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Scientists from University College London and partners have proved that a 50‑gene genomic test can reliably pinpoint hormone‑positive breast‑cancer patients who do not need chemotherapy, potentially sparing millions from toxic side‑effects.Optima Trial Demonstrates Genomic Test Can Identify Low‑Risk PatientsThe Optima trial enrolled 4,429 women aged 40+ across the UK, Norway, Sweden, Australia, New Zealand and Thailand. Participants were split into a standard‑care arm (chemotherapy + hormone therapy) and a test‑guided arm where treatment was decided by the genomic score.Trial Numbers Reveal Near‑Identical Survival RatesFive‑year outcomes were strikingly similar:95% of patients receiving chemotherapy remained alive and recurrence‑free.94% of patients who skipped chemotherapy (low‑score group) were also alive and recurrence‑free.The test classified patients using a score derived from the activity of 50 tumour genes, produced by Veracyte's Prosigna assay.These figures indicate that for low‑score patients, chemotherapy adds little or no survival benefit.Potential Shift in Breast Cancer Treatment GuidelinesProf Rob Stein, chief investigator, says the results “address a longstanding challenge” by moving decision‑making from clinical features to tumour biology. Health systems could see reduced drug costs, fewer hospital visits, and a dramatic drop in chemotherapy‑related toxicity.Future Adoption and Healthcare SavingsWith funding from the NIHR, Veracyte and cancer charities, the study paves the way for rapid guideline updates at bodies like ASCO and NICE. Wider implementation could translate into billions of dollars saved globally and improve quality of life for countless patients. Ongoing monitoring will confirm long‑term outcomes, but the early data suggest a new era of personalised, cost‑effective breast‑cancer care.

The Schreiber family, presiding over a nationwide commercial portfolio via the Midos Group, is at the center of a growing controversy involving two distinct business models: aggressive tax avoidance and the profiteering from the UK's housing crisis. The Dual Nature of the Schreiber Business Empire The investigation reveals a complex web of family-owned entities that appear to operate on opposite ends of the social spectrum. On one side, the Midos Group is accused of exploiting a controversial tax scheme to avoid business rates on empty commercial properties. On the other, a similarly named but ostensibly separate entity, Midos Management Co, is profiting from the UK's chronic shortage of social housing by arranging temporary accommodation for homeless residents. Midos Group: Accused of using the 'faith room' scheme to avoid rates on empty units. Midos Management Co: Collecting fees for arranging temporary accommodation for councils. Key Figures: David Schreiber (Midos Group) and Elizabeth Endzweig (Midos Management Co). Financial Impact of the 'Faith Room' Tax Loophole The core of the tax avoidance allegations centers on a provision that exempts property owners from paying business rates if the space is made available for religious worship. The 'faith room' scheme, marketed by Verity, allegedly involves minimal activity—such as placing a notice and a staff member reading scripture—to create the appearance of worship. Total Savings: Landlords have saved at least £18m through this scheme. Specific Case: Dover District Council is suing for £1.7m of unpaid tax. Properties Involved: Discovery Park in Kent and a disused pub in Clapham, London. Profiting from the Homelessness Crisis While the family allegedly avoids taxes on empty buildings, they are simultaneously capitalizing on the housing emergency. Midos Management Co acts as an intermediary, matching councils with private landlords to house homeless residents. Despite claims of separation, evidence suggests significant overlap between the two entities. Revenue Collected: At least £43m collected on behalf of landlords since 2019. Client Base: Lambeth council and at least four other councils. Directorship Overlap: Elizabeth Endzweig, daughter of David Schreiber, is a co-director of multiple companies sharing the same address as Midos Group. The Future of UK Property Tax Compliance The revelations highlight a growing tension between private profit and public service obligations. With MPs and councils increasingly scrutinizing these arrangements, the 'faith room' exemption is likely to face tighter regulatory oversight. The case sets a precedent for how closely connected family businesses can be without violating anti-avoidance rules, potentially leading to stricter audits of corporate structures in the property sector.

The Partial Internet Restoration Reveals Public AngerThe partial lifting of internet restrictions in Iran has revealed a rising tide of anger about food price inflation as ordinary Iranians decry annual price increases of 308% for vegetable oil, 190% for chicken, and 170% for rice. Iranian authorities began restoring the connection to the global internet that was severed on the first day of the US-Israeli war against the Islamic Republic on 28 February, as it had been during mass protests in January.Connectivity Remains Limited Despite Partial RestorationConnectivity remained patchy on Wednesday, with mobile internet still largely disconnected and many sites remaining restricted. But even the partial restoration was enough to reveal an outpouring of anger over price inflation and food shortages. "Everything is so expensive. It has become a disaster," wrote one user on social media. "You leave the market with a broken heart after spending all your savings. It is unbearable. We have no patience left to lead a normal life."Government Response and Blame-ShiftingPresident Masoud Pezeshkian, who has been given some credit for lifting the internet restrictions, blamed the US for Iran's economic woes, saying Washington "had moved to economic warfare after failing to bring the government down." In a lengthy statement, the ministry of intelligence revealed its concerns that internet freedom could be used for "cognitive warfare", warning that Iran's adversaries aimed to "incite protesters and drag them on to the streets."Hyperinflation Data Reveals Economic CrisisThe government announced the launch of a "resistance economy committee" to crack down on price gouging and address surging shortages, but hyperinflation is now endemic in Iran owing to trade sanctions, exchange rate pressure, and moves taken to reduce subsidies given to traders in January. Data from the International Monetary Fund showed food inflation had risen to between 140% and 200%, pushing overall inflation to 70%. Support for continuing internet restrictions was put at just 9% in a survey published on Wednesday.Government Propaganda and Public ResponseIn an attempt to forestall support for Reza Pahlavi, the son of the late shah, government backers tried to flood the internet with claims directed at "youngsters returning to the internet" that Pahlavi had openly applauded the attacks mounted by Israel and the US. Others expressed simple relief that they could now talk to the wider world. The human rights activist Emadeddin Baghi wrote: "Three bloody months have passed, but not for those who lost a loved one or had their home destroyed. In this period our voices found no echo except on some internal platforms and to the best of our ability we spoke and wrote in defence of the rights of the voiceless."Future Outlook: Digital Rights and Economic InstabilityThe prominent rapper Toomaj Salehi, who was sentenced to death in 2024 for supporting protests in 2022 but was later released, said being connected to the internet was "not a favour to us – it is our right. And without filters as well. Like free elections, freedom of expression, freedom of assembly, freedom of parties, and many other freedoms, these are our rights and not favours," he wrote on X. With public sentiment increasingly turning against the government and economic conditions worsening, Iran faces a precarious future balancing between maintaining control and addressing growing public discontent.

The Geopolitical Shock to US Inflation MetricsUnited States inflation has accelerated to its fastest pace in three years, driven largely by the fallout from the ongoing US-Israel war on Iran. The Personal Consumption Expenditures (PCE) index, the Federal Reserve's preferred gauge for inflation, rose by 3.8 percent over the last year in April, following a 3.5 percent increase in March.The Mechanics Behind the 3.8% SurgeOn a month-over-month basis, the PCE Price Index rose by 0.4 percent in April, a deceleration from the 0.7 percent spike seen in March. The primary driver of this acceleration is the energy sector, with goods prices ticking up by 0.7 percent. Petrol prices surged by 5.5 percent, pushing the average cost of a gallon of petrol to $4.42, up from $4.17 the previous month and $2.98 in February.Food prices rose by 0.5 percent, the largest monthly increase since November 2022.Housing and utility costs jumped by 0.6 percent.Consumer spending increased by 0.5 percent, while the savings rate fell by 2.6 percent, indicating consumers are drawing down reserves.The Fed's Dilemma Under New LeadershipThe surge in price pressures places significant pressure on the Federal Reserve ahead of its first policy meeting under new Chair Kevin Warsh, scheduled for June 16-17. The central bank is tasked with reaching its 2 percent target, and the current data suggests that price pressures are likely to persist over the next few months.Despite the uncomfortable inflation picture, the market is trending upward. The Nasdaq is up 0.6 percent and the S&P; 500 is up 0.5 percent, while the Dow Jones Industrial Average is nearly flat at 0.05 percent.Market Outlook and Future TrajectoryAnalysts predict that the Federal Reserve will maintain the 3.50-3.75 percent interest rate range well into 2027. A recent JPMorgan Chase analysis suggests rates will hold steady until mid-2027, with a potential rate hike expected later in the year rather than a cut. This reflects a cautious approach from policymakers who cannot ignore the supply shock feeding into underlying inflation.

Iran is grappling with a deepening economic crisis as the costs of a prolonged conflict strain public finances and push the regime toward greater authoritarian measures. Ordinary Iranians are bearing the brunt of soaring prices, a collapsing currency and shrinking job prospects. The Economic Collapse Following the Conflict The war has drained state coffers, forcing the government to divert resources from social programs to military spending. This reallocation has reduced subsidies on essential goods, intensified shortages and heightened public discontent. Quantifying the Crisis: Inflation, Unemployment, and Currency Devaluation Inflation has accelerated sharply, with reports indicating double‑digit growth in consumer prices over the past year. Unemployment, especially among youth, has risen as private sector activity stalls under heavy sanctions and reduced investment. The national currency continues to lose value against major foreign currencies, eroding savings and import purchasing power. Regional and Global Implications of Iran’s Struggling Economy The economic turmoil is reshaping Iran’s regional posture. A financially strained regime may pursue more aggressive foreign policies to rally nationalist support, while neighboring markets feel pressure from disrupted trade flows and refugee movements. Outlook: Prospects for Reform or Further Decline Analysts warn that without substantial fiscal relief or a de‑escalation of hostilities, Iran’s economy could enter a prolonged downturn. Potential pathways include limited market reforms, renewed diplomatic engagement to ease sanctions, or continued reliance on state control, each carrying distinct risks for the population and the regime’s stability.

Why Fans Are the Smart Summer Cooling ChoiceThe Guardian’s award‑winning tech journalist measured 16 fans and several evaporative coolers to see how they perform against a typical portable air‑conditioner that draws 1,000W (about 26p per hour). Fans in the test consumed between 8W and 60W, delivering a far lower electricity bill and carbon footprint while still moving enough air to make a noticeable temperature drop.Power Consumption Numbers Show Fans Beat Air‑ConditionersAirCraft Lume – 18W on top setting; could run 56 hours for the cost of one hour of air‑con.Dreo TurboCool misting fan 765S – 22W, best overall cooling performance.Devola desk fan – 12W, cheapest at £64.99.Shark FlexBreeze Pro Mist – 30W, premium misting option at £249.99.Swan Nordic evaporative cooler – 15W, lowest‑energy water‑based cooler at £69.Cooling Comfort Meets Carbon Savings for UK HouseholdsRunning a fan instead of an air‑conditioner can cut summer electricity use by up to 95 %, translating into lower bills and reduced greenhouse‑gas emissions. For a typical UK home, swapping a 1,000W air‑con for an 18W fan saves roughly £23 per month and avoids about 0.12 tCO₂ of emissions.What’s Next for Home Cooling in a Warming Climate?As heatwaves become more frequent, manufacturers are likely to focus on quieter, smarter fans with integrated sensors that adjust speed automatically. Expect more hybrid designs that combine low‑energy misting with airflow optimisation, giving consumers a wider menu of carbon‑friendly cooling solutions.

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The Lead XCENA, a four-year-old chip startup with offices in South Korea and the U.S., has raised $135 million in a Series B round at a valuation of $570 million. The company aims to solve the structural bottleneck in AI infrastructure by designing a chip that places compute capabilities closer to DRAM. Revolutionizing AI Infrastructure with Memory-Centric Architecture Every time you ask ChatGPT a question, your request triggers a data relay race. Information leaves memory, passes through a CPU for preprocessing, travels to a GPU for heavy computation, and then makes its way back — and that entire journey repeats for every single word the AI generates. XCENA's chip, the MX1, connects to the CPU through CXL (Compute Express Link), processing data before it ever needs to leave the memory module. The Data Analysis XCENA's successful funding round reflects investor enthusiasm around the company's potential to significantly reduce AI infrastructure costs. The startup has designed a chip that brings compute capabilities much closer to DRAM, allowing routine data operations to be handled near memory, without the costly round trips between CPUs, GPUs, and memory. This approach could lead to substantial savings for hyperscalers spending tens of billions a year on AI infrastructure. The Impact Analysis The recent rise in memory prices and related stocks points to a broader shift in AI infrastructure toward memory-centric architectures. XCENA's thesis is that "inference isn't just a compute problem; it's increasingly a memory scaling problem." The company's chip aims to handle tasks directly within the memory module itself, reducing the need for multiple servers and cutting costs. The Prediction With mass production chips scheduled to roll off Samsung's foundry lines by the end of 2026, XCENA expects to generate revenue starting in 2027. The company's ideal customers are hyperscalers, and it is in early-stage conversations with several global memory vendors. XCENA's innovative approach and vertical integration could give it a competitive edge in the market.

Glean's Rapid Growth in Enterprise AI Search Glean, a company often described as the Google for enterprise, has reached $300 million in annual recurring revenue (ARR), a three-fold increase from the $100 million milestone it reached just 15 months ago. This growth is particularly remarkable given the increasing competition in the enterprise AI search market from tech giants like Google, Microsoft, and OpenAI. The Competitive Landscape and Glean's Unique Value Proposition According to Glean CEO Arvind Jain, the company's early mover advantage and deep understanding of customers' business needs set it apart from competitors. Glean's AI tools achieve this understanding by connecting to and learning from enterprises' internal software systems, creating a "context graph" that helps reduce AI computing costs. The Cost-Cutting Advantage of Glean's AI Tools Glean's context graph helps enterprises cut AI computing costs by reducing the number of tokens consumed. This results in significant cost savings for customers, making it a major selling point in a market where many companies are struggling with AI budget overruns. Business Model and Pricing Structures Glean offers various pricing structures, including a consumption-based model and a hybrid model that combines a fixed monthly fee with separate usage fees. The company's customers include Databricks, Reddit, Pinterest, and Samsung. The Future Outlook for Glean and Enterprise AI Search As the enterprise AI search market continues to grow, Glean's focus on cost-cutting and its unique value proposition position it well for future success. With a valuation of $7.2 billion and a strong customer base, Glean is poised to remain a leader in the space.