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President Donald Trump escalated rhetoric on Thursday, stating that the United States has yet to begin a full‑scale campaign against Iran’s remaining infrastructure and hinting that bridges and electric power plants could be next targets. The comment followed the release of video showing a U.S. strike on the newly completed B1 bridge that connects Tehran to Karaj, an attack that Iran reports killed eight people and injured 95. Iranian Foreign Minister Abbas Araghchi condemned the strike on civilian infrastructure, describing it as evidence of the “defeat and moral collapse” of the aggressor. In a statement posted on X, he warned that such attacks would not force Iran to surrender. The conflict, now entering its fifth week, has begun to ripple through regional and global markets. Instability around the Strait of Hormuz—a vital conduit for oil and gas—has prompted nations to scramble for alternative shipping routes. Satellite images this week captured smoke over Iran’s Qeshm Island, underscoring the heightened risk to infrastructure near the strategic waterway. Amid stalled negotiations with Iran’s new leadership, Trump’s intensified language comes as the United Nations Security Council prepares to vote on a resolution that could authorize member states to use “defensive means” to keep the strait open. Araghchi warned that any provocative action in the Council would only worsen the situation. Iranian media have begun listing potential retaliation targets, naming major bridges in Kuwait, Saudi Arabia, the United Arab Emirates and Jordan as possible future strike points. The semi‑official Fars News Agency highlighted these crossings as vulnerable following the Karaj bridge attack. The Islamic Revolutionary Guard Corps (IRGC) claimed responsibility for recent strikes on U.S.-linked industrial sites in the Gulf, including steel facilities in Abu Dhabi and aluminium plants in Bahrain. The IRGC warned that if attacks on Iranian industries continue, “the next response will be much more painful” and will focus on the occupier’s core infrastructure. Health infrastructure has also suffered. Iran’s Health Ministry reported that U.S. and Israeli raids severely damaged the Pasteur Institute of Iran, a key research center for diseases such as cholera and COVID‑19. Ministry spokesperson Hossein Kermanpour called the strike “a direct assault on international health security.” WHO Director‑General Tedros Adhanom Ghebreyesus echoed the condemnation, noting that the institute is now unable to deliver health services. The WHO has documented more than 20 attacks on Iranian healthcare facilities since the start of March. In a separate claim, Iranian officials said air defenses downed a second U.S. F‑35 fighter jet over central Iran, suggesting the pilot’s survival was unlikely. The United States has not responded to the allegation. Israel’s military reported a fresh barrage of Iranian missiles, which triggered air‑defence alerts and caused damage to homes, vehicles, and a train station in Tel Aviv. The widening hostilities, combined with threats to critical energy and health infrastructure, highlight the growing regional volatility and its potential to disrupt global markets.

President Donald Trump has taken a significant step to push for pharmaceutical deals by signing an executive order that could impose tariffs of up to 100% on some patented drugs. This move is part of his administration's effort to secure lower prices for medicines.Under the executive order, companies that have signed a 'most favoured nation' pricing deal and are actively building facilities in the US will have a zero-percent tariff. For those that don't have a pricing deal but are building such projects in the US, a 20 percent tariff will apply, but it will increase to 100 percent in four years.A senior administration official stated that companies still have months to negotiate before the 100 percent tariffs kick in. Bigger companies will have 120 days, and 180 days are offered for everyone else.The administration has already reached 17 pricing deals with major drugmakers, 13 of which have signed. The executive order aims to address the threatened impairment of national security posed by imports of pharmaceuticals and pharmaceutical ingredients.Critics, pharmaceutical leaders, and medical groups have warned of the consequences the new tariffs could bring, including increased costs and potential jeopardy to billions in US investments. The pharmaceutical company trade group PhRMA has expressed concerns that taxes on cutting-edge medicines will increase costs and could jeopardize investments.

In a scene reminiscent of Henry James’s observation that the only certainty with a young American abroad is surprise, the current US president continues to bewilder European partners with erratic statements.President Trump has publicly ridiculed British Prime Minister Keir Starmer and the Royal Navy as feeble, mocked French President Emmanuel Macron over personal matters, urged allies to secure their own oil supplies, and declared that withdrawing the United States from NATO is "beyond reconsideration". These comments come as the conflict in Iran, ignited by Trump and Israeli Prime Minister Benjamin Netanyahu, drags on without a clear resolution, fueling his domestic political anxieties.European officials responded not with shock but with weary irritation, noting that Trump’s unpredictability is now a permanent feature of US policy, steering the continent away from the liberal international order. Analysts warn that NATO’s credibility is eroding, turning the alliance into a "paper tiger" even as Russian President Vladimir Putin watches closely.Britain, hoping to serve as a diplomatic conduit between Washington and Brussels, finds its position increasingly precarious. Post‑Brexit economic vulnerabilities and the looming state visit of King Charles to the United States offer little strategic gain and risk becoming a diplomatic embarrassment.Prime Minister Starmer has deliberately avoided direct confrontation with Trump, instead pledging to deepen the United Kingdom’s economic and security ties with the European Union. This shift aims to reassure Labour factions leaning toward the Liberal Democrats and Greens, while also hoping that shared security concerns will coax European capitals into offering more robust economic support.In a world where traditional alliances are fraying, European leaders face mounting pressure to forge genuine security cooperation rather than merely increasing defence spending. The consensus is clear: delay is no longer an option for Europe to secure its own future.

Several ships have successfully navigated the Strait of Hormuz, a vital waterway that has been effectively closed since the start of the war in Iran. The development comes as shipping companies and international leaders work to ensure the passage of critical cargo, including oil and gas supplies that account for about a fifth of the world’s total. A French container ship owned by CMA CGM, the CMA CGM Kribi, which sails under the flag of Malta, is reported to have passed through the strait with cargo. This marks a significant development as it is believed to be the first ship owned by a western shipping line to make the journey. The blockade has led to increased oil and gas prices globally and growing concerns about food security, as a third of the global trade in raw materials for fertiliser normally passes through the strait. International leaders are expected to meet next week to discuss possible solutions, including clearing sea mines and rescuing trapped ships. The UK’s Foreign Secretary, Yvette Cooper, has stated that coordinated action is needed to pressure Iran into reopening the strait. The US President, Donald Trump, has claimed that the US could “easily” open up the strait but that it would require “a little more time”.

The UK’s premier AI research centre, the Alan Turing Institute, has been instructed by its chief public funder, UK Research and Innovation (UKRI), to implement significant organisational changes. The directive follows a UKRI review that found the institute’s strategic alignment and value for money "not yet satisfactory".UKRI, which granted the institute a £100 million, five‑year funding package in 2024 and remains its largest single source of finance, said the review highlighted strong scientific foundations but a lack of clear strategic focus and delivery.Last summer, the government signalled that the institute must undergo a strategic overhaul, urging a shift toward defence and national security while downgrading work on health and the environment—previously two of its three core pillars.Leadership turbulence has accelerated the changes. Chief Executive Jean Innes resigned in September after staff unrest, and chair Doug Gurr stepped down this week to take up a permanent role at the UK competition watchdog.UKRI’s AI programme overseer, Prof. Charlotte Deane, stressed that achieving the UK’s AI ambitions requires institutions that are “focused, effective and aligned to national need.” She added that the review recognises the institute’s value but calls for significant change in several areas.To execute the recommendations, UKRI will work with the institute’s newly appointed chief executive, George Williamson, who comes from a government post centred on national security. The plan includes strengthening governance and placing defence and security at the core of the institute’s mission.The Alan Turing Institute collaborates with universities, private firms and government bodies, while UKRI invests £8 billion annually in UK research and innovation. A spokesperson for the institute acknowledged recent improvements in focus and governance but said it must move “faster and further.”“Working with funders and partners, we will be even more ambitious about the role we can play for the UK, and we welcome the confirmation of our clear, single‑purpose mission with national resilience, security and defence at its core,” the institute said.

The ongoing conflict in the Middle East has significant implications for the UK, particularly in the energy sector. Some have called for the North Sea to be exploited for its remaining oil and gas reserves, citing energy security concerns. However, the climate crisis demands immediate action to reduce greenhouse gas emissions, making it crucial to prioritize renewable energy sources.The North Sea basin is past peak production, with only limited amounts of oil and gas remaining. Moreover, the UK is struggling to meet its 2030 emissions reduction target of 68% compared to 1990 levels and is off track to achieve net zero emissions by 2050. Any revival of homegrown fossil fuel usage would undermine these efforts.The reality of the climate crisis is worsening, with record-breaking heat across the US and devastating floods in Hawaii, northern Australia, and the Gulf states. The UK has also experienced record winter rainfall and the warmest February on record in England and Wales.The article emphasizes that the world is on course to exceed the 1.5C dangerous climate change threshold within the next three years, coinciding with key climate tipping points, such as the melting of the Greenland and West Antarctic ice sheets. The rate of global heating has accelerated since 2015, and without drastic action, the 2C limit will be shattered by the late 2030s.In conclusion, the government must hold its nerve and prioritize climate action by leaving North Sea oil and gas in the ground, rather than doubling down on fossil fuel exploitation. This approach will help reduce emissions, promote renewable energy, and mitigate the worst effects of the climate crisis.

Marks & Spencer has formally urged the UK government and London’s mayor to intensify efforts against retail crime, describing the problem as “more brazen, more organised and more aggressive” following a noticeable surge in shoplifting and violent incidents at its stores.Chief executive Stuart Machin addressed a letter to Home Secretary Shabana Mahmood, while retail director Thinus Keeve wrote to Mayor Sadiq Khan, both demanding additional police resources to target repeat offenders and crime hotspots.Keeve detailed recent attacks on the M&S website, noting that “in the past week alone we have had gangs forcing open locked cabinets, stripping shelves, two men emptying steak displays, a large group ransacking a store and assaulting a security guard, a colleague head‑butted while trying to defuse a situation, and another hospitalised after ammonia was thrown in their face.”He warned that the situation is “worse in London, but it is happening across the country, and it is becoming routine, because it seems there are no consequences.”Police responded to reports of antisocial behaviour in Clapham, south London, where “several hundred young people” gathered after coordinating via TikTok and Snapchat. About 100 officers were deployed, fires were lit on Clapham Common and fireworks set off, and six teenage girls were arrested for incidents “fuelled by online trends”. Five people, including four officers, were assaulted.Mayor Khan condemned the Clapham events as “utterly unacceptable”, pledging that “the culprits will face the full force of the law” and that police are working with social‑media platforms to curb viral content that encourages theft and violence.According to Keeve, the UK recorded roughly 5.5 million shoplifting incidents last year, not counting the “vast number that go unreported”. He added that “every day, more than 1,600 retail workers face violence or abuse,” characterising the trend as systemic and worsening.External affairs head Adam Hawksbee told BBC Radio 4’s Today programme that the rise in retail crime is affecting staff morale, with employees “worried about coming into work and nervous about the journey home.”Office for National Statistics data show that shoplifting offences in England and Wales rose to 519,381 in the year to September 2025, a 5% increase from the previous year’s 492,660, and remain just below the record 530,439 offences recorded in the year to March 2025.Keeve concluded that “without a government seriously cracking down on crime and a mayor that prioritises effective policing we are powerless. We need a stronger, faster and more consistent police response, using tools that already exist to target repeat offenders and crime hotspots, and far greater transparency on crime so the true scale and impact is understood.”

The blockade of the Strait of Hormuz has raised concerns about a potential global food crisis due to its impact on fertiliser supplies. The strait is a critical passage for 20% of global natural gas shipments and a third of the global trade in raw materials for fertiliser.The head of the International Rescue Committee, David Miliband, has warned that the situation is a 'food security timebomb', with the window to avert a massive global hunger crisis rapidly closing.Fertiliser prices have already risen by more than 60% in Egypt, reaching $780 (£586) a tonne, up from about $484 in late February. The Qatar Fertiliser Company (QAFCO), the world's largest single site for urea exports, has been offline for almost a month.The Middle East is the source of about 45% of the global trade in sulphur, a key raw material for fertiliser manufacture. Iran is the fourth-largest global exporter of urea, the most widely used nitrogen fertiliser.A prolonged transport shutdown could disrupt production and increase costs, leading to higher food prices and exacerbating global hunger. The world's poorest countries are among the most vulnerable to fertiliser price rises.

At least 43 civilians were killed and 44 houses set ablaze during an assault by the Allied Democratic Forces (ADF) in Bafwakoa, located in Mambasa territory of Ituri province, according to the Congolese army.Lieutenant Jules Tshikudi Ngongo, the army’s regional spokesperson, said the attack occurred on Thursday and that the death toll could rise as search operations continue.The ADF, a rebel outfit that pledged allegiance to ISIL, has been increasingly targeting civilians in Ituri and the neighboring North Kivu province, despite joint Congolese‑Ugandan military campaigns launched in 2021.Witnesses reported that victims were killed with machetes, some perished in house fires, and two individuals were abducted, according to local customary official Christian Alimasi.The incident underscores the army’s difficulty in containing the ADF, which operates alongside other insurgent groups such as the Rwandan‑backed M23, responsible for seizing the major eastern city of Goma last year.Data from research firm Insecurity Insight indicates the ADF accounted for roughly 25% of civilian‑targeted violence in eastern DRC between 2020 and 2025, reflecting its significant presence in the region.Last year, the ADF’s attacks resulted in 66 deaths and multiple abductions, signalling a troubling escalation in its campaign against local populations.