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The UK medicines regulator has opened an inquiry into a growing number of clinics that sell injectable peptides while promoting them as cures for everything from ageing to injury recovery. The investigation, disclosed by the Guardian, focuses on whether these businesses are breaching the Human Medicines Regulations 2012 by making unauthorised medicinal claims. Interest in peptide‑based treatments has surged in recent years, driven by social‑media influencers, some healthcare professionals, and direct‑to‑consumer marketers. Yet the scientific foundation for most of these claims is weak, with the bulk of research confined to animal models or cell‑culture studies. According to an MHRA spokesperson, any clinic that advertises a peptide as having therapeutic benefits must treat the product as a medicine, which triggers a comprehensive regulatory framework. "If clinics offering peptide injections make medicinal claims for those treatments, the products will be considered medicines and subject to regulation," the agency warned, adding that it will act against any identified breaches. Guardian reporters identified several high‑ranking Google search results that list peptides such as Cortexin (promoted for neuroprotection), BPC‑157 (claimed to aid tissue repair), and Thymosin Alpha (advertised to boost immunity). After being contacted, one clinic removed the statements from its website. Another clinic, while acknowledging the limited human evidence, continued to market seven specific peptides, providing price lists (£350 per month for a single peptide, £450 for two) and offering delivery via vials, syringes, or pre‑filled pens for an additional fee. During a free consultation, a clinician highlighted the experimental nature of the products, noting the absence of large‑scale, randomised clinical trials and recommending a break of four to eight weeks between treatment cycles to mitigate unknown risks. The clinician suggested BPC‑157 for post‑exercise recovery, describing it as a facilitator of cellular repair and blood flow, but warned against its use in smokers or individuals with a family history of cancer due to potential angiogenic effects. The second peptide discussed was MOTS‑C, portrayed as a mitochondrial enhancer that could improve stress resilience, lower insulin resistance, and reduce visceral fat by boosting cellular energy production (ATP). The MHRA confirmed it is reviewing whether the clinician’s statements constitute medicinal claims. The clinic defended its approach, emphasizing that it clearly informs clients that the peptides are not licensed medicines and that the evidence base is largely pre‑clinical. In a broader statement, Lynda Scammell, head of borderline products at the MHRA, explained that peptide products may be marketed as cosmetics, supplements, or medicines, and each case is assessed on its intended use, pharmacological effect, and supporting evidence. She added, "We disregard claims that products are for ‘research purposes’ if it is clear that such claims are being used as an attempt to avoid medicines regulations." Peptides are short chains of amino acids, some of which occur naturally (e.g., insulin). While synthetic peptide analogues like semaglutide and tirzepatide have secured approval for weight‑loss treatments, many of the compounds promoted by these clinics remain experimental and lack the rigorous safety and efficacy testing required for medicinal products.

Liverpool's humiliating 4-0 defeat to Manchester City in the FA Cup quarter-finals has raised concerns about the team's form and manager Arne Slot's future. Slot criticized his team's performance, particularly in the 10 minutes after halftime, where he felt they lacked the 'fighting spirit' needed to compete at a high level. The manner of the defeat will heighten scrutiny of Slot's future, especially with Liverpool's upcoming Champions League quarter-final against Paris Saint-Germain. A similar performance in that tie could prove detrimental to Slot's position as manager. Erling Haaland scored a hat-trick for Manchester City, contributing significantly to their eighth consecutive FA Cup semi-final appearance. Slot emphasized the need for his team to improve defensively and show a better reaction to the loss, particularly against top-tier teams like PSG. Liverpool's Dominik Szoboszlai echoed Slot's sentiments, stating that the team's 'fighting spirit wasn't there enough.' The defeat marks Liverpool's 15th of the season, their most since the 2014-15 season. Liverpool's struggles have been compounded by Mohamed Salah's missed chances, including a penalty when City were 4-0 ahead. Slot, however, chose not to single out individuals, instead focusing on the team's overall performance and the need for improvement.

Analysts say that more than two years of relentless campaigns against Gaza, the Houthis, Lebanon and now Iran have reshaped Israel’s politics, economy and social fabric.Washington, rather than Jerusalem, is likely to decide the ultimate outcome of the conflict that Israeli leaders describe as an “existential battle” with Tehran.According to the Bank of Israel, the cumulative cost of these wars has reached 352 billion shekels (about $112 bn), which translates to roughly 300 million shekels ($96 m) per day. The financial pressure is compounded by the International Court of Justice hearing credible genocide accusations and the International Criminal Court’s arrest warrants for the prime minister and a former defence minister.Domestically, Israelis endure frequent air‑raid alerts and school closures, while many families juggle work and shelter duties. Yet a poll by the Israel Democracy Institute in late March showed that 78 % of Jewish Israelis still support continuing the war, even as a majority doubt that Washington and Israeli planners have fully grasped Tehran’s capabilities.Political commentator Dahlia Scheindlin told Al Jazeera that a “graveness” has settled over the population, noting a grim determination to press on despite exhaustion.Israel’s right‑wing coalition, led by figures such as National Security Minister Itamar Ben‑Gvir and ultra‑Orthodox Finance Minister Bezalel Smotrich, has pushed through a controversial death‑penalty law targeting Palestinians and approved a record $271 bn budget. The budget allocates substantial funds to ultra‑Orthodox and settler communities, a move described by critics as an attempt to shore up Prime Minister Netanyahu’s waning support.Internationally, the United Nations, European Union and several Muslim‑majority states have condemned the new death‑penalty legislation, though Israel has so far avoided direct sanctions.Economists warn that the war’s fiscal impact extends beyond defence spending. A Le Monde analysis highlighted rising defence outlays, lost productivity from reservist mobilisation, and dampened consumer activity. While temporary tax cuts have mitigated fuel‑price spikes caused by Iran’s closure of the Strait of Hormuz, political economist Shir Hever cautions that Israel’s reliance on imported fuel means any relief is short‑lived.Hever likens the current economic trajectory to that of a “totalitarian state,” where military expenses are pursued arbitrarily, ignoring broader economic stability.Ultimately, the war’s duration may hinge more on U.S. policy than Israeli strategy. When asked by Newsmax about progress toward its goals, Prime Minister Netanyahu could only claim the effort was “halfway” achieved.

Israel's ongoing attacks on Lebanon have led to a significant deterioration of the country's healthcare infrastructure. In the past month, 53 medical workers have been killed, 87 ambulances and medical centers destroyed, and five hospitals forced to close, according to Lebanon's Ministry of Public Health.The attacks have resulted in the displacement of 1.2 million people, putting an enormous strain on the already struggling Lebanese healthcare system. Experts and analysts say that Israel's actions are part of a broader strategy to force people out of southern Lebanon.“Israeli strikes and blanket evacuation orders are cutting people off from care and shrinking the space for health services to function,” said Luna Hammad, Lebanon medical coordinator for Doctors Without Borders (MSF). MSF has documented a pattern of attacks affecting healthcare.The destruction of healthcare infrastructure has also led to a significant increase in emergency room admissions. Healthcare facilities are under higher strain than before, with many patients needing treatments like chemotherapy, radiotherapy, and dialysis being transferred further north.Direct attacks on healthcare workers and facilities have been documented by Human Rights Watch (HRW), which has noted repeated, apparently deliberate attacks on medical workers in Lebanon. Medical workers and healthcare facilities are protected under international humanitarian law, and Israel's attacks on medics in 2024 were described as an apparent war crime by HRW.The attacks on healthcare infrastructure during times of war are not new. Forensic Architecture has documented systematic targeting of hospitals and healthcare workers in Gaza. Experts warn that such attacks have compounding effects, including treatable injuries getting worse, war wounds not healing properly, and long-term consequences.Experts and analysts say that the attacks are unlikely to cease as long as the pattern of impunity continues. Lebanon's government has a responsibility to ensure accountability and to give jurisdiction to the International Criminal Court (ICC) to investigate and prosecute war crimes.

The Oklahoma City Thunder delivered a 43-point blow to the Los Angeles Lakers, defeating them 139-96 in a game that will be remembered for its one-sidedness and the injury to Luka Doncic. The Thunder's fourth consecutive win and 16th victory in 17 games showcased their dominance, while the Lakers' four-game winning streak came to an abrupt end.Shai Gilgeous-Alexander led the Thunder with 28 points, complemented by Luguentz Dort's all-around performance and Jalen Williams' impressive stats of 10 points, nine rebounds, and eight assists. The Thunder controlled the game from the outset, building a double-digit lead within four minutes that never dipped below nine points thereafter.The game's most concerning moment came when Luka Doncic suffered a strained left hamstring in the second half. The Lakers' star player will undergo an MRI on Friday to determine the extent of the injury. Doncic's night was already off, as he missed his first four field goals and finished with just 12 points on 3-of-10 shooting, tied for his second-lowest scoring game of the season.The Lakers' worst loss since November 2023 was compounded by the fact that they were outplayed in every facet. Austin Reaves led the Lakers with 15 points, but it was a night to forget for the team as a whole. The Thunder's 139 points were the most surrendered by the Lakers this season, highlighting their defensive struggles.

The 70‑year‑old grandson of H. B. Reese, the man who created Reese’s Peanut Butter Cups, has publicly accused the $42 billion Hershey Company of quietly swapping the original milk‑chocolate and peanut‑butter formulas for cheaper compound coatings and “peanut‑butter‑style crèmes.”Brad Reese’s complaint, first aired on LinkedIn on Valentine’s Day, claims the confectionery giant has been “rewriting recipes” across flagship brands, a practice he describes as an “ingredient drift” that undermines both brand integrity and shareholder value.At a recent investor conference, Hershey announced it would restore the classic recipes for roughly 3 % of select products by next year, while insisting that the iconic Reese’s Peanut Butter Cups have never been altered.Chief Growth Officer Stacy Taffet explained that the company is “transitioning our sweets portfolio to colors from natural sources” and is committed to aligning all Hershey and Reese’s offerings with their historic milk‑ and dark‑chocolate formulas.Reese, however, dismissed the move as a “board‑level accountability problem,” arguing that the delayed rollout has already prompted shareholders to sell stock and that “your consumers are revolting.”In an interview with the New York Times, Reese labeled Hershey’s actions a “PR stunt,” insisting that a genuine commitment would mean an immediate return to the original recipes.Hershey counters that the recipe revisions are not a reaction to Reese’s criticism but stem from a strategic decision made after a 25 % increase in research and development spending aimed at talent, technology, and nutrition science.The dispute has taken on a personal dimension for Reese, who alleges the changes began after Hershey acquired the Reese’s brand in the 1960s. He recounts a recent taste test of Reese’s Unwrapped Chocolate Peanut Butter Creme Mini Hearts, stating, “I had to spit it out—it wasn’t real milk chocolate or real peanut butter.”Reese’s family, speaking to USA Today, clarified that his statements are his own and do not reflect the family’s view, adding that they continue to respect Hershey’s leadership and believe H. B. Reese would be proud of the brand’s current stewardship.Undeterred, Brad Reese retorted on LinkedIn that Hershey is “shooting the messenger,” accusing the company of managing perception rather than fixing the alleged product issues and warning that “the evidence chain isn’t going away.”

Washington, D.C. – In a historic session, the United States Supreme Court examined the Trump administration’s bid to curtail the long‑standing practice of granting citizenship to anyone born on American soil. The hearing drew a sizable crowd of civil‑rights and immigration advocates who decried the proposal as unconstitutional. Lawyers representing the administration argued that the 14th Amendment has been misread for over a century and that citizenship should be limited to children of parents who are legally domiciled in the United States. They contended that the phrase “subject to the jurisdiction thereof” permits the exclusion of infants born to undocumented or temporary‑status parents. Opposing counsel from the ACLU and other groups countered that the amendment’s language, reinforced by the 1898 United States v. Wong Kim Ark decision and the 1952 Immigration and Nationality Act, unequivocally guarantees citizenship regardless of parental status. “The rule was enshrined in the 14th Amendment to keep it out of reach of any official who might try to destroy it,” ACLU attorney Cecillia Wang said. The proceedings were underscored by President Donald Trump’s unprecedented presence in the courtroom, making him the first sitting president to attend Supreme Court oral arguments. Trump left the hearing abruptly, later posting on Truth Social that the United States is “the only country in the world stupid enough to allow ‘birthright’ citizenship.” Protesters such as 21‑year‑old Luis Villaguzman of LULAC expressed personal stakes, noting that the policy would strip benefits from pregnant immigrant mothers and jeopardize their children’s future. “This hits close to home,” he said. Justices probed the administration’s claims, with Justice Kentanji Brown Jackson asking, “Who is domiciled?” while Justice Samuel Alito highlighted the repeated references to “domicile” in the Wong Kim Ark opinion. Justice Brett Kavanaugh questioned why Congress had not clarified the citizenship scope in the 1952 statute, and Justice Amy Coney Barrett warned of the logistical chaos the order could create. Legal scholars warned that the executive order could affect roughly 255,000 infants annually, according to a joint analysis by the Migration Policy Institute and Penn State’s Population Research Institute, potentially creating a “self‑perpetuating, multigenerational underclass.” Outside the court, immigration advocates emphasized the broader implications: the measure could disenfranchise hundreds of thousands of children, many of Latino heritage, and compound the administration’s aggressive deportation agenda. The Court has not set a date for a final ruling, but the hearing offered a glimpse into the judicial scrutiny the case will face as the nation watches a potential reshaping of a core constitutional right.

Closing the Strait of Hormuz has choked a vital artery that carries roughly one‑fifth of the world’s crude oil and LNG, sending energy prices soaring and unsettling global trade. Even if the waterway reopens tomorrow, analysts say the ripple effects will endure for months. Nils Haupt, senior director of corporate communications at German carrier Hapag‑Lloyd, told Al Jazeera that the end of hostilities does not equate to the end of logistics challenges. “Once the bombardments stop, the real work begins,” he said, noting that hundreds of vessels will scramble for berths in Persian Gulf ports, creating a prolonged bottleneck for containers and bulk cargo. According to the International Maritime Organization, about 2,000 ships are currently stranded because of Iran’s partial blockade, with only a handful of vessels from “friendly” nations granted passage. Maritime‑intelligence firm Windward estimates that roughly 400 of those ships are anchored in the Gulf of Oman, waiting for a green light. Diverted traffic has already forced many carriers to reroute via the Suez Canal or take the far longer Cape of Good Hope passage, inflating transit times and costs for shipments bound for Asia and Europe. Oil exports from Saudi Arabia are now being sent around the Red Sea, bypassing the strait entirely. Svein Ringbakken, managing director of the Norwegian Shipowners’ Mutual War Risks Association, cautioned that even with ports operating at full capacity, clearing the backlog of oil, gas and other goods will take months. He added that repeated attacks on regional energy and transport infrastructure have compounded the problem. The International Energy Agency reports that more than 40 energy assets across the Middle East have suffered “severe or very severe” damage, prompting companies such as QatarEnergy, Kuwait Petroleum Company and Bahrain’s Bapco Energies to declare force majeure. Beyond the immediate loss of flow, the shutdown has disrupted exports of petrochemicals, fertilisers and raw materials essential for plastics production, further straining global supply chains. Industry leaders warn that the risk landscape has fundamentally shifted. SV Anchan, chairman of US‑based logistics group Safesea, highlighted the rise of asymmetric threats, including unmanned vessel attacks, which have already accounted for at least 18 confirmed assaults since the conflict began. “A full reopening will only bring normalcy after a sustained period of stability and credible security guarantees,” Anchan said. Insurance costs have exploded as a result. Marco Forgione of the Chartered Institute of Export & International Trade noted that hull and cargo premiums have surged up to 300 %, a pressure point that could force shipping firms to curtail operations if rates remain high. Oscar Seikaly, CEO of NSI Insurance Group, stressed that war‑risk coverage will only normalize when a “truly permanent” security solution is in place, not a partial one. Recent data from Lloyd’s List show that a few vessels have managed to obtain Tehran’s permission to transit, with one ship reportedly paying $2 million for the right to pass. Iranian lawmakers have also moved to formalise transit fees for the strait. Nick Marro, lead global‑trade analyst at the Economist Intelligence Unit, warned that the security guarantees demanded by shippers may be hard to meet, citing the volatile Red Sea experience where commercial traffic remains below pre‑2023 levels. Marro predicts that the Hormuz shutdown will accelerate a broader trend of route diversification, similar to the supply‑chain shifts triggered by the COVID‑19 pandemic. “Geopolitical uncertainty will become a permanent feature of risk management, not a temporary reaction,” he said. Seikaly echoed this outlook, suggesting that exporters will increasingly explore alternative corridors for strategic and political reasons, ultimately reducing traffic through the Strait of Hormuz over the long term.

The MCC has rejected a proposal to rescue Middlesex Cricket Club, which is struggling with financial and governance issues. Middlesex, a long-term tenant at Lord's, has been facing a crisis, prompting a group of distinguished former players, led by former England captain Mike Gatting, to call on chairman Richard Sykes to stand down.The MCC, with annual revenues of around £70m, has been mooted as a potential solution to Middlesex's problems, but it will not happen under their current leadership. While the MCC remains committed to extending Middlesex's lease at Lord's and will provide further help where possible, there are no plans to offer direct financial assistance or become more involved in the running of the club.Middlesex's financial problems are compounded by the fact that they cannot access the £24m they are theoretically owed from the ECB's part-sale of the eight Hundred franchises. The ECB insists that the counties can only use the £500m windfall to clear debt or for major infrastructure projects. Middlesex are exploring taking the club into private ownership, but the process of demutualisation would require a 75% majority vote from a turnout of at least 50% of their membership.The club starts the season against Gloucestershire on Friday in the second division of the County Championship for the third successive year, the eighth out of the last nine years they have spent in the second tier.