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The Lead Crystal Palace and Shakhtar Donetsk prepare to face off in the first leg of the Europa Conference League semi-final, with both teams having compelling stories to tell in this European competition. The match takes place in Krakow with kickoff scheduled for 8pm BST. The Teams' European Journeys Crystal Palace, who took 120 years to win their first major trophy, are seeking to make it "two in two" under Oliver Glasner in his final weeks at the club. They advanced to the semi-finals with a 3-0 win at home against Fiorentina in the first quarter-final leg, followed by a 2-1 loss in the second. Shakhtar Donetsk, led by former Atlético Madrid and Turkey midfielder Arda Turan, are on course for a league title in their manager's first season. The Ukrainian club is eyeing their second European trophy, having won the Uefa Cup in 2009 before the Europa League rebrand. They reached the last four with a 5-2 aggregate victory over AZ Alkmaar. The Ukrainian Club's Resilience Shakhtar's European campaign has been remarkable given the circumstances. All of their "home" Conference League matches this season have been played at the Henryk Reyman Municipal Stadium in Poland due to the ongoing conflict in Ukraine. The club has shown remarkable resilience, having lost most foreign players after special FIFA regulations allowed them to leave for free following Russia's full-scale invasion in 2022. "There is war in Ukraine and yet people live their lives," said Turan. "Every day shows that this nation never gives up." The Road to the Final The winner of this tie will face either Nottingham Forest or Aston Villa in the Europa Conference League final. Shakhtar reached the last four of the Europa League in 2016 and 2020 before the 2022 invasion changed everything for the club.

The Journey from Prototype to ClearanceBuilding a medical device is fundamentally different from standard software development. This week on Build Mode, host Isabelle Johannessen sat down with Robhy Bustami, co-founder and CEO of BioticsAI, to discuss the arduous path from a $100,000 prototype to FDA clearance. Bustami, a Startup Battlefield winner, detailed how his team is building an AI copilot for ultrasound designed to detect fetal abnormalities. The conversation revealed that the traditional startup mantra of 'move fast and break things' is obsolete in the medical sector, replaced by a necessity for extreme precision and coordination.Market Validation and Resource AllocationThe episode provides a strategic look at the 'data' driving medtech success. BioticsAI's recognition as a Startup Battlefield winner serves as a key validation of their technology's potential. However, Bustami emphasized that the primary data point for founders is not just market traction, but the successful navigation of complex regulatory pathways. This requires a significant reallocation of resources—shifting focus from rapid feature deployment to ensuring safety, reliability, and compliance with FDA standards.Shifting the MedTech CultureThe core impact of this discussion lies in the cultural shift it highlights for the industry. As timelines for FDA approval remain uncertain, the ability to maintain team morale and investor confidence becomes a critical operational metric. Bustami noted that building in a regulated industry requires a foundation of trust rather than speed. This signals a broader trend where medtech startups must balance the pressure of hyper-growth with the ethical and legal responsibilities of patient safety.The Future of AI in Healthcare RegulationLooking ahead, the medtech landscape will likely see a consolidation of companies that prioritize long-term compliance over short-term hype. As more AI copilots enter the market, the winners will be those founders who master the art of 'slow and steady' innovation. The next wave of medical breakthroughs will depend not just on algorithmic superiority, but on the ability to build sustainable organizations capable of weathering the regulatory storm.

The Challenges of FDA Approval Surviving the long road to FDA approval isn’t just about building great technology — it’s about keeping your team motivated, finding the right investors, and learning how to operate when timelines are uncertain. Lessons from BioticsAI This week on Build Mode, Isabelle Johannessen sits down with Robhy Bustami, co-founder and CEO of BioticsAI, a Startup Battlefield-winning company building an AI copilot for ultrasound to help detect fetal abnormalities. From a $100,000 prototype to FDA clearance, Bustami shares what it actually takes to build in one of the most regulated industries in the world. Building a Medtech Startup In this episode, they break down what it really looks like to build a medtech startup, including where you can’t “move fast and break things” and that every milestone takes time, coordination, and trust. Key Takeaways Team motivation is crucial during the long FDA approval process Finding the right investors is essential for medtech startups Adaptability is key when dealing with uncertain timelines Future Outlook As the medtech industry continues to evolve, startups like BioticsAI will play a critical role in shaping the future of healthcare technology. With the right approach and mindset, these companies can overcome the challenges of FDA approval and make a lasting impact.

The Kremlin's Shadow in Mali: A Coordinated Assault on StabilityBamako is under siege following a series of coordinated explosions that have left the nation's military leadership in disarray.The Coordinated Assault on BamakoOn April 25, Mali's capital was rocked by a wave of coordinated attacks. The violence was not limited to the capital but spread across the country, indicating a highly organized operation.April 25: Explosions rock Bamako and coordinated attacks across Mali.Target: The residence of the Defense Minister.Outcome: Defense Minister killed, along with his wife and children.Strategic Losses and Leadership VoidThe death of the Defense Minister represents a catastrophic strategic loss for the current administration. The fact that the military leadership briefly disappeared from view suggests a breakdown in command and control during the crisis.Geopolitical Implications and External InfluenceThe title of the episode, "How rebels teamed up to shake Mali and the Kremlin’s grip," hints at a complex geopolitical maneuver. This attack suggests that rebel groups are not acting in isolation but are coordinating efforts to destabilize the government. The involvement of external actors, potentially including the Kremlin, adds a layer of complexity to the conflict, turning a local security crisis into a potential regional flashpoint.The Future of Mali's Internal SecurityWith Bamako under siege and key military figures eliminated, the security situation in Mali is likely to deteriorate further. The coordinated nature of the attacks implies that the rebels have significant resources and planning, posing a severe threat to the regime's survival.

The Musical Collaboration Cellist Paul Watkins and pianist Alessio Bax bring their shared musical impulse to Beethoven's cello sonatas, delivering an unflaggingly eloquent performance. Watkins, a veteran cellist of the Nash Ensemble and the Emerson Quartet, has immersed himself in almost all of Beethoven's chamber music, and this experience shines through in their collaboration. The Sonatas The five sonatas span Beethoven's composing life, from the early sonatas that break new ground in writing for cello and keyboard as equal duet partners, to the later sonatas that harness Watkins's full powers of expression. The expansive third sonata, Op 69, centers on a perky middle movement akin to a symphonic scherzo, while the final pair of sonatas showcase the duo's ability to handle complex passages with tightly controlled restraint. The Performance Watkins and Bax's performance is marked by a light, crisp touch, particularly in the earlier sonatas. The slow, serious introductions lead into extended movements showcasing the virtuosity of the pianist, to which Bax rises with ease. The duo handles the closing passages of the fifth sonata with restraint, then gently clears the air with the introduction to the wrangly little fugue of the finale. The Verdict Overall, Watkins and Bax's performance of Beethoven's cello sonatas is beautifully done, with a deep understanding of the music and a shared impulse to deliver eloquence. The album is available to listen on Apple Music and Spotify.

The Revamped Ad Platform X, under the leadership of Elon Musk, has initiated a phased rollout of its new, AI-powered ad platform. This platform is designed to offer more modern retrieval and ranking systems, making it easier for marketers to create targeted campaigns. Key Features and Expectations The new platform utilizes AI to enhance campaign results, ad placements, and targeting precision. Advertisers can expect continuous improvements and new features. The platform aims to enable rapid and seamless integration of ongoing innovation. The Business Impact Forecasts from eMarketer suggest X's ad business is recovering, with estimated revenues of $2.26 billion in 2025 and $2.46 billion in 2026. This growth is significant, though still half the size of Twitter's 2021 ad business. The Role of AI in Ad Revenue Growth The integration of AI in advertising has contributed to revenue growth across the tech industry. Companies like Google and Meta have experienced a 'digital ad boom,' with AI automating various aspects of marketing and lowering barriers for smaller businesses. The Future Outlook With its new ad platform, X is poised to capitalize on the growing trend of AI-driven advertising. The company's bold move to rebuild its ad platform in a short timeframe reflects its ambition to offer substantially better solutions for advertisers.

The Lead-Up to the 76th FIFA Congress The 76th FIFA Congress is set to take place in Canada, with leading figures of the football world gathering to discuss key issues. The meeting will be overshadowed by the US-Israeli war on Iran and its team's participation in the World Cup. Iranian Delegation's Absence The Iranian delegation will not attend the congress due to issues with Canadian immigration officials. Iranian football officials turned back upon arrival at Toronto's Pearson airport, citing 'unacceptable behaviour of immigration officials.' Human Rights Concerns at the World Cup Human rights group Amnesty International has called on FIFA President Gianni Infantino to use the congress to declare how human rights will be safeguarded at the World Cup. Amnesty urged Infantino to detail 'how he will ensure that the world's biggest sporting tournament does not become a stage for repression and a platform for authoritarian practices.' The #SaveTheCaps Campaign Fans are using the congress in Vancouver to bring attention to the #SaveTheCaps campaign against the potential relocation of the Major League Soccer team Vancouver Whitecaps to Las Vegas. Vancouver Southsiders, the self-proclaimed 'largest support group' of the Whitecaps, has called for a public demonstration ahead of Thursday's congress. What's on the FIFA Congress Agenda? The annual FIFA Congress brings together representatives of all 211 member associations to make key decisions regarding world football governance, finances, and regulations. Thursday's congress will focus on operational and financial issues related to the 48-team World Cup – the largest ever tournament.

The Interception of the Gaza Aid Flotilla Israel has intercepted 22 out of the 58 aid ships traveling through international waters and bound for the besieged Gaza Strip. The ships were part of a second Global Sumud Flotilla aimed at breaking the Israeli blockade by carrying humanitarian aid to Palestinians in Gaza. International Reactions The international community has reacted strongly to Israel's interception of the aid flotilla. Italy, Spain, and Turkey have all condemned the action, with Turkey's Foreign Ministry calling it 'an act of piracy'. Italy's Response Italy has called for the immediate release of Italian nationals on board the flotilla, condemning the seizure of the vessels and urging Israel to respect international law. Spain's Condemnation Spain's Foreign Ministry has 'energetically condemned' Israel's seizure of the flotilla, summoning Israel's charge d'affaires to convey its protest over the detention of the vessels. Turkey's Strong Words Turkey's Foreign Ministry has condemned Israel's seizure of the boats in the flotilla as 'an act of piracy', stating that Israel has violated humanitarian principles and international law. Hamas' Response The Palestinian group Hamas has condemned the interception, accusing Israel of committing a crime without accountability and calling for the release of those detained. Israel's Justification Israel's Foreign Ministry has called the flotilla organizers 'professional provocateurs', stating that its forces acted lawfully to prevent the breach of a lawful blockade.

BoE’s Public Warning Over Inflation Risks From the Middle East WarThe Bank of England released a video statement warning that the conflict in the Middle East is likely to push UK inflation higher in the coming months. Governor Andrew Bailey emphasized that the war’s impact on oil supplies and global commodity markets could erode the progress made toward the 2% inflation target.Key Drivers Behind the Inflation OutlookSharp rise in Brent crude prices since the conflict began, currently hovering around $95 per barrel.Projected increase in household energy bills by 8‑10% over the next quarter.Supply‑chain bottlenecks for food and raw materials, adding 0.3‑0.5 percentage points to headline inflation.Quantifying the Potential Inflation SpikeBoE analysts estimate that core CPI could climb an additional 0.4‑0.6 percentage points by the end of 2026 if oil prices remain elevated. This would lift the overall inflation rate from the current 3.1% to roughly 3.7‑4.0%, breaching the central bank’s comfort zone.Implications for UK Households and the Financial SystemThe anticipated price pressure threatens disposable incomes, especially for low‑ and middle‑income families already coping with post‑pandemic cost-of‑living challenges. Financial markets have responded with a modest rise in gilt yields, and the pound has weakened against the dollar, reflecting concerns over tighter monetary policy.What the BoE May Do NextWhile the Bank has not signaled an immediate rate hike, the warning suggests a readiness to act if inflation accelerates. Possible steps include:Increasing the Bank Rate by 25 basis points in the next policy meeting.Accelerating the tapering of its asset‑purchase programme.Providing forward guidance that underscores a commitment to the 2% target.Analysts expect the BoE to monitor oil price trends closely and adjust policy as needed to prevent a sustained inflationary breakout.