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For the first time, thousands of cancer patients from Black and minority ethnic backgrounds will benefit from an enhanced genetic test offered by the NHS. The new screening expands the panel of DPYD gene variants from four to five, directly addressing a long‑standing bias that left non‑white patients vulnerable to dangerous chemotherapy side‑effects. In England, patients slated for chemotherapy undergo a genetic check that can guide dose adjustments and mitigate adverse reactions such as mouth sores, hair loss, nausea, fatigue, and, in severe cases, death. Up to 40% of the 38,000 individuals receiving fluoropyrimidine‑based chemotherapy each year experience a harmful drug reaction. Previously, the test only targeted four DPYD variants common in people of European descent, meaning many Black patients received inaccurate “all‑clear” results. The addition of a fifth variant—more prevalent among African, Caribbean and other minority groups—means clinicians can now identify patients at risk who were previously missed. Since its rollout at Manchester University NHS Foundation Trust last September, three minority‑ethnic patients have had their initial chemotherapy doses adjusted, lowering their chance of a potentially fatal reaction. Dr Veline L’Esperance, senior clinical adviser at the NHS Race and Health Observatory, called the change “tangible results for patients who have historically been left behind.” She emphasized that the update shifts the discussion on ethnic health inequality from rhetoric to actionable care. Prof Habib Naqvi, chief executive of the NHS Race and Health Observatory, described the development as a “groundbreaking outcome” for chemotherapy safety, while noting that ethnic minorities remain under‑represented in genomic research and biobanks. He warned that broader inclusion is essential for the promised benefits of precision medicine to reach all communities. Prof Dame Sue Hill, chief scientific officer for NHS England, highlighted the significance of discovering the fifth variant: “Personalising chemotherapy based on genetics can save lives and reduce harmful side‑effects, especially for patients of African ancestry.” She added that the North West NHS Genomic Medicine Service has already demonstrated the practical impact of this approach. These steps come amid broader evidence that minority patients in the UK face longer diagnostic waits, more GP visits before a cancer diagnosis, and lower perceived support during treatment. The expanded DPYD test represents a concrete effort to close those gaps and ensure equitable, science‑driven care for all cancer patients.

The 2018 World Cup in Russia served as a high‑profile platform for Vladimir Putin, showcasing his nation and bolstering his personal legitimacy. The tournament was effectively a diplomatic bow to the Kremlin’s ambitions.Fast‑forward to the summer of 2026, and the buildup to the event has taken on a distinctly American flavour, with the competition becoming a backdrop for Donald Trump’s political narrative.The next edition, slated for 2034 in Saudi Arabia, presents a fresh set of challenges. Despite the kingdom’s controversial human‑rights record, the event offers Crown Prince Mohammed bin Salman an opportunity to polish his and the nation’s image. FIFA’s current reluctance to enforce independent oversight of migrant‑worker conditions raises fears that construction could be as deadly as the 2022 Qatar experience.These developments underscore a pressing need to insulate the World Cup from the whims of powerful leaders. One proposed solution is to fragment the tournament—treating it like a monopoly that has become too dominant.Evidence that this approach is feasible already exists: the 2026 World Cup will be co‑hosted by three nations, and the 2030 edition is set to span six countries across three continents (Spain, Portugal, Morocco, Argentina, Paraguay, Uruguay).Building on that, the author suggests a radical redesign: allocate each group stage to a different global city—Paris, Rio de Janeiro, Tokyo, Sydney, Johannesburg, London, the Basque Country, and so on. Knock‑out rounds could be broken into three‑match clusters and scattered worldwide, with the semi‑finals, final, and third‑place match awarded to the highest‑bidding venue.Carbon‑footprint concerns are addressed by noting that teams already travel long distances to a single host nation; distributing groups based on the median distance to participating teams would not significantly increase emissions.Financially, the cost of staging a traditional, single‑host World Cup has ballooned, limiting the pool of viable bidders to those seeking political or economic leverage. A decentralized format would dilute any single leader’s ability—whether Trump, Putin, or the Saudi crown prince—to manipulate the event for personal gain.Decentralisation would still align with FIFA’s stated objectives: expanding the sport’s reach, creating a truly global spectacle, and bringing football closer to fans worldwide.While FIFA claims a fiduciary duty to maximise revenue for its 211 member associations—justifying steep ticket prices and controversial sponsorships—the proposed model could actually enhance revenue by turning each small cluster of matches into premium, high‑value events.Precedent exists in the form of Euro 2020, which, despite being postponed by the pandemic, successfully unfolded across 11 European cities, delivering record‑breaking goal tallies and strong attendance figures.In sum, the most effective way to protect the World Cup’s cultural significance and prevent its exploitation by authoritarian figures may be to deconstruct and disperse it globally, turning a single‑host behemoth into a series of interconnected, locally hosted celebrations of the sport.

Tucker Carlson, the former Fox News host, is set to launch his own publishing imprint, Tucker Carlson Books, in partnership with US-based publisher Skyhorse. The imprint aims to provide a platform for books that might otherwise be censored or shut down.Among the initial titles to be published are Russell Brand's How to Become a Christian in Seven Days, described as a "testimony and guide to a timeless, yet zeitgeist-capturing, grounded, yet psychedelic encounter with Christ." Brand is currently facing charges of rape, sexual assault, and indecent assault in the UK, to which he has pleaded not guilty.Another title set to be published is Milo Yiannopoulos's Ex Gay. Yiannopoulos, a controversial "alt-right" commentator, has previously been shunned by publishers due to his contentious views. His 2017 memoir, Dangerous, was canceled by Simon & Schuster after footage surfaced in which he made comments that appeared to condone sex between adult men and underage boys.Carlson, a former Trump supporter and promoter of right-wing conspiracy theories, was reportedly fired from Fox News in 2023. He soon launched his own media company, Tucker Carlson Network, and the imprint is being launched in partnership with this network.Skyhorse publisher Tony Lyons stated that the imprint will give "a platform to things that would, in many cases, be shut down, be censored, and be covered over by propaganda." Carlson emphasized that Lyons is "just looking for books that nobody else will publish."Skyhorse, which was launched in 2006, claims to be one of the fastest-growing independent book publishers in the US. Its previous publications include Woody Allen's memoir Apropos of Nothing and US Secretary of Health and anti-vaccine activist Robert F Kennedy Jr's The Real Anthony Fauci.

Monarch Collective believes that a number of Women’s Super League (WSL) clubs remain “afterthoughts” for their owners, receiving only marginal capital and expertise. Co‑founder Kara Nortman highlighted this concern during a recent interview.Last month, Monarch became the first women’s multi‑sport group by acquiring a minority stake in the Cleveland WNBA franchise, joining an ownership portfolio that already includes NWSL sides San Diego Wave and Boston Legacy, as well as German club Viktoria Berlin.Since establishing Monarch in 2023—four years after launching Angel City FC with Natalie Portman and Julie Uhrman—Nortman has held informal talks with roughly a dozen English clubs, though no deal has yet materialised. She declined to comment on ongoing negotiations with West Ham United’s women’s side, noting that finding the right English partner has proven “challenging”.Recent years have seen a wave of international interest in WSL clubs, yet many prospective investors perceive the women’s teams as a compliance tool for profitability and sustainability mandates rather than a growth engine. In the past twelve months, clubs such as Chelsea, Aston Villa and Everton have sold stakes in their women’s sides to related‑party entities, while US‑based Bay Collective recently secured majority ownership of Sunderland Women in the WSL2.Monarch’s latest $250 million funding round equips it with the capital to act when a suitable opportunity arises. Nortman explained, “If owners truly believe in their women’s team, they should invite us to ‘supercharge’ it with our cross‑sport expertise. If they only want a token boost, that’s a different story.”Beyond capital, Monarch offers advisory services. Nortman recounted a humorous encounter with fans at Crystal Palace, where a supporter asked if she was a “Wag”, prompting a light‑hearted response that underscored the firm’s community‑focused ethos.Reflecting on Angel City’s trajectory, Nortman noted that Monarch initially invested about $1 million to help the club join the NWSL in 2020. Four years later, Angel City was sold to Disney CEO Bob Iger and his wife for a reported $250 million, making it the world’s most valuable women’s franchise.Looking ahead, Monarch is broadening its scope beyond football and basketball, exploring opportunities in cricket and rugby union. The firm recently opened a London office, led by former Manchester City executive Katharine Curran, to deepen its engagement with the UK sports market.

On a recent weekday evening, a special bus tour whisked art lovers through over twelve galleries and museums that stayed open until midnight, offering a late‑night glimpse of the Abidjan Art Week programme.The after‑hours event, dubbed the Night of the Galleries, was first trialled in January 2024 alongside the Africa Cup of Nations – a tournament that Côte d’Ivoire both hosted and won – and has become a staple of the festival’s third edition, which ran from Tuesday to Sunday.Since its inception, the week has broadened its footprint, moving beyond the city centre to include venues such as the La Rotonde des Arts contemporary‑arts hub in the Plateau district and the Adama Toungara Museum of Contemporary Cultures (MuCAT) in the working‑class neighbourhood of Abobo.Local collectors are emerging in force. MuCAT has hosted the Africa Foto Fair each year since 2022, and the Marché des Arts du Spectacle d’Abidjan – the city’s answer to the Dakar Biennale – is set to launch its 14th edition later this month.A graffiti festival launched two years ago has transformed the perception of street art, with vibrant murals now adorning the façade of the La Pyramide building and several upscale hotels in Plateau.Organisers stress that the festival’s growth should be independent of external validation. This year’s roster featured artists from Cameroon, the Democratic Republic of the Congo and Mali, and the number of participating galleries more than doubled compared with previous editions.Founder Yacouba Konaté, who also directs La Rotonde des Arts, highlighted the festival’s commitment to accessibility, arguing that art should not be seen as an elite pastime.The opening tribute honoured Simone Guirandou‑N’Diaye, a pioneering Ivorian art historian whose legacy lives on through Galerie LouiSimone Guirandou, now run with her daughter Gazelle.Among the week’s highlights, MuCAT presented Murmures d’Archives, a quieter, archival‑focused exhibition that concluded with an artists’ workshop and a DJ set.In the upscale Cocody district, New York‑based artist Ouattara Watts staged a solo show at Galerie Cécile Fakhoury, drawing the Ivorian diaspora into dialogue with the local scene. Watts explained that his work aims to transcend borders, describing it as “a vision that goes beyond any map – it is the cosmos that I paint.”

Conversations about mundane topics are often dreaded, but research suggests that people enjoy them more than they anticipate. A study involving 1,800 volunteers found that participants enjoyed chatting about dull subjects, such as the stock market or vegan diets, more than they expected. The findings indicate that by avoiding potentially dull exchanges, individuals may miss out on the mood boost and health benefits that come with connecting with others. Elizabeth Trinh, a PhD candidate in management and organisations at the University of Michigan, noted that people tend to underestimate how interesting and enjoyable conversations about boring topics can be. Trinh and her colleagues conducted a series of experiments to gauge how people responded to conversations on dull topics. Participants were asked to predict how much they would enjoy discussing topics they considered boring, and then engage in brief conversations about those topics. The results, published in the Journal of Personality and Social Psychology, showed that people consistently found the conversations more enjoyable than they expected. The surprise enjoyment arises because individuals base their expectations on static components, such as the topic and the other person, rather than dynamic components, like the conversation itself. Trinh suggests that people may benefit from lowering the bar for what makes a conversation worth having and reframing conversational goals. Instead of focusing on enjoyment, individuals could think about what they might learn from the conversation. Nicholas Epley, a professor of behavioural science at the University of Chicago, added that the fear of a boring conversation shouldn’t prevent people from starting one. “If a conversation is boring once you’re in it, you also have a surprising amount of power to make it better!”

Recent CDC data reveal a dramatic 1,200% increase in kratom‑related poisonings across the United States over the last ten years, with the most pronounced surge recorded in 2025. Researchers link this rise to the growing presence of 7‑hydroxymitragynine (7‑OH), a synthetically produced compound that mimics kratom’s effects but carries opioid‑like risks. Walter Prozialeck, pharmacology professor at Midwestern University, said the trend was expected, noting that the synthetic alkaloid has entered the market through energy drinks and other products since 2024. Christopher McCurdy of the University of Florida warned that marketing 7‑OH as “enhanced kratom” blurs the line for consumers, turning poison‑control calls into a conflated metric for both natural and synthetic products. By contrast, natural kratom (Mitragyna speciosa)—a Southeast Asian plant used for centuries as a pain reliever—has demonstrated a relatively favorable safety profile in animal and human studies. A 2018 statement from then‑HHS Secretary Brett Giroir rejected the DEA’s push to schedule kratom as a Schedule I substance, citing insufficient evidence of harm. Despite the scientific distinction, several states have moved to implement or propose blanket bans on all kratom products, prompting concern from clinicians and patient advocates. A recent user survey indicated that about 50% of respondents rely on kratom for chronic pain, while roughly 40% use it during addiction recovery. Personal testimonies underscore the plant’s therapeutic role. Jeff Maslan, a 68‑year‑old Californian with severe osteoarthritis, credits kratom with easing opioid withdrawal after multiple surgeries. Similarly, “Steven,” a disabled California resident, describes how kratom eliminated unbearable oxycodone withdrawal symptoms without producing the euphoric “warm fuzzy” feeling typical of opioids. Researchers emphasize that 7‑OH carries genuine opioid hazards, including addiction, severe withdrawal, and respiratory depression that can lead to fatal overdose. In animal models, 7‑OH demonstrated the same respiratory‑depression risk as classic opioids, whereas kratom’s primary alkaloid did not. Prozialeck and colleagues explain that kratom’s pharmacology is more nuanced: it partially activates opioid receptors while also engaging adrenergic and serotonin pathways, resembling a hybrid of a weak opioid and an SNRI‑type antidepressant. This multimodal action likely accounts for its lower euphoric potential and the reported boost in energy among users. Nevertheless, experts caution that kratom is not without risk. Fatal poisonings often involve co‑ingestion of potent opioids such as fentanyl, suggesting that some users may cycle between kratom and stronger substances, raising overdose danger due to reduced opioid tolerance. Additionally, heavy‑metal contamination has been detected in certain kratom batches, though the source—soil, processing, or storage—remains unclear. Given these complexities, the consensus among scholars like Austin Zamarripa (Johns Hopkins) is that natural kratom should remain accessible, while concentrated 7‑OH products merit stricter regulation. “These products may offer meaningful benefits to some individuals, and those benefits could be lost if access is restricted too broadly,” Zamarripa said, urging a differentiated policy approach. As the debate unfolds, patients like Steven worry that a sweeping ban would ignore the nuanced safety profile of the plant. “There’s corn on the cob, there’s high‑fructose corn syrup, there’s whiskey— all derived from corn but fundamentally different,” he remarked, highlighting the need for targeted, evidence‑based regulation rather than a one‑size‑fits‑all prohibition.

The Pivot from Vision Pro to Everyday WearablesApple is reportedly preparing to enter the smart glasses market with a product launch targeted for 2027, signaling a significant strategic shift away from its ambitious mixed reality ambitions.Four Distinct Design PrototypesRectangular Frames: Ranging from large to slim, potentially mimicking the style of CEO Tim Cook.Oval/Circular Frames: Available in both larger and smaller sizes.Color Options: Black, ocean blue, and light brown.A Strategic Retreat from High-End ARThis move represents a retreat from the complex Vision Pro ecosystem, which faced delays and lukewarm reception. Instead, Apple is betting on a simpler form factor similar to Meta’s Ray-Ban glasses.The 2027 Roadmap: Simplicity Over ImmersionThe upcoming device will lack displays, focusing instead on camera lenses for photos, videos, calls, and music. It will also integrate with the long-promised Siri upgrade, aiming to capture the mainstream market rather than the niche enthusiast base.

President Donald Trump's 2027 budget proposal has drawn sharp criticism for its stark prioritization of military spending over healthcare and social welfare programs, despite the US facing a crisis of deaths from avoidable causes. The budget proposes a $1.5 trillion military expenditure, a significant increase from previous years, while cutting the Department of Health and Human Services (HHS) budget by 12%.The US faces a grim reality in healthcare, with deaths from treatable conditions nearly twice the rate of countries like Spain, France, Japan, and Australia. Many Americans struggle to access healthcare due to cost, with the US having the highest out-of-pocket expenses for medical services among its peers. The proposed budget cuts to HHS and other non-defense programs will likely exacerbate these issues.Trump's budget plan also slashes funding for programs like Medicaid and the Affordable Care Act, potentially leaving 15 million Americans without health insurance, according to analysts. The administration's justification for these cuts includes claims of corruption and wasteful spending in certain programs.The budget proposal has been seen as a betrayal by many Americans who supported Trump based on his promises to help working-class individuals. The data suggests that if Trump continues to ignore the needs of his base, he may soon lose their support. American men and women are dying, and these individuals are also Trump's voters.The Pentagon's recent spending on conflicts, such as the war against Iran, has been substantial, with estimates suggesting $12.7 billion in the first six days and $28 billion in just over five weeks. The budget proposal's focus on military spending raises concerns about the impact on the US economy and society.