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Retatrutide Delivers Up to 28% Body‑Weight Reduction in Phase 3 StudyA new weight‑loss drug has helped participants in a sizable trial lose much more weight than other obesity drugs already on the market – up to an average of 28% of their body weight, Eli Lilly announced on Thursday. Phase 3 Trial Design and Dosing RegimenThe Indiana‑based company randomized 2,339 adults with obesity or overweight and at least one weight‑related comorbidity (no diabetes) to receive Retatrutide at 4 mg, 9 mg, 12 mg, or placebo for 80 weeks. The drug is a once‑weekly triple hormone receptor agonist targeting GLP‑1, GIP, and glucagon. Quantitative Outcomes and Safety ProfileAverage weight loss: 70.3 lb (28.3%) at the 12 mg dose.Average loss at 9 mg: 64.4 lb (25.9%).Average loss at 4 mg: 47.2 lb (19.0%).45.3% of 12 mg participants lost ≥30% of body weight.65.3% reduced BMI below 30; 37.5% of those starting with BMI ≥ 40 achieved this.Side‑effects increased with dose: nausea (28.6%‑42.4%), diarrhea (25.2%‑34.1%), vomiting (up to 25%).For comparison, Zepbound yields 15‑20% loss over 72 weeks and Wegovy 14‑19% over 64‑72 weeks. Implications for the Obesity‑Drug LandscapeThe magnitude of loss positions Retatrutide as the most effective pharmacologic option to date, potentially shifting prescriber preference away from existing GLP‑1 monotherapies. Its triple‑agonist mechanism adds glucagon, a hormone absent from current products, which may enhance metabolic control and appetite suppression. Future Outlook: Approval Path and Market PotentialAnalysts expect regulatory submissions within the next year, with a likely U.S. FDA review in 2027. If approved, Retatrutide could capture a sizable share of the rapidly expanding obesity‑treatment market, prompting competitors to explore multi‑agonist formulations.

The Lead: A Spring Showcase of Contrasting Pollination TacticsOn a sunny May morning along a former railway line, thousands of flowers display a startling range of pollination mechanisms—from the violent, explosive release of pollen in broom (Cytisus scoparius) to the precise, almost surgical delivery by white dead‑nettle (Lamium album) and the generous, pollinator‑free bounty of dandelions (Taraxacum officinale).Location: former railway line, May morningSpecies observed: broom, white dead‑nettle, dandelionPrimary pollinators: bumblebees, common carder beeBroom’s Explosive Pollen Release: Violence in the Keel PetalWhen a bumblebee lands on a broom flower it finds no nectar; the moment its abdomen contacts the keel petal, ten stamens and a coiled stigma burst free, slamming pollen onto the insect and delivering a “gut‑punch.” The trap is triggered in almost every flower, ensuring both pollen export and collection in a single, forceful act.Mechanism: explosive stamens and stigma releaseEffect on pollinator: brief contact, no nectar rewardOutcome: simultaneous pollen deposition and collectionWhite Dead‑Nettle’s Precise Pollen Transfer: Gentle EngineeringIn contrast, white dead‑nettle hides its stamens inside a hooded standard petal. A visiting common carder bee probes the flower’s throat for nectar; hidden stamens deposit a dab of pollen onto the bee’s thorax, which is later deposited on the next flower’s fork‑tipped stigma. The process is subtle, causing no apparent distress to the pollinator.Mechanism: concealed stamens within hooded petalPollinator interaction: gentle pollen placementResult: efficient cross‑pollination with minimal disturbanceDandelions’ Redundant Generosity: The Free Lunch for BeesDandelions produce abundant nectar and pollen but are apomictic, setting seed without fertilisation. For bumblebees the flowers are an “all‑you‑can‑eat” buffet, providing essential spring energy even though the plant does not rely on pollinators for reproduction.Reproductive strategy: apomixis (self‑seeded)Pollinator role: energy source, not required for seed setEcological benefit: supports pollinator populations during early seasonEcological Implications: Why Diverse Strategies MatterThe coexistence of violent, precise, and redundant pollination tactics illustrates the evolutionary arms race between plants and their visitors. Violent mechanisms like broom’s may deter less efficient pollinators, while gentle precision maximises pollen placement. Redundant generosity, as seen in dandelions, supports pollinator populations during scarce periods, indirectly sustaining ecosystem health.Evolutionary pressure: plant‑pollinator co‑adaptationCommunity impact: varied strategies sustain diverse pollinator assemblagesConservation insight: preserving a mix of pollination types benefits ecosystem resilienceLooking Ahead: Future Directions for Plant‑Pollinator CoevolutionAs climate change reshapes flowering phenology, the balance between these strategies could shift. Species that can both attract a wide range of pollinators and ensure successful fertilisation—whether through force, finesse, or self‑sufficiency—may gain a competitive edge, influencing future biodiversity patterns.Potential shift: altered timing of flower bloom and pollinator activityAdaptive advantage: flexible pollination mechanismsResearch focus: monitoring how climate impacts plant‑pollinator dynamics

Weekly Wildlife Roundup: Top Predator StoriesThe latest Guardian wildlife column spotlights three notable predator encounters that illustrate how large and medium‑sized carnivores are adapting to a rapidly changing environment.Leopard Lurks Near Human SettlementsA leopard was observed prowling close to a rural village, prompting both awe and concern among residents.Location: Rural community bordering protected landBehavior: Stealthy movement along forest edges, no direct conflict reportedSignificance: Highlights the thinening buffer between protected habitats and human activityFox's Fortunate Encounter Highlights Urban AdaptationA fox managed to evade a potential roadkill scenario, showcasing its agility and growing comfort in suburban settings.Incident: Narrowly escaped a busy roadway after being spotted by local observersAdaptation: Utilises garden waste and small mammals in urban green spacesImplication: Demonstrates the species' resilience and the need for safe wildlife corridors in citiesCoyote's Clever Behavior Signals Expanding RangeIn a separate observation, a coyote displayed problem‑solving skills while foraging near a suburban park.Behavior: Used a fallen branch to access a bird feederRange: Sightings are moving further north than historic recordsEcological Impact: Potential competition with native mesopredatorsWhat These Predator Movements Mean for Ecosystem ManagementCollectively, the sightings point to a broader trend of predators navigating fragmented landscapes, which raises questions for land‑use planners and conservationists.Increased human‑wildlife interactions demand proactive conflict‑mitigation measuresHabitat corridors become critical for maintaining genetic flowMonitoring programs must adapt to track both apex and mesopredators across mixed‑use zonesLooking Ahead: Conservation Priorities for Apex and MesopredatorsFuture efforts should focus on integrating community education, habitat connectivity, and data‑driven management to ensure coexistence.Promote citizen‑science reporting to fill observation gapsInvest in green infrastructure that accommodates predator movementDevelop region‑specific guidelines that balance agricultural, urban, and wildlife needs

The Lead: Japan's World Cup AmbitionsJapan have been late bloomers in terms of World Cups, only reaching the tournament for the first time in 1998 – but since then they have been at every edition. While they have never gotten past the last 16, their current crop of players is surely the most talented in the national side's history.Statement Victory: Japan's Rising International StatusJapan were the first team – outside the hosts – to qualify for the 2026 World Cup. The Samurai Blue have beaten Germany, Brazil, England and Spain since 2022. Their recent 1-0 win at Wembley against England in March, courtesy of a Kaoru Mitoma goal, sent a clear statement about their growing international prowess.Key Players: Mitoma's Absence and Kubo's PromiseJapan's preparations were dealt a blow with star player Kaoru Mitoma missing the tournament due to a hamstring injury. However, Japanese right-winger Takefusa Kubo has promised to fill the void. The 24-year-old has had a fantastic season at Real Sociedad, where he has tormented the best defences of La Liga and helped his side lift the Copa del Rey.Team Structure: Strong Backbone and Tactical FlexibilityWhile coach Hajime Moriyasu's side relish unleashing their attacking talent when possible, they can be pragmatic when needed – playing a low block and keeping things tight – and have a strong backbone. Former Arsenal defender Takehiro Tomiyasu has made the 26-man squad, despite not playing for the Samurai Blue for almost two years due to injuries. In midfield, Wataru Endo offers versatility alongside his leadership and defensive screening, while Daichi Kamada of Crystal Palace offers creativity in the middle of the park.Group Analysis: Path Through Group FJapan will surely qualify from Group F, with their opener against the Netherlands likely to be the stiffest test but also an opportunity to send a statement about their intentions. Tunisia and Sweden will probably not have enough quality to contain the Japanese, but the Blue Samurai certainly will not want to be getting complacent.Future Outlook: Breaking the Last 16 BarrierJapan may well break their last 16 hex – but the last eight will likely be as far as it goes for a side whose limitations will probably catch up with them. The psychological weight of so many last 16 exits is something the Blue Samurai will have to find a way to shrug off if they are to achieve greater success in 2026.Squad Breakdown: Key Names to KnowGoalkeepers: Zion Suzuki, Keisuke Osako, Tomoki Hayakawa.Defenders: Yuto Nagatomo, Shogo Taniguchi, Ko Itakura, Tsuyoshi Watanabe, Takehiro Tomiyasu, Hiroki Ito, Ayumu Seko, Yukinari Sugawara, Junnosuke Suzuki.Midfielders: Wataru Endo, Junya Ito, Daichi Kamada, Ritsu Doan, Ao Tanaka, Kaishu Sano, Takefusa Kubo, Yuito Suzuki.Forwards: Daizen Maeda, Koki Ogawa, Ayase Ueda, Keito Nakamura, Kento Shiogai, Keisuke Goto.

Lead: A Bold Fusion of Realism and HorrorClaire Fuller returns with Hunger and Thirst, a novel that fuses the gritty texture of social realism with the unsettling atmosphere of gothic horror. Set in 1987, the story follows Ursula, a young woman haunted by the deaths of her mother and a later, more sinister companion, while the narrative oscillates between documentary‑style observation and nightmarish spectacle.Fuller Blends Social Realism with Gothic Horror in 'Hunger and Thirst'The novel opens with Ursula’s traumatic childhood—spending two days trapped in a Moroccan bathroom by her mother’s corpse after a dengue fever death. By sixteen, she drifts through seven children’s homes before landing a postroom job at Winchester School of Art, where she meets the volatile Sue and her boyfriend Vince. Their obsession with horror films like The Shining and The Stepford Wives steers the plot toward a derelict house, the Underwood, where a seance and a reenactment of a past murder blur the line between art and atrocity. Fuller’s prose captures the “porousness” of identity, as characters literally and figuratively inhabit each other’s bodies.Publication Details and PricingPublisher: Fig TreeRelease price: £18.99Publication year: 2026Previous award: Fuller’s 2021 Costa‑winning Unsettled GroundSocial Critique of Thatcher‑Era Care System Through HorrorThe novel uses its horror framework to expose the under‑resourced British care system of the 1980s, a period when Thatcher’s government prioritized nuclear families over community support. Ursula’s movement between children’s homes and a “halfway house” populated by addicts and ex‑prisoners illustrates the systemic neglect that left many youths adrift. By juxtaposing this social critique with visceral horror, Fuller argues that the genre can convey truths about societal failure more starkly than conventional realism.Potential Legacy and Reader ReceptionFuller’s “outrageous aesthetic gamble” may set a new benchmark for literary horror that does not sacrifice social urgency. If readers and critics embrace the novel’s dual narrative—documentary‑style observation paired with gothic terror—it could inspire a wave of fiction that treats horror as a vehicle for political commentary. The book’s blend of “intense feeling” and “intimate portrayal” positions it as a contender for future literary awards and a touchstone for authors exploring the intersection of genre and social critique.

The Lead: A Bold Re‑imagining of Garland’s Final YearsThe Guardian’s review opens by noting that Drag Race star Jinkx Monsoon brings her celebrated Judy Garland impersonation to a new narrative context—a love triangle set in 1960s London. The revival of Peter Quilter’s 2005 play shifts focus from Garland’s early exploitation to her later struggles with addiction and a fraught personal life.The Production’s Narrative Twist: Love, Addiction, and Queer IconographyMonsoon’s Garland is caught between steadfast pianist Anthony (Adam Filipe) and opportunistic suitor Mickey (Jacob Dudman).The script juxtaposes private hotel scenes with public performances at Talk of the Town, highlighting the clash between fame and personal decay.Queer themes surface through Anthony’s admiration and Mickey’s homophobic contempt, underscoring Garland’s status as a queer icon.Musical Direction and Visual Design: Orchestrating EmotionMusic direction by Nick Barstow and arrangements by Leo Munby anchor the drama, with Garland’s torch songs—"Just in Time" and "You Made Me Love You"—serving as emotional pivots.Designer Jasmine Swan creates a stark white‑curtain stage, while lighting designer Prema Mehta introduces a Technicolor‑inspired transition that mirrors Garland’s cinematic legacy.Critical Reception: Performance Nuances and Structural FlawsMonsoon’s vocal performance is praised for its dynamic range, capturing both triumph and fragility.The review notes repetitive hotel scenes that, while authentic to addiction’s grind, can feel grindingly static.Supporting characters are deemed functional, serving more as narrative devices than fully fleshed personalities.Future Outlook: Potential for a One‑Woman ShowcaseThe critic suggests that Monsoon’s talent hints at a possible solo rendition of Garland’s story, which could amplify the intimate connection she already establishes with the audience. The show runs at Soho Theatre Walthamstow until 21 June, offering theatre‑goers a chance to experience this layered homage before any further developments.

English Heritage has finished a 7‑metre‑high, £1 million reconstruction of a 4,500‑year‑old Neolithic hall, called the Kusuma Neolithic Hall, near the Stonehenge visitor centre. The structure is slated to open to the public this summer and will later serve as an immersive educational hub for schools. Recreating a 4,500‑Year‑Old Neolithic Hall at Stonehenge The hall is based on the archaeological footprint of Durrington 68, a “square‑in‑the‑circle” building discovered two miles from Stonehenge. Excavations first began in 1928 by Maud Cunnington and were revisited in 2007 by the Stonehenge Riverside Project. The reconstruction features a horseshoe‑shaped ring of post holes and four massive internal roof‑support pillars, mirroring the original layout. Experimental archaeologist Luke Winter oversaw the design, using Neolithic carpentry studies and pollen data to ensure authenticity. Every timber was shaped with replica stone tools, and the frame was aligned with the winter solstice – the shadow of the central post falls precisely on the midsummer sunrise. £1 Million Investment and Volunteer Workforce Cost: £1 million Construction period: nine months Volunteer involvement: >100 volunteers contributed hand‑crafted timber work Opening: Summer 2026 Future educational capacity: aim to serve nearly 100,000 students annually by 2031 Educational and Cultural Impact on Heritage Tourism The hall forms the first phase of English Heritage’s broader educational expansion, which will also include the Clore Discovery Lab and Weston Learning Studio, scheduled for completion by the end of 2026. By offering a free, hands‑on experience – from making prehistoric cheese to shaping pottery – the project is expected to boost visitor numbers and deepen public engagement with Neolithic heritage. Curator Win Scutt emphasizes that the reconstruction highlights the communal spirit of Neolithic societies, providing a tangible illustration of how ancient peoples built collective monuments as expressions of social identity. Future Role in Neolithic Research and Learning Beyond tourism, the hall serves as a living laboratory for researchers. The experimental construction process has already shifted expert confidence from a 50 % to a 75 % likelihood that the original Durrington 68 structure was roofed. Ongoing studies will use the hall to test hypotheses about building techniques, seasonal alignments, and social organization. As the site opens to schools, it will become a model for immersive archaeology, potentially inspiring similar reconstructions across the United Kingdom and informing curriculum development for the national education programme on the Neolithic period.

Gaël Monfils turned Court Philippe‑Chatrier into a celebration arena on Thursday, teaming with his wife Elina Svitolina to win a star‑studded exhibition titled “Gael & Friends.” The night blended tennis, music and heartfelt tributes as the French favorite prepared for his final French Open appearance.The Celebration Match on Court Philippe‑ChatrierThe event featured a line‑up of current and former champions, including Novak Djokovic, Jannik Sinner, Alexander Zverev, Stefanos Tsitsipas, Naomi Osaka, Maria Sakkari and rising American Iva Jovic. Former Davis Cup teammates Jo‑Wilfried Tsonga and Richard Gasquet added nostalgic moments, while Monfils and Svitolina capped the night by clinching the exhibition.Numbers Behind the Night: Titles, Appearances, and Age13 ATP titles won over his career.39 years old at the time of the farewell.19th main‑draw appearance at Roland Garros.Two‑decade professional journey, highlighted by a 2008 semifinal run.Key contributions to France’s Davis Cup finals in 2010 and 2014.Why Monfils’ Farewell Resonates Across French TennisMonfils’ charisma has long made him a crowd‑puller, and his willingness to blend entertainment with sport created a unique bond with French fans. The exhibition underscored his role as a cultural ambassador for tennis in France, reinforcing the sport’s popularity beyond pure competition.Looking Ahead: Monfils’ Legacy and French Tennis FutureWhile a Grand Slam title eluded him, Monfils leaves a legacy of showmanship and perseverance that younger French players can emulate. His final match against compatriot Hugo Gaston in the first round will be watched as a symbolic passing of the torch to the next generation.

The LeadA friend of mine was recently left in tears after filling up the car she relies on to drive to work. Thanks to the US-Israeli attacks on Iran, prices at the pumps have soared. She wasn't sure how her family was going to make it to the next paycheck.It is a personal story and a distressing one, but the big picture is truly obscene. Fossil fuel companies are raking in monstrous, unearned war profits taken from the pockets of people like you, me, my friend, and any of us who fills up a vehicle or pays an energy bill.The War-Profits Bonanza$30m an hour: that's the pure, unearned profits banked by the world's top 100 oil and gas companies in the first month of the conflict in Iran, purely due to the spike in the oil price. Now the first numbers are in, and that $30m may have been a major underestimate.Shell's profit for the first three months of 2026 more than doubled to $6.9bn, as did BP's, to $3.2bn. TotalEnergies profits also surged by more than 50%, up to $5.8bn. Even in the Gulf itself, where the flow of oil through the strait of Hormuz has been heavily restricted, some companies have still flourished. Aramco, the state oil company of Saudi Arabia, saw its profits soar by 26% to $33.6bn in the first quarter.The Financial Impact on ConsumersThose four companies alone, benefiting not just from the oil price hike but also bumper oil-trading profits, made $23m an hour for the whole of January, February and March. And the Iran conflict only started on 28 February.To get some idea of the scale of this, imagine I gave you $6,200. What would you do? Pay off a loan? Book a fancy holiday? A second later, I give you another $6,200; then again, for hours, weeks and months. That is the rate of profit of just those four companies.There is plenty more to come for the industry. Oil and gas supplies will take months to return to prewar levels, and reserves are getting dangerously low. Even if the oil price remains at today's level of about $100 a barrel, those 100 companies will make $234bn by the end of the year. Remember, the companies, and petrostates such as Russia, have done no extra work for this, just ridden a soaring oil price. Also remember, you are paying for this. Where I live in the UK, household energy bills are about to jump by £209 ($280) a year for the average home.The Industry's Climate ObstructionThe profits are extreme, but not new: big oil and gas has been wildly profitable for decades. It has made an average $1tn a year in pure profit for about 50 years. The fossil fuel sector also benefits from explicit subsidies that totalled $1.3tn in 2022, according to the International Monetary Fund.These riches have funded the lobbying and campaigns that block climate action and have done so for years, long after the science became crystal clear. As an example of the consequences, the UK's official climate advisers said on Tuesday that all care homes and hospitals will need air conditioning within the coming 10 years, to stop the heat killing people.The Green Transition AccelerationBut here's that silver lining I promised: these peak profits contain the seeds of their own downfall. Sky-high fossil fuel prices are pushing people, companies and nations to supercharge their rush towards green power for the simple reason that it is now cheaper and more reliable. Solar power does not need to transit through the strait of Hormuz, as Bill McKibben has observed.The numbers on the surge in renewable energy deployment, already exponential, are not yet in, but they will almost certainly be huge. Green funds are already attracting billions of dollars in new investments and one consultancy estimates that an oil price of $100 a barrel will drive $4tn of extra green investment by 2030.Big oil remains a formidable political force but, on the ground, people are already voting with their feet. Sales of new electric cars in the UK leapt by 59% in April, for example. The pain and anger of today's energy crisis may yet become a critical turning point in confronting the climate crisis.