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A new large‑scale randomized trial presented at the European Congress on Obesity in Istanbul indicates that the oral GLP‑1 antagonist orforglipron can help patients retain the majority of weight lost with injectable therapies such as tirzepatide (Mounjaro) and semaglutide (Wegovy).Trial Shows Oral Orforglipron Preserves Most Weight After Switching from InjectablesThe study, funded by Eli Lilly, followed 376 US patients who had been on tirzepatide or semaglutide injections for 72 weeks and then randomized them to a daily orforglipron tablet or placebo for an additional year.Participants were previously on weekly GLP‑1 jabs that typically produce 15‑20% body‑weight loss.After the injection phase, subjects were switched to oral therapy or placebo for 12 months.Primary endpoint: proportion of weight loss retained at 12 months.Quantitative Outcomes: 75% vs 49% Retention for Tirzepatide Users, 80% vs 38% for Semaglutide UsersWeight‑loss maintenance differed markedly between the pill and placebo groups:Tirzepatide cohort: 75% of lost weight retained with orforglipron vs 49% with placebo.Semaglutide cohort: 80% retained with the pill vs 38% with placebo.Secondary benefits—blood pressure, cholesterol, and glycaemic control—were also sustained in the pill arm.Implications for Obesity Management and Healthcare CostsExperts highlighted the broader significance:Dr Louis Aronne (Weill Cornell Medicine) emphasized that treating obesity directly can simultaneously improve glucose, lipid, and blood‑pressure metrics.Dr Marie Spreckley (University of Cambridge) noted patient preference for oral therapy due to convenience, storage, and lower cost.Dr Simon Cork (Anglia Ruskin University) warned that injectable GLP‑1 drugs, while highly effective, are expensive and limit long‑term accessibility for both private payers and the NHS.The findings suggest a potential shift toward oral agents that maintain efficacy while reducing financial and logistical burdens.Future Outlook: Oral GLP‑1 Therapies Could Redefine Chronic Obesity CareIf further trials confirm these results, orforglipron could become a cornerstone of chronic obesity management, enabling earlier intervention (BMI 25‑27) and possibly preventing progression to severe obesity.Regulators and payers will likely scrutinize cost‑effectiveness models, but the prospect of a cheap, daily tablet that sustains weight loss may reshape treatment algorithms worldwide.

The World's Longest Football DerbyCarlisle and Barrow will play each other next season in the Cumbrian derby in the National League. The clubs are located at opposite ends of Cumbria and the distance between the two grounds is some 78 miles by car. But this is not the greatest distance between two teams involved in a 'derby'.When considering derbies, we are looking for matches between teams that are linked based upon their proximity or geography, rather than simply historical rivalries like the 'clásico' between Real Madrid and Barcelona.UK Derbies: The Cumbrian ContenderWithin the UK, the Cumbrian derby certainly looks the furthest derby by distance. If we are staying in England, the closest we can get to 78 miles is the A49 derby between Shrewsbury Town and Hereford United, separated by 51 miles, although it should be said that the two teams have not met since the latter was dissolved in 2014.In England, thoughts immediately go to Crystal Palace and Brighton, dubbed the M23 derby, but a quick search reveals that Selhurst Park is a mere 46 miles from the Amex Stadium. It is also 46 miles that separate the stadiums of Plymouth Argyle and Exeter City, the Devon derby. Just behind are Ipswich and Norwich – the East Anglian derby (AKA El Tractico or the Old Farm) – with Portman Road and Carrow Road 45 miles apart.International Long-Distance DerbiesFarther afield, we must mention the derby between Persib Bandung and Persija Jakarta, who take part in the Indonesia derby, or Laga Klasikal as it is locally known, with Persib's Gelora Bandung Lautan Api Stadium lying 108 miles away from Persija's Jakarta International Stadium in Indonesia's capital.Italy is fertile ground for a host of famous derbies, and it is here that we find some of the longest-distance derbies. Of course there is the Derby d'Italia between Milan and Juventus, with 85 miles separating San Siro and Juve's Allianz Arena in Italy's north-west. The Derby di Sicilia between Palermo and Catania spans a whopping 134 miles across the breadth of Sicily, while the Derby delle Isole (Derby of the Islands) between Palermo and Sardinian club Cagliari goes even further – a full 250 miles across the Tyrrhenian Sea.The Champion: New Zealand's 386-Mile DerbyOur winner, though, comes from New Zealand's North Island. With Auckland FC only entering the A-League Men in 2024-25, the New Zealand derby between themselves and Wellington Phoenix is still very much in its infancy but has already blossomed into something substantial. In February, just the sixth edition of the derby, a comical own goal from Wellington goalkeeper Josh Oluwayemi sparked a 5-0 thrashing by Auckland, prompting Phoenix coach Giancarlo Italiano to resign immediately after the defeat. With 386 miles between the two grounds, the NZD is our clear winner.The Evolution of Geographic DerbiesThe existence of such long-distance derbies challenges our traditional understanding of what constitutes a local rivalry. In an era where football has become increasingly globalized, these geographic matchups represent unique connections between communities separated by vast distances. The New Zealand derby, in particular, showcases how even in a country with a relatively small population, football can create intense rivalries across significant geographical divides.The Future of Long-Distance DerbiesAs football continues to evolve, we may see more long-distance derbies emerge, particularly in regions with expanding leagues or where new clubs are formed to serve underserved areas. The New Zealand derby between Auckland and Wellington Phoenix is a prime example of how modern football infrastructure and scheduling can create meaningful rivalries regardless of distance. With the increasing popularity of travel and fan engagement, these long-distance derbies may become even more significant in the future of football culture.Double Winners in FootballDeji Elerewe has won the title with both Bromley (League Two) and Lincoln (League One) this season. Has any other player managed the same feat?We covered this answer 10 years ago in a previous Knowledge, but regular contributor Dirk Maas has come in clutch with some additions, although he does clarify that he has limited his search to the top five leagues in Europe in this century.There are several examples of players winning titles with different teams in the same season, including:Jonas Urbig with Köln (2. Bundesliga) and Bayern Munich (Bundesliga) in 2024-25Leigh Griffiths with Celtic (Scottish Premiership) and Wolverhampton (League One) in 2013-14Urby Emanuelson with Ajax and Milan in 2010-11Daniel Amartey with Leicester City and FC Copenhagen in 2015-16Timothy Weah with Paris Saint-Germain and Celtic in 2018-19Khvicha Kvaratskhelia with Napoli and PSG in 2024-25There are also alternative cases where seasons happen at different times of year, such as David Beckham achieving this by picking up an MLS winner's medal with LA Galaxy and a Ligue 1 winner's medal with Paris Saint-Germain in 2012-13.

The Ruislip Abuse Documentary Takes Prime Time on Channel 4Do You Know This Man? airs at 10pm on Channel 4. It follows survivors Laura Hughes, Lauren Preston and Mary Sharp as they confront drug dealer Martin Butler, whose house became a party venue that led to multiple rapes. The programme blends courtroom testimony with personal recollection, highlighting the lasting trauma and the victims' resilience.Hannah Fry Explores Anti‑Ageing Science on BBC TwoAt 7.30pm, the new series The Future With Hannah Fry launches. The first episode travels from US bio‑hackers to Japanese butterfly research, probing how emerging science could extend human lifespan.Travel, Comedy and Drama Fill BBC One’s Primetime Line‑up8pm – Race Across the World: Teams reach Mongolia, facing harsher terrain and colder weather.9pm – Amandaland: A pretentious coffee‑shop saga in South‑West London turns into a clash of digital‑marketing egos.9.30pm – Only Child: The second series deepens the comic chemistry of a pensioner and his out‑of‑work actor son.9pm – Kidnapped By My Mum (BBC Three): A harrowing documentary revisits the 2017 disappearance of Alex Batty and his later rescue.Why These Programs Matter for British TelevisionAll four channels are prioritising real‑life narratives that blend investigative journalism with human‑interest storytelling. By airing a rape‑survivor documentary alongside a science‑focused series, broadcasters signal a willingness to tackle difficult subjects while still delivering entertainment.What to Expect Next SeasonIf audience metrics stay strong, we can anticipate more documentary‑driven slots on primetime, especially on Channel 4 and BBC Three, and further expansion of science‑communication formats like Hannah Fry’s series.

Roberto Sanchez, the left‑leaning presidential candidate of Juntos por el Peru, has been formally accused of financial crimes, with prosecutors seeking a five‑year‑four‑month prison term and a permanent ban from holding the presidency.Undisclosed Campaign Contributions Trigger Criminal ChargesProsecutors allege that Sanchez and his brother William Sanchez received more than 280,000 Peruvian soles (≈ $81,720) in contributions and membership fees between 2018 and 2020, which were omitted from the party’s financial disclosures to the National Office of Electoral Processes.Financial Scope of the AllegationsUndisclosed amount: 280,000 solesPeriod covered: 2018‑2020Proposed sentence: 5 years 4 months imprisonmentAdditional penalty: permanent disqualification from the presidencyPotential Ripple Effects on Peru’s Run‑off ElectionThe charges emerge just after electoral authorities confirmed Sanchez’s place in the June 7 run‑off against conservative rival Keiko Fujimori. A conviction could bar him from office, reshaping the dynamics of a contest that currently shows Fujimori leading with 17.17 % of the vote and Sanchez at 12 %.Judicial Timeline and What It Means for VotersA judge is slated to rule on May 27 whether the case proceeds to trial. If the case moves forward, Sanchez may be unable to campaign effectively, potentially boosting Fujimori’s chances or opening space for other candidates.

The Lead In a United States court, OpenAI chief executive Sam Altman has rejected claims from fellow tech mogul Elon Musk that he betrayed the artificial intelligence company’s original vision. Altman's Testimony On the witness stand on Tuesday, Altman instead framed Musk as a competitor obsessed with exercising control over OpenAI. “It does not fit with my conception of the words ‘stealing a charity’ to look at what has actually happened here,” Altman told the court. The Dispute Over OpenAI's Equity “An early number that Mr Musk threw out was that he should have 90 percent of the equity to start,” Altman told the jury. “It then softened, but it always was a majority.” The Impact on OpenAI's Future The outcome of the trial could determine the future of OpenAI, its leadership, and products like ChatGPT. As part of his lawsuit, Musk is pushing for the removal of Altman and Brockman. The Trial's Implications The trial comes as OpenAI prepares for a potential initial public offering that could see it valued at $1 trillion, a historically large sum. The AI industry has become a driver of eye-watering investment in recent years, with the United Nations estimating that the global market could be worth $4.8 trillion by 2033.

OpenAI CEO Sam Altman testified on Tuesday in an Oakland federal courtroom, confronting allegations from Elon Musk that the company breached its founding agreement by converting to a for‑profit structure.Altman’s Testimony Highlights the For‑Profit Conversion DisputeDuring his appearance, Altman recounted his career and directly addressed Musk’s claims that he “swindled” Musk into co‑founding OpenAI and that the nonprofit was improperly turned into a profit‑driven venture. He emphasized that discussions about a for‑profit arm in 2017 never materialised due to ownership disagreements and that Musk’s demand for total control made him uncomfortable.Financial Stakes: $134 bn Redistribution Claim and $1 tn Valuation Target$134 bn – amount Musk seeks to redistribute to OpenAI’s nonprofit side.$1 tn – valuation OpenAI aims for in its upcoming public offering.Three‑week trial duration, with closing arguments scheduled for Thursday.Implications for OpenAI’s IPO Plans and AI Industry GovernanceThe outcome will shape OpenAI’s ability to proceed with its planned IPO and could set precedents for how hybrid nonprofit‑profit AI entities are regulated. A ruling against OpenAI might force a restructuring that could delay or diminish the $1 tn market debut, while a victory would reinforce the current governance model that separates nonprofit oversight from for‑profit operations.What the Closing Arguments Could Mean for OpenAI’s FutureWith the jury set to deliberate after Thursday’s closing statements, analysts anticipate three possible scenarios: (1) a verdict that upholds OpenAI’s structure, clearing the path for the IPO; (2) a partial ruling requiring financial adjustments but allowing the company to remain operational; or (3) a full reversal that could trigger a major re‑organization or sale. Stakeholders are watching closely as the decision will influence investor confidence across the broader AI sector.

Dimon’s Warning Over the Future of JP Morgan’s £3bn London HQJamie Dimon, chief executive of JP Morgan, told Bloomberg TV in Paris that the bank could abandon its planned £3 billion headquarters in Canary Wharf if a new Labour prime minister proves hostile to banks.Political Trigger: Potential Labour Leadership ChangeThe warning is tied to the uncertainty surrounding Keir Starmer. If Starmer is replaced by a successor who reverses the current “positive business environment” – especially after recent tax concessions – the project could be cancelled.Current plan: 23,000 UK staff, >50% to be housed in the tower.Location: Canary Wharf, London.Timing: announced November 2025, construction slated to start 2027.Financial Stakes: Cost, Tax Burden, and Staffing NumbersEstimated construction cost: £3 billion (≈ $3.8 billion).JP Morgan reported net income of $57 billion (£43 billion) in 2025.Dimon claims the bank has already paid roughly $10 billion in extra UK taxes (bank surcharge and levy).Requested discount on business rates for the tower.Broader Implications for the UK Financial Services SectorA withdrawal would signal to other foreign banks that political risk can outweigh the UK’s market size, potentially derailing planned IPOs and dampening investment banking activity.Investment banking sources warn IPO pipelines could be “derailed”.City stability is linked to consistent fiscal policy and leadership continuity.What Could Happen If a New Prime Minister Targets Banks?Analysts expect three possible scenarios:Renegotiation: JP Morgan seeks further tax relief or guarantees before proceeding.Project suspension: Construction is paused pending political clarity, increasing costs.Cancellation: The tower is scrapped, reducing UK office‑space demand and signaling a shift in foreign investment strategy.Stakeholders will watch the Labour leadership contest closely, as the outcome could reshape the UK’s attractiveness to global banks.

Pentagon Releases 162 UFO Files Following Trump DirectiveThe U.S. Department of Defense made public 162 previously classified documents on unidentified flying objects after a direct request from President Donald Trump. The dossier pulls together material from the FBI, NASA, and the U.S. Department of State, offering the first large‑scale glimpse into the government’s historic UFO investigations.Key Revelations Inside the Declassified PacketsReports span from the 1940s Cold War era to recent 2020‑2025 sightings.Several files contain radar logs and pilot testimonies that were never previously disclosed.NASA’s involvement is limited to satellite imagery analyses, not direct UFO research.The State Department documents focus on diplomatic communications about foreign sightings.While the content is largely procedural, a handful of entries describe unexplained aerial phenomena that defy conventional explanations.Political Fallout and Public ReactionConspiracy theorists have seized on the release, flooding social platforms with speculation about extraterrestrial cover‑ups. Simultaneously, critics argue the timing—just weeks before the midterm election cycle—suggests a calculated distraction to shift attention from domestic policy battles.Implications for National Security and PolicyAnalysts note that the files, though not confirming alien technology, underscore gaps in inter‑agency data sharing on aerial anomalies. The declassification may pressure lawmakers to formalize a permanent oversight committee, ensuring future sightings are evaluated with consistent standards.Looking Ahead: Transparency vs. Narrative ControlExperts predict two parallel tracks: increased public demand for full transparency on UFO investigations, and a governmental push to frame the narrative within national‑security parameters. Upcoming congressional hearings are likely to reference the newly released documents, setting the stage for a prolonged debate over how much of the unknown should remain classified.

The Leadership Shift at Microsoft Israel The head of Microsoft's Israeli subsidiary will step down in the wake of an inquiry that has scrutinised its business dealings with the Israeli military. The Inquiry into Microsoft's Dealings with Unit 8200 Microsoft ordered the inquiry last year in response to a Guardian investigation revealing the military had used the company's technology to operate a powerful surveillance system that collected Palestinian civilian phone calls on a mass scale. The inquiry found that Unit 8200, Israel's elite spy agency, used Microsoft's Azure cloud platform to store a vast trove of intercepted calls from Gaza and the West Bank. Microsoft concluded that its initial findings showed Unit 8200 had violated its terms of service, which prohibit the use of its technology to facilitate mass surveillance. The Impact on Microsoft Israel The Israeli business newspaper, Globes, reported on Monday that Haimovich's departure followed a major controversy at the subsidiary relating to violations of Microsoft's code of ethics. Several other managers had also left their positions. Haimovich was summoned by the inquiry team after they visited Microsoft Israel's offices near Tel Aviv. The Future of Microsoft's Israel Operations Haimovich did not respond to a request for comment. In an email to staff announcing his departure last week, he said he had positioned Israel as "one of Microsoft's fastest-growing markets worldwide". Microsoft has previously said its senior executives such as Nadella were unaware Unit 8200 was using Azure to store intercepted Palestinian communications.