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The ongoing conflict between the US and Israel and Iran has significantly altered the dynamics of the nuclear programme negotiations. Former US envoys who dealt with Iran have stated that the US-Israeli attack on Iran and Tehran's subsequent closure of the Strait of Hormuz have given Iran new tools and resolve to resist pressure to shutter its nuclear programme.Two senior negotiators for the Joint Comprehensive Plan of Action (JCPOA), the Obama-era agreement to limit Iran's nuclear uranium enrichment in exchange for sanctions relief, said the Trump administration's war had handed Iran a coveted weapon by demonstrating its ability to cut off the Strait of Hormuz, an economic chokehold that one negotiator said would help Iran 'balance the asymmetry of power' with the US.Alan Eyre, a former diplomat who helped negotiate the JCPOA, noted that 'this administration, to say it more politely, cannot unsoil the bed. There's no way to get back to the status quo ante before this war started.'In 2018, Donald Trump withdrew the US from the JCPOA, which barred Tehran from enriching its uranium to weapons-grade. Trump called the deal 'one of the worst and most one-sided transactions' the US had ever entered into.However, after a strategy of high pressure – first through returning sanctions and then, after Trump's return to power in 2025, a war that was meant to destroy Iran's nuclear and ballistic missile capabilities – the current US administration has found itself in more complex negotiations than before its campaign of economic and military strikes.Robert Malley, a Yale lecturer who was former special envoy to Iran under Joe Biden and a lead negotiator on the JCPOA, said: 'The strait of Hormuz wasn't an issue before the US decided to strike. You have all the issues inherited from the past, but you just added a few, because the US has handed Iran a tool that it always had, but it never thought of using, or never felt it could.'The chances for a comprehensive agreement addressing all of the US and Iran's grievances appear slim. While the Obama administration sought to negotiate exclusively on Iran's nuclear programme in the lead-up to the 2015 agreement, the Trump administration has sought a broader deal limiting Iran's ballistic missiles programme and its support for regional proxies, such as Hezbollah in Lebanon and the Houthis in Yemen.

Congresswoman Yassamin Ansari – an Iranian‑American representative from Arizona – publicly labeled President Donald Trump an “evil human being” who aspires to be an emperor, and urged that he be removed from office in light of the escalating war with Iran. Ansari, whose parents fled the Iranian regime in the 1970s, issued a statement after Trump’s threat to annihilate Iran’s civilization was followed by a tentative two‑week cease‑fire. She expressed relief for the 90 million Iranians who had spent a harrowing day fearing a nuclear catastrophe. In a phone interview, the 34‑year‑old lawmaker described Trump as “mentally unstable, deeply troubled, and solely self‑interested,” adding that his policies have stripped basic services from average Americans while enriching his family. Ansari warned that Trump’s rhetoric – promising an “America first” stance yet launching strikes on seven nations – constitutes a clear danger to both Iran and the United States, and she called for the cabinet or Congress to intervene under the 25th Amendment. She cited a series of controversial foreign‑policy moves, including the alleged illegal kidnapping of Venezuelan leader Nicolás Maduro, threats to seize Greenland, erosion of NATO credibility, and talk of taking over Cuba. In Iran, she argued, the administration has already committed war crimes by targeting schools, bridges and hospitals. Ansari also highlighted the broader humanitarian fallout: destroyed civilian infrastructure, a collapsing economy, soaring food‑security risks, and mass starvation. She relayed a conversation with a young Iranian doctor who described doubled prices and a dire economic outlook, urging the U.S. to cease attacks on civilian targets. Beyond Trump, the congresswoman announced plans to introduce articles of impeachment against Defense Secretary Pete Hegseth, accusing him of repeatedly violating his oath by facilitating war‑crimes. She criticized Vice‑President JD Vance for not mobilising the cabinet to remove Trump, and warned that the current crisis represents a “five‑alarm‑fire moment” unprecedented in modern American history. Ansari’s remarks come amid a shifting Iranian diaspora sentiment. While some Iranian‑American groups initially celebrated the war’s onset, many now view the U.S. and Israeli bombing campaigns as counter‑productive, fearing they bolster the hard‑line regime. Following the death of Supreme Leader Ayatollah Ali Khamenei, the regime’s grip appears tighter, with his son Mojtaba Khamenei assuming leadership. Ansari stressed that the Islamic Revolutionary Guard Corps remains entrenched, and that the regime continues to exploit civilian suffering for propaganda. She concluded by urging Americans to recognise Iran’s rich cultural heritage and to reject the notion that bombing will liberate its people, emphasizing that the United States must avoid actions that only strengthen an authoritarian government.

Netflix's vast library of content often includes films that were initially intended for theatrical release but end up being off-loaded to the streaming platform. The latest example is 'Thrash', a shark thriller that was previously known as 'Beneath the Storm' and 'Shiver'. Despite its promising premise, the film fails to deliver, with critics calling it a messily made, choppily edited and entirely misfiring cavalcade of bad decisions and dodgy accents.The film, directed by Norwegian director Tommy Wirkola, tells the story of a hurricane that destroys a town while also thrusting a pack of bull sharks into the streets and homes of those unlucky enough to still be there. However, the film's distracting sense of inauthenticity and lack of suspense make it a disappointing watch. The cast, including Bridgerton's Phoebe Dynevor and Djimon Hounsou, struggle to elevate the poorly written characters and lackluster dialogue.'Thrash' is now available on Netflix, but it's unlikely to be a hit with viewers. The film's cheap production values and lack of originality make it feel like a low-budget B-movie, rather than a film that was once intended for theatrical release. With Netflix spending around $18bn on content last year, it's surprising that they would accept a film of such poor quality.

The Al‑Aqsa Mosque compound in occupied East Jerusalem reopened after a 40‑day closure imposed by Israeli authorities.Verified video footage released by Al Jazeera shows crowds streaming through the gates early Thursday, with approximately 3,000 worshippers attending the morning prayers.The ban had been total—or limited to a few dozen faithful—at Christian, Jewish and Muslim sites since the US‑Israeli war on Iran began on February 28. Israel frequently imposes restrictions, especially on Palestinian worshippers.The Islamic Waqf Department in occupied Jerusalem confirmed that the doors of Al‑Aqsa would be opened to all worshippers from dawn; the Jordanian‑affiliated authority managing the site offered no further details.Volunteers and caretakers were seen preparing courtyards and prayer areas to receive the faithful, while Israeli officials announced the simultaneous opening of the Church of the Holy Sepulchre on Wednesday evening.Israeli police attributed the decision to “updated instructions from the Israeli Home Front Command” and highlighted a massive security deployment, with hundreds of police officers and border guards stationed throughout the Old City and surrounding roads to “secure visitors.”Jerusalem’s holy sites have endured strict security measures and repeated closures during the six‑week regional war, curtailing celebrations of Lent, Passover, Ramadan and, for the first time since Israel’s 1967 occupation, Eid al‑Fitr prayers at Al‑Aqsa.The lifting of the ban arrives just in time for Orthodox Christians, who observe Easter on Sunday, a week after Catholic and Protestant celebrations.Continued Raids in the Occupied West BankIsraeli forces continued operations across the occupied West Bank. In Nablus, a woman was detained and a man assaulted during an early‑morning raid, according to the Palestinian news agency Wafa.The Ramallah‑based Palestinian Health Ministry reported that Israeli forces fatally shot 28‑year‑old Alaa Khaled Mohammed Sbeih near the village of Tayasir on Wednesday night; the Israeli military said an off‑duty soldier fired at a stone‑thrower.Wafa added that six young men were detained in Tayasir, while troops stormed homes in Ya’bad, south of Jenin, destroying the contents of three houses. Additional raids hit the villages of Qusra and Awarta, though no arrests were reported there.The United Nations Office for the Coordination of Humanitarian Affairs (OCHA) estimates that more than 1,100 Palestinians have been killed by Israeli forces and settlers in the West Bank since 2023, with at least 10,000 people forcibly displaced.

Argentina's lawmakers have given the green light to a bill championed by President Javier Milei that permits mining in sensitive glacier and permafrost regions. The move has sparked fierce criticism from environmentalists, who argue it jeopardizes vital water sources. The bill, which was already approved by the Senate in February, passed with 137 votes in favor, 111 against, and three abstentions in the Chamber of Deputies after a marathon 12-hour debate. This development is seen as a significant victory for Milei, who has been pushing for looser regulations to attract large-scale mining projects. Environmentalists have expressed deep concerns that the reforms will undermine protections for glaciers and permafrost, which are crucial for water supplies. Thousands of people demonstrated outside parliament, with some protesters clashing with police. Banners displayed slogans such as 'Water is more precious than gold!' and 'A glacier destroyed cannot be restored!' The bill allows for mining of metals like copper, lithium, and silver in the Andes mountains. Argentina is a major producer of lithium, a critical component for the global tech and green energy sectors. The central bank forecasts that mining exports could triple by 2030. Milei, who does not believe in man-made climate change, argues that the bill is necessary for economic growth. 'Environmentalists would rather see us starve than have anything touched,' he has stated. The reform gives provinces more power to decide which areas to protect and which to exploit economically. Environmental activist Flavia Broffoni countered that 'the science is clear' and that creating a 'sustainable mine' in a periglacial environment is not possible. With nearly 17,000 glaciers and rock glaciers in Argentina, concerns over glacial reserves shrinking due to climate change add urgency to the debate.

Israeli airstrikes devastated Lebanon on Wednesday, killing more than 300 people and wounding 1,165 in a span of just 10 minutes. The strikes, which targeted over 100 sites across the country, have been described as one of the deadliest mass killings in Lebanon since the end of the civil war in 1990.Omar Rakha, a survivor, recounted his terrifying experience: he was bleeding and face down on the street when he realized a building next to his in Beirut's Barbour neighborhood had been destroyed by two Israeli bombs. The neighborhood, once considered safe, felt like a war zone.The Israeli military claimed it had targeted Hezbollah 'command and control centers' in the bombing campaign dubbed 'Operation Eternal Darkness.' However, residents and Lebanese officials argue that the strikes mainly killed civilians. Lebanon's prime minister, Nawaf Salam, accused Israel of targeting 'densely populated residential neighborhoods' and killing unarmed civilians in breach of international law.Dr. Ghassan Abu-Sittah, a surgeon at the American University of Beirut Medical College, described the overwhelming influx of wounded, including children pulled from under the rubble. 'The youngest was an 11-month-old. I had to operate on him just to relieve some pressure in the head,' he said.The airstrikes have escalated tensions and raised concerns about the potential for further conflict. The war in Lebanon, which started after Hezbollah launched rockets at Israel on March 2, has left around 1,800 people dead and 5,873 wounded.

George Clooney has publicly denounced Donald Trump's threat to Iran that 'a whole civilization will die tonight', labeling it a war crime. Speaking to 3,000 high school students in Cuneo, Italy, Clooney emphasized that making such threats crosses a line of decency.'Some say Donald Trump is fine,' the 64-year-old actor stated. 'But if anyone says he wants to end a civilization, that's a war crime. You can still support the conservative point of view but there must be a line of decency, and we must not cross it.'The White House responded through communications director Steven Cheung, who retorted: 'The only person committing war crimes is George Clooney for his awful movies and terrible acting ability.'Clooney, a longtime Democratic supporter and donor, has been vocal about his political views for decades. He has previously criticized Trump, who has responded with personal attacks against Clooney.In a statement, Clooney referenced the Genocide Convention and the Rome Statute, defining a war crime as 'when there is intent to physically destroy a nation.' He challenged the administration to defend their stance.The ongoing feud between Clooney and Trump has been marked by public criticisms and counter-attacks. Despite their political differences, Clooney mentioned once being on good terms with Trump before his presidency.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Argentina's congress has approved a bill promoted by President Javier Milei that authorizes mining in ecologically sensitive areas of glaciers and permafrost, sparking widespread environmental protests. The bill, which was already approved by the senate in February, will make it easier to mine for metals such as copper, lithium, and silver in frozen parts of the Andes mountains.The chamber of deputies approved the amendment with 137 votes in favor, 111 against, and three abstentions after nearly 12 hours of debate. Environmentalists argue that the legislative changes will weaken protections for crucial water sources, with thousands protesting outside parliament, holding banners with slogans such as “Water is more precious than gold!” and “A glacier destroyed cannot be restored!”Seven Greenpeace activists were arrested earlier in the day after scaling a statue outside parliament and unfurling a banner urging lawmakers “not to betray the Argentine people”. The passage of the amendment is a new coup for Milei, who pushed through looser labor laws in February despite repeated street protests.Environmental activists, such as Flavia Broffoni, argue that there is no possibility of creating a 'sustainable mine' in a periglacial environment. Argentina has nearly 17,000 glaciers or rock glaciers, with glacial reserves in the north-west shrinking by 17% in the last decade due to climate change.Milei, a free-market radical who does not believe in human-made climate change, says the bill is necessary to attract large-scale mining projects. The Central Bank of Argentina estimates that the country could triple its mining exports by 2030. Supporters argue that the bill will provide legal certainty and clear definitions, while critics, such as Enrique Viale, warn that it threatens the water supply for 70% of Argentinians.