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Shaw's Professionalism Secures Manchester City's Historic DoubleManchester City head coach Andrée Jeglertz has highlighted the mental fortitude of prolific striker Khadija Shaw, crediting her ability to block out contract speculation for her continued excellence on the pitch. Shaw scored the opening goal in the 4-0 victory over Brighton, helping City complete a domestic double by lifting the Women's FA Cup at Wembley.Wembley Triumph Amid Contract SpeculationThe 29-year-old Jamaica international has been in scintillating form throughout the cup run, netting in the quarter-final and semi-final before nodding in from an Alex Greenwood cross on Sunday. Despite being heavily linked with Chelsea since March and initially deciding to leave the club in early May, Shaw delivered a dramatic performance that silenced her critics and secured her future.Resolving the Contract SagaJeglertz was effusive in his praise for Shaw's demeanor during a turbulent period. "I'm very impressed how she handled that," he stated. "She has never shown any kind of 'mood' that has affected her performance. Of course, she is a person, like everybody else, so of course, she will know about all the writing, she knows about that, but at the same time she has been so professional all the time."Teammate Rebecca Knaak echoed this sentiment, noting the difficulty of maintaining focus amidst the background noise. "It's quite hard as a player to still focus then, and that's exactly what she did. She’s always turned up in all the games for us. She’s so important for us and I’m just incredible happy that she’s staying."Brighton's Path to the Next LevelWhile City celebrated their historic achievement, Brighton head coach Dario Vidosic acknowledged the challenge of facing a clinical striker. Despite Brighton enjoying greater possession and having 12 efforts at goal compared to City's 14, Shaw's clinical nature proved decisive in the heavy scoreline.Vidosic expressed pride in his side's bravery on the ball but admitted the loss will serve as motivation for the upcoming season. "This will hurt for a little while, but hopefully we can use that motivation and that fire for next season," he said. With Brighton looking to build on their strong campaign—which included knocking out Arsenal—they plan to retain their core squad while targeting new signings to strengthen specific areas.

The LeadA daily pill has shown remarkable results in doubling survival time for patients with pancreatic cancer, the world's deadliest form of the disease. According to clinical trial results presented at the American Society of Clinical Oncology's annual meeting, this breakthrough treatment represents a potential revolution in how we approach a cancer that has seen limited progress for decades.The Breakthrough Drug: DaraxonrasibThe drug in question, daraxonrasib, works by targeting a protein called Kras that fuels nearly all pancreatic cancers. This mechanism represents a significant advancement in treatment strategy, as Kras has been notoriously difficult to target effectively. The drug functions as a Ras(On) multi-selective inhibitor, capable of turning off the Kras protein to stop cancer growth regardless of which variant is present.Impressive Trial ResultsIn the clinical trial involving 500 patients with advanced pancreatic cancer, the results were striking. Those who took daraxonrasib lived an average of 13.2 months, compared to just 6.6 to 6.7 months for patients who received chemotherapy. This represents a near doubling of survival time, with the added benefit of fewer side effects compared to traditional chemotherapy treatments.Industry Impact and Expert ReactionsThe findings have been hailed as a "gamechanger" and "grand slam" by experts in the field. Dr. Rachna Shroff, chief of oncology at the University of Arizona Cancer Center, described the results as "landscape-changing" and "unprecedented survival." When she first read the trial results, conducted by researchers at the Dana-Farber Cancer Institute in Boston, she wept, noting the profound impact this could have on patients after 16 years of treating pancreatic cancer.Dr. Julie Gralow, Asco's chief medical officer, echoed these sentiments, calling the study a "home run" and suggesting it was actually a "grand slam" in terms of its significance.The Ras RevolutionOver 90% of patients with the most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (mPDAC), have a mutation in the Kras gene. This discovery has long been considered the "holy grail" in cancer research, particularly for pancreatic cancer where the mutation is nearly ubiquitous and an early driver of cancer growth.Paula Hanford, chief executive of UK-based Pancreatic Cancer Action, called this one of the most significant developments in treatment she had ever seen. Similarly, Anna Jewell, director of services, research and innovation at Pancreatic Cancer UK, described the results as "exciting," noting that the drug gives patients "months more precious time with their loved ones."Future Outlook and ApplicationsThe success of daraxonrasib opens doors for similar treatments targeting Ras genes in other cancers. Experts at the conference noted that because Ras genes fuel various types of cancer, there is hope for breakthroughs in treating lung and colon cancers as well, with similar drugs already in development for these conditions.However, challenges remain in ensuring these promising treatments become widely available to patients. As Jewell pointed out, tragically half of all people with pancreatic cancer die within just three months of diagnosis, making the rapid implementation of such treatments crucial.

The Lead: Unprecedented Cancer Treatment SuccessDoctors have hailed "unprecedented" trial results that show a triple-action cancer jab can eradicate entire tumours in patients. In an international trial spanning 11 countries, the injection was offered to patients whose cancer had spread or come back and whose disease had failed to respond to other treatments.The Breakthrough: Amivantamab's Triple-Action ApproachThe jab, called amivantamab, shrank the tumours of more than a third of patients, with dramatic changes seen within weeks. In 15 of them, doctors found the drug had melted away their tumours altogether.The smart jab targets cancer in three ways. It blocks both EGFR (epidermal growth factor receptor), a protein that helps tumours grow, and MET, a pathway that cancer cells often use to escape treatment. It also helps activate the immune system to attack the tumour.The Clinical Trial Data: Impressive Response RatesIn the trial, 102 patients with head and neck cancer, the world's sixth most common cancer, were given the jab. Tumours shrank or disappeared completely in 43 patients, including 28 whose tumours shrank significantly and 15 who saw them eradicated entirely.Patients receiving amivantamab lived for a median of 12.5 months overall after starting treatment, despite having a form of cancer with very poor outcomes, once standard treatments stop working.The Impact Analysis: New Hope for Treatment-Resistant CancersKevin Harrington, professor in biological cancer therapies at the Institute of Cancer Research, London (ICR), said: "These are unprecedentedly strong responses in patients whose disease has become resistant to both chemotherapy and immunotherapy. This is a group of patients for whom treatment options are extremely limited, so seeing this level of benefit is very striking."Researchers also highlighted that the trial focused on people with head and neck cancers that did not include those with human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. That is particularly significant, they said, since head and neck cancers not caused by HPV are usually harder to treat, making progress in this group hugely important.The Patient Experience: Transforming Quality of LifeOne of the first patients to benefit was Carl Walsh, 56, who was diagnosed with tongue cancer in May 2024 and joined the OrigAMI-4 trial at the Royal Marsden in July 2025. "I was initially treated with both chemotherapy and immunotherapy, which unfortunately were not successful," he said. "At that point, I was recommended for the OrigAMI-4 trial. I'm now on my 17th cycle of treatment and I'm very pleased with the progress so far."Unlike many cancer treatments, amivantamab is given as a tiny jab under the skin rather than via an intravenous drip, making treatment quicker and more convenient for patients and much easier to deliver in outpatient clinics.The Future Outlook: Expanding Treatment ApplicationsThe results will be presented on Sunday in Chicago at the world's largest cancer conference, the annual meeting of the American Society of Clinical Oncology (Asco).Amivantamab, developed by Johnson & Johnson, is now being evaluated in about 60 clinical trials, primarily for lung cancer, but also for colorectal, brain and gastric cancers.Prof Kristian Helin, the chief executive of the ICR, said: "This study demonstrates how the development of new treatments through rigorous cancer research may lead to meaningful advances, even for patients with very limited treatment options. Achieving this level of tumour response and encouraging survival outcomes in such a challenging-to-treat group represents a significant step forward."

The Host Nation's Tactical RenaissanceThe United States enters the 2026 World Cup as hosts with a mandate to modernize its footballing identity. After a disappointing group-stage exit at the Copa América in 2024, the USMNT appointed Mauricio Pochettino to lead the charge. The team is now focused on shedding its "bunker-and-counter" reputation in favor of a more stylish, possession-based approach, despite the challenge of facing elite opposition without a clear statistical advantage in individual talent.Pochettino's Tactical Experimentation and Formation ShiftsPochettino has faced significant tactical fluctuation since taking charge. While he previously favored a high press, he has shifted toward a mid-block defense to limit opponent touches in the final third. The system operates as a 3-2-5 in possession and a 4-4-2 or 5-3-2 in defense. However, this adaptability was tested recently in a 5-2 thrashing against Belgium, highlighting the difficulty of balancing personnel with structural integrity.Formation Fluidity: The team attempts to string passing sequences up the channel, utilizing a pair of attacking midfielders and a double-pivot behind them.Defensive Strategy: Focus has shifted to establishing a mid-block to limit final-third touches rather than aggressive high pressing.Personnel Challenges: A thin center-back corps has forced Pochettino to switch between a back three and a back four, causing inconsistency.Group D Fixtures and Squad Selection StrategyThe USA was placed in Group D, facing Paraguay, Australia, and Turkey. The squad features a mix of proven veterans and rising stars. The coaching staff prioritized squad harmony over individual ego, sending personalized messages to selected players. Key selections include Christian Pulisic as the talisman and Folarin Balogun as the primary striker, following the departure of veteran forwards.Star Player: Christian Pulisic (27, Milan) remains the face of the program, despite a recent goal drought.One to Watch: Folarin Balogun, committed to the USA over England and Nigeria, offers a $40m+ market value and clinical finishing.Unsung Hero: Chris Richards provides the surest presence along the backline, crucial for the team's defensive stability.Bridging the Gap in Individual QualityThe core philosophy is to control games rather than just survive them. Pochettino acknowledged that the USMNT lacks players in the global top 100 compared to powerhouses like Belgium and Portugal. Consequently, the strategy relies on collective cohesion and tactical discipline to bridge the gap in individual quality. The team aims to prove it can play "stylishly" while still delivering results against top-tier opposition.Home Advantage and the Road to Knockout StagesWith the tournament on home soil, the pressure is immense. The USA is expected to be competitive, particularly in the opening match against Paraguay. The success of the campaign will likely depend on Pochettino's ability to settle on a consistent XI and whether the squad's improved chemistry translates into performance on the biggest stage.

The World Health Organization (WHO) is deploying its highest leadership to the Democratic Republic of the Congo (DRC) as the nation grapples with its 17th Ebola outbreak, a crisis exacerbated by the absence of approved vaccines for the specific viral strain. The Strain of Survival: Lack of Vaccines for Bundibugyo The current outbreak is caused by the Bundibugyo strain, a distinct variant from the more common Zaire strain. This distinction is critical because while previous DRC outbreaks had established vaccines and treatments, the Bundibugyo strain currently has no approved vaccines or treatments. WHO Director-General Tedros Adhanom Ghebreyesus emphasized the critical role of health workers in Bunia, the capital of Ituri province, stating they are the "backbone of this response." As of the latest reports, one patient has recovered, offering a glimmer of hope amidst the challenges. Quantifying the Crisis: Confirmed Cases and Regional Spread The scale of the outbreak is significant, with latest government figures revealing a total of 1,077 suspected cases and 246 suspected fatalities. The confirmed data shows 121 confirmed cases and 17 confirmed deaths, though authorities estimate the true number of casualties may be higher. The crisis has not been contained within DRC borders; Uganda has confirmed eight cases, including one death, prompting the government to close its borders for at least four weeks. Confirmed Cases: 121 Confirmed Deaths: 17 Suspected Cases: 1,077 Suspected Fatalities: 246 Ugandan Cases: 8 Geopolitical and Logistical Barriers to Containment Containment efforts are severely hampered by logistical shortages and regional instability. Health workers are operating with scant supplies, resorting to wearing expired medical masks in some areas. Furthermore, the volatile security situation in eastern DRC, where armed groups vie for power, has led to attacks on health centers and public distrust of authorities. The WHO chief made a direct appeal to these armed groups, urging a brief ceasefire to allow health workers to operate safely. The Race for a Vaccine and a Ceasefire The global community is mobilizing resources to combat the spread. The DRC government has released $20m to fund the response, while the United States has allocated an additional $80m, bringing total US aid to $112m. On the scientific front, the Africa Centres for Disease Control and Prevention (Africa CDC) has pledged to have a vaccine and medicine ready against the Bundibugyo strain by the end of 2026. Until then, experimental treatments will be used strictly in clinical trials, highlighting the urgent need for scientific breakthroughs to match the speed of the virus's spread.

Lead: Sleep Deprivation Emerges as a Possible Driver of Early-Onset CancerResearch presented at the American Society of Clinical Oncology’s annual meeting in Chicago suggests that irregular sleeping patterns could be a significant, yet modifiable, risk factor for cancers diagnosed before age 50.The Study Linking Sleep Disruption to Early-Onset CancerTwo investigations led by MD Anderson Cancer Center analysed health records of over 18 million U.S. adults aged 18‑50. Participants with chronic insomnia showed a markedly higher incidence of bowel, breast, uterine, and ovarian cancers compared with well‑rested peers.Key Numbers Highlight the Scale of the IssueGlobal early‑onset cancer cases rose from 1.82 million (1990) to 3.26 million (2019), an 80% increase in three decades.Cancer deaths among people in their 30s, 40s, or younger climbed 27% over the same period.In the MD Anderson cohorts, insomnia was associated with up to three‑fold higher cancer risk within five years.Why This Matters for Public Health and Clinical PracticeThe data position sleep quality alongside genetics and lifestyle as a potential lever for curbing the surge in early‑onset cancers. Experts caution that the studies show association, not causation, but note that sleep deprivation can impair immune function and promote behaviours (smoking, poor diet, reduced exercise) that are already linked to cancer.Looking Ahead: Research, Screening, and Prevention StrategiesStakeholders anticipate a wave of longitudinal studies to test whether improving sleep can lower cancer incidence. In the meantime, clinicians are likely to incorporate sleep assessments into risk‑stratification tools, while public‑health campaigns may emphasise sleep hygiene alongside anti‑smoking and sun‑safety messages.

Fatalities Spark Global Scrutiny of the Kambo Healing RitualThe kambo ceremony—an ancient Amazonian rite that applies frog secretions to skin burns—has claimed at least six lives in the past two decades, including the recent death of UK wellness coach Kristian Trend (40). The surge in high‑profile fatalities is driving governments and health experts to demand stricter regulation of a practice that lacks scientific validation.Recent Deaths Highlight Risks of the Frog‑Poison CeremonyIn April 2026, Kristian Trend died after a “cleansing ceremony” in the United Kingdom, reigniting media calls for a ban. Earlier incidents include:2008 – 52‑year‑old man in Brazil.2018 – Italian man with pre‑existing heart conditions.2019 – Australian woman Natasha Lechner (39) seeking relief from chronic back pain.October 2021 – Australian Jarrad Antonovich (death linked to a perforated oesophagus).2024 – Mexican actress Marcela Alcazar Rodríguez (33) during a cleansing ritual.These cases illustrate the ritual’s unpredictable physiological effects, ranging from violent vomiting and hyponatremia to sudden cardiac arrest.Known Mortality Figures and Regulatory LandscapeMedical literature now records six confirmed deaths associated with kambo worldwide. A 2025 review in *Cureus* recommended tighter regulation after documenting severe reactions. Current legal status varies:Brazil banned sale and marketing in 2004.Chile prohibits importation.Australia classified kambo as a poison in 2021.United States deems it illegal; a 2025 US embassy advisory warned citizens against use in Peru.In the UK, frog poison can be purchased but is not a licensed medicine.Public Health and Legal Implications Across ContinentsThe ritual’s spread into Western “wellness” circles—particularly in the UK, US, Brazil, and Australia—poses a public‑health challenge. Health agencies warn that the peptide cocktail in kambo can cause:Severe nausea, vomiting, and diarrhoea.Rapid blood‑pressure drops and fainting.Cardiac arrhythmias and potential organ toxicity.Hyponatremia leading to brain swelling or death.Indigenous leaders, such as Yamanawa chief Joaquim Luz, have condemned commercial exploitation, emphasizing cultural appropriation and safety risks.Prospects for Regulation and Consumer ProtectionGiven the mounting evidence, experts anticipate a coordinated push for:Standardized licensing of practitioners where the ritual is permitted.Clear labeling and prohibition of online sales of raw frog secretions.Public‑education campaigns highlighting the lack of clinical efficacy.International cooperation to monitor cross‑border trade of the toxin.If authorities act swiftly, the next wave of fatalities could be averted, and the balance between cultural tradition and modern health safety may be better defined.

UK Study Reveals Air Pollution's Impact on Children's Lung DevelopmentResearch shows that air pollution is slowing the lung growth of children in the UK. Scientists tracked the lung function of more than 5,000 people who were born in and around Bristol in the 1990s. Their health was assessed from birth onwards and their lungs were tested as they grew up, at eight and 15 years old and then as adults, aged 24, when their lung function should have reached its maximum.Longitudinal Study Tracks Lung Function From Birth to AdulthoodProf Ann Hansell, of the University of Leicester, who led the study, said: "Much of the evidence on health effects of air pollution relates to adults or pregnancy, but we think it's highly plausible it has impacts on growth and development of children. Those whose lungs didn't grow to maximum potential in childhood may be more vulnerable to the respiratory diseases of later life because they have a lower reserve."Dr Katie Eminson, also of the University of Leicester and a first author of the study, explained: "Lung function was measured using spirometry by trained technicians. Participants were asked to take a deep breath in, then blow out as hard and as fast as possible into a mouthpiece. A machine measured both the amount of air they can breathe out and the speed of that breath, providing an indication of how well their lungs are working."Pollution Exposure Linked to Reduced Lung CapacityThe researchers calculated the children's air pollution exposure in each trimester of pregnancy and then for each year of early childhood. This included particle pollution as well as nitrogen dioxide, a gas that comes mainly from diesel cars and fossil gas boilers.Hansell noted: "We spent literally years creating the particulate air pollution exposure estimates in pregnancy and early life, including sourcing road traffic data from Bristol city council that are not available in the national database."The researchers allowed for other factors that can affect children's health, including premature birth, breastfeeding, parental smoking and home conditions including damp.They found that breathing more air pollution during pregnancy, infancy and early childhood can slow lung development all the way up to early adulthood. The greatest impact was during adolescence, which is the time when lung growth accelerates.Health Implications Extend Beyond Respiratory SystemThose with reduced lung function face multiple health risks. "They are also more vulnerable to poorer health generally," Hansell explained. "For instance, low lung function in adults is associated with the same level of risk of heart disease as having high cholesterol. Research has also shown that people whose lung health has been affected by air pollution may be at greater risk of heart disease."An earlier study found that air pollution was reducing the growth of children's lungs in east London. There, the average nine-year-old's lungs were between 90 and 100 millilitres smaller than they should be—approximately the volume of two hen's eggs.Studies on children in Sweden showed that lung growth increased when air quality improved. Reductions in air pollution might have also allowed the Bristol children's lung growth to return closer to normal rates.Call for Action on Air Quality ProtectionEminson concluded: "While the effects in individual children are small and unlikely to have immediate clinical consequences, they shouldn't be dismissed. Because lung function tends to track from childhood into adulthood, small differences early in life may have implications for long-term health. This reinforces the importance of reducing exposures and protecting children's environments."

Lead: Messi Confirmed as Argentina Captain for 2026 World CupLionel Messi will lead Argentina’s defense at the 2026 World Cup, as national coach Lionel Scaloni unveiled a 26‑man squad on Thursday, dispelling lingering injury doubts.Scaloni Announces Squad and Leaves Out Rising Star Franco MastantuonoScaloni’s roster retains 17 members of the 2022 title‑winning side and adds a mix of veterans and newcomers. Notably, Real Madrid prospect Franco Mastantuono was omitted despite his reputation as a top prospect.26‑man squad announced17 players from 2022 championsKey exclusions: Mastantuono, Emiliano Buendía, Paulo DybalaNumbers Behind the Selection: Squad Composition and Recent FormThe squad features:Goalkeepers: Emiliano Martínez, Gerónimo Rulli, Juan MussoDefenders: 8 players, including Lisandro Martínez (Manchester United) and Cristian Romero (Tottenham Hotspur)Midfielders: 7 players, with Enzo Fernández (Chelsea) and Alexis MacAllister (Liverpool)Attackers: 8 players, headlined by Messi (Inter Miami)Messi’s recent MLS match ended with a 73rd‑minute substitution due to left‑hamstring fatigue, but Scaloni says further tests are pending.Strategic Impact: What Messi’s Captaincy Means for Argentina’s Title DefenseKeeping Messi as captain reinforces continuity after the 2022 triumph and signals confidence despite his injury scare. The blend of experienced World Cup veterans and emerging talent aims to maintain the team’s tactical flexibility across a tournament that will span three host nations.Looking Ahead: Fitness Outlook and Argentina’s Group‑Stage ProspectsMessi’s recovery timeline hinges on “clinical and functional progress,” according to Inter Miami. If cleared, Argentina opens against Algeria in Kansas City on June 16, followed by matches versus Austria and Jordan. The squad’s depth suggests they can remain competitive even if Messi’s minutes are limited.