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British Prime Minister Keir Starmer declared that the United Kingdom will not participate in the United States’ proposed blockade of the Strait of Hormuz, distancing London from President Donald Trump’s latest escalation against Iran.Speaking on BBC Radio, Starmer said, "We are not supporting the blockade," and added that the UK will not be "dragged into the US‑Israel war on Iran."The Strait of Hormuz is a strategic chokepoint through which about 20 % of the world’s oil supplies transit in peacetime. Starmer stressed that reopening the waterway is vital for global energy security and that the UK’s diplomatic efforts over recent weeks have focused on that goal.Meanwhile, the US Central Command announced it would block all maritime traffic entering or leaving Iranian ports from 14:00 GMT, though it provided few details on how the blockade would be enforced. The statement claimed the action would be applied impartially to vessels of all nations, yet it also noted that ships bound for non‑Iranian ports would not be impeded.President Trump, in a lengthy social‑media post, framed the operation as a mission to clear mines and prevent Iran from profiting from control of the strait.In a parallel diplomatic move, French President Emmanuel Macron said France and the United Kingdom will convene a conference in the coming days aimed at restoring freedom of navigation, reaffirming that “no diplomatic effort will be spared” to end the US‑Israel conflict over Iran.Nicole Grajewski, an assistant professor at Sciences Po, warned that the US blockade constitutes “more than a minor coercive signal” and effectively marks a resumption of hostilities.Other allies echoed criticism: Spanish Defence Minister Margarita Robles called the plan “makes no sense,” Turkish Foreign Minister Hakan Fidan urged “negotiations with Iran and the swift reopening of the strait,” and Chinese Foreign Ministry spokesman Guo Jiakun emphasized that the strait’s security is “in the common interest of the international community.”Starmer’s stance reflects a careful balancing act—maintaining NATO solidarity while refusing to endorse direct military pressure on Iran—highlighting the complex geopolitics surrounding one of the world’s most crucial maritime corridors.

Tanya Khovanova has long been a leading voice in the world of recreational mathematics, authoring a popular blog and running the Number Gossip site where enthusiasts can inquire about any number.She now debuts her first book, Mathematical Puzzles and Curiosities, co‑written with fellow puzzle‑enthusiasts Ivo David and Yogev Shpilman. Published by World Scientific, the volume offers fresh challenges and inventive twists on classic problems.To give readers a taste, Khovanova selected three puzzles for the Guardian column:1. Battleships – As a naval admiral you must choose between sending a single vessel with a success probability of P % or two vessels each with a P/2 % chance, where the mission succeeds if at least one ship does. Which strategy maximises the odds?2. The Two Oracles – You face two respondents, Randie, who answers randomly, and Rando, who randomly decides to tell the truth or lie before each answer. Is there a method to distinguish them?3. Bad Maths – A student computes 5548 − 5489 as 59, claiming the “548” cancels out. He then experiments with a subtraction of the form XXYZ − XYZW (distinct digits) and observes the result is XW. How many digits in the new expression match those in the original calculation?Solutions to the trio were later posted online (update), but readers were urged to avoid spoilers until the scheduled reveal.Khovanova also reminds fans that she has been curating puzzles for the Guardian every other Monday since 2015 and welcomes new submissions via email.

For the first time, thousands of cancer patients from Black and minority ethnic backgrounds will benefit from an enhanced genetic test offered by the NHS. The new screening expands the panel of DPYD gene variants from four to five, directly addressing a long‑standing bias that left non‑white patients vulnerable to dangerous chemotherapy side‑effects. In England, patients slated for chemotherapy undergo a genetic check that can guide dose adjustments and mitigate adverse reactions such as mouth sores, hair loss, nausea, fatigue, and, in severe cases, death. Up to 40% of the 38,000 individuals receiving fluoropyrimidine‑based chemotherapy each year experience a harmful drug reaction. Previously, the test only targeted four DPYD variants common in people of European descent, meaning many Black patients received inaccurate “all‑clear” results. The addition of a fifth variant—more prevalent among African, Caribbean and other minority groups—means clinicians can now identify patients at risk who were previously missed. Since its rollout at Manchester University NHS Foundation Trust last September, three minority‑ethnic patients have had their initial chemotherapy doses adjusted, lowering their chance of a potentially fatal reaction. Dr Veline L’Esperance, senior clinical adviser at the NHS Race and Health Observatory, called the change “tangible results for patients who have historically been left behind.” She emphasized that the update shifts the discussion on ethnic health inequality from rhetoric to actionable care. Prof Habib Naqvi, chief executive of the NHS Race and Health Observatory, described the development as a “groundbreaking outcome” for chemotherapy safety, while noting that ethnic minorities remain under‑represented in genomic research and biobanks. He warned that broader inclusion is essential for the promised benefits of precision medicine to reach all communities. Prof Dame Sue Hill, chief scientific officer for NHS England, highlighted the significance of discovering the fifth variant: “Personalising chemotherapy based on genetics can save lives and reduce harmful side‑effects, especially for patients of African ancestry.” She added that the North West NHS Genomic Medicine Service has already demonstrated the practical impact of this approach. These steps come amid broader evidence that minority patients in the UK face longer diagnostic waits, more GP visits before a cancer diagnosis, and lower perceived support during treatment. The expanded DPYD test represents a concrete effort to close those gaps and ensure equitable, science‑driven care for all cancer patients.

Conversations about mundane topics are often dreaded, but research suggests that people enjoy them more than they anticipate. A study involving 1,800 volunteers found that participants enjoyed chatting about dull subjects, such as the stock market or vegan diets, more than they expected. The findings indicate that by avoiding potentially dull exchanges, individuals may miss out on the mood boost and health benefits that come with connecting with others. Elizabeth Trinh, a PhD candidate in management and organisations at the University of Michigan, noted that people tend to underestimate how interesting and enjoyable conversations about boring topics can be. Trinh and her colleagues conducted a series of experiments to gauge how people responded to conversations on dull topics. Participants were asked to predict how much they would enjoy discussing topics they considered boring, and then engage in brief conversations about those topics. The results, published in the Journal of Personality and Social Psychology, showed that people consistently found the conversations more enjoyable than they expected. The surprise enjoyment arises because individuals base their expectations on static components, such as the topic and the other person, rather than dynamic components, like the conversation itself. Trinh suggests that people may benefit from lowering the bar for what makes a conversation worth having and reframing conversational goals. Instead of focusing on enjoyment, individuals could think about what they might learn from the conversation. Nicholas Epley, a professor of behavioural science at the University of Chicago, added that the fear of a boring conversation shouldn’t prevent people from starting one. “If a conversation is boring once you’re in it, you also have a surprising amount of power to make it better!”

Scientists at London's Institute of Cancer Research and the RCSI University of Medicine and Health Sciences in Dublin have announced a new AI-driven approach to identify how patients with advanced bowel cancer will respond to bevacizumab, a drug recently introduced by the NHS. The method uses PhenMap, an AI tool that integrates complex data on the genetic makeup of tumors, allowing researchers to track patterns of how different patients react to the drug. This development aims to spare potentially thousands of patients from being given drugs that would be ineffective in fighting their cancers. In the UK alone, nearly 10,000 cases of advanced bowel cancer are identified every year, with young adults seeing a particular rise in diagnoses. Bowel cancer has the second-highest mortality rate of any cancer, behind only lung cancer. While survival rates can be as high as 98% when caught early, the five-year survival rate for advanced bowel cancer can be as low as 10%. The study tracked 117 European bowel cancer patients who had been treated with chemotherapy and bevacizumab. Researchers identified a group of patients who all had the same gene mutation and were at a high risk of having negative reactions. The scientists behind the tests now hope to expand the number of patient samples and see if the results can be used in treatments for other types of cancer. Anguraj Sadanandam, a professor in stratification and precision medicine at the ICR, said: “Once bowel cancer spreads to other parts of the body, there are very few treatment options available for patients. It is therefore positive that patients can now access the targeted drug bevacizumab on the NHS. However, we know that the majority of patients won’t benefit from the drug, meaning thousands of people in England could be facing unpleasant side effects unnecessarily.” Sadanandam added that while the findings were encouraging, the tool would need to be tested on a larger cohort to be validated. “In future, I hope this approach will lead to a test that can be used by clinicians, to ensure patients receive personalised care that has the highest chance of working against their cancer.”

Brian Cox’s latest live show, ‘Emergence’, draws its spark from Johannes Kepler’s 1609 treatise ‘The Six‑Cornered Snowflake’. Cox explains that Kepler’s wonder at the symmetry of snowflakes, written during a Prague snowstorm, embodies the modern scientific quest to understand the origins of patterns we observe.He says the show explores three realms: what we know, what we don’t know, and what may remain unknowable. This framework sets the stage for his reflections on the biggest unanswered questions in science.If he could answer any scientific mystery, Cox would choose the existence of life beyond Earth. He points to current missions—two spacecraft heading to Jupiter’s moons and the James Webb Space Telescope probing exoplanet atmospheres—as promising avenues that might soon reveal a biosignature.When asked about the future of technology, Cox warns that the trajectory of artificial intelligence is still opaque, making it both thrilling and potentially hazardous. He adds that quantum computing is another frontier with wildly divergent timelines—some experts see breakthroughs within five years, others doubt they’ll arrive in a lifetime—highlighting the revolutionary yet unpredictable nature of these tools.Cox also reflects on his shifting stance toward social media. He admits moving from early optimism about its democratizing power to a more critical view of its noise and misinformation, while acknowledging its complex impact on politics and public discourse.On personal advice, Cox stresses the importance of following one’s passion: “Do what you most enjoy,” he says, recalling his own journey from a teenage musician to a celebrated astronomer, supported by parents who encouraged his interests.He shares a memorable fan encounter: at an ELO concert, a man introduced himself as Paul McCartney after asking a question about Saturn’s moon Enceladus—an encounter that left Cox “overwhelmed” as a lifelong Beatles fan.When asked about a pop‑culture stance, Cox admits he is largely out of touch, but notes that musical innovation seems to have plateaued since the 1980s, contrasting the rapid evolution of earlier decades.One of his favorite astronomical facts is the staggering number of observable galaxies: about two trillion. He highlights how, within a century, humanity moved from debating whether other galaxies existed to quantifying an immense cosmos, also measuring its age at roughly 13.8 billion years.Brian Cox will tour ‘Emergence’ across Australia from 5 to 30 May 2026.

The recent return of the Artemis II mission to Earth has been hailed as a major achievement for NASA, marking the first crewed mission to the moon in over 50 years. The mission, which included astronauts Reid Wiseman, Victor Glover, Christina Koch, and Jeremy Hansen, broke a distance record and demonstrated the capability to sustain human life beyond lower-Earth orbit.However, the celebration has been overshadowed by proposed budget cuts to NASA, with Donald Trump announcing a 23% reduction in funding, including a 46% cut for space science initiatives. Critics argue that these cuts, described as 'extinction-level', would severely impact NASA's ability to achieve its ambitious goals in deep space exploration.NASA Administrator Jared Isaacman defended the budget proposal, stating that the levels are sufficient to meet mission priorities. However, Casey Dreier of the Planetary Society expressed concerns, highlighting the contradiction between the budget proposal and previous statements by NASA leadership.The Artemis program faces significant challenges ahead, including the development of a permanent lunar base. Despite these concerns, NASA is already looking ahead to Artemis III, scheduled for next year, which will test human lunar landing systems.Artemis II has been hailed as a crucial step in the US space program, providing a significant advantage in the new space race with China. The mission's success has brought renewed attention to the importance of continued investment in space exploration and the need for a stable and supportive budget.

When wages have been stagnant for almost two decades and a simple tube of toothpaste now costs nearly £7 at a major supermarket, the claim that “money can’t buy happiness” feels increasingly dismissive. The argument rests on a narrow view of what money can achieve. Spending cash solely on material goods yields only short‑lived pleasure. In contrast, the ability to afford time, experiences and mental‑health support expands one’s sense of freedom and purpose. Even basic needs such as leisure have become commodified; more disposable income simply translates into more opportunities to pursue what matters. As someone diagnosed with ADHD, I have learned—through personal trial rather than formal neuroscience—how to secure a steady supply of dopamine. The cheapest route is not a quick thrill, but activities that provide lasting satisfaction, such as novel experiences and moments of awe. One vivid example came during a winter trip to rural France, where two feet of snow turned the landscape into a scene straight out of Narnia. The awe‑inspiring view was a reminder that nature’s restorative power is often accessible only to those who can afford the travel, in my case a budget flight with Ryanair. Research supports the intuition that higher income correlates with greater happiness. A 2023 study by psychologists at Princeton and the University of Pennsylvania found that people with higher earnings report higher life satisfaction, though money cannot resolve non‑financial sources of unhappiness. Even the world’s richest are not immune to the paradox. Earlier this year, Elon Musk—on track to become the first trillionaire—tweeted that anyone who says “money can’t buy happiness” must be missing something. While Musk’s wealth may not guarantee personal joy, the same resources could provide a foundation for happiness for billions facing financial strain. Nevertheless, hoarding wealth like a dragon does not equate to fulfillment. The column suggests that redirecting a portion of vast fortunes toward travel, cultural enrichment, and shared experiences could transform isolated wealth into collective well‑being. In short, financial stability reduces stress and broadens horizons. It allows individuals to invest in the intangible assets—time, relationships, awe‑inducing experiences—that truly enrich life.

The Artemis II mission is set to make a profound impact on the world, inspiring future generations to pursue careers in science, technology, engineering, and mathematics (STEM). The crew's journey represents a significant milestone in space exploration, uniting people across the globe in their quest for knowledge and discovery.As the world watches, the Artemis II mission is poised to ignite a sense of wonder and curiosity about the vastness of space and the possibilities that lie beyond our planet. By pushing the boundaries of human exploration, the crew is embodying the spirit of adventure and cooperation that defines humanity's pursuit of excellence.