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The UK medicines regulator has opened an inquiry into a growing number of clinics that sell injectable peptides while promoting them as cures for everything from ageing to injury recovery. The investigation, disclosed by the Guardian, focuses on whether these businesses are breaching the Human Medicines Regulations 2012 by making unauthorised medicinal claims. Interest in peptide‑based treatments has surged in recent years, driven by social‑media influencers, some healthcare professionals, and direct‑to‑consumer marketers. Yet the scientific foundation for most of these claims is weak, with the bulk of research confined to animal models or cell‑culture studies. According to an MHRA spokesperson, any clinic that advertises a peptide as having therapeutic benefits must treat the product as a medicine, which triggers a comprehensive regulatory framework. "If clinics offering peptide injections make medicinal claims for those treatments, the products will be considered medicines and subject to regulation," the agency warned, adding that it will act against any identified breaches. Guardian reporters identified several high‑ranking Google search results that list peptides such as Cortexin (promoted for neuroprotection), BPC‑157 (claimed to aid tissue repair), and Thymosin Alpha (advertised to boost immunity). After being contacted, one clinic removed the statements from its website. Another clinic, while acknowledging the limited human evidence, continued to market seven specific peptides, providing price lists (£350 per month for a single peptide, £450 for two) and offering delivery via vials, syringes, or pre‑filled pens for an additional fee. During a free consultation, a clinician highlighted the experimental nature of the products, noting the absence of large‑scale, randomised clinical trials and recommending a break of four to eight weeks between treatment cycles to mitigate unknown risks. The clinician suggested BPC‑157 for post‑exercise recovery, describing it as a facilitator of cellular repair and blood flow, but warned against its use in smokers or individuals with a family history of cancer due to potential angiogenic effects. The second peptide discussed was MOTS‑C, portrayed as a mitochondrial enhancer that could improve stress resilience, lower insulin resistance, and reduce visceral fat by boosting cellular energy production (ATP). The MHRA confirmed it is reviewing whether the clinician’s statements constitute medicinal claims. The clinic defended its approach, emphasizing that it clearly informs clients that the peptides are not licensed medicines and that the evidence base is largely pre‑clinical. In a broader statement, Lynda Scammell, head of borderline products at the MHRA, explained that peptide products may be marketed as cosmetics, supplements, or medicines, and each case is assessed on its intended use, pharmacological effect, and supporting evidence. She added, "We disregard claims that products are for ‘research purposes’ if it is clear that such claims are being used as an attempt to avoid medicines regulations." Peptides are short chains of amino acids, some of which occur naturally (e.g., insulin). While synthetic peptide analogues like semaglutide and tirzepatide have secured approval for weight‑loss treatments, many of the compounds promoted by these clinics remain experimental and lack the rigorous safety and efficacy testing required for medicinal products.

After a prolonged period of uncertainty, the County Championship returns on Good Friday with renewed vigor, its schedule finally settled and the controversial three‑year Kookaburra ball trial abandoned.The England and Wales Cricket Board (ECB) is now trialling a full‑substitute system in domestic matches. Unlike the traditional “covering fielder” approach, a player can be replaced by a fully‑playing substitute for injury, illness or significant life events such as the birth of a child or a family health crisis.Alan Fordham, the ECB’s head of cricket operations, highlighted the change: “Most seasons we get three or four questions about a player being replaced to witness the birth of a child… the answer will now be yes.” He also recalled the Blair Tickner incident, where the New Zealander’s wife was diagnosed with leukaemia during a match, forcing him to continue playing with a ten‑man side.The substitute scheme is being tested at the ICC’s request, which asks member boards to experiment domestically before considering a similar rule for Test cricket. By allowing replacements for personal emergencies, the ECB has moved further than counterparts in India, Australia and South Africa.To curb potential abuse, any player replaced for illness or injury must observe an eight‑day “stand‑down” period before returning. Derbyshire head coach Mickey Arthur praised the intent but warned of loopholes, noting that the rule does not account for bye weeks, season‑ending fixtures or the transition from red‑ball to white‑ball cricket.Following a disappointing Ashes winter, the ECB is keen to restore the Championship’s relevance. Managing director Rob Key signalled that England‑team places are no longer guaranteed, urging county coaches and players to re‑engage.England head coach Brendon McCullum, speaking to counties via Zoom, stressed the competition’s value for talent identification, especially for players adept against high pace and spin. He also announced the return of Troy Cooley as the ECB’s pace‑bowling lead.Test captain Ben Stokes backed the message, urging players to seize the early weeks of the Championship as a platform for national selection: “It’s a great opportunity for a lot of people around the country… use it to push your case forward.”Enthusiasm is palpable across the counties. Glamorgan, back in Division One for the first time since 2005, aim to showcase their spinners. Lancashire chase promotion despite the late loss of Mitch Perry, while Surrey, Nottinghamshire and Warwickshire marshal their senior talent. Even clubs hit by setbacks—Leicestershire, plagued by injuries and the sudden withdrawal of captain Peter Handscomb, and Sussex, docked 12 points before the season began—remain determined as they kick off their fixtures at Grace Road.

In the northeastern Indian state of Assam, the redrawing of electoral constituency boundaries has sparked concerns about the erosion of Muslim representation in the state's legislative assembly. The move, which was implemented in 2023, has been criticized as an example of 'gerrymandering' – the manipulation of electoral boundaries to favor a dominant group or party.The changes have resulted in Muslims forming the majority in about 20 of the state's 126 constituencies, down from around 35 previously. This shift is seen as a significant blow to the political representation of Assam's 11 million Muslims, who make up more than 34% of the state's population.Critics argue that the BJP's Hindu majoritarian policies are being implemented in Assam, which could serve as a template for the rest of India. The party has been accused of using techniques such as 'cracking,' 'packing,' and 'stacking' to weaken the electoral influence of Muslims.The delimitation exercise has been defended by the BJP as a means of protecting the political rights of 'indigenous people,' a reference to Assamese-speaking individuals. However, opponents claim that the move is a thinly veiled attempt to reduce the political power of Bengali-speaking Muslims in the state.For many Muslims in Assam, the changes have left them feeling politically emasculated. As Islam Uddin, a retired teacher from Katigorah, put it, 'We have been politically emasculated.' Another Muslim voter, Nabab Mezbahul Alam, described the situation as being like having 'hands, feet, and head to move and see, but [being] muted.'

Tottenham Hotspur has officially announced the appointment of Roberto De Zerbi as their new head coach, signing him to a five-year contract. The Italian manager, renowned for his daring and aggressive possession-based approach, faces a significant challenge as he takes over with the club precariously positioned just above the relegation zone.Spurs are set to play seven matches to end the season, with their next fixture scheduled against Sunderland on the upcoming Sunday. Notably, De Zerbi's contract does not include any break clause in the event of Tottenham being relegated.De Zerbi expressed his delight in joining the club, stating, “I am delighted to be joining this fantastic football club, which is one of the biggest and most prestigious in the world. In all my discussions with the club’s leadership, their ambition for the future has been clear – to build a team capable of reaching great achievements and to do that playing a style of football that excites and inspires our supporters.”The appointment of De Zerbi comes after Igor Tudor, the interim manager, parted ways with the club by mutual consent. Tudor had taken over temporarily following the departure of Thomas Frank on February 14.De Zerbi previously managed Brighton & Hove Albion, where he achieved significant success, leading the club to a sixth-place finish in the Premier League and qualification for the Europa League. His tenure at Marseille also yielded impressive results, with a second-place finish in Ligue 1 and Champions League qualification.Despite his successes, De Zerbi is also known for his volatile personality and has had public disagreements with players and clubs in the past. The immediate concern for Spurs will be whether De Zerbi can adapt quickly and lead the team to avoid relegation.

Tottenham Hotspur has confirmed the appointment of Roberto De Zerbi as their new head coach on a five-year contract. The Italian manager, described by Pep Guardiola as “one of the most influential managers in the last 20 years,” joins Spurs after a successful stint at Brighton & Hove Albion.De Zerbi's appointment comes at a crucial time for Tottenham, who have struggled in recent seasons. His predecessor, Igor Tudor, had a disastrous interim spell, and the team is in need of a new direction. De Zerbi's managerial style, characterized by energetic pressing and fast transitions, has drawn praise from fans and pundits alike.During his time at Brighton, De Zerbi led the club to a sixth-place finish in the Premier League and secured European football for the first time. His success at Brighton has created high expectations, and Tottenham fans will be hoping he can replicate this success at Spurs.However, De Zerbi's departure from Brighton was marked by controversy, as he fell out with the club's owner, Tony Bloom, over squad recruitment. This has raised concerns about his ability to work with the Spurs hierarchy.De Zerbi's appointment is seen as a gamble by the Spurs hierarchy, given his tendency to shoot from the hip and his history of disagreements with Brighton’s owner. Nevertheless, his ambitious and influential managerial style has generated excitement among Tottenham fans.The 46-year-old Italian manager will have no time to implement his favoured 4-2-3-1 system with only seven games remaining to ensure Premier League survival. Assurances of major summer investment to reshape the squad to his vision will be a prerequisite for success.At a club that has been drifting for some time, perhaps De Zerbi can give Tottenham some desperately needed new direction. His ability to adapt to a new country and team was evident during his time at Marseille, where he led the team to second place in Ligue 1.

Tottenham Hotspur Football Club is embroiled in a desperate bid to avoid a financially ruinous slide into the Championship. The club's current predicament is a result of internal sabotage, leadership burdens, and immense dissatisfaction among the rank and file. With only seven games remaining in the Premier League season, Spurs are searching for their third head coach of the season, having already seen off Thomas Frank and Igor Tudor. The club's hierarchy appears to be acting with a sense of urgency, but their approach has been chaotic and improvisational, with one ill-judged managerial appointment following another. Roberto De Zerbi, currently managing Brighton, has emerged as a potential candidate, despite reservations from three separate fan groups due to his public backing of Mason Greenwood during his time at Marseille. De Zerbi's managerial CV is marked by occasional incidents of insubordination, making him an unconventional choice for a team in crisis. However, he is believed to be interested in taking over at Spurs, albeit preferring to do so in the summer. The club is reportedly offering him tempting financial inducements to take the reins immediately and navigate the team through the relegation battle. The stakes are high, with Spurs currently hovering just one place and point above the drop zone. A winless season so far in 2026 has put the club on the brink of disaster. The next managerial appointment will be crucial in determining the club's fate, and fans will be anxiously waiting to see if the hierarchy can make the right decision.

Tottenham Hotspur is on the verge of appointing Roberto De Zerbi as their new manager following productive talks on Monday. The Italian coach has emerged as the club's top choice to replace Igor Tudor, who left his interim position on Sunday after failing to improve the team's form.De Zerbi, who recently parted ways with Marseille, is now the only viable candidate for the role, with Spurs not engaging with other potential candidates. The club aims to secure his services on a long-term contract, believing he can help them stay in the Premier League and build for the next season.The potential appointment of De Zerbi could also impact Mauricio Pochettino's chances of returning to the club. Pochettino, currently managing the US national team, had been considered for an emotional return to Spurs in the summer, but De Zerbi's possible arrival might rule out that move.De Zerbi's backing of Mason Greenwood during his time at Marseille has raised concerns among some Tottenham supporter groups. Greenwood was charged with attempted rape and assault in 2022, although the case was later discontinued. Despite these concerns, Spurs seem willing to overlook them to secure De Zerbi's appointment.The situation at Tottenham is critical, with the team currently one point and one place above the relegation zone and having gone 13 league matches without a win – their worst run since the 1934-35 season. De Zerbi's task would be to turn the team's fortunes around and secure their Premier League status.

Robert F Kennedy Jr, the US health secretary, has unveiled a chaotic and unpredictable agenda for public health policy under his 'Make America Healthy Again' (Maha) initiative. His approach tends to favor personal choice and autonomy over large-scale, mandatory public health interventions, such as childhood vaccine requirements.The Maha agenda has raised concerns over the potential risks associated with injectable peptide drugs. Mr. Kennedy plans to open up the sale of 'about 14' of these drugs to the public, despite the US Food and Drug Administration (FDA) restricting 17 peptides in 2023 due to 'potential significant safety risks'. None of these peptides have been proven to be safe or effective for human use.The peptides in question are often promoted for biological enhancement, such as increasing muscle mass or cognitive benefits, but the evidence for these effects in humans is thin. Reports of people self-administering peptide therapies, usually bought from China 'for research use only', are widespread, particularly in Silicon Valley.The Maha project wants to make the grey market the only market, effectively sanctioning mass public use of unproven treatments. Peptides are clearly drugs and shouldn’t be allowed for widespread use without rigorous clinical trials. Opening loopholes for sale would undermine the precautionary principle that has successfully led public health policy for generations.It is also worth noting that other governments are unlikely to be as cavalier as Mr. Kennedy about peptides. However, people everywhere will continue to call for more personal choice and more bodily autonomy, and those conversations are important. The case for safety, proof, and regulation must be made to ensure that public health policy prioritizes the well-being of individuals.

Tottenham Hotspur have sacked manager Igor Tudor after just 44 days in charge, with the club struggling to avoid relegation from the Premier League. Tudor managed the team for seven games, securing only one point from his five league matches.The final straw came with last Sunday's 3-0 home defeat by Nottingham Forest, which left Tottenham one point and one place above the bottom three. A potential demotion to the Championship would be catastrophic for the club's prestige and revenues.Tudor's departure comes amid a backdrop of human tragedy, with the manager informed of the death of his father, Mario, after the Forest game. The club aimed to handle the situation with sensitivity towards the Croatian manager.Tudor's brief tenure included two Champions League matches against Atlético Madrid, with Tottenham ultimately losing 7-5 on aggregate. His time at Spurs began with a difficult period, including league defeats to Arsenal, Fulham, and Crystal Palace.The club has gone 13 league games without a win, their worst run since 1934-35 when they were relegated from the old Division One. Tudor's approach and tactics were questioned, particularly his decision to substitute goalkeeper Antonin Kinsky after just 17 minutes in the first leg against Atlético Madrid.Tudor had been tasked with bringing organisation, intensity, and competitive edge to the squad, but ultimately failed to achieve this. The club is now searching for a new manager, with Bruno Salter set to take training in the interim.