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The Plant That Changed MedicineGoat's rue or French lilac, Galega officinalis, is a wild plant often grown in gardens for its clusters of attractive lilac or white flowers. For centuries, the plant was used to treat diabetes. Its key ingredient was later identified as galegine, which lowers blood glucose levels but has toxic side-effects.From Natural Remedy to Synthetic SolutionEventually, galegine led to the development of the synthetic drug metformin, now the classic treatment for diabetes by controlling blood sugar. Metformin has none of the toxic side effects of galegine and is now one of the most prescribed drugs in the world. For many years, however, metformin was vilified and banned in many countries because of its association with galegine.The Emergence of a Medical MultitaskerMetformin is now becoming something of a super drug for its anti-cancer effects, cardiovascular protection, delaying the onset of diabetes, and helping some people lose weight. It may even lower the risks for cognitive decline, dementia, strokes, slow aging and increase life expectancy.Understanding the MechanismExactly how metformin achieves all these remarkable wonders is not entirely understood, but it is not bad for a drug that originally came from an attractive wild plant. The scientific community continues to research the multiple pathways through which this simple compound derived from a garden plant can have such profound effects on human health.

The Imperative for Labour to Address Social Care If a new Labour leader wants to underline their determination to wrestle with Britain’s political challenges, it is hard to think of a better place to start than with the creaking social care settlement. The History of Unfulfilled Promises A new collection of essays, to be published by the Fabian Society this week, urges the government – whoever leads it – to crack on with creating a “national care service” more closely aligned to the NHS, and ensure it is properly funded. Nine years ago, Theresa May launched a plan to fund care costs, promising that no one would have to sell their home in their lifetime to pay for their care. The plan was called a “dementia tax” by Labour and was widely credited as a contributing factor in the Conservatives’ worse-than-expected 2017 election performance. The Financial Impact of Inaction The sorry history of politicians failing to grip the issue is partly indicative of the fiscal constraints they are increasingly forced to work with. But it also seems to mark a kind of learned helplessness – an unwillingness to make an argument. The Impact on the Nation That leaves families still selling their homes to fund care, and fretting about how long the proceeds will last, as they witness their relative’s heartbreaking decline. Meanwhile, the cash-strapped care sector still struggles to meet growing need. A New Approach for the Future Burnham has talked in recent years about replacing inheritance tax with a progressive “care levy” in order to fund a national care service. Labour has not been idle: radical plans for a statutory negotiating body for care workers’ pay are progressing.

The LeadFalling seriously ill, like falling in love, can happen all of a sudden – although this film is not exactly about either. Ryusuke Hamaguchi's new movie, co-scripted with the Franco-Japanese screenwriter Léa Le Dimna and his first not set entirely in Japan, is a bold and high-minded if rather pedagogic work that spreads itself over three hours. It's tender and sometimes beautifully made, but also contrived and occasionally features some too-good-to-be-true caring characters. Frankly, it's rather precious.The Film's International VisionHamaguchi and Le Dimna have taken as their starting point the nonfiction book "You and I: The Illness Suddenly Get Worse" by Makiko Miyano and Maho Isono, a meditative correspondence between a philosopher and medical professional on the subjects of love and mortality. Hamaguchi has opened this out to create a drama set in Paris and Kyoto, and it's incidentally hard not to suspect that Hamaguchi, like many a celebrated movie director spending so much time on the international festival circuit, has been led to create an uneasy international mixture.Care Home Dynamics and CharactersMarie-Lou (Virginie Efira) is the director of a private care home in Paris called the Garden of Freedom, where they practise a care technique called "humanitude," a time-consuming patient-centred approach that exasperates old-fashioned nurse Sophie (Marie Bunel). It needs more staffing facilities than the home is prepared to provide and, in any case, Marie-Lou has a bad habit of being patronising to those who question her. For all that, there are some lovely scenes with caregivers and patients, and these observant, unfussily compassionate moments are where the film works best.Cross-Cultural ConnectionsMarie-Lou is stressed and overworked, and her life is upended when she encounters an autistic Japanese teen called Tomoki (Kodai Kurosaki) in the street, apparently lost; he is being looked after by his grandfather, Gorô (Kyōzō Nagatsuka), an actor in town performing in an experimental piece about psychiatric care in which Tomoki is encouraged to take part if he feels like it. The show is directed by Mari (Tao Okamoto), and her stylish calm and intelligence entrances Marie-Lou; they are clearly on the verge of an intense friendship and perhaps more, although the film is reticent on this last point.Philosophical Exchanges and Narrative ConcernsMarie-Lou comes to a performance, stays for the Q&A; afterwards and reveals herself to be fluent in Japanese, asking questions of Mari in that language which touch on Mari's very serious illness. Some in the audience rather plaintively – and understandably – call for the conversation to be in French, though this film comes close to being insufferable when Gorô solemnly tells everyone that their exchange was so intimate and meaningful that the audience should be content with simply sensing that.The Film's Strengths and WeaknessesAll of a Sudden works best entirely outside the exotically overwritten, overthought bond between Mari and Marie-Lou. The realist set pieces are very moving, showing us patients with dementia surrounded by their families, and also showing us, often with photos of their younger selves in demanding jobs, how these patients have changed. The film's high concept is a little self conscious.All of a Sudden screened at the Cannes film festival.

The LeadRenowned actress Linda Bassett reflects on her distinguished career spanning decades of theatre work, her celebrated collaboration with playwright Caryl Churchill, and her upcoming role in Alexander Zeldin's "Care" at the Young Vic. Known for her understated yet powerful performances, Bassett shares insights into her approach to acting and the profound impact of theatre on her life.The Career JourneyBassett's path to acting wasn't conventional. Despite coming from a non-theatrical family, she discovered her passion at age four when she was unexpectedly thrust into a Sunday school Easter play. "I was in bliss," she recalls. Her formative years included ushering at the Old Vic during Laurence Olivier's legendary tenure, where she witnessed groundbreaking performances and even sold ice creams during intermissions.After briefly studying English at Leeds University, where she focused on drama rather than academics, Bassett began creating devised work in Leeds and Coventry. This experience, she suggests, "made me a bit gobby," developing her confidence to make suggestions as an actor, though she admits she sometimes oversteps when working with certain playwrights.The Churchill ConnectionBassett's most significant artistic relationship has been with playwright Caryl Churchill, beginning with "Fen" in 1983 and continuing through to "What If If Only" in 2021. She describes auditioning for Churchill as "enormous" because it launched her on a particular trajectory. Her disconcerting clarity has made her a peerless interpreter of Churchill's work, which some audiences find forbidding."They're not hard to watch," Bassett protests of Churchill's plays. She recalls her iconic monologue in "Escaped Alone" where the phrase "terrible rage" is repeated 25 times in succession. "It was the only thing to say at that point. The words fed the feeling, and it was the audience who felt it, not me, which is ideal." Churchill's writing, she notes, is "so distilled, no excess baggage," requiring actors to find "the one way" to play them.From Call the Midwife to CareDespite notable film roles including "East Is East" and "Calendar Girls," many audiences know Bassett as stern nurse Phyllis in the BBC's "Call the Midwife." "Complete strangers come up and say, I love you. My wife loves you, my mother loves you. It's extraordinary," she remarks of the public's connection to the character. Despite playing Phyllis for over a decade, she found fresh aspects to explore, learning "how to be" more matter-of-fact and practical than her natural disposition.Currently rehearsing Alexander Zeldin's "Care" at the Young Vic, Bassett plays Joan, a woman who after caring for her family begins showing signs of dementia and needs care herself. "She's convinced, as many people are, that she's just in for respite. She never loses the idea that she's going home," Bassett explains. The role draws from personal experience; after a heart attack, she spent two weeks recuperating in a care home, giving her "an insight into what it's like when you become helpless."The Actor's Philosophy"Every part is an education," Bassett states. "That's the glory of being an actor. You learn about human feelings and frailty and rottenness. The writer puts their soul on the page, and you inhabit that. I've always felt I was a writer's actor." This philosophy has guided her selective approach to roles, resulting in a "remarkably free of crap" CV despite turning down numerous opportunities.Though she hasn't performed as many classics as she might have hoped—"I think I'm seen as a working-class actress"—Bassett values the authenticity she brings to her roles. With Zeldin directing "Care," she appreciates his desire for "absolute truthfulness," which "suits me down to the ground." As she prepares for this new challenge, she acknowledges the nerves: "Every new part you're starting again. It's a bit scary, but I think we'll be all right."The Future of TheatreAs a veteran performer who has witnessed theatre's evolution, Bassett remains committed to the medium's power. She recalls the impact of Ronald Pickup's messenger speech in Peter Brook's production of Seneca's "Oedipus": "People fainted every night. You didn't see anything, his voice was enough. That's the power of theatre, isn't it?"Looking ahead, Bassett continues to seek roles that challenge her and explore the human condition. Whether through her meticulous interpretation of complex playwrights like Churchill or her willingness to portray the vulnerability of aging in "Care," she remains dedicated to the craft that has defined her life. "Every part is an education," she reiterates, and with each new role, Linda Bassett continues to learn, grow, and enrich the theatrical landscape.

Executive Overview: A Light‑Hearted Take on Midlife UpheavalThe Guardian’s review praises Charline Bourgeois‑Tacquet’s A Woman’s Life as a hectic, garrulous comedy that treats its protagonist’s emotional turbulence with breezy optimism. Léa Drucker leads as Gabrielle, a maxillofacial surgeon whose professional and personal worlds collide during a Cannes screening.Charline Bourgeois‑Tacquet’s Narrative Choice: Comedy Meets Midlife CrisisThe film follows Gabrielle, a brilliant surgeon battling budget cuts and demanding interns while navigating a strained marriage to Henri (Charles Berling). A chance encounter with writer Frida (Mélanie Thierry) sparks a passionate same‑sex affair, propelling the story into a series of whimsical set‑pieces, from a promenade ballet to a remote Alpine retreat with Italian novelist Erri De Luca.Budget Constraints and Professional Stakes as Plot DriversGabrielle’s hospital faces budget cuts, creating tension that underpins her professional confidence.The film juxtaposes her high‑stakes surgical work with personal distractions, highlighting the fragility of work‑life balance.While no specific figures are given, the narrative treats financial pressure as a catalyst for Gabrielle’s emotional openness.Why the Film Resonates: Gender, Age, and Sexual Fluidity on the Cannes StageIt foregrounds a mature female protagonist confronting both career challenges and a same‑sex romance, rare in mainstream festival fare.The supporting cast—Henri’s teenage step‑children, Gabrielle’s dementia‑stricken mother Arlette (Marie‑Christine Barrault), and the non‑professional author Erri De Luca—adds layers of inter‑generational perspective.The light‑hearted tone invites audiences to consider serious topics without the weight of melodrama.Looking Ahead: Bourgeois‑Tacquet’s Prospects After CannesGiven the film’s positive reception and its blend of humor with socially relevant themes, Bourgeois‑Tacquet is positioned to attract further festival invitations and potential distribution deals. The review suggests that while the final act feels slightly contrived, Drucker’s performance ensures the film remains engaging, hinting at a promising trajectory for both the director and the cast.

Charities Call for a New Clean Air Act Before the King's Speech More than 60 charities representing over 230,000 members have urged the incoming Labour government to introduce a Clean Air Act that would ban wood‑burning, remove diesel vehicles from roads and compel local councils to cut pollution. Details of the Lobbying Push and Proposed Measures The letter, signed by groups such as Mums for Lungs and led by founder Jemima Hartshorn, repeats Labour’s 2023 opposition promise to make clean air a human right. It calls for an outright ban on non‑essential wood‑burning stoves, a phase‑out of existing units, and support for rural households to switch to low‑carbon heating such as heat pumps. Financial and Complaint Data Highlight the Scale of the Problem Air‑pollution costs the UK economy about £27bn a year, linked to asthma, cancer and dementia. From August 2024 to August 2025, there were 15,195 wood‑burning complaints in England, yet only 24 fines were issued. Recent data show a surge in wood‑burner sales in urban areas, despite evidence that particles from wood are as toxic as coal‑derived emissions. Implications for UK Air Quality Policy and Rural Economies Experts such as Stephen Holgate, special adviser to the Royal College of Physicians, describe the lack of enforcement as a “disgrace”. The Stove Industry Association (SIA) has lobbied both the Scottish and UK governments, influencing the Future Homes Standard that currently permits wood‑burning installations in new builds. Industry spokespeople argue that a ban would “negatively impact the UK’s manufacturing and rural economies”, while charities stress the public‑health imperative. What the Next Parliamentary Session May Hold for Clean‑Air Legislation With the King’s Speech imminent, the pressure is on Labour to reverse the omission of a Clean Air Act from its manifesto. If the government adopts the charities’ recommendations, we could see the first statutory ban on wood‑burning and stricter diesel restrictions within the next year; otherwise, the status quo of voluntary guidance is likely to persist.

Researchers at the University of Edinburgh and the UK Dementia Research Institute have uncovered that lacunar strokes are driven by the widening of small brain arteries rather than the previously assumed blockage by fatty deposits.Study Links Lacunar Strokes to Arterial Widening, Not BlockageThe investigation, published on Wednesday, 2026-05-10, examined 229 patients who suffered either a lacunar or a mild non‑lacunar stroke. Advanced neuroimaging revealed that patients with widened small vessels were more than four times as likely to experience a lacunar stroke.Key Numbers Highlight the Scale of the Issue35,000 UK residents experience lacunar strokes each year.Lacunar strokes represent 25% of all strokes in the UK.Study cohort: 229 stroke patients.Widened arteries increased lacunar stroke risk by > 4‑fold.Less than 1% of UK research funding is allocated to stroke.Implications for Treatment and Funding PrioritiesThe findings explain why common anti‑platelet drugs such as aspirin are less effective for lacunar strokes. Maeva May, director of policy at the Stroke Association, called the research “a potential game‑changer” and urged greater investment, noting that stroke remains the fourth leading cause of death in the UK.Joanna Wardlaw, professor of applied neuroimaging, emphasized the need for therapies that target microvascular damage rather than large‑vessel atherosclerosis.Looking Ahead: Targeted Microvascular Therapies and Policy ShiftsFuture research will likely focus on drugs that protect or restore the integrity of small brain vessels. Policymakers are being pressed to increase the proportion of health research funding dedicated to stroke, aiming to translate laboratory breakthroughs into clinical practice more rapidly.

The LeadResearchers at Imperial College London have shown that a single 25 mg dose of psilocybin can produce detectable anatomical changes in the brain that persist for at least a month, offering fresh clues about how psychedelics may alleviate mental‑health disorders.Single Dose of Psilocybin Triggers Measurable Brain Structure Changes28 healthy volunteers with no prior psychedelic experience participated.Participants received a low “placebo” dose (1 mg) followed, a month later, by a full psychedelic dose (25 mg).Brain activity was monitored with EEG, functional MRI, and diffusion tensor imaging (DTI).Diffusion Tensor Imaging Reveals Reduced Nerve Tract DiffusionOne month after the psychedelic dose, DTI scans showed a drop in water diffusion along front‑to‑mid‑brain nerve tracts, suggesting either pruning of existing fibres or growth of new, unmyelinated connections. The same participants also exhibited a surge in EEG‑measured brain entropy within an hour of dosing.Potential Ripple Effects on Psychedelic TherapeuticsThe anatomical shift mirrors patterns seen in ageing and dementia—where diffusion typically increases—hinting that psilocybin may promote a rejuvenating “entropic brain” state. Researchers linked the magnitude of entropy spikes to deeper psychological insight and improved wellbeing, reinforcing the hypothesis that structural plasticity underlies therapeutic outcomes. Senior author Robin Carhart-Harris described the result as “remarkable”.What This Means for Future Psychedelic Research and TreatmentLarger, longitudinal studies are needed to confirm durability of the changes.If replicated, DTI could become a biomarker for assessing psychedelic efficacy.The findings may accelerate clinical trials targeting depression, anxiety, and addiction.While promising, the study’s small sample size and indirect imaging methods warrant caution, but the evidence moves the field closer to a mechanistic understanding of psychedelic‑induced neuroplasticity.

Uncovering the Trauma of Mozambique's Civil War Lasting from 1977 to 1992, the Mozambique civil war left deep scars on the psyche of the whole nation. In his second feature, Inadelso Cossa attempts to grapple with the psychological wreckage of this harrowing period by combing through his own family history; returning to the village where he grew up, the film-maker conducts a series of interviews with his grandmother, whose testimony is rendered unreliable by her worsening dementia. The Blurred Lines Between Reality and Memory The film wavers between real and imagined truths, a liminal state echoed by the evocative cinematography. Nocturnal sequences, in which wooden sheds, grassy fields, and even Cossa’s grandmother, are wrapped in a cloak of darkness inspire a deceptive sense of calm. In the dead of night, though, the spectres of the past linger. Voices of the Past Cossa also speaks to other historical witnesses: Macuacua and Zalina, an older couple, spend much of their screen time bickering but these domestic moments are underlined with unease. A former soldier, Macuacua was once a participant in the violence against civilians but his life now, however, is marred by poverty. In a striking scene, Macuacua holds up a tree branch shaped like a rifle and reenacts a patrol route from his youth with astonishing matter-of-factness. A New Perspective on History For Cossa, history is distilled in these kinds of gestures, moving beyond linear time. Although the film is bookended by archival footage, the director prioritises non-traditional forms of documentation, such as monologues, songs, and reenactments. While this approach embodies the slipperiness of memory, it also renders the film difficult to follow on occasion. The Film's Impact But across these streams of oral history, what we find are not merely facts and figures, but feelings, in which pain and healing entwine. Where to Watch The Nights Still Smell of Gunpowder is on True Story from 1 May.