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Early‑stage evidence from a University of Bristol randomised controlled trial suggests that the anti‑inflammatory drug tocilizumab may improve symptoms in patients with moderate‑to‑severe depression who have not responded to standard antidepressants.Trial Overview: Testing Tocilizumab for Treatment‑Resistant DepressionThe study examined whether blocking the IL‑6R receptor could alleviate depressive symptoms. Key design elements:Participants: 30 adults with moderate‑to‑severe depression unresponsive to conventional medication.Intervention: Intravenous tocilizumab versus placebo.Duration: four‑week double‑blind period.Outcomes measured: depression severity, fatigue, state anxiety, and quality of life.Key Numbers: Sample Size, Remission Rates, and NNTAlthough the trial was not powered to reach statistical significance, observed trends were notable:Depression remission: 54% in the tocilizumab group vs 31% in the placebo group.Number Needed to Treat (NNT): 5, meaning five patients would need treatment for one additional remission.For comparison, the NNT for first‑line SSRIs is approximately 7.The lack of robust statistical proof reflects the small cohort, underscoring the need for larger studies.Potential Shift in Depression Treatment ParadigmsResearchers describe the trial as an “important milestone” because it is:One of the first randomised trials to test immunotherapy for depression.The inaugural study targeting the IL‑6R pathway in this context.A proof‑of‑concept for selecting patients based on biological markers.Given that up to one‑third of depressed patients do not improve with existing pharmacotherapies, a biologically driven approach could expand therapeutic options and move psychiatry toward more personalised care.What Comes Next: Larger Studies and Clinical ImplicationsThe investigators plan to:Conduct larger, multi‑centre trials to confirm efficacy and safety.Explore longer treatment durations and dosage optimisation.Assess whether IL‑6R blockade can be combined with existing antidepressants.If subsequent trials replicate these findings, immunotherapy could become a viable adjunct or alternative for treatment‑resistant depression, potentially reshaping clinical guidelines and drug development pipelines.

The Guardian is launching a feature aimed at exposing the hidden financial habits that often plague modern relationships. The publication is seeking couples who maintain a "financial veil" over their spending habits—whether it is a recurring Pret subscription or an addiction to online shopping—to participate in a unique transparency experiment. The Guardian's Financial Transparency Experiment This initiative invites participants to record and share their money diaries in the presence of a journalist, offering anonymity to encourage honesty. The goal is to move beyond abstract statistics and capture the raw reality of how money is managed—or hidden—within intimate partnerships. Target Audience: Couples with undisclosed spending habits. Methodology: Recorded money diaries with journalist oversight. Privacy: Responses can be anonymous or published with consent. The Psychology Behind the Secret Ledger The call for stories highlights a pervasive issue: financial infidelity. Many individuals feel a sense of shame or a desire for autonomy regarding their spending, leading them to conceal purchases from their partners. This feature aims to analyze the root causes of this secrecy, ranging from a lack of trust to differing financial philosophies. Why Open Books Are Becoming the New Norm As financial literacy becomes a priority, the stigma around joint accounts and shared spending is fading. This feature underscores a broader shift where financial transparency is increasingly viewed as a cornerstone of a healthy, long-term relationship rather than a sign of distrust. What This Feature Could Reveal About Modern Couples By collecting these diaries, the Guardian is poised to uncover trends in how couples negotiate money. The data collected will likely reveal that while spending habits differ, the desire for financial honesty is a universal goal, paving the way for more open conversations in the future.

The Shift in Generative Audio CapabilitiesStability AI has significantly advanced its generative audio capabilities with the release of Stability Audio 3.0, a new family of models capable of producing professional-grade music tracks exceeding six minutes in length. This release marks a critical evolution in the company's strategy to compete in the rapidly expanding AI music market.Expanding the Horizon of Generative AudioThe new model family is designed with a tiered approach to accommodate various use cases, from on-device sound effects to full-length compositions.Small SFX (459M parameters): Optimized for on-device sound effects with a limit of two minutes.Small (459M parameters): Suitable for short music generation on devices.Medium (1.4B parameters): Capable of generating full compositions up to 6 minutes 20 seconds.Large (2.7B parameters): The top-tier model for complex, structured audio generation.Scaling from Seconds to Full CompositionsThe leap in capability is evident in the output duration. The Medium and Large models can maintain musical structure and melodic tone for over 6 minutes 20 seconds, a significant upgrade from the previous Stable Audio 2.0, which was limited to 47 seconds or 2 minutes depending on the model.Navigating the Licensed Data LandscapeAs competition heats up with players like Google and ElevenLabs, Stability AI is differentiating itself through a strict adherence to licensed data. The company has secured partnerships with Warner Music Group and Universal Music Group, ensuring the models are built on ethically sourced datasets.Furthermore, the company is pivoting towards professional markets by hiring industry veterans. Ethan Kaplan, formerly of Universal Audio and Fender, has been appointed to lead the professional music offering, signaling a strategic shift toward tools that professional musicians can actually use.The Professionalization of AI Music ToolsThe industry is moving away from purely consumer-facing tools toward licensed, professional-grade suites. As legal battles over data usage continue, companies that prioritize licensing partnerships and hire experienced music executives will likely dominate the long-term market.

A Fresh, Chaotic Comedy Shakes Up British TVBBC’s Proper Ladies, a ten‑minute short set in a faith school, has ignited a social‑media frenzy for its “messy, chaotic, and funny” take on teenage life, drawing comparisons to Derry Girls and Some Girls.Inside “Proper Ladies”: A 10‑Minute Short About Muslim SchoolgirlsCreated by writer Sabrina Ali and based on her award‑winning stage play Dugsi Dayz, the short follows four detention‑room girls—prefect Salma (played by Samira Tahlil), entrepreneur Munira (Ebada Hassan), fashion‑focused Yasmin, and emo‑leaning Hani (Kosar Ali)—as they navigate rivalries, rebellion and absurd antics.Key scenes include a monologue about a fire‑alarm cover‑up and a subplot involving laxatives slipped into a teacher’s drink.The headteacher, portrayed by Mark Silcox, is humorously revealed to wear a toupee.Executive producer Michaela Coel supported the adaptation, offering Ali a place in her River Library writing sanctuary.Social Media Buzz and Viewer EngagementThe short’s first fan edit amassed 100,000 likes, signalling strong audience resonance. However, the cast also endured a wave of racist and Islamophobic abuse online, prompting some members to step back from social platforms.Redefining Muslim and Black Representation on ScreenAli aims to shift how Black and Muslim characters are positioned, using comedy to allow audiences to “recognise something human” without feeling instructed. She highlights the importance of open casting calls that attracted first‑time actors, expanding access to the industry.What’s Next for “Proper Ladies” and Similar StoriesThe pilot is currently in development for a full series, potentially charting a four‑year journey from stage to screen. Its success could encourage more authentic, diverse comedies in British television and inspire further investment in under‑represented voices.

Rookies Face a Steeper Learning Curve in Their First NFL WeekThe newly drafted trio arrived in New York with high expectations, only to discover that the NFL demands instant adaptation, from condensed meetings to a vastly larger playbook.Inside the Jets' First‑Round Selections: Bailey, Sadiq, and CooperDavid Bailey, a Texas Tech edge rusher taken second overall, Kenyon Sadiq, an Oregon tight end selected No. 16, and Omar Cooper, an Indiana wide receiver chosen No. 30, spent their inaugural week at 1 Jets Drive navigating practice drills, meetings and a sea of new faces.What the Numbers Reveal About the Jets' Draft StrategyThree first‑round picks in a single draft—a rare concentration of talent.36 players on trial alongside the rookies, bringing the total new personnel to roughly 100 individuals.Practice sessions are described as “shorter, more efficient” compared with college, indicating a shift toward high‑intensity, low‑volume training.How Early Impressions Signal Shifts in Team Culture and Player DevelopmentThe rookies note a more controlled practice tempo, increased vocal coaching, and a culture that expects players to “pick it up and learn quick.” This reflects the Jets’ emphasis on mental acuity and rapid assimilation, potentially accelerating the development curve for young talent.What to Expect from the New Jets Trio in the Coming SeasonsAll three acknowledge the need to shed “detrimental tendencies” from college and to master the extensive playbook. If they translate their adaptability into on‑field production, the Jets could see immediate upgrades at edge, tight end and receiver positions, offering fans a glimpse of a revitalized offense and defense within the next two years.

The Lead: A New Global OrderRussian President Vladimir Putin and his Chinese counterpart, Xi Jinping, have signed a joint declaration following their meeting in Beijing, focusing on building a "multipolar world and a new type of international relations". The two countries also announced that they had signed a large package of deals solidifying bilateral cooperation in the future.The meeting came just days after United States President Donald Trump completed his own visit to China for a two-day summit with Xi.Establishing a Multipolar World OrderOn Wednesday, the Chinese Foreign Ministry said: "The two countries will also issue a joint statement on advocating for a multipolar world and a new type of international relations." Russian presidential aide Yuri Ushakov described this declaration as a 47-page policy document.A "multipolar world" is understood as one in which economic, military and diplomatic power and influence are placed in the hands of three or more countries, rather than just one or two."Xi is calling for a more multipolar world, where the US has less power and influence," Al Jazeera's Katrina Yu reported from Beijing as the meeting was under way.Both Putin and Xi have spoken out against the "unipolar" hegemony that they say the US has over the world.In 2022, shortly after the beginning of Russia's war with Ukraine, Putin accused the US of stoking hostilities in Ukraine to maintain its global influence."They need conflicts to retain their hegemony," Putin said during a speech. "The era of the unipolar world order is nearing its end."Chinese state media reported that during the latest meeting, Xi said to Putin: "The tide of unilateral hegemony is running rampant."Russia-China Relations Reach Unprecedented LevelA press statement posted on the Kremlin website said relations between Russia and China had reached "a truly unprecedented level and continue to develop".The Chinese Foreign Ministry statement said: "Both sides should follow the trend of peace, development, cooperation, and win-win results to promote higher-quality development of China-Russia relations."The statements added that bilateral cooperation extends to the worlds of economics, sport, education and the media.The Kremlin statement adds that this year marks the 70th anniversary of partnership between the Russian TASS news agency and the Chinese Xinhua news agency.Deepening Economic Cooperation and Moving Away from the US DollarThe Kremlin statement said Beijing and Moscow had signed around 40 intergovernmental, interagency and corporate documents. "Many of these focus on the further deepening of our economic cooperation," it noted.The statement added that, last year, trade between the two countries reached almost $240bn, while the Chinese statement said bilateral trade grew by 20 percent in the first four months of this year.Since the war in Ukraine broke out in February 2022, Russia has become increasingly reliant on Chinese technology and manufacturing. Last month, Bloomberg reported that Russia now imports more than 90 percent of the technology targeted by US and European Union sanctions via China, using Chinese suppliers and intermediaries to obtain components with military and dual‑use applications vital to drone production and other defence industries."Both sides should build on this momentum, deepen the alignment of China's 15th Five-Year Plan with Russia's development strategy until 2030, promote the upgrading of mutually beneficial cooperation in various fields, and serve the development and revitalization of both countries," the Chinese ministry statement said.The Kremlin statement said that nearly all import and export transactions between Russia and China are in roubles and yuan. "In other words, we have actually created a stable system of mutual trade that is protected from external influence and negative trends in the global markets," it said.Securing Energy Supplies Through Siberia 2 PipelineThe Kremlin said on Wednesday that an understanding had been reached for the route and construction of the long-delayed joint Siberia 2 pipeline, but details are still being negotiated. Once completed, the pipeline will transport 50 billion cubic metres of Russian gas annually to China via Mongolia, significantly expanding energy flows between the two countries.The Kremlin's statement said that Russia and China are actively cooperating in the sphere of energy."Our country is one of the largest exporters of oil, natural gas (including LNG) and coal to China. We are definitely ready to continue to ensure reliable and uninterrupted supplies of these types of fuel to the rapidly growing Chinese market," the statement said.As European markets have largely closed to Russia as a result of the war in Ukraine, China has emerged as a crucial buyer of Russian oil and other energy products, benefitting from steep discounts on Russian products.In December 2022, the Group of Seven (G7), the EU and Australia placed a cap on the price of Russian oil at $60 per barrel, ostensibly to reduce Russia's ability to fund its war in Ukraine. The cap was later reduced to around $48 by the EU and the United Kingdom.Expanding Educational and Scientific TiesBoth statements said Xi and Putin had agreed to expand student exchange programmes and cooperation between universities and research platforms to boost joint scientific research.

One Week Left to Secure a Spot at TechCrunch Disrupt 2026 via Startup Battlefield 200Founders have until May 27 to submit their applications for Startup Battlefield 200, the premier showcase that feeds directly into TechCrunch Disrupt 2026 (Oct 13‑15). The program offers equity‑free funding, global media coverage, and a chance to pitch in front of 10,000+ attendees, leading VCs, and the TechCrunch audience.Numbers That Show the Battlefield’s Track Record200 startups will be selected for the 2026 cohort.$100,000 in equity‑free funding awarded to the winner.Over 1,700 companies have competed historically, raising more than $32 billion collectively.More than 250 exits, including acquisitions by Microsoft, Google, Salesforce, Uber, and Amazon.Why the Battlefield Remains a Launchpad for Category‑Defining StartupsThe competition prioritizes promise over polish—pre‑launch products, zero revenue, and bold visions are welcomed. Alumni such as Dropbox, Cloudflare, Discord, Fitbit, Trello, and Mint all passed through this crucible, proving that early exposure can translate into market‑changing outcomes.What the Final Applications Could Signal for the 2026 Disrupt LineupGiven the surge of last‑minute submissions, the final batch may surface emerging trends across AI, climate tech, health‑tech, and decentralized finance. Startups that demonstrate a clear, scalable impact are likely to dominate the Disrupt Stage, shaping investor focus for the remainder of the year.

The Final Countdown: Startup Battlefield 200 Application Window Closing Your shot at VC access, global visibility, TechCrunch coverage, and $100,000 in equity-free funding is gone in a week. Startup Battlefield 200 applications close May 27. If you're building a breakout startup — or know a founder who is — this is the moment to act. Showcase Opportunity at TechCrunch Disrupt 2026 Apply today for the opportunity to take the stage at TechCrunch Disrupt 2026, October 13-15, alongside 200 of the world's most promising early-stage startups. Pre-Series A founders, consider this your final countdown reminder: the strongest startups are already entering the arena, and the application window is closing fast. If your startup has already been nominated, don't wait to complete your application. This final week moves quickly, and last-minute submissions risk getting buried as applications surge ahead of the deadline. Know a startup that deserves the spotlight? Nominate them now so they still have time to apply before May 27. The Battlefield Legacy: From Pitch to Industry Giants Some of the most consequential companies in tech history didn't launch with splashy fundraising announcements. They started with a pitch. Dropbox demoed to a room full of skeptics. Cloudflare took the stage before most people understood what edge networking meant. Discord was still a scrappy gaming startup called Hammer & Chisel. They all passed through the same crucible: Startup Battlefield 200. That's not a coincidence — it's a pattern. And it starts with an application. What Makes a Battlefield Startup Startup Battlefield 200 has never been a competition for the most polished companies. It's a competition for the most promising ones. Pre-launch is fine. No revenue is fine. What matters is whether what you're building genuinely changes something — not incrementally, but meaningfully. If you or a founder you know is building something impactful, then the application itself becomes the first pitch. The Value Proposition: Beyond the Prize Money Selected startups will showcase live on the Disrupt Stage in front of 10,000+ attendees, leading VCs, global media, and the broader TechCrunch audience. This is your opportunity to gain investor exposure, receive direct VC feedback, and prove your company belongs among the next generation of category-defining startups. Every one of the 200 selected companies receives: Equity-free funding of $100,000 for the winner Exposure to thousands of attendees, VCs, and media A chance to pitch on either the Disrupt Stage or the Pitch Showcase Stage You don't need to make the top 20 for this experience to change your trajectory. Impressive Alumni Success: $32 Billion Raised and Counting More than 1,700 companies have competed in Startup Battlefield 200. Together, they've raised over $32 billion and generated more than 250 exits, including acquisitions by Microsoft, Google, Salesforce, Uber, and Amazon. The network runs so deep that alumni have even acquired each other: Dropbox acquired fellow Battlefield 200 alum DocSend in 2021. This is also the same launchpad that helped accelerate companies like Fitbit, Trello, and Mint. Behind every one of those outcomes was a founder willing to make a bet on themselves publicly, in front of people who were paying attention. Who Should Apply: The Promising, Not Just the Polished We're looking for ambitious early-stage startups building innovative, potentially category-defining products. Applications are open globally across all industries. Most selected companies are pre-Series A, though select Series A startups may qualify on a case-by-case basis. To apply, startups should have: A working product or prototype A clear vision for how they're changing their industry A passionate founding team Thousands apply every year. Only 200 are selected. Just 20 finalists pitch live on the Disrupt Stage. One startup takes the crown and wins $100,000 in equity-free funding. The Deadline Imperative: Why Waiting Could Cost You The founders who wait until they feel ready often wait too long. You do not need to be polished. You need to be promising. If you've been sitting on this, here's the reality: the worst outcome is you don't get selected this cycle — and you come back next year with a stronger application because you went through the process. The stage matters. The community lasts. The milestone is real. But the deadline is now one week away. Final Call to Action: Submit Before May 27 If you're building something category-defining — or know a startup that deserves the spotlight — submit your nomination and complete your application before May 27. Get started by nominating and applying here.

The Collapse of Heylo Investment Firms More than £52m in public money earmarked for social housing is at risk after the partial collapse of one of England's fastest-growing housing providers, Heylo Housing. Financial Exposure and Risks Two of the investment companies run by the Heylo group, which is backed by the asset managers BlackRock, have gone into administration, leaving the government regulator scrambling to find a rescue deal to protect taxpayers' money and prevent 3,500 social homes switching to the private sector. One company owes £46.46m in unsecured credit to Homes England. The other company owes Homes England £6.21m. Homes England has estimated its total grant exposure is nearer £43m. Impact on Social Housing The grant is typically recycled when it is paid back to provide more social homes, and could help fund about 500 new homes for social rent, but it would be lost if an insufficient bid is made for the stricken companies. The administrators, PWC, have assured about 3,500 residents in more than 100 council areas they will not lose their homes and should continue to pay their mortgage and rent as usual. Regulatory Challenges The saga has exposed serious flaws in a deregulation of housing conducted by the previous government and has raised questions about attracting new investors into social housing, and giving public money to for-profit companies. The Regulator of Social Housing (RSH) is hoping the homes can stay in the social housing sector, if it is able to persuade another regulated landlord to buy the stock. Future Outlook The RSH, the investors, and the administrators are hoping that Heylo's homes can stay in the social housing sector and at least partially protect the public grant involved. However, this outcome is far from certain and at least some of public money may have to be written off.