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US President Donald Trump has issued a stern warning to Iran, stating that the Tuesday deadline for Tehran to agree to free passage through the Strait of Hormuz is final. Failure to comply will result in US strikes on Iranian infrastructure, he emphasized.On Monday, Trump described an Iranian proposal aimed at ending the conflict as 'a significant step' but insufficient to avert US action. The proposal, which includes 10 clauses such as an end to conflicts in the region, a protocol for safe passage through the Strait of Hormuz, the lifting of sanctions, and reconstruction, was conveyed to the US via intermediaries.The Iranian proposal was put forward after Pakistan suggested a 45-day ceasefire, which Iran reportedly rejected, seeking a permanent end to hostilities instead. Iran's diplomatic mission head in Cairo, Mojtaba Ferdousi Pour, stressed that Tehran would only accept an end to the war with guarantees that it wouldn't be attacked again.The Strait of Hormuz, a critical waterway through which about 20% of the world's oil supplies pass, has been a focal point of the conflict. Trump's threat to destroy Iranian infrastructure unless the strait is reopened has caused oil prices to surge and shaken the global economy.Earlier on Monday, Israel struck a key petrochemical plant in Iran's South Pars gas field, killing two commanders of the Islamic Revolutionary Guard Corps. Israel claimed responsibility for the strike, which appeared separate from Trump's threats.The White House confirmed that a ceasefire proposal was under consideration but stated that Trump had 'not signed off' on it. The conflict, sparked by Israeli and US attacks on Iran on February 28, has seen Iran fire missiles at targets across the Middle East.Trump has been vocal about his stance, suggesting that Iran's leaders are 'animals' who have killed tens of thousands of protesters and expressing that he is 'highly unlikely' to postpone the deadline. When asked about concerns that attacks on infrastructure could be classified as war crimes, Trump responded that he is 'not worried about it,' emphasizing that allowing Iran to have a nuclear weapon would be a greater war crime.

Iran's Deputy Foreign Minister, Seyed Abbas Araghchi, has stated that messages from the US conveyed through intermediaries, including Witkoff, do not constitute negotiations. This development comes amid ongoing diplomatic efforts to revive the Iran nuclear deal. The comments highlight the complexities of indirect communication between the US and Iran, with Araghchi emphasizing that such messages are not a substitute for direct negotiations. The situation underscores the challenges in achieving a diplomatic breakthrough, with both sides maintaining their positions on the nuclear issue.

Israeli and U.S. forces launched a series of air strikes on Tuesday that struck Tofigh Daru Research and Engineering Company, one of Tehran’s largest producers of anaesthetics and anti‑cancer medicines. The state‑run firm, owned by the Social Security Investment Company, saw its drug‑production line damaged, according to an official post on X. In the north‑western city of Zanjan, a separate strike hit the Husseiniya Azam, a Shia congregation hall adjacent to a mosque. Iranian Red Crescent teams rescued two people from the rubble; one of the victims died and several others were injured. Further attacks were reported in the western province of Kermanshah, where a civilian contracting company in Qasr‑e Shirin – a border town with Iraq – was hit. One person was killed and eight injured, the Mehr news agency said. Heavy bombing was also confirmed in Isfahan, a strategic hub for Iran’s defence industry and home to key nuclear facilities such as Natanz. Local officials indicated that the strikes may have targeted “military sites,” though the exact locations and damage assessments remain unclear. Iranian officials condemned the operations. Former foreign minister Javad Zarif denounced the targeting of the pharmaceutical plant as a deliberate attack on a medical facility, calling the aggressors “desperate” and accusing them of “diabolical delusions.” Governor‑level security official Akbar Salehi echoed these concerns, noting that the strikes appeared aimed at military installations without specifying which ones. The broader conflict has already claimed 1,937 Iranian lives since the joint U.S.–Israeli campaign began on 28 February, while 20 Israelis have been killed. Recent Israeli interceptions using the Iron Dome and David’s Sling systems have limited damage on Israeli soil, but impact sites were reported in Tel Aviv, Bnei Brak and Petah Tikva. Amid the escalating violence, diplomatic channels remain active. U.S. Secretary of State Marco Rubio told Al Jazeera that communications between Washington and Tehran continue, primarily through intermediaries, and that the U.S. aims to achieve its war objectives “in weeks, not months.” Pentagon chief Pete Hegseth added that negotiations to end the conflict are “very real, ongoing and gaining strength.” Iran’s Islamic Revolutionary Guard Corps (IRGC) claimed a retaliatory strike, saying it hit an Israeli container ship in the Gulf with a ballistic missile and that Iranian drones targeted a group of U.S. Marines near a UAE military base. Public sentiment in Iran has turned sharply hostile, with pro‑state demonstrations erupting in Tehran as citizens protest the continued air raids. The atmosphere, described by Al Jazeera’s Tohid Asadi as a “cloud of mistrust,” reflects growing frustration over diplomatic dead‑ends and the relentless cycle of attacks.

US Secretary of State Marco Rubio has assured that the Strait of Hormuz will reopen after the ongoing conflict with Iran. In an exclusive interview with Al Jazeera, Rubio emphasized that the strait will be reopened either with Iran's consent or through an international coalition including the US.The conflict began on February 28 with US-Israeli strikes on Iran. Despite US President Donald Trump stating that the US is pursuing diplomacy, Rubio mentioned ongoing direct talks between the US and Iran, primarily through intermediaries. Iran has denied these talks are happening.Rubio called on Iran to take concrete steps to end its nuclear programme and cease manufacturing drones and missiles. He accused Iran of seeking nuclear weapons to threaten and blackmail the world, which Tehran denies.The situation remains volatile, with speculation about a possible US troop deployment in Iran. Rubio warned of severe consequences if Iran keeps the strait closed after the conflict ends. The White House has considered various military options, including a special forces operation to seize enriched uranium stored in Iran.

In an exclusive interview with Al Jazeera, US Secretary of State Marco Rubio revealed that President Donald Trump favors diplomacy as a means to end the conflict with Iran. Rubio emphasized that direct talks between the US and Tehran are currently underway through intermediaries.Earlier, Trump threatened to target Iran's civilian energy infrastructure, including power plants, oil wells, and Kharg Island, if Tehran did not reopen the Strait of Hormuz. Despite these military threats, Rubio's comments suggest a preference for diplomatic engagement.

The Middle East remains embroiled in a cycle of violence, with Iranian barrages targeting Israel, Gulf Arab states, and northern Iraq on Tuesday. This escalation comes a day after US President Donald Trump claimed that the US was in 'very good' talks with Iran to end the war in the region soon.Despite Trump's optimistic remarks, multiple official sources in Tehran have denied any talks are underway. Iranian parliament speaker Mohammad Bagher Ghalibaf stated, 'No negotiations have been held with the US … fake news is used to manipulate the financial and oil markets.' The Iranian government remains wary of US offers of negotiation, citing past experiences where talks were followed by attacks, such as the surprise attack that killed the supreme leader Ali Khamenei and dozens of senior officials.Potential intermediaries, including Pakistan, Oman, Egypt, and others, have confirmed tentative efforts to establish channels of communication between Washington and Tehran. Iranian Foreign Minister Abbas Araghchi has been engaging in discussions with his counterparts in several countries, including Azerbaijan, Egypt, Oman, Pakistan, Russia, South Korea, Turkey, and Turkmenistan.The diplomatic activity follows a significant escalation of threats between the US and Iran over the weekend, with both sides trading warnings of potential strikes. On Monday, Trump delayed a deadline for Iran to open the Strait of Hormuz for shipping or face targeted airstrikes on its power stations. This brief reprieve drove down oil prices and boosted stocks, with the deadline now set to expire on Friday.Benjamin Netanyahu has stated that Israel will continue to strike Iran and Lebanon, targeting Hezbollah, the Iran-backed Islamist militant movement. The Israeli prime minister warned, 'There's more to come.'The conflict has already had significant economic impacts, with oil prices rising to $104 (£77) a barrel, up more than 40% since Israel and the US started the war on 28 February. Analysts warn of durable and deep disruption to the supply of oil and gas from the region, even if hostilities end rapidly, with severe economic consequences worldwide.