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A new large‑scale randomized trial presented at the European Congress on Obesity in Istanbul indicates that the oral GLP‑1 antagonist orforglipron can help patients retain the majority of weight lost with injectable therapies such as tirzepatide (Mounjaro) and semaglutide (Wegovy).Trial Shows Oral Orforglipron Preserves Most Weight After Switching from InjectablesThe study, funded by Eli Lilly, followed 376 US patients who had been on tirzepatide or semaglutide injections for 72 weeks and then randomized them to a daily orforglipron tablet or placebo for an additional year.Participants were previously on weekly GLP‑1 jabs that typically produce 15‑20% body‑weight loss.After the injection phase, subjects were switched to oral therapy or placebo for 12 months.Primary endpoint: proportion of weight loss retained at 12 months.Quantitative Outcomes: 75% vs 49% Retention for Tirzepatide Users, 80% vs 38% for Semaglutide UsersWeight‑loss maintenance differed markedly between the pill and placebo groups:Tirzepatide cohort: 75% of lost weight retained with orforglipron vs 49% with placebo.Semaglutide cohort: 80% retained with the pill vs 38% with placebo.Secondary benefits—blood pressure, cholesterol, and glycaemic control—were also sustained in the pill arm.Implications for Obesity Management and Healthcare CostsExperts highlighted the broader significance:Dr Louis Aronne (Weill Cornell Medicine) emphasized that treating obesity directly can simultaneously improve glucose, lipid, and blood‑pressure metrics.Dr Marie Spreckley (University of Cambridge) noted patient preference for oral therapy due to convenience, storage, and lower cost.Dr Simon Cork (Anglia Ruskin University) warned that injectable GLP‑1 drugs, while highly effective, are expensive and limit long‑term accessibility for both private payers and the NHS.The findings suggest a potential shift toward oral agents that maintain efficacy while reducing financial and logistical burdens.Future Outlook: Oral GLP‑1 Therapies Could Redefine Chronic Obesity CareIf further trials confirm these results, orforglipron could become a cornerstone of chronic obesity management, enabling earlier intervention (BMI 25‑27) and possibly preventing progression to severe obesity.Regulators and payers will likely scrutinize cost‑effectiveness models, but the prospect of a cheap, daily tablet that sustains weight loss may reshape treatment algorithms worldwide.

First Ascent: The Allure of Carn Ffoi’s Jagged EdgeThe Guardian’s Country Diary captures a solitary climber’s obsession with a dark, looming rock outcrop on the brow of a Pembrokeshire hill. From a modest “home away from home,” the author watches the storm‑washed landscape settle, the wind drying the volcanic stone and setting the stage for a daring bouldering session.On‑Ground Details: Route‑Finding Without a GuidebookWithout a phone or detailed topos, the climber relies on a hand‑drawn booklet of routes that proves indecipherable. Instead, he scouts a potential line on the lee side of the boulder, warms his fingers, and visualises the climb in his mind before committing to the overhanging block.Physical Metrics: Climb Length, Elevation Gain, and Weather ConditionsClimb height: approximately 4‑5 metres of vertical gain.Elevation gain from base to summit: ~12 m above sea level.Wind: post‑storm gusts around 15‑20 km/h, drying the rock surface.Temperature: mild coastal chill, roughly 12 °C.Why This Matters: Highlighting Remote Coastal Climbing in WalesThe piece underscores a growing niche of climbers seeking untouched tors along the Welsh coast. The volcanic geology offers a texture “rough as old bark,” while the surrounding landscape—sandy Trefdraeth Bay, gorse scrub, and distant fishing boats—provides a dramatic backdrop that differentiates these sites from inland crags.Looking Ahead: Future Exploration of Pembrokeshire’s TorsAfter topping the boulder, the author spots a freshly‑moulted adder, a reminder of the area’s rich biodiversity. The encounter, combined with the panoramic sea view, suggests that Pembrokeshire’s tors will continue to attract adventurous climbers and nature enthusiasts alike, encouraging more detailed route documentation and sustainable access initiatives.

Charities Call for a New Clean Air Act Before the King's Speech More than 60 charities representing over 230,000 members have urged the incoming Labour government to introduce a Clean Air Act that would ban wood‑burning, remove diesel vehicles from roads and compel local councils to cut pollution. Details of the Lobbying Push and Proposed Measures The letter, signed by groups such as Mums for Lungs and led by founder Jemima Hartshorn, repeats Labour’s 2023 opposition promise to make clean air a human right. It calls for an outright ban on non‑essential wood‑burning stoves, a phase‑out of existing units, and support for rural households to switch to low‑carbon heating such as heat pumps. Financial and Complaint Data Highlight the Scale of the Problem Air‑pollution costs the UK economy about £27bn a year, linked to asthma, cancer and dementia. From August 2024 to August 2025, there were 15,195 wood‑burning complaints in England, yet only 24 fines were issued. Recent data show a surge in wood‑burner sales in urban areas, despite evidence that particles from wood are as toxic as coal‑derived emissions. Implications for UK Air Quality Policy and Rural Economies Experts such as Stephen Holgate, special adviser to the Royal College of Physicians, describe the lack of enforcement as a “disgrace”. The Stove Industry Association (SIA) has lobbied both the Scottish and UK governments, influencing the Future Homes Standard that currently permits wood‑burning installations in new builds. Industry spokespeople argue that a ban would “negatively impact the UK’s manufacturing and rural economies”, while charities stress the public‑health imperative. What the Next Parliamentary Session May Hold for Clean‑Air Legislation With the King’s Speech imminent, the pressure is on Labour to reverse the omission of a Clean Air Act from its manifesto. If the government adopts the charities’ recommendations, we could see the first statutory ban on wood‑burning and stricter diesel restrictions within the next year; otherwise, the status quo of voluntary guidance is likely to persist.

Trump's Beijing Visit Marks First U.S. Leader in a DecadePresident Donald Trump departed for Beijing ahead of a two‑day summit with President Xi Jinping, the first U.S. head of state to set foot in China since 2017. The high‑stakes meeting comes after weeks of stalled U.S. attempts to enlist Beijing’s help in reviving Iran negotiations and easing tensions in the Strait of Hormuz.Trade, Technology and Taiwan: Core Bargaining ChipsThe agenda is expected to centre on four pillars: trade (especially U.S. agricultural exports and Boeing sales), advanced semiconductor and rare‑earth restrictions, the Taiwan question, and the Iran war. Washington will press China for higher purchases of U.S. goods, while Beijing will seek relief from U.S. export controls on chip‑making equipment and a loosening of rare‑earth export curbs.Economic Stakes: Tariffs, Rare Earths and Energy FlowsChina controls roughly 90 % of global rare‑earth refining, a critical input for chips, EVs and military hardware.The United States has imposed tariffs on some Chinese goods that have risen to above 100 % in the past year.China buys more than 80 % of Iran’s shipped crude, giving it leverage over Tehran’s oil revenue.U.S. officials hope to secure new Chinese purchases of American beef, soybeans and aircraft.Geopolitical Ripple Effects: Iran, the Strait of Hormuz and Global OrderAnalysts see the Iran conflict as a rare area of overlapping interest: both Washington and Beijing benefit from stable energy flows through the Gulf. However, Beijing is unlikely to fully align with U.S. pressure on Tehran, preferring to protect its own oil‑buyer relationship. The summit also tests the durability of the “strategic rivalry‑dependency paradox” that binds the two economies.What the Summit Could Signal for Future U.S.–China RelationsA “successful” outcome for Trump would be visible trade wins—new Chinese purchase commitments, limited tariff pauses, or a framework for rare‑earth cooperation—that can be sold to domestic voters ahead of the 2026 midterms. For Xi, success means preserving China’s strategic autonomy while extracting economic predictability without appearing to concede to U.S. demands. Most experts expect a limited, issue‑by‑issue agreement rather than a comprehensive deal, leaving the deeper structural rivalry largely intact but temporarily managed.

Lead: Massive Street Demonstrations Across ArgentinaTens of thousands of Argentines converged in major cities on Tuesday to denounce the Javier Milei administration’s cuts to the public university system, a cornerstone of the nation’s tuition‑free higher‑education model.Thousands Take to Streets as Milei’s Cuts Target Tuition‑Free UniversitiesProtesters marched from central Buenos Aires toward the presidential palace, chanting against budget shortfalls that they claim undermine the foundations of higher education. The public university system has been tuition‑free since 1949 and has produced five Nobel laureates.Estimated protest size: tens of thousands nationwide.Key locations: Buenos Aires, Córdoba, Rosario.Government stance: Alejandro Alvarez, undersecretary for university policy, called the march “completely political”.Budget Shortfalls and Salary Declines Highlight Fiscal StrainCongress approved a law last year to finance operating costs and raise academic salaries in line with soaring inflation, but the Milei government has refused implementation and is challenging the legislation in court.University operating‑cost financing law: passed 2025.Real‑term professor salaries have fallen by about one‑third since Milei took office in late 2023.Unemployment and real wages are also declining, contributing to sliding approval ratings for Milei.Erosion of Higher‑Education Foundations Threatens Social MobilityThe cuts strike at a system that has historically enabled social mobility and scientific achievement. Public anger is amplified by corruption allegations surrounding Manuel Adorni, Milei’s cabinet chief, whose alleged lavish spending contrasts sharply with his official salary.Public universities: tuition‑free, historically elite‑producing.Corruption probe: media reports on extravagant expenses by Adorni.Political climate: protests include a broad cross‑section of ages and political leanings.Future Trajectory: Potential Escalation and Policy Reversal ScenariosIf the government continues to block the financing law, protests may intensify, potentially forcing a legislative or judicial reversal. Conversely, a negotiated settlement could restore funding, stabilizing university salaries and tempering social unrest.

The World's Longest Football DerbyCarlisle and Barrow will play each other next season in the Cumbrian derby in the National League. The clubs are located at opposite ends of Cumbria and the distance between the two grounds is some 78 miles by car. But this is not the greatest distance between two teams involved in a 'derby'.When considering derbies, we are looking for matches between teams that are linked based upon their proximity or geography, rather than simply historical rivalries like the 'clásico' between Real Madrid and Barcelona.UK Derbies: The Cumbrian ContenderWithin the UK, the Cumbrian derby certainly looks the furthest derby by distance. If we are staying in England, the closest we can get to 78 miles is the A49 derby between Shrewsbury Town and Hereford United, separated by 51 miles, although it should be said that the two teams have not met since the latter was dissolved in 2014.In England, thoughts immediately go to Crystal Palace and Brighton, dubbed the M23 derby, but a quick search reveals that Selhurst Park is a mere 46 miles from the Amex Stadium. It is also 46 miles that separate the stadiums of Plymouth Argyle and Exeter City, the Devon derby. Just behind are Ipswich and Norwich – the East Anglian derby (AKA El Tractico or the Old Farm) – with Portman Road and Carrow Road 45 miles apart.International Long-Distance DerbiesFarther afield, we must mention the derby between Persib Bandung and Persija Jakarta, who take part in the Indonesia derby, or Laga Klasikal as it is locally known, with Persib's Gelora Bandung Lautan Api Stadium lying 108 miles away from Persija's Jakarta International Stadium in Indonesia's capital.Italy is fertile ground for a host of famous derbies, and it is here that we find some of the longest-distance derbies. Of course there is the Derby d'Italia between Milan and Juventus, with 85 miles separating San Siro and Juve's Allianz Arena in Italy's north-west. The Derby di Sicilia between Palermo and Catania spans a whopping 134 miles across the breadth of Sicily, while the Derby delle Isole (Derby of the Islands) between Palermo and Sardinian club Cagliari goes even further – a full 250 miles across the Tyrrhenian Sea.The Champion: New Zealand's 386-Mile DerbyOur winner, though, comes from New Zealand's North Island. With Auckland FC only entering the A-League Men in 2024-25, the New Zealand derby between themselves and Wellington Phoenix is still very much in its infancy but has already blossomed into something substantial. In February, just the sixth edition of the derby, a comical own goal from Wellington goalkeeper Josh Oluwayemi sparked a 5-0 thrashing by Auckland, prompting Phoenix coach Giancarlo Italiano to resign immediately after the defeat. With 386 miles between the two grounds, the NZD is our clear winner.The Evolution of Geographic DerbiesThe existence of such long-distance derbies challenges our traditional understanding of what constitutes a local rivalry. In an era where football has become increasingly globalized, these geographic matchups represent unique connections between communities separated by vast distances. The New Zealand derby, in particular, showcases how even in a country with a relatively small population, football can create intense rivalries across significant geographical divides.The Future of Long-Distance DerbiesAs football continues to evolve, we may see more long-distance derbies emerge, particularly in regions with expanding leagues or where new clubs are formed to serve underserved areas. The New Zealand derby between Auckland and Wellington Phoenix is a prime example of how modern football infrastructure and scheduling can create meaningful rivalries regardless of distance. With the increasing popularity of travel and fan engagement, these long-distance derbies may become even more significant in the future of football culture.Double Winners in FootballDeji Elerewe has won the title with both Bromley (League Two) and Lincoln (League One) this season. Has any other player managed the same feat?We covered this answer 10 years ago in a previous Knowledge, but regular contributor Dirk Maas has come in clutch with some additions, although he does clarify that he has limited his search to the top five leagues in Europe in this century.There are several examples of players winning titles with different teams in the same season, including:Jonas Urbig with Köln (2. Bundesliga) and Bayern Munich (Bundesliga) in 2024-25Leigh Griffiths with Celtic (Scottish Premiership) and Wolverhampton (League One) in 2013-14Urby Emanuelson with Ajax and Milan in 2010-11Daniel Amartey with Leicester City and FC Copenhagen in 2015-16Timothy Weah with Paris Saint-Germain and Celtic in 2018-19Khvicha Kvaratskhelia with Napoli and PSG in 2024-25There are also alternative cases where seasons happen at different times of year, such as David Beckham achieving this by picking up an MLS winner's medal with LA Galaxy and a Ligue 1 winner's medal with Paris Saint-Germain in 2012-13.

In a recent Guardian column, Jonathan Liew reframes Sir David Attenborough as a quiet radical whose public persona masks a long‑standing critique of capitalism and a call for wealth redistribution, juxtaposing this stance with the largely apolitical tone of his 2026 centenary celebration.Attenborough’s Radical Economic Vision RevealedDuring a 2020 BBC interview, the 100‑year‑old naturalist argued for a “utopian future” where “those who have a great deal, perhaps, will have a little bit less, and those that have very little will have a little more.” This stance aligns with broader eco‑socialist ideas and contrasts sharply with the profit‑driven narrative of contemporary capitalism.Centenary Broadcast: Celebration Over Substance?The BBC One tribute featured celebrity tributes, a royal birthday letter delivered by CGI fauna, and a polished showcase of Attenborough’s wildlife footage, yet the climate crisis was not mentioned once. The event’s focus on spectacle over policy underscores how his radical views are often sidelined in mainstream media.Quantifying Attenborough’s Media Reach and TrustPolls repeatedly rank Attenborough as the most trusted figure in the United Kingdom, granting him a unique platform to shape public opinion. However, the absence of concrete policy advocacy in his high‑profile appearances limits the translation of that trust into measurable political pressure.Implications for Environmental Advocacy and Public DiscourseAttenborough’s depoliticised image makes him an appealing messenger for a broad audience, but it also allows powerful interests to co‑opt his environmental narrative without demanding systemic change. The tension between his activist instincts and the sanitized public persona raises doubts about whether his influence can drive the “tough and bloody compromises” needed for climate mitigation.Future Role: From Symbolic Figure to Policy Catalyst?As Attenborough enters his eleventh decade, the key question is whether future broadcasts will integrate his radical economic ideas with concrete climate policy proposals. If his platform begins to foreground systemic redistribution alongside biodiversity storytelling, he could shift from a symbolic guardian of nature to a catalyst for substantive environmental legislation.

Executive Summary: Trump‑Xi Summit Sets the Stage for a US‑China Power Contest Donald Trump will meet Xi Jinping in Beijing on May 14‑15, 2026. The talks, delayed by the US‑Israel war on Iran, are expected to focus on trade, debt, military spending and emerging technologies, marking the first US presidential visit to China in nearly a decade. Trade Metrics Highlight China’s Export Supremacy According to the World Bank’s WITS, China exported $3.59 trillion of goods in 2024, surpassing the US’s $1.9 trillion. China now leads 145 economies in trade volume, while the US trails with a trade deficit of roughly $1.2 trillion (imports $3.12 trillion vs exports $1.9 trillion). Top Chinese exports: Machinery & electrical machines $1.68 trillion, metals $286 bn, textiles $268 bn. Top US exports: Machinery & electrical machines $447 bn, mineral products $364 bn, chemicals $245 bn. Numbers Behind the Trade Gap, Debt and Military Budgets In 2024 China posted a trade surplus of over $1 trillion, while the US ran a deficit of about $1.2 trillion. Government debt stands at 115 % of GDP for the US and 94 % of GDP for China, with the US national debt exceeding $39 trillion. Military spending in 2025 was $954 bn for the US (3.1 % of GDP) versus $336 bn for China (1.7 % of GDP). Strategic Implications for the Global Power Balance The data underscore a shift: China now leads in export volume, rare‑earth reserves (44 million tonnes vs US 1.9 million tonnes), and green‑energy investment ($290 bn vs US $97 bn). The US retains advantages in AI corporate spending ($109 bn in 2024) and semiconductor technology. Both powers dominate global military outlays, together accounting for over half of worldwide defence spending. Outlook: What the May Summit May Determine Analysts expect the summit to address tariff levels (US average tariff on Chinese imports ~31.6 %), rare‑earth supply security, and coordination on climate‑energy policy. A de‑escalation could stabilize trade flows and reduce debt‑driven fiscal pressures, while a hard‑line stance may deepen the bifurcation of technology supply chains and reinforce competing growth models.

The Trump-Xi Summit: A Pivotal Moment in US-China Relations Donald Trump's state visit to China this week – the first by the US president in nearly a decade – comes amid a time of geopolitical upheaval, a new and intractable conflict in the Middle East, and a sometimes rocky relationship between the world's two major superpowers. There is much for Trump and Xi Jinping to discuss, but a few key issues are likely to dominate the agenda. Five Critical Issues on the Summit Agenda The high-stakes meeting between the two leaders addresses several pressing matters that could reshape the global landscape: The Iran Conflict and Hormuz Strait Crisis Trump is eager for China to lean on Tehran to advance peace talks and reopen the strait of Hormuz. To now, Beijing has sat back and watched the US struggle against Iran, at least publicly. But with about half of China's crude oil imports passing through the strait, Xi does want the waterway unblocked. China knows its exports will suffer if a global recession results from an oil supply crisis. Complicating the picture, the US this week put sanctions on several Chinese firms accused of assisting Iranian oil shipments and supplying satellite imagery allegedly used in Iranian military operations, claims that Beijing denied. Trump's arrival comes after Iran's foreign minister, Abbas Araghchi, visited Beijing last week. Taiwan: The Flashpoint in US-China Relations Beijing is keen to push the US on Taiwan, with Trump saying he is prepared to raise the issue of arms sales to the island, which China claims as a breakaway territory despite never having ruled it. In December, Trump authorised an $11bn arms package for Taiwan, the largest weapons sale ever to the island, but no shipments have been made yet. Xi may seek changes in how the US refers to Taiwan. Ideally, from the perspective of Beijing, this would be a statement from Washington "opposing" Taiwan's independence rather than "not supporting" it. Taiwan will be watching closely. Just two weeks ago, China's foreign minister in a phone call with Marco Rubio urged the US to "make the right choices" on Taiwan. With Trump known to veer off script, John Kirby, a former US state department and Pentagon spokesperson cautioned: "They just have to be so extraordinarily precise when you're talking about Taiwan because, quite frankly, the stakes are enormously high." The AI Cold War: Technological Supremacy at Stake China and the US are locked into a race on artificial intelligence that is becoming something of a technological cold war. In April, the White House accused China of stealing US AI labs' intellectual property on an industrial scale, claims Beijing denied. Meanwhile, Beijing has been frustrated by Washington's reluctance to allow Nvidia to export its most powerful processing chips to China. In January, the White House said Nvidia could export its second most powerful chip, the H200, but no shipments have been sent yet. Analysts and ethics leaders hope Trump and Xi will discuss non-binding AI guidelines, including sharing information about AI misuse and safety, which are seen as critical guardrails amid the advent of AI weaponry and military adoption. Trade War: Rare Earth Minerals and Economic Leverage Trump has repeatedly threatened China over trade, imposing tariffs above 140% last year. But Xi held some cards of his own and did not fold. Instead, China blocked exports of its rare earth minerals and magnets to the US. Trump, finally, backed down. The US has depleted notable levels of its weapons arsenal in the war against Iran, with many weaponry components requiring critical minerals that are linked to supply chains dominated by China. China is expected to announce purchases related to Boeing airplanes, American agriculture and energy, US officials have said. In turn, Beijing wants the US to ease curbs on exports of advanced semiconductors. Beijing also wants to reduce barriers to investment in the US, and hopes to establish a Board of Investment to match the Trump-back Board of Trade. Fentanyl: The Drug War and Political Posturing Fentanyl is a key item on Trump's agenda this week, Politico reported, citing an administration official granted anonymity to preview the closed-door sessions. The US has long accused Chinese businesses of knowingly supplying the chemical precursors to Mexican cartels who use them to make the drug. Trump knows that being seen to press China hard over fentanyl and precursors plays well with his Maga base. But Trump lost important leverage on the fentanyl front when China defied his tariffs threats. In March, the US and China clashed over fentanyl and trade at a UN drugs meeting. China wants to be removed from the state department's annual list of "major drug transit or illicit drug producing countries", due to be updated in September.