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The Lead: Rubio's Diplomatic Mission to IndiaUnited States Secretary of State Marco Rubio will travel to India on Saturday for a three-day visit taking in Kolkata, Agra, Jaipur and New Delhi. He will discuss energy security, trade and defence cooperation with senior Indian officials, US State Department spokesperson Tommy Pigott said in a statement on Tuesday.The visit comes as relations between US President Donald Trump and India's Prime Minister Narendra Modi continue to fluctuate, making Rubio's diplomatic mission particularly significant in the current geopolitical landscape.The Quad Context: Strategic Alignment in the Indo-PacificRubio is spending a few days in India ahead of a meeting of foreign ministers from the informal Quad security forum comprising the US, Japan, Australia and India in New Delhi on May 26. The Quad, or the Quadrilateral Security Dialogue, has been referred to as "the Asian version of NATO". It was formed as a response to the rising power of China and has carried out joint military and naval exercises in the Indo-Pacific region.Rubio's meeting with other leaders of the Quad will also be seen as a sign of the US reaffirming its commitment to the Indo-Pacific region, which has become increasingly important in global geopolitics.The Economic Leverage: Adani Case and Russian Oil SanctionsRubio's visit comes days after the Trump administration moved to dismiss US criminal fraud charges against Indian billionaire Gautam Adani in a case in which he is accused of bribing Indian officials with as much as $265m to secure contracts and of lying to US investors to secure a solar energy project in India, allegations that his company has long denied.The case was dropped by the US Department of Justice (DOJ) after Adani pledged a $10bn investment in the US. In an X post on Monday, US Treasury Secretary Scott Bessent announced another 30-day extension of a sanctions waiver allowing purchases of Russian seaborne oil to aid "energy-vulnerable" countries hit by the Iran war, reversing plans not to grant an extension.This extension has temporarily eased pressure on major Russian oil buyers such as India, which has previously faced US criticism for its reliance on discounted Russian crude.The Regional Impact: US Balancing Act Between India and PakistanRubio's visit comes after months of improving relations between the US and Pakistan, India's arch enemy. In April last year, India and Pakistan became embroiled in armed conflict after attackers killed 26 people in Pahalgam, a popular tourist spot in Indian-administered Kashmir. Following the Pahalgam attack, New Delhi scaled back diplomatic ties with Islamabad and suspended the Indus Waters Treaty.On May 7, India struck nine sites in Pakistan and Pakistan-administered Kashmir with missiles, which Islamabad said killed dozens of civilians. A ceasefire – for which Trump claimed credit – was eventually brokered on May 10. However, tensions between the South Asian neighbours continue to simmer."PM Modi told President Trump clearly that during this period, there was no talk at any stage on subjects like India-US trade deal or US mediation between India and Pakistan," Indian Foreign Secretary Vikram Misri said last June.The Future Outlook: Navigating Complex Geopolitical WatersAnalysts say that Rubio's visit to India is part of Washington's attempt to mend bilateral ties with New Delhi following tension between Trump and Modi last year. Sadanand Dhume, senior fellow for India, Pakistan and South Asia at the Council on Foreign Relations (CEFR), wrote in an article for the CEFR website on Thursday that Rubio is going to India in "repair" mode.Last October, Indian Foreign Secretary Shyam Saran told The Wire: "The 25-year upward trajectory of India-US relations has certainly plateaued, if not started declining". The coming months will be crucial in determining whether Rubio's visit can successfully reset the relationship or if the current tensions will continue to define US-India relations.

The Road to Wembley Hull City owner Acun Ilicali is set to take his team to Wembley for a chance to secure a Premier League spot. The Turkish media mogul has been at the helm of Hull since January 2022 and has overseen a tumultuous period, including multiple coaching changes and playoff battles. The Coaching Carousel Ilicali has changed coaches several times, which some attributed to his ego. However, he claims it was due to his 'lack of ego,' as he aims to correct mistakes and find success. The current coach, Sergej Jakirovic, was appointed after a series of changes, and Ilicali is optimistic about the team's chances. Overcoming Adversity The team has faced challenges, including the 'spygate' scandal involving Southampton. Despite this, Hull secured sixth place on the final day and defeated Millwall to reach the playoffs. Ilicali is proud of his team's achievement and believes they have a good chance of promotion. Financial Commitment and Future Plans Ilicali has invested significantly in the team, spending over £100m and owning every player who started the recent win against Millwall. He is committed to long-term recruitment and is optimistic about the team's future prospects. Premier League Ambitions If Hull City secures promotion, Ilicali is aware of the challenges they will face in the Premier League. He cites Sunderland as an example of a team that can survive their first season and progress. Ilicali is not afraid of failure but is focused on helping the team learn and grow.

What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

The Legacy of Mohamed Salah at Liverpool Mohamed Salah's departure from Liverpool marks the end of an era for the Egyptian forward, who has been a key player for the club since his arrival in 2017. With 257 goals and 441 appearances, Salah has cemented his place in Liverpool's history books. A Career of Achievements Third-highest goalscorer in Liverpool's history Won the Premier League title, Champions League, and numerous other honors Four-time Premier League Golden Boot winner Hat-trick of clean sweeps of the Professional Footballers' Association and Football Writers' Association footballer of the year awards The Impact of Salah's Departure Salah's departure has been marked by controversy, with the player publicly criticizing manager Arne Slot and the team's style of play. However, it is seen as a necessary move for both parties, with Salah seeking a new challenge and Liverpool looking to refresh their squad. The Future for Salah and Liverpool As Salah moves on to a new chapter in his career, Liverpool will look to build on the foundations he has helped establish. With a legacy that will be remembered for generations to come, Salah's impact on the club will not be forgotten.

The Lead: Demands for Transparency on £5m Gift The defence secretary, John Healey, has urged Nigel Farage to provide transparency about the £5m gift he received from a billionaire businessman, in particular over whether any of the sum could have been linked to Russia-connected profits. In a letter to the Reform UK leader, Healey also asked him to address the possibility that the war against Iran might boost the revenues of AML Global, an aviation fuel company owned by Christopher Harborne, who gave Farage the £5m in 2024. Farage initially supported the US-Israeli attacks on Iran. The Financial Inquiry: Scrutinizing the Gift's Origins The letter, seen by the Guardian, asked Farage to confirm that none of the sum was "derived from transactions with Russian state-linked energy companies", and to give assurances that AML Global had complied fully with all sanctions on Russian energy since the full-scale invasion of Ukraine in 2022. In a statement to the Guardian, AML Global said it had complied fully with all UK and international sanctions, and screened any business partners to ensure the same. The Political Fallout: Investigation and Disclosure The Guardian revealed last month that shortly before the 2024 general election, Farage was given £5m by Harborne, a British-Thai dual citizen based in Thailand. Farage did not disclose the money at the time, and it only emerged when the Guardian reported it. He has argued that because it was an unconditional gift, and received before he announced he would run for parliament, there was no need to declare it once he did become an MP. However, after a complaint from the Conservatives, Farage faces a formal investigation by the parliamentary standards watchdog, Daniel Greenberg, into whether he should have done. The Geopolitical Concerns: Russia and Iran Connections In the letter, Healey noted that AML Global supplies jet fuel through a network of "main and regional oil companies" covering more than 1,200 locations worldwide, including central Asia, the Gulf and eastern Europe. Healey asked Farage to confirm that none of the profits which helped finance the £5m gift came from transactions with Russian state-linked energy companies, that AML Global had fully complied with all Russia sanctions, and that "no fuel sourced from Russian-controlled refineries has passed through its supply chain". The Public Interest: Demands for Open Books Citing previous comments by Farage about Russia – for example, that Nato "provoked" Russia's invasion of Ukraine by expanding eastwards – Healey said this wider situation "places Reform UK under a Russian cloud that only transparency can lift". On Iran, the letter asked Farage to say whether he was aware of a potential benefit to Harborne's company from rising aviation fuel prices when he made supportive comments about the attack on Iran, which led to Iran blockading the strait of Hormuz. Healey added: "The public is entitled to ask whether your financial interests were impacting on your political positioning and your initial support for throwing the UK armed forces headlong into a war in the Middle East without a plan."

The End of an EraPep Guardiola will leave Manchester City at the end of the season after a decade in charge, the club has confirmed, bringing an end to one of the most successful eras in English football and one of the most influential managerial reigns of all time.The departure of the 55-year-old Catalan coach will close the book on a remarkable chapter that has seen City transform into a footballing juggernaut. Guardiola had arrived in Manchester with a resume already stuffed with silverware from Barcelona and Bayern Munich, taking over from Manuel Pellegrini in July 2016.The Trophy-Laden ReignGuardiola, who took charge of City in 2016, has won six Premier League titles – including four in a row – three FA Cups, five League Cups and the Champions League, but his side have not won the league in two years.Although City sealed the domestic cup double this season, Guardiola saw his dreams of a seventh Premier League crown dashed when they drew 1-1 at Bournemouth on Tuesday to hand Arsenal the title, with City set to finish second. His final game in charge is Sunday's home fixture against Aston Villa.The Tactical RevolutionAfter inheriting a successful club financed by the Abu Dhabi United Group, Guardiola will walk away having built a footballing empire after overseeing a paradigm shift in Premier League tactics. As Guardiola faced the challenge of adapting to England's famously fast-paced and physical league, possession became an art form and a defensive tool at City as his teams craved complete control.The result was not just utter dominance – evidenced by record-breaking campaigns like the 100-point 2017-18 season with 106 goals scored – but also relentless consistency year after year, including a record four league titles in a row. Guardiola's squads set new standards, forcing other teams to evolve, while City's financial muscle, combined with shrewd signings such as the much-sought-after striker Erling Haaland helped deliver the treble in 2022-23.The Changing LandscapeHowever, the spectre of the 115 charges of alleged breaches of the Premier League's financial rules looms large over his tenure at the club. His rivalry with former Liverpool manager Jurgen Klopp raised the bar in the Premier League so high that even 97 points proved insufficient for the Anfield side to claim the title in 2018-19.More recently, Guardiola has faced a challenge from his protege and former coaching assistant Mikel Arteta, who took charge at Arsenal and finished second behind City twice before ultimately winning the trophy this season.The Guardiola LegacyGuardiola looked back fondly at his time in Manchester, remembering how the city came together after the Manchester Arena attack while also describing how the club helped him through a tough period when he lost his mother to COVID."The fans, the staff, the people of Manchester, you gave me strength when I needed it most," he added. "Players don't forget – every single instant, moment, me, my staff, this club, everything. What we have done, we have done it for all of you. And you have been just exceptional. You don't know it yet, but you are leaving a legacy.""Don't ask me the reasons I'm leaving. There is no reason, but deep inside, I know it's my time," Guardiola said in a statement on Friday. "Nothing is eternal, if it was, I would be here. Eternal will be the feeling, the people, the memories, the love I have for my Manchester City."

The Deadliest Day in Recent Honduran HistoryGunmen have killed at least 25 people, including six police officers, in attacks across Honduras. The attacks marked Thursday as one of the most violent days the country has seen in recent years. They came despite ongoing efforts by the government to rein in organised crime and violence.Details of the Coordinated AttacksNineteen people were killed as gunmen raided a palm plantation in the municipality of Trujillo in the north of the country. A leader of one rural group told the AFP news agency that those killed were employees of an armed group controlling a plantation. However, local media indicated that armed suspects had fired indiscriminately on labourers. They reported that the oldest victim was 61.Meanwhile, in the west near the Guatemalan border, six police officers were killed in another shooting in the municipality of Omoa. Police report that the officers had travelled to the area as part of an operation to quash gang activity. However, they were ambushed.After the two attacks, the National Police issued a statement, saying it "will proceed immediately with a direct intervention in the affected areas." "The state will act firmly to capture those responsible, protect vulnerable communities and guarantee comprehensive justice for all affected victims," it added.The Human Cost of ViolencePhotos showed bodies, some wearing thick rubber boots for work, strewn on the ground outside the plantation in Trujillo. The attacks represent a significant loss of life in a single day, highlighting the extreme danger faced by ordinary citizens and security forces alike in Honduras.The National Police has vowed to respond forcefully to the attacks, but the scale of violence suggests that the security situation in Honduras remains precarious despite government efforts to address the problem.Honduras' Ongoing Security CrisisHonduras is struggling to crack down on gang violence. Until January, many parts of the country were under a state of emergency launched in 2022. That emergency decree ended, however, with the inauguration of right-wing President Nasry "Tito" Asfura, a close ally of United States President Donald Trump, who has prioritised a hardline approach to security in Latin America.The attacks will, therefore, raise concerns over security, but also civil liberties. Laws passed earlier this week will allow authorities to designate gangs and drug cartels as terrorist groups. A new anti-organised crime unit has also been created.Root Causes: Land Conflict and Organized CrimeThe Trujillo shooting occurred near the Aguan River Valley, where armed groups, involved in narcotrafficking and palm oil extraction, have been fighting over land for decades. Trujillo police chief Carlos Rojas told local media that the groups occupy and illegally exploit several large African palm plantations, using money from the crops to obtain weapons.Local farmer groups, however, accuse transnational agribusiness corporations of sponsoring the criminal groups to carry out land occupations and prevent residents from reclaiming disputed lands. According to Reuters, more than 150 people in the area have been killed or disappeared, with environmental and land rights activists a particular target.Honduras is one of the most dangerous countries in the world for such activists. Earlier this month, police arrested several individuals, including a mayor, for plotting the assassination of a prominent environmental campaigner in 2024.Future Outlook for Security in HondurasThe recent surge in violence suggests that Honduras' security challenges are far from resolved despite the new administration's hardline stance. The combination of organized crime, land disputes, and narcotrafficking creates a complex security environment that cannot be addressed through law enforcement measures alone.International attention and cooperation, particularly with the United States, may play a crucial role in addressing the root causes of violence. However, the immediate priority for the Honduran government will be to demonstrate its ability to protect citizens and restore a sense of security in the affected regions.

The Economic Crisis in War-Torn LebanonBeirut, Lebanon – Mario Habib, a 51-year-old barber who opened his shop in 2006 just before war broke out between Israel and Hezbollah, is now living through another conflict. Twenty years later, his business in Furn el-Shebbak neighborhood is struggling as Lebanon's economy deteriorates under the weight of renewed war and global fuel crisis. "The price of running the generator is killing me," Habib said. "Everything has gotten more expensive, the price of petrol doubled, the supermarket is more expensive, even the products [I use for my business] got more expensive."Regional Conflict Disrupts Fuel Supplies and Economic GrowthIsrael's war on Lebanon and the broader US-Israel war on Iran are severely damaging Lebanon's fragile economy. Supply issues have particularly affected oil from the Gulf region, which has largely stopped flowing since the US and Iran blockaded the Strait of Hormuz. In Lebanon, which was already suffering from a severe economic crisis, there is less work and people are losing their jobs at an alarming rate.Despite Lebanon's government expressing optimism about the country's economy in 2025, with the World Bank recording a modest 3.5 percent GDP growth that year, the renewed conflict has erased those gains. In March 2026, inflation reached an 18-month high in Lebanon. Lebanon's Bank Audi now predicts that there will be 0 percent GDP growth in 2026 if the war continues.Economic Indicators Show Deteriorating ConditionsInflation reached an 18-month high in March 2026Bank Audi projects 0% GDP growth for 2026 if war continuesLebanon had recorded 3.5% GDP growth in 2025Reconstruction and recovery costs estimated at $11bn by World BankWar-related losses in 2026 estimated at $3bn (with more expected)Oil prices have increased approximately 65% since MarchCompounding Crises Create Perfect Economic StormLebanon's current economic crisis is not solely the result of recent conflicts. The country has been facing multiple compounding crises for years:2019: Financial mismanagement led to a banking crisis, cutting people off from their savings2020: Beirut port explosion killed 218 people and devastated infrastructure2021-2022: Worsening state services and mass emigration2023-2024: Hezbollah-Israel war displaced thousands of Lebanese2024: Israel intensified attacks, displacing more than one million people2026: Renewed Israeli attacks have displaced over 1.2 million people"This is a war that comes after a war," said Sami Zoughaib, an economist and research manager at The Policy Institute, a Beirut-based think tank. "It comes after institutional collapse. It comes after one of the worst financial crises in history."Societal Impact and Economic VulnerabilityThe economic crisis is disproportionately affecting Lebanon's most vulnerable populations. According to the World Bank, agriculture, commerce, and tourism—sectors accounting for 77 percent of economic losses—are key income sources for low-wage and informal workers now at significant risk.Remittances, which were approximately $6.6bn in 2023, are expected to drop significantly in 2026 due to rising oil prices. The 65% increase in oil prices since March particularly affects remittances from Gulf countries, which are crucial to Lebanon's economy.The displacement crisis has mostly impacted Lebanon's Shia community, from which Hezbollah draws its support. However, economists warn that the economic fallout could exacerbate societal divisions, with political elites potentially scapegoating displaced people for the country's economic problems—a pattern seen in the past with Syrians and Palestinians.Future Outlook: Economic Collapse or Recovery?Should the current pattern of conflict continue, Lebanon's economy could soon become unviable, with many investors deciding that opening or operating businesses is not worth the potential returns. The impact has been felt across the country, with no community left untouched by the economic consequences of war.While some areas have been hit harder than others, economist Sami Zoughaib warns that Lebanon may be reaching a point of no return. "That is, for me, very dangerous," Zoughaib said, referring to the potential for political elites to exploit economic divisions for their own gain.For ordinary Lebanese citizens like Mario Habib, the immediate concern is survival. Despite rising costs and reduced business, Habib refuses to raise his prices. "I always prefer that the person who comes here is comfortable," he said. "A lot of things are more expensive, but I prefer to be conservative on this. I feel like if you come to me, you want to be happy and relaxed."

The Unseen Toll of War The conflict in Mali has had a profound impact on the mental health of its citizens. Beyond the physical destruction and loss of life, the war has left a lasting legacy of psychological trauma. Living with Trauma Survivors of the war often struggle with anxiety, depression, and post-traumatic stress disorder (PTSD). These conditions can make everyday tasks challenging and affect relationships with family and friends. The Need for Support Addressing the mental health needs of Malians affected by the war is essential for the country's recovery. This includes providing access to mental health services and supporting community-based initiatives. A Path Forward By acknowledging the mental trauma caused by the war, Mali can begin to heal and rebuild. It is crucial for the international community to provide support and resources to help the country address this critical issue.