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GSK has revealed promising early results for its treatment for gynaecological cancers, Mocertatug Rezetecan (Mo-Rez), as its chief executive, Luke Miels, seeks to speed up drug development at the group.The company reported that in an early-stage trial, Mo-Rez shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.GSK acquired the Mo-Rez cancer treatment, an antibody-drug conjugate (ADC), from China’s Hansoh Pharma in late 2023, and has trialled it in 224 patients around the world, including the UK, over the past year. Few patients needed to stop treatment because of side-effects, the most common being nausea. It is administered every three weeks via intravenous infusion.Combined with data from a separate, intermediate trial in China, these results give GSK the confidence to go straight to late-stage trials, with five clinical studies planned globally in the next few months, including on patients in the UK.Presenting the results at the Society of Gynecologic Oncology’s annual meeting on women’s cancer in Puerto Rico, Hesham Abdullah, GSK’s global head of cancer research and development, said: “Treatment of gynaecological cancers remains a major challenge, with a pressing need for new therapies that offer improved response rates. With Mo-Rez we now have compelling evidence of a promising clinical profile.”Endometrial cancer affects 1.6 million women globally, with 417,000 new cases each year. Ovarian cancer affects 843,000 people, with 240,000 new cases annually.Abdullah described Mo-Rez as a “key asset” in the company’s growing cancer portfolio, expected to be a blockbuster drug with peak annual sales of more than £2bn, which GSK hopes will help it achieve its 2031 sales target of £40bn.

The collapse of talks between the US and Iran has sent shockwaves through global markets, fuelling fears of a prolonged energy crisis and rising inflation. The failure to reach a peace deal has left large numbers of oil tankers stuck in the Persian Gulf, with oil prices fluctuating wildly in response to the uncertainty.US Vice-President JD Vance has blamed the collapse of the talks on Tehran's refusal to abandon its nuclear weapons programme, while Iranian sources have hit back at what they describe as 'excessive' demands from Washington. The stalemate has raised concerns about the long-term impact on the global economy, with governments and central banks warning of higher inflation and interest rates.Mohamed El-Erian, an adviser to Allianz, has cautioned that uncertainty will continue to dominate assessments of the financial impact from the conflict. 'Absent a swift resumption of negotiations, the immediate reaction of financial markets when they open for the trading week will be to push oil prices higher and borrowing costs higher,' he said.The International Monetary Fund and World Bank's spring meetings in Washington will focus on the war's impact on the global economy, with the IMF's managing director, Kristalina Georgieva, indicating that the fund will present three scenarios predicting lower economic growth and higher inflation. The IMF is also expected to highlight the impact on vulnerable economies.In the short term, oil prices have ended the week lower, with Brent crude at $94.26 a barrel and West Texas Intermediate crude at $95.63 a barrel. However, global stock markets have rebounded after a temporary ceasefire was announced, with the S&P; 500 close to its level before the US-Israeli attacks on Iran began.

OpenAI, a leading AI company, has recently released a 13-page policy paper titled 'Industrial Policy for the Intelligence Age,' which calls for a reimagining of the social contract around 'a slate of people-first ideas.' This move is part of an aggressive effort by major AI players to reshape the narrative around their industry, as public disapproval of AI is increasing.OpenAI's paper proposes ideas such as a four-day workweek and a public wealth fund that would return profits directly to citizens. While the company presents these ideas as a starting point for a broader conversation, critics argue that they are more of a public relations ploy than a genuine policy document.OpenAI spent nearly $3m on lobbying in 2025, and its president, Greg Brockman, co-founded a pro-AI Super Pac that raised more than $125m last year. The company is also backing a bill in Illinois that would shield AI firms from liability in cases where an AI model causes serious societal harms.Critics argue that these efforts are aimed at undermining independent efforts to regulate the industry and that the company's proposals shift responsibility away from the company and towards the public and lawmakers. As public distrust of AI grows, the industry is looking for ways to reframe the debate and influence regulation.A Pew Research Center survey found that only 16% of Americans believe that AI will help people think more creatively, while only 5% of Americans believe it will help people better form meaningful relationships. An NBC News poll found that only 26% of voters had a favorable opinion of AI, with a net negative rating.

This week Anthropic revealed that its latest AI system, dubbed Mythos, is so powerful that the company will not make it publicly available, arguing that the potential risks outweigh commercial incentives.U.S. Treasury Secretary Scott Bessent convened senior banking executives to discuss the implications of the model, underscoring growing governmental concern over advanced AI capabilities.In the United Kingdom, Reform MP Danny Kruger wrote to the government urging an immediate dialogue with Anthropic, warning that Claude Mythos could pose "catastrophic cybersecurity risks" to the nation.Critics such as AI researcher Gary Marcus questioned the hype, suggesting that Anthropic’s co‑founder Dario Amodei may possess strong technical skills but is "graduated from the same school of hype and exaggeration" as OpenAI’s Sam Altman.Beyond the policy debate, Anthropic has mounted a striking media offensive. The startup secured a 10,000‑word profile in the New Yorker, two feature pieces in the Wall Street Journal, and a Time magazine cover that placed founder Amodei alongside the Pentagon and U.S. Defense Secretary Pete Hegseth.Co‑founder Jack Clark and Amodei appeared on separate New York Times podcasts, fielding questions about machine consciousness and the model’s potential to "rip through the economy." Their "resident philosopher" even discussed with the WSJ whether Claude, Anthropic’s commercial product used for cryptocurrency trading and missile‑target designation, possesses a "sense of self."Anthropic’s public‑relations lead, Danielle Ghiglieri, celebrated the coverage on LinkedIn, describing the Time cover as a "mad dash" that finally let the company tell its own story.However, the company’s PR triumphs have not been without missteps. In early April, Anthropic inadvertently released part of Claude’s internal source code, though it assured that no customer data or credentials were exposed.Experts remain skeptical about the unverified claims surrounding Mythos. Dr. Heidy Khlaaf of the AI Now Institute warned that the vague marketing language could be an attempt to attract investment without substantive scrutiny.Cybersecurity specialist Jameison O’Reilly acknowledged the model’s novelty but downplayed Anthropic’s assertion of discovering "thousands of zero‑day vulnerabilities," noting that in a decade of offensive operations, zero‑days were rarely needed to achieve objectives.Anthropic also faces operational constraints. The firm has imposed usage caps on its popular Claude model and now requires customers to purchase additional compute capacity for third‑party tools, suggesting that infrastructure limitations may be a practical reason for withholding Mythos.As the race to dominate the emerging AI market intensifies, Anthropic’s strategy appears to blend genuine safety concerns with a calculated publicity push, positioning Mythos as a strategic signal that the company remains "open for business" while keeping the technology under tight control.

The latest analysis by HR consultancy Hamilton Nash shows that 54 employment tribunals in England, Scotland and Wales cited remote‑working issues in 2025 – a 13% decline from the previous year and the first drop since the pandemic began.This marks the end of a six‑year upward trend during which tribunal filings related to remote work surged tenfold from the pre‑COVID baseline of 2019. The number of cases peaked at 62 in 2024 but fell sharply to just six in 2025.According to the Office for National Statistics, 28% of working‑age adults in Great Britain now operate in a hybrid model, splitting time between a traditional office and another location such as home. Yet many large employers, notably financial giants Goldman Sachs and JPMorgan Chase, have intensified return‑to‑office mandates, with some demanding five days a week on site.Employment experts attribute the unexpected dip to broader labour‑market dynamics. The UK unemployment rate rose to a near five‑year high of 5.2% in Q4 2025, while job vacancies have continued to fall, shifting bargaining power back toward employers. As Jim Moore, employee‑relations partner at Hamilton Nash, explains, “Top talent did vote with their feet for a while, but that has changed because of wider issues in the labour market and people saying: ‘I am going to stay put and keep my head down.’”Legislative changes may also be curbing tribunal filings. The amended Employment Relations Act, which introduced a right to request flexible working from day one of a new job in April 2024, appears to encourage employees to resolve disputes internally rather than through the courts.Moore warns that tribunal numbers represent “the tip of the iceberg,” noting that much workplace conflict never reaches a public hearing. Adding to employer confidence, a 2024 tribunal decision rejected a senior manager’s claim against the Financial Conduct Authority for the right to work entirely from home, a ruling that, according to Hill Dickinson partner Padma Tadi‑Booth, “may give some encouragement to employers” to tighten office‑attendance policies.Consequently, some firms are already planning to raise on‑site requirements, moving from two to three days a week or mandating a higher percentage of total working hours in the office.Nevertheless, the backlog of employment tribunals remains a significant hurdle. Over 500,000 cases were pending last year, and claimants can expect waits of up to three years for a hearing, potentially deterring future filings.

The Women's Super League (WSL) is experiencing a critical loss of momentum as the season approaches its climax, due to an extended international break that has left fans and teams alike facing a lengthy period without matches. This 11-day window for up to three international fixtures has created a significant gap in the schedule, coming at a time when interest in the league should be swelling. The break, which includes nearly four weeks without WSL fixtures, poses a challenge for teams and fans. For instance, Everton drew 5,292 fans to the Merseyside derby before going a month without a game. Similarly, Leicester, bottom of the Women’s Super League, do not play at home between 29 March and 3 May, missing a crucial opportunity to rally fan support. Sarina Wiegman, England’s head coach, has expressed concerns about the congested agenda and the amount of games players participate in, stating her preference for a two-match international break over three. This sentiment is echoed by various teams and players who see the extended break as a disruption to the rhythm of the domestic season. While some, like Charlton head coach Karen Hills, view the break as a necessary reset moment for players, both mentally and physically, the overall impact on the league's momentum and fan engagement is significant. The WSL's growth and the development of a fan culture are hindered by such gaps in the schedule, making it challenging for new fans to integrate match-going into their routine. Looking ahead, similar disruptions are expected in 2027, 2028, and 2029 due to scheduled three-game international windows. This ongoing issue highlights the need for a more cohesive scheduling approach to support the growth and continuity of women’s football.

The U.S. Central Command (CENTCOM) reported that the destroyers USS Frank E. Peterson and USS Michael Murphy "transited the Strait of Hormuz and operated in the Arabian Gulf" as part of a mission to clear sea mines allegedly laid by Iran’s Islamic Revolutionary Guard Corps (IRGC).Admiral Brad Cooper hailed the operation as a turning point in the U.S.–Israeli campaign against Iran, saying the navy was establishing a "new passage" to restore safe commercial flow. Iran’s Khatam al‑Anbiya Central Headquarters immediately rejected the claim, stating that any vessel movement in the strait remains under the "Armed Forces of the Islamic Republic of Iran" and that the U.S. report is "strongly denied." The strait, a narrow chokepoint through which roughly 20% of the world’s oil and natural gas transits, has been a flashpoint since the February 28 U.S.–Israel attacks that prompted Iran to restrict passage to pre‑approved ships. The closure spiked global fuel prices and disrupted both commercial and military traffic. Analysts, such as Maria Sultan of the South Asian Strategic Stability Institute, argue that any U.S. navigation would require Tehran’s explicit permission, underscoring the strategic leverage Iran holds over the waterway. Simultaneously, senior delegations from the United States and Iran met in Islamabad for historic face‑to‑face talks—the highest‑level engagement since the 1979 Islamic Revolution. The negotiations, sparked by a preliminary ceasefire announced earlier in the week, focus on contentious issues including Iran’s nuclear program, frozen assets, and the future of Israeli operations in Lebanon. Both parties acknowledge that control of the Strait of Hormuz remains a major point of disagreement. Iran has signaled willingness to temporarily reopen the channel for commercial shipping but insists on maintaining leverage, proposing tolls to compensate for war damages. The United States, however, deems continued Iranian control a "non‑starter." U.S. President Donald Trump used his Truth Social platform to assert that Iran is "losing big" and to downplay the strait’s importance to the United States relative to its allies, claiming the mine‑clearing effort benefits nations such as China, Japan, South Korea, France, and Germany. Al Jazeera’s on‑the‑ground correspondents noted that despite a "deficit of trust," negotiators are working late into the night to bridge gaps, though fundamental disagreements over the strait’s governance persist.

Pakistan dispatched a mixed fleet of fighter and support aircraft to King Abdulaziz Air Base in Saudi Arabia’s Eastern Province on Saturday, marking the first visible military action under the mutual defence agreement signed in September 2025. The Saudi Ministry of Defence confirmed the landing, noting the deployment aligns with the collective defence clause that obliges each signatory to treat an attack on the other as an attack on itself. At the same time, Islamabad is hosting direct US‑Iran negotiations aimed at halting weeks of regional fighting triggered by Iran’s missile and drone strikes on Gulf targets after the US‑Israeli killing of Supreme Leader Ali Khamenei on 28 February. Foreign Minister Ishaq Dar told reporters he personally warned Iranian leaders in early March that Pakistan must honour its obligations to Riyadh. Tehran, seeking assurances that Saudi soil would not be used for attacks against it, received such guarantees, Dar added. Despite these diplomatic overtures, Iranian attacks on Saudi facilities – including key bases and a US embassy building – have persisted. In early March, Pakistan’s army chief, Field Marshal Asim Munir, flew to Riyadh to discuss measures to curb Iranian strikes within the framework of the defence pact. Four days before the jet deployment, Prime Minister Shehbaz Sharif phoned Crown Prince Mohammed bin Salman, pledging that Pakistan would stand “shoulder to shoulder” with Saudi Arabia. The two leaders also agreed to accelerate a $5 billion Saudi investment package earmarked for Pakistan. Saudi Finance Minister Mohammed al‑Jadaan met Sharif, Dar and Munir in Islamabad on Saturday, underscoring the economic dimension of the partnership. Saudi Arabia hosts roughly 2.5 million Pakistani workers, whose remittances are vital to Pakistan’s fragile economy, and has repeatedly provided financial assistance. Security analyst Imtiaz Gul told Al Jazeera the deployment was not intended as a military escalation but as a “messaging tool” to remind Tehran of Pakistan’s treaty obligations. “Three jets won’t make much of a difference militarily,” he said, noting Saudi Arabia’s own sizable air force. Michael Kugelman, senior fellow for South Asia at the Atlantic Council, described the move as “a risky gambit.” He warned that if Iran refuses concessions, Pakistan could be drawn closer to Saudi Arabia, potentially invoking the defence pact in a renewed conflict.

Iraq's parliament has elected Nizar Amedi as the country's new president, ending a political deadlock that had paralyzed government formation. Amedi, nominated by the Patriotic Union of Kurdistan (PUK), secured 227 votes in a second round of voting on Saturday, comfortably defeating independent candidate Muthanna Amin Nader, who received 15 votes.He becomes the sixth Iraqi head of state since the removal of Saddam Hussein in a US-led invasion in 2003. Speaking to parliament after the vote, Amedi acknowledged the weight of what lies ahead, pledging to work alongside all three branches of government and committing to the principle of 'Iraq First'.Amedi also condemned attacks that had targeted Iraq during the US-Israel war on Iran. The election comes as Iraq is still absorbing the shockwaves of the weeks-long war, which was halted with a ceasefire announced earlier this week.Attention now turns sharply to the choice of prime minister, a far more consequential and politically explosive question. Under Iraq's sectarian power-sharing system, the prime minister must be a Shia Muslim, the parliamentary speaker a Sunni, and the president a Kurd.Amedi now has 15 days to formally task the nominee of the largest parliamentary bloc with forming a cabinet, which must then be assembled within 30 days. Amedi, 58, is a career public servant who spent decades at the heart of Iraqi political life, previously serving as a senior aide to two former presidents and as environment minister between 2022 and 2024.Iraq has gone almost 150 days without a new government since the November elections.