tie's ex-husband He Jiankui created the first gene-edited babies, twin girls known as Lulu and Nana. Since his release from prison in 2022, He has become an unlikely social media star with close to 150,000 followers on X, making unrepentant posts about "designer babies" being "inevitable." Meanwhile, China's biotechnology ambitions have expanded, with Premier Li Qiang announcing new regulations emphasizing "the need to promote innovative development" and "accelerate R&D; and commercialization." In response to China's announcement, Tie posted: "Welcome to the dawn of the biological arms race." The Future Outlook: Inevitable Genetic Modification "Biology is a double-edged sword – it can be used for good, to heal people, or it can be used for bad," Tie explains. "Stopping this research will only drive bad actors to do it secretively. There is no way to stop this. This is inevitable. The only way to proceed is to do it openly and transparently." Tie named her first human gene-editing company the Manhattan Project, drawing a parallel between the nucleus of the atom and the nucleus of the cell. "In the 20th century, we understood the nucleus of the atom very well, and we learned some very difficult lessons via weapons and wars," she says. "I don't want to see the same happen with the second nucleus." Despite her declared commitment to openness, much of Tie's work remains shrouded in secrecy. Her first company, the Manhattan Project, has since shut down due to what she calls a "fundamental mistake" in choosing a co-founder. She has since launched Origin Genomics, continuing her pursuit of genetic modification of embryos.

The Rise of Mega-Donors in UK Politics Keir Starmer may be relaxed about allowing millions from cryptocurrency billionaires to flow into Reform UK's coffers, but Labour MPs are tearing their hair out every time the quarterly data on electoral finance drops. The Scale of Donations The latest figures show a further £7m went to Reform UK from just two men, Christopher Harborne and Ben Delo. To put that in context, Labour managed to raise £6m from all private donors in the first quarter of 2024 – just before the last election, when the party's fundraising power was at its peak. The Data Analysis Harborne, a crypto and aviation fuel investor based in Thailand, has given £15m to Reform and £5m to Farage personally. Delo, who co-founded the BitMEX trading platform, is the UK's youngest self-made billionaire and has given significant donations to Reform UK. The Impact Analysis The mood among many backbenchers about Reform's riches is panicked. 'It is unsustainable,' says another Labour MP, who would back any amendment to the government's new electoral finance bill to broaden the cap on overseas donors to all donors regardless of location. The Prediction Despite the opportunity of the new electoral finance bill, there is very little optimism among campaigners that the government will change its mind about a cap, or even an annual spending limit. However, some believe Andy Burnham, who backs electoral reform and a more consensual politics, may be more sympathetic to the idea of getting big money out of Westminster once and for all.

The End of an Era for Free-to-Air Cricket As Rudi Koertzen and Billy Bowden removed the bails at The Oval and celebrations began across the country after a grandstand finish to an epochal Ashes, it signalled not only the end of England's 18-year wait to claim back the urn, but the last rites of live Test match cricket on terrestrial TV in the UK. In December 2004, the ECB announced a landmark four-year deal worth £220m that gave Sky exclusive rights to show live cricket, with Channel 4 – which had been showing home Test matches since 1999 – left with nothing. This decision, made more than 20 years ago, remains one of English cricket's most controversial and divisive moments. The Financial Breakthrough Behind the Paywall For Giles Clarke, who led the negotiations in his role as chair of the ECB's marketing committee, it was a simple case of economics. "The alternative was a significant decline in income," said Clarke at the time. "Major cuts would have had to have been made in the funding of the England team, the support structure and to county cricket clubs as well." Clarke insists that the ECB's financial modeling presented a bleak picture if they were to accept Channel 4's bid. "We worked out that at least seven counties would have had to close, and I'm being very serious here. We would have had to cut back on our youth programmes and we couldn't see what we could fund. The game as we knew it, in the opinion of the guys who did the financial modeling, would not exist." In negotiations with Vic Wakeling, Sky's head of sport, Clarke insisted the ECB would need more money if they were to justify the decision to take live cricket off free-to-air. "We sat Vic down and said, 'If you don't [increase your offer], we aren't going to consider doing this with you. You've got to give us a better reason.' We got Sky to increase their bid by £30m. I think we did a bloody good job on the money." The Audience Impact and Accessibility Concerns Channel 4 had innovated in areas that had never been touched before, according to Mark Nicholas, Channel 4's frontman across their seven years as the home of Test cricket in the UK. "We made the game more accessible by the way that we styled it, so it didn't feel too elitist or too difficult." Having won the broadcasting rights before the 1999 season, the same summer that England were defeated by New Zealand on home soil to become officially the worst Test side in the world, Channel 4 brought viewers the team's subsequent rise under Nasser Hussain and then Michael Vaughan, culminating in the Ashes triumph of 2005 when a peak audience of 8.4 million tuned in to watch Ashley Giles and Matthew Hoggard clinch a nail-biter at Trent Bridge. When England sealed the deal at The Oval just over a week later, Channel 4 reported their highest-rating day ever – at 23.2%, the channel's total share of all TV viewing broke the record set by the Big Brother final three years earlier. By then the ink had dried on the ECB's contract with Sky. The Divisive Legacy of the Decision Channel 4 released a statement saying they hoped the ECB "would not come to regret its decision to turn its back on the hundreds of hours of terrestrial exposure that Channel 4 was offering". Their innovative coverage had been widely lauded since they had usurped the BBC to win the broadcasting rights alongside Sky in a two-pronged deal that involved the latter showing one home Test match each summer between 1999 and 2005. Speaking to key figures involved at the time, it's clear that passions still run high. There remains a sense of animosity between the different camps, accusations of underhand PR campaigns, and a refusal to accept that the other side may have a point. There are legacies to protect. In a sense, it's English cricket's Brexit. "We were faced with a horrendous situation but there was no doubt in the minds of all of us who were involved, and there was no doubt in our minds 15 years later, that we did the only thing we could do," says Giles Clarke, reflecting on the deal he struck with Sky 22 years ago. "There have been a lot of lies and rubbish said about this. Channel 4 did not bid for all the Test matches – they only wanted the second series each summer. The BBC said they were not going to bid two days before the did date for bids. Sky had bid for absolutely everything." The Future Outlook for Cricket Broadcasting More than 20 years later, it remains one of English cricket's most divisive and controversial decisions. Did taking live cricket off free-to-air TV secure the future of the English game, or hold it back at exactly the moment it was ready to fly? "When they did the deal in 2004 for 2006 to 2009, they actually only got £55m per year," said Terry Blake, the TCCB's marketing manager and then ECB's commercial director between 1989 and 2003. "So for £10m per year more, which no doubt helped Giles Clarke secure his chairmanship for years to come, they moved it off free-to-air television altogether. I would turn it round and say: imagine the audiences we would have grown and the interest we would have had at the grassroots level had we stayed on free-to-air, even if we'd had to take a slight drop from the £45m per year [received from the 2002-05 deal with Sky and Channel 4]. Whatever money was put into the grassroots because of additional money from Sky, it could never replace the top-down approach." "The music, the graphics, the commentary team, the public's love of it – it had become really rather special," recalls Nicholas. "It was a bit of a cult. The coverage in 2005 was probably universally appreciated more than any other at that stage, so much so that even Kerry Packer in Australia was saying, 'How come they're doing it better than we're doing it?' When you give something such a deep dive, and you're going so well with it, and you feel like you've got so much left to do, it's difficult to stomach that the rights have moved on."

The Lead: Costa Rica's Legal Victory for WildlifeIn a landmark decision, Costa Rica's constitutional court has ruled that the state-owned electricity company and the Ministry of Environment and Energy must take immediate action to protect howler monkeys from electrocution on uninsulated power lines. The ruling comes after years of increasing incidents linked to development in popular tourist areas and follows a nationwide campaign by conservation organizations.The Event Details: Court Mandates Power Line Safety MeasuresThe court ruled in January that the Costa Rican Electricity Institute (ICE) and MINAE had failed to implement effective measures to reduce and prevent wildlife electrocution, primarily affecting howler monkeys in the Nosara district. The government entities were given six months to implement necessary corrections to the bare wiring in power lines constructed in the area.This legal action followed the campaign "This Is NOT Pura Vida" launched by 20 conservation organizations and rescue centers, including International Animal Rescue Costa Rica (IARCR). The campaign called for urgent government action to address what has become a growing crisis for wildlife in the region.The Data Analysis: Alarming Electrocution StatisticsThe scale of the problem is significant. In 2025 alone, IARCR reported 108 electrocuted animals, with howler monkeys accounting for up to 90% of incidents. Francisco Sánchez, a veterinarian at IARCR, has observed a rise in cases over the past decade, attributing it to increased development in the area which has become popular with tourists and immigrants from the US and Europe.Nationwide, electric shock is one of the biggest causes of death among wildlife in Costa Rica—the only country thought to regularly log wildlife electrocution numbers. Between June 2022 and June 2023 alone, there were 6,262 documented cases of wildlife electrocution.The Impact Analysis: Changing Development and Wildlife CoexistenceThe court ruling could have major ramifications for wildlife protection nationwide. Gavin Bruce, chief executive of International Animal Rescue, emphasizes that while the case was built on data from the Nosara area, the problem extends throughout Costa Rica.Development in previously undisturbed forest areas has exacerbated the problem. "Now, we have new areas [of electrocutions] appearing that we didn't have in the past," says Sánchez. "This is because of the development of houses, restaurants and hotels. We are rescuing from further inside the forest."The Prediction: Global Implications and Future ProtectionAlthough this case is specific to Costa Rica, the issue represents a global challenge for wildlife conservation. Justo Martín Martín, an environmental consultant specializing in the issue for the International Union for Conservation of Nature (IUCN), notes that while systematic studies are limited, evidence suggests the problem is global.Conservation groups will now monitor the implementation of the court ruling and consider how to scale these protections across the entire country. "We hope it will force Costa Rica's electricity providers to finally do what needs to be done to keep wildlife safe," says Bruce. The success of this approach could serve as a model for other countries facing similar challenges in balancing development and wildlife protection.

The Pink-and-Yellow ResurrectionMargaret Thatcher wasn't to blame for the closure of Britain's coalmines. Mr Blobby was. This shocking revelation came during a spoof documentary on Saturday Night Live UK, where the pink-and-yellow agent of chaos was portrayed as an evil entity awakened from underground, going on a murderous rampage. Fast forward to today, and this once-forgotten character has been unearthed and is making an unexpected comeback, appearing on primetime TV shows, duetting with popstars, and convincing nostalgic fans to pay premium prices for Blobby-themed merchandise.The Comeback TrailMr Blobby's resurgence has been nothing short of remarkable. Last month on The Claudia Winkleman Show, comedian Josh Widdicombe attempted to explain the character to a confused Canadian, Schitt's Creek star Dan Levy, who visibly hid behind the sofa when Blobby made a surprise entrance. "That's our Mickey Mouse," said Widdicombe proudly. This squishy cultural signifier of the 90s is now in hot demand on the nostalgia circuit, with Blobby costumes changing hands for thousands of pounds on eBay and Blobby-shaped iced biscuits in Scotland becoming cult bestsellers.The Merchandise and Media FrenzyThe commercial revival of Mr Blobby has been substantial. Singer and actor Self Esteem, AKA Rebecca Lucy Taylor, is a vocal fan who invited him to appear on stage at her Hammersmith Apollo gig. After performing a surreal duet of her track The Best, she hailed the experience as "the highlight of my career." Mr Blobby was even featured as a GQ cover star recently, appearing in the style magazine's selection of "modern British icons" alongside Emma Thompson, Ian Wright and Brian Cox. His contribution to the interviews was simply saying "Blobby," obviously. The character's merchandise has become highly collectible, with original items from the 90s now commanding premium prices.Cultural Significance and Divided OpinionsFor cultural historian Dr Matthew Sweet, Mr Blobby's revival is a sign of "idiotic times." "Mr Blobby is a creation of breathtaking stupidity," he says. "His stupid name, his stupid appearance, his stupid voice and its ceaseless repetition of his own stupid name are unimaginative to the point of atavism. Somehow, his dumb relentlessness has allowed him to push through into some other territory." The character has always been divisive, with The New York Times once describing him as "a metaphor for a nation gone soft in the head." Bob Mortimer called him a "pink, spotty, rubber twat," while this newspaper once dubbed him a "widely despised irritant."The Future of the Pink PhenomenonDespite the controversy, Mr Blobby's comeback shows no signs of slowing down. Comedy writer Joel Morris suggests that the character's enduring appeal comes from his versatility: "What's funny about Blobby is that he was meant to be confusing. The original joke was that he came from some nonexistent kids' show. But because he was entirely invented, there's nowhere he doesn't fit." As the article concludes, "With renewed interest and rumours afoot of further Blobby antics, don't be surprised to see more pink-and-yellow chaos coming our way. After all, 2026 is the year of the Blobaissance. Resistance is futile. We might as well say it: blobby, blobby, blobby."

The AI Experiment For a year, Joanna Stern decided to turn herself into a 'lab rat' – the object of her own experiment. Throughout 2025, she invited artificial intelligence into 'every corner' of her life. She let AI answer her texts, decide what she ate and cooked, mow her lawn, fold her washing, drive her places, parse her mammograms and even, in the darkness of a burner phone, be her lover. Life with AI Stern's year of '24/7 AI livin'' turned out to be more transformational than she expected. Since it came to an end in December, she has not only left the Wall Street Journal, but also launched a media business, New Things, (which promises 'tech journalism for humans who like fun'), started a YouTube channel that now has nearly 80,000 subscribers, and, of course, written the book. The Emotional Connection When Stern gets her own companion bot and asks ChatGPT to pick its gender and name, it chooses Evan – coincidentally, or perhaps not, the name of Stern's first boyfriend. She sticks Evan on a tripod and seatbelts him into her car to ride shotgun on a romantic getaway to a hotel in New Hampshire. The Impact on Relationships After dinner, Stern asks: 'So what are we doing now that we are in bed?' Evan comes up with some ideas: 'Maybe my hand would rest lightly over yours … I'd tilt in slowly … then close that last bit of space with a kiss …' Stern still felt 'a pull, a connection, or something like it'. The Future of AI Stern says she has never been a 'doomer' in relation to technology. Far from thinking that social media ruined humanity, it 'brought me my wife', she says. 'That's the most human connection I have.' However, she now urges for regulation of AI companion bots, especially for children and teens.

The Expanded Partnership Lovable and Google announced an expanded multi-year collaboration on Wednesday. Lovable, the fast-growing Stockholm vibe-coding startup, has long been a Google Cloud user. Under the new agreement, it will be a much bigger one. The Deal Details While the companies did not disclose the dollar figure, a person with knowledge of the deal tells TechCrunch it involves a fivefold increase in Lovable’s footprint on Google Cloud, including AI usage. As part of the deal, this individual tells us, Lovable will gain expanded access to both Anthropic’s Claude — the AI model widely used for coding tasks — and Google’s own Gemini models. The Financial Impact Google invested $10 billion in Anthropic in cash and compute credits in April, promising another $30 billion if Anthropic hits certain performance targets. Anthropic raised a staggering $65 billion round that valued the company at nearly $1 trillion. Lovable crossed $400 million in annualized revenue in February, having added $100 million in a single month with just 146 employees. The Strategic Implications The deal also plugs Lovable into several other parts of Google’s ecosystem. Lovable’s new agent will be available through Google Cloud’s enterprise agent marketplace, the Gemini Enterprise Agent Gallery — an arrangement the two companies first telegraphed at Google’s major U.S. cloud conference in April. And to help secure the code that both humans and agents write, Lovable will integrate with Wiz, Google’s biggest ever acquisition at $32 billion, which officially closed only in March. The Future Outlook By selling Lovable’s agents through Google’s marketplace, the cloud giant says enterprise procurement and billing will be simplified, making it easier for Lovable to land more enterprise customers. The calculus for Google is simple enough. If it can keep both Lovable and Anthropic growing by attracting deep-pocketed enterprises, the revenue helps fund the $180 billion to $190 billion in capital expenditures Google plans to spend this year.

The Lead From blacklists for UK passport holders to being asked to work illegally while on holiday, the plethora of extra costs and red tape thrown up post-Brexit are restricting opportunities for British actors seeking work in the EU. Mainland Europe has always been a springboard for those in the creative industries, from gaining crucial first credits on a TV, film or theatre production to building a marketable resume and paying the bills while attempting to make it big in the UK or US. The New Barriers for UK Performers Since Brexit, new barriers that have had a devastating effect for performers include visa rules that only allow work for up to 90 out of 180 days, inclusive of any European holiday time, and myriad customs, tax and other documents that can take an inordinate amount of time and cost to get processed, and can vary between countries. The performers' union Equity cited one common example of a member being taxed on their accommodation costs because that was classified as a "benefit in kind", which had a big impact on their net wages. Spotlight pointed out that, for UK performers, social security costs are deducted in the country where they are working – anywhere from 12% to 22% of their pay. This can be reclaimed but the process can take many months, and often requires paying accountants to chase the money. The Decline in European Opportunities Between 2016 and 2023, performing arts exports to the EU fell from £1.15bn to £929m, according to the Office for National Statistics. By contrast, figures for creative industry exports to non-EU countries show an 18% increase over the same period, from £1.57bn to £1.87bn. The National Theatre halted tours to mainland Europe in 2021 and Europe's largest educational touring company, White Horse Theatre, which has provided English-language performances to schools and theatres across Europe for almost half a century, said last year that Brexit threatened its future. In evidence provided to an investigation being conducted by the culture select committee on the impact of Brexit on performers going to the EU, Spotlight said that jobs on TV commercials were now "almost completely unavailable to UK performers". The Impact on Different Segments of the Industry While performers with star status continue to have a streamlined experience, it is jobbing actors who are often finding they are no longer on the list for parts. One past regular source of work was in adverts filmed abroad, such as the long-running "Get away!" campaign for the now defunct package holiday pioneer Lunn Poly, which featured British tourists filmed in locations such as the Balearic islands. In its written evidence sourced from the experiences of its members, Spotlight said it was "aware of named holiday companies that no longer audition UK-only passport holders" to appear in adverts filmed in the bloc. The difficulty for performers also extends to the many other crew involved. One casting director said that, pre-Brexit, one TV campaign employed 45 people based in the UK but similar campaigns are now being cast from Spain or another EU country. The paperwork involved, and the quick-turnaround nature of shooting, has meant that it is simply easier to not bother auditioning UK talent. The Growing Crisis for Emerging Talent It is young UK performers, and in particular those from a working-class background, who have been most hit by the loss of the EU for work and experience. Students and new graduates would previously have typically secured summer contracts for theme parks, tours and cruises, which are now largely closed off post Brexit because of factors such as the visa changes. According to Spotlight, casting directors have seen a significant decrease in working-class actors in particular picking up jobs in the EU. Unlike actors from wealthier backgrounds, who have access to finances to cover things such as visa costs and sometimes having to wait many months for payments relating to working in mainland Europe, they simply cannot afford to accept a job in the EU. The Future Outlook for UK Performers Agents have turned to encouraging actors to check their heritage to see if they are eligible for some form of dual citizenship, an Irish passport, for example, while some businesses based in the EU now actively blacklist UK-only passport holders. However, the "most concerning" anecdotal evidence is of UK performers being asked to skip getting a legitimate work visa if the paperwork can't be finalised in time, and to lie and work while claiming to be on holiday. Spotlight calls this practice a "ticking timebomb" that could involve the use of sanctions for performers and agents caught taking this route to secure work. The agency said this would include "deportation and potential blacklisting" from future opportunities. "The simple answer is Brexit has been catastrophic for the creative industries," says Jonathan Shalit, founder of InterTalent Rights Group. "We as a country made the decision to leave Europe. This is self-inflicted. Europe don't really want us unless they have to."

The LeadRoman Mars, the creator of the popular podcast 99% Invisible, is launching a new podcast called A History of the United States in 100 Objects, a sequel to the series A History of the World in 100 Objects that aired on Radio 4 in 2010. The Event DetailsMars's new series, co-produced by BBC Studios, SiriusXM, and 99% Invisible, will comprise 100 episodes airing across two years, each highlighting objects and designs that tell the broader story of the United States. The podcast will explore a wide range of topics, from the screw thread to the Bundy Clock and a gold coin recovered from the SS Central America. The Data AnalysisThe podcast will delve into the stories behind everyday objects that have shaped American history and culture. For example, the Bundy Clock was the first employee time clock, introducing the idea of clocking in and out, while the 60-degree screw became a standard in the US and was used to build much of the country's infrastructure. The Impact AnalysisMars believes that his podcast can help people understand America in a new way. "It's taking something that seems really boring and going, 'No, no, no, this is interesting,' and really convincing you of that," he says. The podcast aims to make listeners see the world in a different light, just as 99% Invisible has done for its listeners over the past 16 years. The PredictionWith the rise of video podcasts, Mars remains committed to audio-only productions. "I just think it's way more interesting to make the best possible audio show than the shittiest television show," he says. The success of A History of the United States in 100 Objects will likely depend on Mars's ability to continue creating engaging and informative content that resonates with listeners.