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On 15 May, **BioOrbit** launched its compact **Box‑E** payload aboard a **SpaceX** rocket, beginning a six‑week orbital trial to grow ultra‑pure protein crystals for self‑injectable cancer therapies. Box‑E’s Orbital Test: Microgravity Enables Ultra‑Pure Protein Crystals The microwave‑sized unit will float aboard the International Space Station, where microgravity eliminates the disruptive effects of Earth’s gravity on crystal formation. The resulting crystals are more stable, allowing drug formulations that are impossible to achieve on the ground. Mission duration: ~6 weeks in orbit Target output: thousands of litres of fluid per box per year Goal: Produce cancer‑drug crystals that can be stored in a fridge and self‑injected £9.8 Million Funding Round and UK Space Agency Contract Last month **BioOrbit** closed a **£9.8 million** Series A round led by **LocalGlobe** and **Breega**, earmarked for the orbital test and scaling of the hardware. Earlier in March the company secured a **£250,000** contract from the UK Space Agency to manufacture drugs in microgravity. Potential Disruption of Cancer Treatment Delivery Current immunotherapies such as Merck’s **Keytruda** require lengthy IV infusions in hospitals. By crystallising the active protein, **Box‑E** could enable high‑concentration, low‑viscosity formulations suitable for pen‑injectors, reducing treatment time from hours to minutes and extending shelf‑life. Roadmap to Commercialisation and Market Size **BioOrbit** projects that, if orbital tests succeed, multiple **Box‑E** units could be stacked to meet the demand of a blockbuster drug within a handful of boxes. The company estimates a market of **$22.7 trillion** for in‑space manufacturing across sectors, with pharmaceuticals a key segment. Clinical trials and regulatory approval are expected to take at least five years before the new formulations reach patients. Future Outlook for Space‑Based Pharma Beyond cancer, the crystallisation platform could be applied to the roughly 70 % of top‑selling drugs that are currently administered intravenously. Partnerships with major pharma groups are already being explored, and competitors such as **Varda Space Industries** are also pursuing in‑orbit drug processing, signaling a burgeoning industry.

The Shift in BHP's Climate Strategy BHP, the world's largest miner, has been a significant player in the global mining industry. However, recent internal documents leaked to the Guardian and the ABC's Four Corners program have revealed that the company is backtracking on its climate action plans. The Leaked Documents The leaked documents, dubbed the BHP files, show that the company has halted or delayed several key projects aimed at reducing emissions. These projects include: A 50-megawatt solar farm and 20MW battery at its Jimblebar mine, which was effectively shelved soon after being approved and funded by the board in mid-2023. A huge system of almost 500MW solar, wind and battery that could power a small city, which has been significantly delayed and will not progress in its current form until 2031 at the earliest. An iron ore processing plant that could have prevented 1.7m tonnes of emissions a year, which was dumped despite being described as 'well-aligned' with its climate transition action plan. The Impact on Climate Goals BHP's decision to backtrack on its climate action plans has raised concerns among experts and environmental groups. The company's failure to urgently decarbonize could put national climate targets, including a 43% cut below 2005 levels by 2030, in doubt. The Future Outlook BHP has stated that it is still focused on its emissions reductions goals and has reduced emissions by 36% on 2020 levels. However, experts argue that the company's actions are not in line with its public commitments, and it needs to take more drastic measures to achieve its climate goals.

The Rise of Usman Tariq Usman Tariq, a 30-year-old mystery spinner from Pakistan, is set to make his debut in the T20 Blast for the Bears. His journey to professional cricket is nothing short of remarkable. After spending his early 20s working for a car-parts company in Dubai, Tariq watched a biopic of India's MS Dhoni and decided to pack it in to pursue his cricketing dream. Overcoming Challenges Tariq's bowling action has been subject to scrutiny, with some questioning its legitimacy. However, he has been tested twice and cleared within a week. He attributes his unique action to a congenital condition that gives him an elbow joint that is split, allowing him to bowl with two elbows. Developing His Skills Tariq has developed around six different deliveries, including a devilish carrom ball. His release point is something he mixes up, with a low-slung, side-arm delivery that is not dissimilar to Sri Lanka's Lasith Malinga. Batters have plenty to think about when facing him. The T20 Blast The T20 Blast has undergone changes this year, with 12 group games down to 9 and two groups of six. Teams play two sides outside of their group, leading to new fixtures. The men's Blast now runs straight through to an earlier Finals Day at Edgbaston on 18 July. A Promising Future Tariq is a prime example of an overseas player who can now bounce seamlessly from one tournament to the other. With his unique action and developing skills, he will certainly be one to watch in the T20 Blast and the Hundred.

The Championship ShowdownThe Scottish Premiership title decider between Celtic and Hearts delivered high drama and contrasting emotions as the established powerhouse Celtic defeated the underdog Hearts, crushing their hopes of a championship fairytale. The match represented more than just three points—it was the culmination of a season's worth of aspirations for Hearts and the defense of dominance for Celtic.Emotional RollercoasterDavid Squires' cartoons perfectly captured the diverging emotional trajectories of the two sets of fans. For Celtic supporters, the victory brought unbridled joy as their team secured another title. For Hearts fans, the match represented soul-crushing pain as their dreams of an unlikely championship were extinguished in the decisive encounter.The Fairytale That Wasn'tHearts entered the match as the sentimental favorites, with many observers rooting for the underdog to break Celtic's stranglehold on Scottish football. The team had exceeded expectations throughout the season, building momentum and belief that they could achieve the unthinkable. However, in the ultimate test, Celtic's experience and quality proved decisive, maintaining their position as Scotland's dominant force.What's Next for Scottish FootballWith another title secured, Celtic reinforces their position as the benchmark in Scottish football. For Hearts, the challenge will be to channel the disappointment of this near-miss into motivation for future campaigns. The match highlights the competitive gap that still exists in Scottish football, but also demonstrates the potential for exciting narratives when underdogs dare to challenge the established order.

The Legacy of Sue Barker's French Open Win Sue Barker, one of Britain's leading TV sports presenters for nearly three decades, has always been more comfortable asking questions than answering them. However, her own achievements on the tennis court are a testament to her remarkable athleticism and skill. As the 50th anniversary of her French Open triumph approaches, we revisit her historic win and its lasting impact on British tennis. Sue Barker's Historic Win at Roland Garros In 1976, Barker won her first and only Grand Slam title at Roland Garros, defeating Renata Tomanova in three sets. This victory marked a significant milestone in her career, making her the last British player, man or woman, to triumph in Paris. Barker's win was all the more impressive given that she was the No 1 seed in the tournament, with Chris Evert, Martina Navratilova, and Billie Jean King all absent. The Impact of Barker's Win on British Tennis Barker's achievement has a claim to be one of the most underrated in British sport. Her win inspired a generation of British tennis players, including Jo Durie, who felt motivated by Barker's success. Durie, four years younger than Barker, recalls: "If she can do it then maybe I can do it." Barker's legacy extends beyond her own career, as she paved the way for future British tennis stars. A Career Cut Short by Injury Despite her impressive career, Barker's potential was ultimately curtailed by injury. Ranked No 3 at her peak in 1977, she possessed a formidable forehand that earned her victories over top players like Evert, Navratilova, and King. However, her career was cut short, and she retired in 1984. Barker reflects on her career, saying: "Winning the French Open was magical... Of course, I thought it was the first of many, so I didn't really celebrate that well. If I'd known it was my only one I really would have gone to town." A Lasting Legacy As the tennis world celebrates the 50th anniversary of Barker's French Open win, her achievement serves as a reminder of her enduring legacy. Despite some controversy surrounding her nationality on the Coupe Suzanne Lenglen trophy, Barker remains proud of her accomplishment. Her story serves as an inspiration to aspiring tennis players and a testament to the power of dedication and perseverance in sports.

The Scene of Celebration The mounds of detritus pile up outside Finsbury Park station, like an offering to a vengeful deity. A deity gone rogue for the evening, demanding tribute specifically in the form of empty food cartons and abandoned Lime bikes. A deity that has finally decided to break the habit of 22 years. The Essence of Arsenal What is Arsenal? Not really a place: the tube station is named after the team rather than a locality, rebranded in the 1930s at the request of Herbert Chapman, and in honour of the club rather than – as many Spurs fans have cheekily suggested – because otherwise people wouldn’t know where to get off. It draws its fanbase as readily from Ithaca and Indore as it does from Islington, from south London as much as north. Most of its players and staff live in the Hertfordshire commuter belt. It shares its city with at least half a dozen other perfectly competent clubs, many of which actively despise it. The Metropolitan Swagger and Angst Modern football loves nothing more than to divide its audience. Tiers of membership, tiers of pricing, tiers of devotion, tiers of worth. Red, silver, gold, platinum, hospitality. Local and foreign. And yet, here in the lit north London night, there are no partitions left. All the market segments have dissolved into a single human mass: just people in a place, desperate to seek out others, to see if everyone is feeling the way they’re feeling, communion as a form of verification. The Impact on the Community At times over the past few decades, it has felt increasingly hard to call this city one’s own. Tainted money sloshes through the gutters and sewers, luxury apartment blocks go up for nobody to live in, areas divide ever more starkly along lines of affluence, cherished cafes and businesses go under, longstanding residents get priced or Brexited out. Every state primary school in the borough of Islington is operating under capacity, according to the most recent available figures. Two were forced to close last summer. The Future Outlook This is not guaranteed to work. It will not protect you against fate, ridicule, springtime Guardiola, Emi Buendía smashing one in the last minute. It will not protect you against the crying laughing emojis piling up in your WhatsApp groups. It will not protect you against the doubts that gnaw away in your darkest moments: that you are not special, that this club is at heart like all the others, a capitalistic enterprise built to sell sportswear. That this is the club of Visit Rwanda and Thomas Partey. That City will find a way again.

The Lead: McCullum’s firm‑grip promise after winter tour errorsEngland head coach Brendon McCullum has pledged to use a “firm grip” to address alcohol‑related and attitude problems that surfaced during the team’s disappointing winter tours of New Zealand and Australia.Winter tour setbacks and on‑field failuresThe side struggled in the away Ashes series, losing 4‑1, and McCullum admitted “mistakes were made” by players under pressure.Loss in Ashes: 4‑1 defeatMcCullum’s age: 44Captain Ben Stokes’ morale “may have waned” in AustraliaMcCullum’s cultural reset: firm grip and open dialogueIn an ECB interview, McCullum said the squad’s core culture is “really good” but occasional lapses require “a firm grip” to prevent repeat mistakes. He emphasized that differences of opinion with captain Ben Stokes are healthy and that no “clear‑the‑air” talk was needed because “there was nothing to clear the air about”.Impact on upcoming summer Tests and squad selectionMcCullum is confident the team can improve against New Zealand, Pakistan, and future series versus India and Australia. He highlighted the return of Jacob Bethell, pending a finger injury from the IPL, as a potential boost.First Test vs New Zealand at Lord’s – next ThursdayKey players: Ben Stokes, Jacob BethellFuture outlook: aiming for a feared, adaptable England sideMcCullum envisions a side that can “play brave when it needs to, play smart when it needs to” and handle pressure in any condition. If England can sharpen its decision‑making and maintain discipline, McCullum believes “the ultimate success” is within reach.

The Lead A live recording of Wagner's Ring Cycle, conducted by Fabio Luisi with the Dallas Symphony Orchestra, has been released on 13 CDs. This ambitious project, captured in 2024, showcases Luisi's clearheaded approach and keen sense of operatic architecture. Luisi's Operatic Vision Luisi, with his strong record in leading large-scale operatic works, brings a compelling perspective to this recording. His approach is marked by a supple way with phrasing and a deep understanding of Wagner's architectural vision. The Vocal Cast The cast is led by Mark Delavan as Wotan, whose voice carries the right authority. Daniel Johansson shines as a lyrical Siegfried, while Lise Lindstrom brings a committed performance as Brünnhilde. Sara Jakubiak stands out as a radiant Sieglinde. The Performance Details Conductor: Fabio Luisi Orchestra: Dallas Symphony Orchestra Release format: 13 CDs Recording year: 2024 The Impact Analysis This recording is significant for its live performance aspect, which can often provide ideal conditions for capturing the energy and spontaneity of opera. Luisi's expertise in leading such large-scale works makes this set a valuable addition to any Wagner enthusiast's collection. The Prediction Given the quality of the performance and the production, this recording is likely to receive critical acclaim and be well-received by fans of classical music and opera. It sets a high standard for future live recordings of Wagner's works.

The Revival of Sugar Bob Mould has never seemed to have much interest in looking back. The bridges to a Hüsker Dü reunion were burned long before drummer and songwriter Grant Hart died in 2017; the notion that Mould might revive Sugar, the band who scored three unlikely UK Top 10 albums of ferocious alt-rock in the mid-90s, seemed ridiculous. But here we are: after three New York shows, Mould, David Barbe and Malcolm Travis are touring the UK and Ireland. The Performance Some things have changed: the seething sea of moshers at 90s shows is now a placid lake of the nodding middle-aged. Travis, 73, seems to drum with the minimum amount of movement possible, wisely given the searing heat inside the Forum. Others haven’t: JC Auto, which closes the main set, remains brutal and churning, thrillingly intense. Mould still stomps in circles around the stage like a man furiously searching for his lost remote control. The Music Mould, arguably, is the man who brought melody to American hardcore punk, and Sugar continued his desire for big tunes and searing guitars. When he plays alone, it can be hard sometimes to pick out the melodies behind the trebly sheets of guitar, but the ballast of the rhythm section holds the tunes in place, and the pop smarts of If I Can’t Change Your Mind and Gee Angel burst out of the PA. The Vocal Dynamics The songs sung by Barbe don’t fare quite so well – his voice is smooth and high and gets a little lost in the mix. You can hear he’s singing during Company Book, but it’s more a texture than a selection of words, floating atop the guitars. That same texture, though, adds depth to his harmonies, giving Sugar a warmth that not all their contemporaries could manage. The Future There’s no time for messing around, just a furious charge through 23 songs in 90 minutes, including two recorded for the reunion – Long Live Love and House of Dead Memories – suggesting that Sugar might stick around to do more than tour gen X nostalgia. We can only hope. Sugar play Ulster Hall, Belfast, 26 May; then tour the UK and Ireland until 4 June