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A recent Cochrane review analyzing 17 clinical trials involving over 20,000 people with mild cognitive impairment or dementia has concluded that anti-amyloid drugs have a 'trivial' effect on cognition and dementia severity over 18 months.The review, which assessed seven anti-amyloid drugs, found that improvements in functional ability were 'small at best' and that the drugs caused more swelling and bleeding in the brain than the placebo.The findings are a blow to the new wave of drugs designed to slow Alzheimer's by clearing clumps of amyloid protein that build up in the brain. Despite initial hype, with some regulators approving drugs like lcanemab and donanemab, many countries have stopped short of providing them through public health services due to concerns over their effectiveness and cost.Critics of the review argue that it combines results from older, failed drugs with those from newer, more effective medicines, which may skew the conclusions. However, the review's authors defend their approach, stating that all the drugs aimed to remove amyloid from the brain and assessed the impact on patients in a similar way.The review's lead author, Edo Richard, notes that the effect sizes are too small for patients and caregivers to notice, and that the drugs are also 'burdensome' due to the need for regular intravenous drug infusions and MRI scans.Experts in the field, such as Robert Howard, express concerns that the drugs may not truly alter the course of Alzheimer's, and that it's unfair to raise expectations in patients. Meanwhile, Alzheimer's Research UK argues that the review's conclusions are limited by its methodology and that anti-amyloid treatments will not be the whole answer to curing Alzheimer's.

Pope Leo XIV has embarked on a significant visit to Cameroon, a country grappling with sectarian conflict. During his three-day trip, he delivered a powerful speech calling for peace, justice, and an end to corruption. The Pope's message resonated with the nation's struggles, as he urged leaders to 'examine our conscience and take a bold leap forward.'The Pope's visit to Cameroon is part of a 10-day tour of Africa, which began in Algeria. His itinerary includes a 'peace meeting' in Bamenda, a city in the northwest that has been engulfed in fighting from separatist forces. In a notable gesture, the separatist forces have announced a three-day pause in hostilities during the Pope's visit.However, the Pope's message of peace and coexistence has not been universally well-received. US President Donald Trump has publicly criticized the Pope, accusing him of being 'weak on crime' and too close to the political left. The Pope has responded diplomatically, stating that he has 'no fear' of the Trump administration and will continue to advocate for peace and criticize war.The Pope's visit to the Great Mosque of Algiers earlier in the week highlighted the importance of tolerance and unity in a world plagued by conflict. He emphasized that despite differences in beliefs and ways of worship, people can 'live together in peace.'

England has taken a significant step towards qualifying for the FIFA Women's World Cup 2027 after Lauren Hemp's early goal secured a 1-0 win over defending champions Spain at Wembley Stadium in London.The victory marked England's third successive win, moving them above Spain to the top of group A3. Only the winners from each of the League A groups will earn direct passage to next year's tournament in Brazil.The match saw England take the lead in just three minutes as Alessia Russo set up Hemp, who scored past Cata Coll. Spain threatened an equaliser, with Irene Paredes heading just over, but Hannah Hampton's crucial saves preserved England's lead.The win also celebrated Keira Walsh's 100th England cap and honoured Euro 2022-winning goalkeeper Mary Earps in an international retirement ceremony.In other matches, Norway thrashed Slovenia 5-0 and Germany remained unbeaten with a 5-1 victory over Austria. The Netherlands took the lead in Group A2 with a 2-1 win over France, while Denmark took control of Group A1 with a last-gasp 2-1 victory over Sweden.

Chinese President Xi Jinping has met with Russian Foreign Minister Sergey Lavrov, calling for closer and stronger strategic coordination between Beijing and Moscow. The meeting took place in the Great Hall of the People in Beijing, where Xi emphasized the need to firmly defend their legitimate interests and safeguard the unity of Global South countries.Xi described the stability and certainty of China-Russia relations as particularly precious in an international landscape marked by change and chaos. This comes as the world faces growing fears over the shutdown of the Strait of Hormuz, which could trigger a global food crisis as critical fertiliser and fuel exports are blocked.Lavrov told a news conference after meeting Xi that Moscow could compensate for China’s energy shortages as shipping through the strait remains choked. China and Russia are not formal military allies but maintain extremely close economic and political ties, with Xi signing a 'no limits' strategic partnership with President Vladimir Putin in 2022.The visit by Lavrov to Beijing this week also included meetings with other leaders, such as Spanish Prime Minister Pedro Sanchez, Abu Dhabi’s Crown Prince Mohamed bin Zayed Al Nahyan, and Vietnamese leader To Lam. In talks with Sanchez, Xi warned that the world was facing 'chaos and turmoil' and 'a contest between justice and force', urging closer cooperation.

For the first time in decades, Israel and Lebanon have held direct talks, signaling a potential new era in their diplomatic relations. The negotiations, which took place recently, are seen as a crucial step towards resolving longstanding conflicts and fostering cooperation between the two nations.The talks come as both countries seek to address shared concerns and navigate the complex Middle East geopolitical landscape. While details of the discussions remain scarce, the fact that they are occurring directly is being hailed as a significant diplomatic breakthrough.Observers note that this development could have far-reaching implications for regional stability and peace efforts. As Israel and Lebanon continue to engage in dialogue, the international community watches closely, hopeful that these talks will pave the way for lasting peace and cooperation in the region.

On April 15, 2026, French law enforcement carried out arrests of students who were demonstrating against a recently introduced anti‑Semitism law. The police action took place during a protest that sought to challenge the legislation’s perceived impact on freedom of speech and the rights of minority groups.Authorities reported that the arrests were made to maintain public order, while protest organizers argued that the law could be used to suppress legitimate dissent. The incident highlights the tension between government efforts to curb hate crimes and concerns from civil‑rights groups about potential overreach.Observers note that the crackdown may influence public perception of the new law and could affect future demonstrations across France. The episode underscores the broader debate in Europe over how best to balance security measures with the protection of fundamental liberties.

England's women's football team is on a roll, maintaining a 100% record in their World Cup qualifying group after a win against Spain. While their target is to win a first world title, the journey is long, and several players have enhanced their prospects of selection. Eight players from the recent match against Spain look set to be in the first-choice XI for the World Cup, including Hannah Hampton, Lucy Bronze, and Lauren Hemp. Senior players like Leah Williamson and Ella Toone will also be key when they return from injuries. Three players who started against Spain have significantly boosted their chances. Centre-backs Esme Morgan and Lotte Wubben-Moy were exemplary, helping England keep a clean sheet against the world champions. Morgan, 25, and Wubben-Moy, 27, have had to be patient during Sarina Wiegman's tenure but did not look out of place. Morgan said she was proud of the team's concentration and organisation, while Wiegman praised them, saying, 'They showed up today. It says a lot about them. They should be proud of themselves.' Another player who impressed was Lucia Kendall, the 21-year-old Aston Villa midfielder tasked with taking on Barcelona's Patricia Guijarro. Despite a quiet evening, Kendall worked hard and nearly scored from close range. Wiegman also displayed trust in Laura Blindkilde Brown, who came on as a 72nd-minute substitute to help close out the victory. Her contributions to Manchester City's likely title success will enhance her chances for 2027. The upcoming match against Iceland will provide further opportunities for players like Jess Park, who has been in inspired form for Manchester United. New faces Erica Meg Parkinson and Keira Barry have received their first senior call-ups and will look to make an impression.

The inspectorate suggests that some forces have shown good practice, including the use of polygraphs, or lie detectors, on suspects. It emphasizes that all forces should have access to this tool to identify new offenses and safeguard victims.

The British Board of Film Classification (BBFC) has begun using an AI tool to help identify content that triggers compliance issues, such as violence, nudity, and bad language, in TV shows.The technology was used to classify the UK catalogue of HBO Max, including The Pitt and a Game of Thrones spinoff, A Knight of the Seven Kingdoms. The Pitt received a 15 rating, while A Knight of the Seven Kingdoms received an overall rating of 18, with most episodes rated 15.The AI tool was built especially for HBO and helps direct compliance officers to the most contentious moments, doing "a lot of the heavy lifting," according to David Austin, the BBFC chief executive. However, he emphasized that human review is still crucial, as the AI tool was initially too cautious, mistakenly flagging an on-screen splash of red paint as human blood.The BBFC system, trained on the regulator's guidelines, produced a time-coded report that a human compliance officer then reviewed. The organization completed the classification of HBO Max's entire catalogue in six months, a process that would have normally required over four years of viewing by a compliance officer.