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Retatrutide Delivers Up to 28% Body‑Weight Reduction in Phase 3 StudyA new weight‑loss drug has helped participants in a sizable trial lose much more weight than other obesity drugs already on the market – up to an average of 28% of their body weight, Eli Lilly announced on Thursday. Phase 3 Trial Design and Dosing RegimenThe Indiana‑based company randomized 2,339 adults with obesity or overweight and at least one weight‑related comorbidity (no diabetes) to receive Retatrutide at 4 mg, 9 mg, 12 mg, or placebo for 80 weeks. The drug is a once‑weekly triple hormone receptor agonist targeting GLP‑1, GIP, and glucagon. Quantitative Outcomes and Safety ProfileAverage weight loss: 70.3 lb (28.3%) at the 12 mg dose.Average loss at 9 mg: 64.4 lb (25.9%).Average loss at 4 mg: 47.2 lb (19.0%).45.3% of 12 mg participants lost ≥30% of body weight.65.3% reduced BMI below 30; 37.5% of those starting with BMI ≥ 40 achieved this.Side‑effects increased with dose: nausea (28.6%‑42.4%), diarrhea (25.2%‑34.1%), vomiting (up to 25%).For comparison, Zepbound yields 15‑20% loss over 72 weeks and Wegovy 14‑19% over 64‑72 weeks. Implications for the Obesity‑Drug LandscapeThe magnitude of loss positions Retatrutide as the most effective pharmacologic option to date, potentially shifting prescriber preference away from existing GLP‑1 monotherapies. Its triple‑agonist mechanism adds glucagon, a hormone absent from current products, which may enhance metabolic control and appetite suppression. Future Outlook: Approval Path and Market PotentialAnalysts expect regulatory submissions within the next year, with a likely U.S. FDA review in 2027. If approved, Retatrutide could capture a sizable share of the rapidly expanding obesity‑treatment market, prompting competitors to explore multi‑agonist formulations.

Lead: A Bold Fusion of Realism and HorrorClaire Fuller returns with Hunger and Thirst, a novel that fuses the gritty texture of social realism with the unsettling atmosphere of gothic horror. Set in 1987, the story follows Ursula, a young woman haunted by the deaths of her mother and a later, more sinister companion, while the narrative oscillates between documentary‑style observation and nightmarish spectacle.Fuller Blends Social Realism with Gothic Horror in 'Hunger and Thirst'The novel opens with Ursula’s traumatic childhood—spending two days trapped in a Moroccan bathroom by her mother’s corpse after a dengue fever death. By sixteen, she drifts through seven children’s homes before landing a postroom job at Winchester School of Art, where she meets the volatile Sue and her boyfriend Vince. Their obsession with horror films like The Shining and The Stepford Wives steers the plot toward a derelict house, the Underwood, where a seance and a reenactment of a past murder blur the line between art and atrocity. Fuller’s prose captures the “porousness” of identity, as characters literally and figuratively inhabit each other’s bodies.Publication Details and PricingPublisher: Fig TreeRelease price: £18.99Publication year: 2026Previous award: Fuller’s 2021 Costa‑winning Unsettled GroundSocial Critique of Thatcher‑Era Care System Through HorrorThe novel uses its horror framework to expose the under‑resourced British care system of the 1980s, a period when Thatcher’s government prioritized nuclear families over community support. Ursula’s movement between children’s homes and a “halfway house” populated by addicts and ex‑prisoners illustrates the systemic neglect that left many youths adrift. By juxtaposing this social critique with visceral horror, Fuller argues that the genre can convey truths about societal failure more starkly than conventional realism.Potential Legacy and Reader ReceptionFuller’s “outrageous aesthetic gamble” may set a new benchmark for literary horror that does not sacrifice social urgency. If readers and critics embrace the novel’s dual narrative—documentary‑style observation paired with gothic terror—it could inspire a wave of fiction that treats horror as a vehicle for political commentary. The book’s blend of “intense feeling” and “intimate portrayal” positions it as a contender for future literary awards and a touchstone for authors exploring the intersection of genre and social critique.

Lead: War Day 84 Marks a Shift Toward DiplomacyThe conflict between Iran and the United States entered its 84th day with renewed diplomatic activity. Both sides are exchanging draft proposals, and US Secretary of State Marco Rubio highlighted "some good signs" while President Donald Trump warned of "very drastic" action if Tehran refuses to relinquish its uranium stockpiles.Mediated Negotiations Gain MomentumPakistani officials are conducting "intense mediation activity" in Tehran, according to Al Jazeera correspondent Almigdad Alruhaid. Senior Iranian sources say negotiators are close to a draft framework, though others caution that a final agreement remains premature.Pakistani mediation is accelerating to prevent further escalation.US‑Iran red‑line shift: Cato Institute senior fellow Doug Bandow stresses the need for both parties to move beyond entrenched nuclear red lines.Key Figures and Financial Stakes7,200 civilians rescued from rubble by the Iranian Red Crescent.More than two dozen MQ‑9 Reaper drones destroyed, losses estimated at $1 bn (≈20% of pre‑war inventory).At least 42 US aircraft damaged or destroyed, total losses near $2.6 bn.US has paused a $14 bn arms sale to Taiwan to preserve munitions for the Iran campaign.Regional and Military ImplicationsCentcom reports the USS Abraham Lincoln strike group remains at "peak readiness" in the Arabian Sea, signaling continued pressure despite diplomatic overtures. Meanwhile, Israeli strikes in southern Lebanon and new US sanctions on Hezbollah allies heighten the risk of a broader regional flare‑up.Outlook for a Potential DealIf the current draft proposals survive scrutiny, a diplomatic settlement could emerge within weeks, easing military pressure and opening pathways for humanitarian aid. However, the dual track of high‑cost equipment losses and political warnings from both Washington and Tehran suggests that any agreement will require substantial concessions on nuclear constraints and future US military commitments in the region.

The LeadIn the stolid world of German football, few moments have been as seismic as Bayer Uerdingen's 2-1 victory over Bayern Munich in the 1985 German Cup final. This giant-killing act, now celebrated as the 'Miracle of Berlin,' represented a rare inversion of the natural order in a nation dominated by football's traditional powerhouses.The Historic UpsetOn May 26, 1985, at Berlin's Olympic Stadium, Uerdingen—then a modest club from Krefeld with a population of around 300,000—defeated the seven-time cup holders Bayern Munich. The Bavarians, who had also won three consecutive European Cups between 1974-1976, were considered football aristocracy. Horst Feilzer and Wolfgang Schäfer scored for Uerdingen, while Dieter Hoeness netted Bayern's only goal. The victory was particularly significant as it was the first time the DFB-Pokal final had been staged in the former German capital.Under coach Kalli Feldkamp and chairman Arno Eschler, Uerdingen had only been promoted to the Bundesliga a couple of years earlier. Their team was devoid of household names, featuring the Funkel brothers (Friedhelm and Wolfgang) in midfield, while Bayern boasted stars like a young Lothar Matthäus and Klaus Augenthaler.The Rise and FallThe cup victory was not a one-off for Uerdingen. The following season, they reached the European Cup-Winners' Cup semi-finals, with their quarter-final tie against East Germany's Dynamo Dresden becoming club lore as the 'Miracle of the Grotenburg' after an improbable second-leg comeback. That match attracted 18 million television viewers, and the club finished third in the Bundesliga in the season after their cup triumph.Despite this brief period of success, Uerdingen's star faded. The club, backed by chemicals giant Bayer AG, could not sustain their upward trajectory. Today, they remain a distant memory in German football, their moment of glory a footnote in the sport's history.The LegacyUerdingen's victory remains one of the greatest cup shocks in German football history. It demonstrated that even in a sport dominated by established powerhouses, underdogs could occasionally triumph. As chairman Arno Eschler famously hoped after the victory: 'Ich hoffe dass dies keine einmmailie' [I hope this is not a one-off]. While Uerdingen couldn't build on their success, their 'Miracle of Berlin' continues to be celebrated as one of football's great fairy tales.

The LeadA friend of mine was recently left in tears after filling up the car she relies on to drive to work. Thanks to the US-Israeli attacks on Iran, prices at the pumps have soared. She wasn't sure how her family was going to make it to the next paycheck.It is a personal story and a distressing one, but the big picture is truly obscene. Fossil fuel companies are raking in monstrous, unearned war profits taken from the pockets of people like you, me, my friend, and any of us who fills up a vehicle or pays an energy bill.The War-Profits Bonanza$30m an hour: that's the pure, unearned profits banked by the world's top 100 oil and gas companies in the first month of the conflict in Iran, purely due to the spike in the oil price. Now the first numbers are in, and that $30m may have been a major underestimate.Shell's profit for the first three months of 2026 more than doubled to $6.9bn, as did BP's, to $3.2bn. TotalEnergies profits also surged by more than 50%, up to $5.8bn. Even in the Gulf itself, where the flow of oil through the strait of Hormuz has been heavily restricted, some companies have still flourished. Aramco, the state oil company of Saudi Arabia, saw its profits soar by 26% to $33.6bn in the first quarter.The Financial Impact on ConsumersThose four companies alone, benefiting not just from the oil price hike but also bumper oil-trading profits, made $23m an hour for the whole of January, February and March. And the Iran conflict only started on 28 February.To get some idea of the scale of this, imagine I gave you $6,200. What would you do? Pay off a loan? Book a fancy holiday? A second later, I give you another $6,200; then again, for hours, weeks and months. That is the rate of profit of just those four companies.There is plenty more to come for the industry. Oil and gas supplies will take months to return to prewar levels, and reserves are getting dangerously low. Even if the oil price remains at today's level of about $100 a barrel, those 100 companies will make $234bn by the end of the year. Remember, the companies, and petrostates such as Russia, have done no extra work for this, just ridden a soaring oil price. Also remember, you are paying for this. Where I live in the UK, household energy bills are about to jump by £209 ($280) a year for the average home.The Industry's Climate ObstructionThe profits are extreme, but not new: big oil and gas has been wildly profitable for decades. It has made an average $1tn a year in pure profit for about 50 years. The fossil fuel sector also benefits from explicit subsidies that totalled $1.3tn in 2022, according to the International Monetary Fund.These riches have funded the lobbying and campaigns that block climate action and have done so for years, long after the science became crystal clear. As an example of the consequences, the UK's official climate advisers said on Tuesday that all care homes and hospitals will need air conditioning within the coming 10 years, to stop the heat killing people.The Green Transition AccelerationBut here's that silver lining I promised: these peak profits contain the seeds of their own downfall. Sky-high fossil fuel prices are pushing people, companies and nations to supercharge their rush towards green power for the simple reason that it is now cheaper and more reliable. Solar power does not need to transit through the strait of Hormuz, as Bill McKibben has observed.The numbers on the surge in renewable energy deployment, already exponential, are not yet in, but they will almost certainly be huge. Green funds are already attracting billions of dollars in new investments and one consultancy estimates that an oil price of $100 a barrel will drive $4tn of extra green investment by 2030.Big oil remains a formidable political force but, on the ground, people are already voting with their feet. Sales of new electric cars in the UK leapt by 59% in April, for example. The pain and anger of today's energy crisis may yet become a critical turning point in confronting the climate crisis.

Meta has reached a confidential settlement with Breathitt County Schools in Kentucky, ending a lawsuit that alleged the company’s social networks are engineered to be addictive and cause mental‑health harm to students.Meta Settles Kentucky School District Lawsuit Over Alleged Addiction DesignThe settlement was announced less than three weeks before the case was set to go to trial in federal court in California. While the exact terms were not disclosed, Meta emphasized its ongoing work on safety tools such as Teen Accounts and parental controls.Financial Stakes and Settlement LandscapeThe Kentucky district originally sought more than $60 million to cover mental‑health services and a 15‑year remediation program.Meta’s settlement follows similar agreements by TikTok and Snap with the same group of roughly 1,200 school districts.Recent jury verdicts ordered Meta and YouTube to pay $6 million in damages and Meta to pay $375 million in civil penalties for related claims.Implications for Social Media Regulation and Child SafetyThe case adds pressure on the industry to redesign features such as infinite scrolling and autoplay video, which plaintiffs argue are deliberately addictive. Lawmakers and advocacy groups are citing these lawsuits as evidence that existing self‑regulation is insufficient, potentially accelerating federal or state legislation aimed at protecting minors online.Future Legal Battles and Industry OutlookAttorneys for the remaining school districts say they will continue pursuing justice, with another 1,200 districts still in litigation. Upcoming trials include an individual case in California and a Tennessee attorney‑general suit slated for July, while a federal case by the Tucson Unified School District is scheduled for January 2027. The outcomes of these cases will likely shape the next wave of social‑media liability and could force broader industry changes.

Police Expand Probe into Prince Andrew's Alleged MisconductThames Valley Police (TVP) announced that their “unprecedented investigation” into Prince Andrew, 66 now covers a wide range of possible offences – from sexual misconduct to fraud and the illegal sharing of confidential information. The force is urging witnesses to contact them via the official online portal with any relevant details. Scope, Timeline and Key Evidence GapsFebruary 2026 – Prince Andrew arrested and questioned under criminal caution on suspicion of misconduct in public office (MIPO) linked to his role as a British trade envoy.Investigators are seeking original US Department of Justice documents that reference alleged information sharing with Jeffrey Epstein. Only printed extracts have been obtained so far.TVP is reviewing a claim from a US‑based woman who says she was taken to Windsor in 2010 for sexual purposes; the police have contacted her lawyer but have not opened a full criminal investigation.Three other UK forces are conducting separate criminal inquiries stemming from the same Epstein files, while the Metropolitan Police declined to open its own probe. Potential Political and Institutional RepercussionsThe investigation touches several sensitive arenas: the credibility of the royal household, the legal definition of MIPO for a trade envoy, and the UK’s cooperation with US authorities on high‑profile financial crimes. If evidence confirms that the prince used his diplomatic position to pass confidential information, it could trigger a constitutional debate over the limits of royal privilege and the Crown’s role in public office. What the Next Months May Hold for the InquiryPolice expect the probe to extend well into 2027, contingent on obtaining the original Epstein documents and completing forensic analysis of seized material from the prince’s Norfolk and Windsor residences. Formal discussions with the Crown Prosecution Service are already underway, suggesting that charges could be considered once the evidentiary threshold is met. Meanwhile, the appeal for public tips aims to fill information gaps that could accelerate the timeline.

The LeadAt this time of year a sinister-looking substance can often be sighted around Britain's coast: a frothy foam piled up along the shoreline or appearing in long ribbons offshore. People sometimes assume this foam is the result of pollution or sewage dumping. In fact it is a common natural phenomenon produced by a combination of algae and weather.The Science Behind Sea FoamSea algae start to grow in April as conditions warm. The most common sort, phaeocystis, is not toxic and forms part of the marine food chain. When the algal bloom dies it leaves a brown scum of organic material with surfactant properties, which, like soap, lowers the surface tension of the water.Formation of Coastal FoamThese natural surfactants create foam when the water is disturbed. Breaking waves churn up the water and produce yellowish-brown foam along the shoreline. This may be so abundant that fragments blow about like thistledown.Wind Patterns and Foam LinesWind blowing over the sea creates rotating horizontal cylinders of water, like submerged rolling pins. These rotating currents, known as Langmuir circulation, push water downward at one point and up in another. Sea foam gathers in long parallel lines in the calm sections, known as windrows, foam lines, or drift lines.Understanding the Appearance and SmellSea foam may look unnatural, as well as unsightly, and it sometimes smells foul. But it is generally natural and harmless.

The Lead The Royal Exchange's 50th anniversary season production, 'Even These Things', is a bold attempt to encapsulate the complex history of Manchester. The play explores themes of identity, community, and belonging through three seemingly unrelated scenes. MAPPING MANCHESTER'S HISTORY The play is built from three scenes, each set in a different time period. The first scene is set in 1846 and features a heavily pregnant Irish immigrant, Annie Donovan, who brushes shoulders with Friedrich Engels on her way to a fist fight. The second scene is set in 1996 and describes the city-centre life of an ordinary Saturday, with a community cast playing out whimsical vignettes. The final scene takes place after the IRA bomb outside the Arndale Centre and features a tender exchange between two strangers of Irish heritage. THE POWER OF COMMUNITY The play's cumulative meaning may be tricky to grasp, but as the scenes rub up against each other, what emerges is a thoughtful, rich and complex picture of home. The connections between the scenes are elliptical, but they ultimately reveal a city with a shared history and a strong sense of community. THE FUTURE OF MANCHESTER The play suggests that, however difficult, a future is possible. The final scene's chat about miscarriage and childbirth between two strangers of Irish heritage meeting in the park some months after the attack on an Ariana Grande concert brought the city together, implies that the city can heal and move forward. CONCLUSION 'Even These Things' is a bold and ambitious production that successfully maps Manchester's complex history. The play's themes of identity, community, and belonging are timely and thought-provoking, making it a must-see for anyone interested in theatre and the city of Manchester.