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Researchers at the University of Edinburgh and the UK Dementia Research Institute have uncovered that lacunar strokes are driven by the widening of small brain arteries rather than the previously assumed blockage by fatty deposits.Study Links Lacunar Strokes to Arterial Widening, Not BlockageThe investigation, published on Wednesday, 2026-05-10, examined 229 patients who suffered either a lacunar or a mild non‑lacunar stroke. Advanced neuroimaging revealed that patients with widened small vessels were more than four times as likely to experience a lacunar stroke.Key Numbers Highlight the Scale of the Issue35,000 UK residents experience lacunar strokes each year.Lacunar strokes represent 25% of all strokes in the UK.Study cohort: 229 stroke patients.Widened arteries increased lacunar stroke risk by > 4‑fold.Less than 1% of UK research funding is allocated to stroke.Implications for Treatment and Funding PrioritiesThe findings explain why common anti‑platelet drugs such as aspirin are less effective for lacunar strokes. Maeva May, director of policy at the Stroke Association, called the research “a potential game‑changer” and urged greater investment, noting that stroke remains the fourth leading cause of death in the UK.Joanna Wardlaw, professor of applied neuroimaging, emphasized the need for therapies that target microvascular damage rather than large‑vessel atherosclerosis.Looking Ahead: Targeted Microvascular Therapies and Policy ShiftsFuture research will likely focus on drugs that protect or restore the integrity of small brain vessels. Policymakers are being pressed to increase the proportion of health research funding dedicated to stroke, aiming to translate laboratory breakthroughs into clinical practice more rapidly.

The Lead: Hantavirus Outbreak on Cruise Ship Two Britons who were medically evacuated from the hantavirus-hit cruise ship MV Hondius are showing improvement in hospitals, according to global health officials. The outbreak, which has been linked to three deaths, has prompted international health authorities to monitor the situation closely while assuring the public that the risk remains low. Patient Updates: Improving Conditions in Hospitals A British passenger, understood to be a 69-year-old man, was taken to South Africa on April 27 and is receiving care at a private health facility in Sandton, Johannesburg. Another Briton, Martin Anstee, 56, an expedition guide, was taken off the MV Hondius on Wednesday and flown to the Netherlands to receive specialist medical care. Dr Maria Van Kerkhove, from the World Health Organization (WHO), reported positive developments: "I am very happy to say the patient in South Africa is doing better, and the two patients in the Netherlands we hear are stable. So that is actually very good news." Outbreak Statistics: Confirmed Cases and International Impact Eight suspected cases of hantavirus Five confirmed by lab tests Three deaths linked to the outbreak Passengers from 12 nations affected Seven British people among those who left the ship The outbreak has been connected to a birdwatching trip to Argentina, Chile, and Uruguay that two of the passengers went on before boarding the ship. The Andes virus variant, linked to this outbreak, has an incubation period of up to six weeks, potentially leading to more cases. Global Health Response: International Coordination Spanish authorities have given permission for the ship to anchor in the Canary Islands, despite concerns from locals and officials. The MV Hondius left Cape Verde at 3.15pm local time on Wednesday and is estimated to arrive at the port of Granadilla in Tenerife in the early hours of Sunday. Two doctors are on board along with infectious disease experts from the WHO and the European Centre for Disease Prevention and Control, who are conducting a medical assessment of everyone on board. The UK Health Security Agency has been asked to confirm it has been in touch with all seven Britons who left the ship on April 24. Future Outlook: Low Risk but Continued Monitoring While the risk to the public is low, Dr Tedros Adhanom Ghebreyesus, the director-general of the WHO, emphasized that there could be more cases due to the incubation period of the Andes virus. However, the WHO is not expecting the outbreak to become an epidemic, citing a similar outbreak in Argentina in 2018-19 which led to 34 cases. "While this is a serious incident, WHO assesses the public health risk as low," Dr. Tedros stated, thanking the ship's operator for its cooperation and acknowledging the difficult situation faced by passengers and crew.

The Strait of Hormuz Standoff Exchanges of fire between Iran and the US demonstrate the serious instability of the situation in the Middle East. Though the US strikes late on Thursday were just “a love tap”, according to the US president, Donald Trump, the reality is that neither side can continue the high-stakes standoff in the strait of Hormuz indefinitely. Iran's Resilience Iran retains the ability to threaten and inflict damage on tankers passing through the strait of Hormuz and effectively halt all other shipping. More than 1,550 vessels remain trapped in the Gulf, while on Wednesday and Thursday no merchant ships transited the strait, according to S&P; Global Market Intelligence. The US Blockade Diplomats who have dealt with Iranian negotiators complain that Tehran loves to act as if it has endless time. It does not. The parallel US blockade to the east of the strait, where two US carrier strike groups are now operating, also prevents Iran from exporting its crude. US Central Command has turned back 52 vessels since 13 April – and there are reports from within Iran of rising inflation, unemployment and unpaid wages. The Impact on Iran Iran has no close allies at this moment of isolation. China is believed to be supplying drone parts, similar to its help to Russia, and there have been reports that it may try to covertly send Tehran handheld air defence systems, but this is basic defensive weaponry. The Future Outlook Trump, however, is fickle and impatient. The US president has the political problem of needing to resolve an economic crisis he essentially created – while showing progress on the nuclear issue. Higher inflation is already affecting large parts of the world economy, and the impact of oil shortages is particularly acute in Asia. It is an unstable outcome, and still, two sets of militaries face each other, locked and loaded.

Lead: Chaos in the Madrid Dressing RoomTwo days of physical confrontations have left Federico Valverde with stitches after a head‑on clash with teammate Aurélien Tchouaméni. The incident, confirmed by the club on Thursday, underscores a season of internal strife that could jeopardise Real Madrid’s chances in the upcoming El Clásico.The Training‑Ground Clash That Sparked the FalloutDay 1: A heated exchange during Wednesday’s session at Valdebebas escalated into a verbal spat.Day 2: Valverde accused Tchouaméni of leaking the dispute, leading to a physical tussle where Valverde fell onto a table and suffered head trauma.Aftermath: Valverde required stitches; both players were summoned for internal investigations.Performance Impact: A Club Without SilverwareReal Madrid sit on a zero‑trophy haul this season, with a record of 24 wins and six losses under Xabi Alonso. The unrest adds pressure to a side that risks handing the league title to Barcelona in Sunday’s El Clásico.Broader Implications: Managerial Uncertainty and Potential Mourinho ReturnPresident Florentino Pérez is reportedly weighing a high‑profile appointment, with rumors linking José Mourinho to the job. A Mourinho comeback could either stabilise volatile egos or deepen the club’s “agitator” reputation.Outlook: What Comes Next Before El Clásico?Potential disciplinary actions for Valverde and Tchouaméni.Speculation over Alonso’s future – his contract is set to expire at season’s end.Possible tactical reshuffle ahead of the Barcelona clash.Fans’ morale remains low, with booing directed at Vinícius Júnior and calls for a squad overhaul.

The LeadThis felt a hugely significant victory in the Scottish title race. Celtic require only two more of them to successfully defend the league. For the Rangers manager, Danny Röhl, yet another second-half capitulation will only increase murmurings about his capability of delivering success at Ibrox. Rangers will end this season trophyless and third in a two-horse race – remarkably, given the tens of millions spent on assembling their squad.The Title Race ImplicationsCeltic have moved to within a point and three goals of Hearts. Next stop for Martin O'Neill and his players is Motherwell on Wednesday evening. With Hearts hosting Falkirk at the same time, there is the increasing possibility of the title being decided when the Edinburgh club visit Celtic Park on Saturday. Supporters of Celtic and Hearts are likely to have run out of fingernails by then.Maeda's Match-Winning PerformanceCeltic anxiety here was confined to a first-half spell. Mikey Moore had sent Rangers in front, the Tottenham loanee pouncing after Youssef Chermiti's shot was blocked into his path. Impatience was rising among the home support as Yang Hyun-jun pulled Celtic level. Yang met an Arne Engels cutback, with Rangers appealing in vain for offside against Benjamin Nygren.The teams traded chances for the remainder of the first period but it was Celtic who rose to the occasion thereafter. Daizen Maeda stole in front of Emmanuel Fernandez to prod O'Neill's team in front. Rather than offer a strong response, Rangers wilted. Maeda's second of the game was a stunner, the Japanese flicking the ball up before producing an outrageous overhead kick that looped over Jack Butland. A Bojan Miovski header that hit the bar in stoppage time was the sum of Rangers' reply.Rangers' Season WoesFor Rangers, this defeat represents another significant setback in what has been a disappointing season. Despite substantial investment in their squad, they find themselves trophyless and third in a league that should have been a two-horse race. Manager Danny Röhl faces increasing pressure as questions mount about his ability to deliver success at Ibrox, with this second-half capitulation likely to intensify those concerns.

The New Sports Policy Pakistani players and teams will be able to participate in multilateral events hosted by India, but bilateral events remain off the table, India's sport ministry said on Wednesday. Simplified Visa Process India also said the visa process for sportspersons and officials will be simplified while office bearers of international sport governing bodies will be granted multi-entry visas. The Impact on Bilateral Sports “In so far as bilateral sports events in each other’s country are concerned, Indian teams will not be participating in competitions in Pakistan. Nor will we permit Pakistani teams to play in India,” the ministry added. There has been a long freeze in bilateral cricket between the nuclear-armed neighbours, who have not played a full series since 2012-13 and now meet largely at neutral venues. India's Sports Hosting Ambitions India is set to host the Commonwealth Games in 2030, and they have also bid for the 2036 Olympics and the 2038 Asian Games in Ahmedabad. The Future of Sports Diplomacy “With regard to international and multilateral events, in India or abroad, we are guided by the practices of international sports bodies and the interest of our own sportspersons,” the ministry said in a memorandum. “It is also relevant to take into account India’s emergence as a credible venue to host international sports events.”

The Diplomatic Overlap in BeijingIranian Foreign Minister Abbas Araghchi met his Chinese counterpart Wang Yi in Beijing on Wednesday, signaling a critical juncture in the US-Iran war. The visit comes as efforts to broker a peace deal accelerate, particularly following the United States president's announcement of a pause on attempts to forcibly open the Strait of Hormuz.Economic Stakes in the Strait of HormuzThe timing of the meeting underscores the immense economic pressure driving the diplomatic push. The disruption to shipping through the strait, which handles roughly one-fifth of the world's oil and gas, has sent shockwaves through the global economy. For China, which relies heavily on Gulf energy flows, the blockade poses a direct threat to its economic stability and trade routes.China’s Delicate Balancing ActThroughout the conflict, China has navigated a complex geopolitical tightrope. While Wang Yi condemned US and Israeli military actions as "illegitimate," Beijing has stopped short of fully endorsing every Iranian move. China has vetoed UN Security Council efforts to condemn Iran and resisted US sanctions on Chinese firms purchasing Iranian oil, all while urging regional stability.The Window for Diplomatic BrokerageAnalysts suggest the coming days are critical for China to leverage its unique position. With a draft UN resolution reportedly revised to secure Russian and Chinese support, Beijing has a rare opportunity to position itself as a global diplomatic broker. A successful intervention would not only stabilize the region but also grant China greater influence among Gulf energy producers and enhance its image as a credible peacemaker.

Chad's National Mourning DeclarationChad has declared three days of national mourning after a Boko Haram ambush in the volatile Lake Chad Basin on Wednesday left two generals dead. This follows an assault by the Nigeria-based group two days earlier on the Barka Tolorom military base near Lake Chad, which saw at least 24 soldiers dead, with the army reporting that a "significant number" of attackers were also killed.Boko Haram's Deadly Attacks in Lake Chad Basin"From Wednesday, May 6 at midnight to Saturday, May 9 at midnight … in memory of the martyrs who fell on the field of honour during the attacks by terrorist groups that occurred on May 4 and 6", the government said in a statement. The Lake Chad region, a vast expanse of water and marshland dotted with remote islands, shared between Nigeria, Cameroon, Niger and Chad, has witnessed a surge in activity in recent months by Boko Haram's JAS faction, including kidnappings and assaults on security forces.Casualties and Regional ImpactLake Chad's islands and marshes provide a haven for Boko Haram's rival hardline splinter faction, the ISIL affiliate in West Africa Province (ISWAP). In October 2024, an attack on a military base in the Lake Chad Basin by Boko Haram left about 40 Chadian soldiers dead. These attacks represent a significant escalation in violence in an already volatile region.Chad's Ongoing Struggle with TerrorismChad President Mahamat Deby responded to the killings by launching a counteroffensive aimed at "destroying Boko Haram's capacity to cause harm". When the operation ended in February 2025, the army claimed Boko Haram had "no more sanctuary on Chadian territory" but the attacks on security forces have continued. The landlocked Central African country has faced years of instability marked by rebellions, armed groups and coups, with prolonged economic activity making Chad among the poorest nations in Africa.Future Outlook for Lake Chad SecurityThe persistence of Boko Haram attacks despite military operations suggests that the terrorist group maintains significant capabilities in the region. The declaration of national mourning underscores the gravity of the situation, but without addressing the root causes of instability in the Lake Chad Basin, including poverty, governance issues, and environmental challenges, the region may continue to face security threats for the foreseeable future.

The Deadliest Assault in Central Mali Dozens of people have been killed in attacks reportedly carried out by al-Qaeda-affiliated fighters in central Mali, the deadliest assault since armed groups launched a widespread coordinated assault late last month. Attack Details and Casualties According to local, security and administrative sources speaking to the AFP news agency on Thursday, attacks on the villages of Korikori and Gomossogou in the Mopti region killed at least 30 people a day earlier. Three sources – including an aid worker, a diplomat and a security source – separately told the news agency Reuters that the assailants had hit two unnamed localities in Mopti, killing at least 50 on Wednesday. The Resurgence of Violence in Mali The latest attacks come a day after armed fighters stormed the Kenieroba Central Prison, a recently built complex about 60km (37 miles) southwest of Bamako, which houses 2,500 prisoners, including at least 72 inmates considered “high value” by the Malian state. The Threat and Military Response During a news conference in Bamako on Wednesday, Malian army commander Djibrilla Maiga said fighters were attempting to reorganise after the April ⁠attacks, which killed Defence Minister Sadio Camara and drove Russian troops aligned with Mali’s leaders from ⁠the strategic northern town of Kidal. “The threat is still present,” Maiga said, though he added that the military was disrupting their manoeuvres.