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The Personal Mission Behind the InvestmentReed Jobs, son of Apple co-founder Steve Jobs, is bringing his oncology-focused venture capital fund Yosemite to the UK, seeking investment opportunities in cancer care. The 34-year-old's mission is deeply personal, stemming from witnessing his father's death from a rare form of pancreatic cancer in 2011 at age 56. "I saw my dad have cancer when I was a kid, and unfortunately that happens far too often. And that really motivated me to try to transform outcomes for other people out there," Jobs explains.Yosemite's Healthcare Investment StrategyThe San Francisco-based venture fund, named after the California national park where his parents married, manages over $1 billion in assets and has already invested in approximately 20 healthcare startups. Yosemite focuses on innovative approaches to cancer treatment, including gene therapy, cancer vaccines, radiopharmaceuticals, and artificial intelligence. Notable investments include Tune Therapeutics, Azalea Therapeutics, Chai Discovery, and Sage Care in the US, with several UK companies in their portfolio that haven't been publicly announced.Financial Backing and International PartnershipsYosemite receives investment from LifeArc, a UK not-for-profit group focused on rare diseases that was established in 2000 as part of the UK's Medical Research Council. The fund also has partnerships with Oxford and Cambridge universities, where it has provided philanthropic grants. Additional backing comes from US biotech company Amgen, Massachusetts Institute of Technology, Memorial Sloan Kettering Cancer Center in New York, and billionaire investor John Doerr, following a fundraiser earlier this year.UK's Position in Global Cancer Research"Research here is world class," Jobs states during his visit to London for a life sciences conference hosted by LifeArc. The UK's strong academic institutions and research environment make it an attractive location for healthcare investment. Yosemite's international investment strategy includes the UK, where the fund aims to connect with pharmaceutical partners and academics to advance cancer treatment possibilities.Future Vision for Cancer TreatmentJobs envisions a future where cancer shifts from being an "end-stage disease" to an illness that is diagnosed early, monitored, and treated—similar to advances made with HIV and cardiovascular disease. "Today far too many cancers are either diagnosed incidentally, because there's no good early biomarker, or only diagnosed once they are metastatic and extremely advanced," he notes. The fund is particularly focused on immunotherapy, which Jobs identifies as "one of the areas I think is going to have the most promise for patients in the next couple of decades."

The Trump-Xi Summit: Style Over SubstanceAmerican strength back on the world stage," crowed the White House social media post: a curious remark, when the attached video showed the stars and stripes fluttering beneath a long row of Chinese flags, and People's Liberation Army soldiers marching in unison.This week's visit to Beijing offered the kind of style that Donald Trump enjoys – parading troops, a banquet and a polite if not markedly enthusiastic welcome from a strongman he called "really a friend" – but little apparent substance. The public account of the encounter will be partial: Mr Trump's former adviser John Bolton has claimed that in previous conversations the US president begged Xi Jinping for help to win re-election and urged him to "go ahead" with internment camps for Uyghurs in Xinjiang. But this meeting appears to have been about stabilising the relationship, not shifting it.The Trade War Stalemate and Rare Earths LeverageChaotic US planning for a trip deferred due to the Iran war may have contributed to the lack of tangible outcomes. But the overall impression is of a wary stalemate. Just over a year ago, the US imposed 145% tariffs on China. Beijing hit back with its own tariffs and, critically, curbs on desperately needed rare earths exports, forcing Mr Trump to retreat. The US national security strategy announced a new focus on the western hemisphere. Military assets have been moved from Asia to the Middle East. US hawks have been muted, with China policy appearing to be directed primarily via the trade secretary, Scott Bessent.US Strategy: Biding Time While Reassessing Global PositionThe US hopes to establish alternative sources of rare earths. Deng Xiaoping urged China to "hide its light and bide its time" in foreign policy; now US officials joke of adopting his strategy. But others think that the US needs to move fast to tighten controls on exports of advanced technologies, and make serious progress in "de-risking" supply chains. They fear Mr Trump, who likes quick wins, is trading long-term national security for short-term economic gain.China's Pursuit of Technological and Economic SupremacyFor China, its economic, technological and security progress are inextricably linked. It wants time to surpass the US on all scores. Last month Beijing ordered Meta to unwind its purchase of Manus, a Chinese-founded AI firm. It also introduced new measures to punish companies compliant in sanctions against Chinese firms.Mr Xi called the Beijing meeting a "milestone". That's better understood as a marker on a long journey than a major achievement. China believes it is on the path to restored greatness, while Chen Yixin, minister for state security, wrote scathingly in December that US hegemony is "increasingly unsustainable … At home, its democracy is mutating, its economy decaying, and its society fracturing … abroad, its credibility is rapidly going bankrupt, its hegemony is crumbling, and its myth is collapsing."Global Implications: Allies and the Waiting GameUS allies are engaging more with China. But Washington's slide has complications too for Beijing. The China scholar Sam Chetwin George this week delineated its contemplation of a greater security role, arguing: "A country built on an anti-imperial story has arrived at the point in which it must, with some reluctance, assume a greater share of the burdens of empire." Its handling of the Iran war is instructive: it would like it to be over, but has no eagerness to act as mediator, wary of expending its own assets or leverage.The two great powers are playing the waiting game. The rest of the world watches.

Unexpected Visitor Triggers Deer Rescue at Norwich M&S;Store employees heard a frantic call: “There’s a deer trapped in an escalator.” The unusual emergency unfolded on a Tuesday at the central Marks & Spencer on Rampant Horse Street, prompting a rapid response from local wildlife experts.How a Muntjac Deer Got Trapped in a Store EscalatorThe animal, a female muntjac, slipped into the space between two glass panels beside the handrail of the ground‑floor escalator. It became wedged upside down, its foot caught in a metal piece, leaving it immobilised and panicked.Ian Haywood, a sanctuary worker, reached into the narrow gap, freed the deer and covered it with an M&S; blanket to calm it while staff kept the area clear.Rescue Statistics and Sanctuary CapacityThe rescued deer, nicknamed “Lucky Lucy,” suffered only a superficial cut on its foot.Hillside Animal Sanctuary cares for roughly 100 other rescued deer alongside other wildlife.Rescues of wild deer are routine for the sanctuary, occurring “once every day, sometimes two or three times.”Implications for Retail Safety and Urban WildlifeThe incident highlights the challenges of urban wildlife navigating commercial spaces. It underscores the need for:Improved signage and barriers to deter wildlife entry.Staff training on handling unexpected animal encounters.Collaboration between retailers and local wildlife organisations.Public reaction has been largely supportive, praising the swift action of both Marks & Spencer staff and the sanctuary.What Could Prevent Future Escalator Encounters?Experts suggest several preventative measures:Installing wildlife‑proof screens on escalator glass panels.Regular monitoring of store perimeters for signs of animal activity.Community outreach to raise awareness about wildlife movement in urban areas.By adopting these steps, retailers can reduce the likelihood of similar incidents while ensuring the safety of both customers and local fauna.

The Allure of Sonic ExtremesBowel-shuddering basslines. Drum fills that bounce off the walls like gunfire. Guitars resembling a pneumatic drill drilling into another pneumatic drill. A truly loud gig stays with you, figuratively and literally, as anyone who has spent the days after one accompanied by a troubling ringing in their ears can confirm.Last week, prompted by an old Alistair Cooke column suggesting that Janis Joplin's group Big Brother and the Holding Company was noisy enough to cause permanent hearing damage in guinea pigs, The Guide asked readers to share their own loudest gig experiences. The response was overwhelming, with countless readers sharing memories of eardrum-piercing encounters with all manner of bands and artists, across genres and decades.The Technical Frontiers of Live SoundWe should probably insert the obligatory disclaimer here: loud gigs can be genuinely bad for your ear health – just look at the brilliant early 80s post-punk band Mission of Burma, who had to disband for the best part of two decades due to guitarist Roger Clark Miller's punishing tinnitus. The environments that Burma and bands before them played in were a sonic wild west, with minimal soundproofing in venues or, in the ear canals of the people performing in those venues.Thankfully technology has moved on since then: many concertgoers now carry decent pairs of earplugs, and venues often provide free alternatives at the bar. Yet some still succumb to the cheap, inadvisable thrill of experiencing music completely unprotected.The Auditory Cost of Musical PassionThe physical consequences of extreme volume are well-documented. Mission of Burma's hiatus due to tinnitus represents just one example of how loud performances can have lasting health effects. The human ear can withstand approximately 85 decibels continuously for eight hours, but at 110 decibels – the level of many rock concerts – safe exposure time drops to less than two minutes.Despite these risks, the pursuit of sonic intensity continues. As one reader noted about seeing Swans in 1987: "You couldn't think of anything other than the noise while it was happening. People streamed out. I stayed and now wear hearing aids. But it was extraordinary." This trade-off between auditory safety and musical transcendence remains central to concert culture.Cultural Significance of VolumeVolume in live music has always been tied to cultural significance. From Deep Purple in the 1970s to modern experimental acts, extreme sound has been used to create immersive experiences that transcend mere entertainment. Guardian critic Alexis Petridis described seeing My Bloody Valentine: "Earplugs were distributed at the door. Even wearing them, the quite extraordinary volume was inescapable. It made your clothes move, independently of your body."Different genres approach loudness differently. Doom metal acts like Sunn O))) use volume as an atmospheric tool, while electronic artists such as Rosalía incorporate orchestral elements at jet-landing volume. Each approach creates a unique sensory experience that defines the relationship between performer and audience.The Future of Loud Music and Hearing ProtectionAs awareness of hearing health grows, the future of loud concerts may involve a balance between intensity and safety. Advances in hearing protection technology – from high-fidelity earplugs that preserve sound quality while reducing volume to in-ear monitors for performers – suggest that extreme sonic experiences need not come at the cost of long-term hearing damage.Yet the fundamental appeal of overwhelming sound likely remains. As Laura Snapes wrote about experiencing Angine de Poitrine: "I felt like I'd been lashed to the prow of Mad Max's rig as it screamed through the desert (this is a compliment)." The pursuit of transcendent musical experiences – even when they leave our ears ringing – appears to be an enduring aspect of human culture.

The Science Behind Cold Exposure and Weight Loss Wearing an ice vest or taking daily cold showers could help people lose weight, according to researchers. Despite the growing popularity of cold-water swimming and freezing plunges, to date there is minimal data on the health benefits of cold exposure. But a study of 47 adults with obesity or overweight has found that regular exposure to cold temperatures led to fat loss. The Study's Methodology and Findings Researchers at the University of Nottingham and the Leiden University Medical Center (LUMC) in the Netherlands gave half the participants an ice vest and waist wrap to wear for two hours every morning, while continuing their daily lives. The vests and waist wrap were worn on top of a thin T-shirt and contained gel-filled cooling packs that had been kept overnight in the freezer and maintained a temperature of 15C. In six weeks, participants lost 0.9kg (2lb), made up almost entirely of body fat, whereas the control group did not lose any weight and put on 0.6kg (1.3lb) on average. The Impact of Cold Exposure on Metabolism The lead researcher, Dr Mariëtte Boon, of LUMC, said: “This is one of the first studies looking at the impact of cold exposure over a prolonged period of time, involving people with overweight and obesity.” She added: “Vests like this can be worn at home and so cold exposure could be a simple and inexpensive addition to lifestyle strategies for weight loss such as healthy eating and physical activity.” The Potential for Cold Showers as a Weight Loss Tool The researchers, jointly funded by the Dutch Heart Foundation and the British Heart Foundation, are investigating whether other forms of regular cold exposure could reduce obesity, inflammation and prevent heart disease. The authors are conducting a separate study of 34 women in the Netherlands to see if cold showers also promote fat loss. Half of the women will have their shower on the coldest setting for 90 seconds every morning.

Santa Clara County filed a lawsuit this week alleging that Meta Platforms knowingly monetises fraudulent ads that generate roughly $7 bn in annual revenue, adding to a growing slate of legal actions against the social‑media giant.The County’s Allegations Against Meta’s Ad EcosystemThe complaint claims Meta “facilitates and monetises” deception by allowing scam ads to run unless the company is at least 95 % certain the advertiser is fraudulent. Below that confidence threshold, advertisers are charged a premium fee to keep their ads live. The lawsuit cites internal documents showing the use of sophisticated AI tools that target “vulnerable consumers” with schemes ranging from bogus financial products to fake celebrity fund‑raisers.Scam categories include cryptocurrency schemes, false medical cures, ineffective supplements, and celebrity impersonations.California residents reported over $2.5 bn in losses to scammers in 2024, with seniors disproportionately affected.Financial Stakes: $7 B in Scam‑Ad Revenue and $200 B Corporate TurnoverMeta’s annual revenue exceeded $200 bn in 2025, underscoring the scale of the alleged $7 bn scam‑ad stream. The lawsuit arrives alongside a separate consumer‑protection case filed by the Consumer Federation of America, which also targets Meta’s profit‑driven approach to scam mitigation.Broader Implications for Platform Liability and Consumer ProtectionThe suit follows a March 2026 California jury verdict that held Meta and YouTube liable for addictive design features harming a young user, a decision viewed as a bellwether for future platform‑responsibility claims. Combined with recent rulings in New Mexico and a $375 m jury award for child‑endangerment, the Santa Clara action could pressure Meta to overhaul its ad‑review algorithms and increase transparency.What the Future Holds for Meta’s Legal LandscapeMeta spokesperson Andy Stone described the lawsuit as a distortion of the company’s motives, emphasizing ongoing anti‑scam efforts, including the removal of 159 million scam ads last year and partnerships with law‑enforcement agencies. Nonetheless, legal analysts expect intensified scrutiny, potential regulatory interventions, and further class‑action filings as state prosecutors treat the platform’s ad‑monetisation model as a public‑policy issue.

Runway, the New‑York‑based AI video‑generation startup valued at $5.3 billion, announced a strategic shift toward building “world models” – AI systems that learn from observational video data – positioning itself directly against Google’s Genie and other deep‑pocketed rivals.Runway's Pivot from Video Generation to World ModelsFounded in 2018 by three NYU Tisch alumni—two from Chile and one from Greece—Runway first gained traction with its Gen‑4.5 video‑generation model, powering workflows for Lionsgate, AMC Networks and the film Everything Everywhere All At Once. In December 2025 the company released its first world model and plans a second launch within the year, aiming to create AI that “understands how the world works” rather than merely processing text.Co‑founders: Anastasis Germanidis (co‑CEO), Cristóbal Valenzuela (co‑CEO), Alejandro Matamala‑Ortiz (Chief Innovation Officer)Current footprint: 155 employees across New York, London, San Francisco, Seattle, Tel Aviv and TokyoKey product evolution: from “anyone a filmmaker” to “anyone a great filmmaker” and now to “AI that can simulate reality”Funding Milestones and Revenue GrowthRunway’s capital raise and revenue trajectory underscore the high‑stakes nature of the world‑model race.Total capital raised: $860 millionLatest round (Feb 2026): $315 million from strategic partners including AMD Ventures and NvidiaValuation: $5.3 billionAnnual recurring revenue (Q2 2026): $40 million addedCompetitor funding: Luma AI ($900 million), World Labs ($1.29 billion), OpenAI (~$175 billion), Alphabet (parent of Google) $4.86 trillionImplications for Hollywood, Robotics, and Drug DiscoveryThe shift to world models could ripple across several high‑impact sectors.Media & Entertainment: Faster, AI‑driven editing and content creation for studios and ad agencies.Robotics & Gaming: Simulated environments for training autonomous agents without costly physical trials.Life Sciences: Potential to accelerate drug discovery and climate modeling by running “digital twin” experiments.Runway’s recent robotics unit already reports real‑world deployments, hinting at cross‑modal applications that combine video, sensor and textual data.Future Outlook: Can Runway Outpace Deep‑Pocketed Rivals?Experts agree that scaling world models will hinge on compute access and sustained funding.Compute challenge: Need for dedicated large‑scale GPU clusters; Runway currently partners with CoreWeave and Nvidia but has not disclosed dedicated capacity.Competitive pressure: Google’s Genie model, Meta’s research, and well‑funded startups are all pursuing similar multimodal AI.Strategic advantage: Founder diversity and a scrappy, revenue‑first culture may allow Runway to iterate faster than Silicon‑Valley incumbents.If Runway can translate its video‑generation dominance into robust world models, it could become a foundational AI infrastructure provider. Failure to secure the required compute or to demonstrate clear cross‑industry value could see it eclipsed by better‑funded rivals.

The LeadAs Eurovision celebrates its 70th anniversary, some of the most iconic figures from the competition share their untold stories. Not many 70-year-olds spend their nights with pop singers in sparkly catsuits or nightmarish monsters barking out heavy metal, but these Eurovision veterans have experienced it all. From winning while sick with fever to becoming internet memes overnight, their tales reveal the unique magic and challenges of Europe's most beloved music competition.The Metal Monster's VictoryMr Lordi, frontman of Finnish metal band Lordi and winners in 2006, recalls how their journey began with no expectations: "When we were invited to enter the Finnish national contest to be the Eurovision entry, we thought we had absolutely no chance. We just wanted some free TV for our new album." Despite their casual approach, they won the popular vote by a landslide.Their arrival in Athens created a media frenzy: "We'd arrive in the press room in our full costumes, you know, just minding our own business. Then the press would go: 'Oh, fucking hell, that's Lordi!' and run to us." Their unconventional approach drew both attention and complaints from other contestants.Despite their eventual victory, Lordi's performance was far from perfect: "On the night, that performance was one of the worst versions I personally have ever delivered of Hard Rock Hallelujah. I was sick with a fever. And it's so hot in that costume you have your own mobile sauna with you."The aftermath was unexpectedly harsh: "Within a year, the backlash started. A lot of metal and rock people really resented us for winning. They thought we had sold out. But then, surprisingly fast, normal people started joining in."The Saxophone SensationSergey Stepanov, saxophonist of Moldovan band SunStroke Project who placed 22nd in 2010 and 3rd in 2017, shares how Eurovision changed his life completely. "Going to Eurovision was always a dream for me. When I was young, I would watch with my mother, and the artists performing seemed so different from us they were like spacemen."Their first experience in Oslo was modest but impactful: "We did not have a lot of money. All we had to make people remember us was our energy, our music – and how much fun we had." Their unexpected fame came later: "After we came back, my friend called me and said: 'You are a meme: Epic Sax Guy. You are famous in the United States!' Until that moment, I had no idea what a meme was."Their return in 2017 brought even greater recognition: "When we went back in 2017, we were about to go on stage when our producers gave me the phone. It was the president of Moldova. He said: 'Guys, are you ready to do a miracle?' We went out and came third."Steppanov describes the transformative power of that moment: "The moment I started to do my moves in 2017, the crowd got so loud I couldn't even hear what I was playing. At that point, I knew my life wouldn't be the same afterwards."The Zero Points ExperienceJames Newman, who represented the UK in 2021 and became the second British act to score nul points, shares his experience of the competition. While the article cuts off before detailing his full story, the heading suggests a dramatic experience that contrasts with the triumphs of other Eurovision participants.

Tech companies are rapidly cutting middle‑manager layers as AI promises to do more with fewer people, with firms such as Coinbase, Block, Meta and Amazon announcing sweeping restructurings that shift managers into hybrid supervisor‑producer roles.AI‑Powered Management Flattening Across Major Tech FirmsCEOs have framed AI as a catalyst for flattening hierarchies, pledging to eliminate “unnecessary management layers.” Recent moves include:Coinbase laid off 14% of its workforce while eliminating “pure managers.”Block cut 40% of staff and assigned some engineering managers up to 175 direct reports.Meta increased managers’ span of control and required them to contribute code, as described by former manager Prateek Singh.Amazon raised the employee‑to‑manager ratio by at least 15% to boost ownership.Numbers Illustrating the Scale of the Managerial CutbacksOpenings for middle‑manager jobs in the US fell 42% at the end of 2025 compared with the 2022 peak (Revelio Labs).Middle managers made up 13% of the US workforce in 2022 (Harvard Business School).Block’s internal charts show some managers handling up to 175 reports, far above the traditional 6‑12 range.How the New Structure Reshapes Work and Risks EmergingAnalysts warn that the shift places extra pressure on remaining managers, who must now act as both supervisors and producers.Managers may rely on AI agents for asynchronous updates, reducing face‑to‑face mentorship.Potential for flawed AI‑generated decisions to cascade into security or operational failures.Reduced human interaction could hurt employee motivation, especially for less‑experienced or marginalized teams.What the Future Holds for Middle Management in an AI EraExperts predict a continued decline in traditional middle‑manager roles, with companies investing in upskilling and AI‑augmented decision‑making.Companies will need to redesign coordination processes and provide training for broader decision authority.Fewer promotion pathways may increase talent attrition, prompting firms to rethink career ladders.Hybrid “player‑coach” models could become the norm, blending technical contribution with limited people‑management duties.