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The Familiar FinalYou could be forgiven for having a sense of deja vu before a fourth Champions League final between the Spanish champions, Barcelona, and French champions, Lyonnes, on Saturday evening.The three-time champions and eight-time champions played each other in the final of Europe's premier competition three times in six years between 2019 and 2024, with Lyonnes earning a 4-1 win over the Catalan giants in 2019 and a 3-1 win in 2022 before Barcelona delivered a 2-0 defeat of the French side in 2024.However, predicting the outcome could not be harder and Barcelona's talismanic No 11, Alexia Putellas, said there is little that can be discerned from those previous meetings. "We can't compare seasons and we can't compare finals," said the two-time Ballon d'Or winner. "Our squad has evolved a lot, so previous finals don't have an influence on the final we are playing tomorrow."The Tactical Chess MatchA lot has changed. Most notably, Lyonnes are now managed by Jonatan Giráldez, who was a coach at Barcelona as they claimed their maiden UWCL title and at the helm for their second and third. Few managers are better equipped to return Lyonnes to the top of European football after a three-year hiatus than the man who understands the way Barça work and exactly how they ended the domination of the French side.As a result, the tactical approach of those on the sidelines is perhaps the most interesting piece of the puzzle in Oslo's Ullevaal Stadion.Giráldez said of Barça's development since he left: "They have some different players but their identity remains the same; this will to dominate and apply pressure. Not thinking about the result as much as about the show and the performance, that's their identity. I feel privileged to face Barcelona as I'm grateful for the experience I had there and I wish them the best – except when we have to win!"Master and ApprenticeOne of Giráldez's two assistants, Pere Romeu, replaced him when he departed for Washington Spirit in June 2024. "We are the two teams that have done the most in this competition to reach the final in recent years," said Romeu. "Tomorrow is going to be a very demanding match. Tomorrow is going to be a match with a lot of quality from both teams. Tomorrow is going to be a match that, as in all finals, is going to be decided by small details. We are going to try to take care of and control it to the maximum."The 32-year-old Barcelona manager won a domestic treble in his first season in charge, but fell short in the Champions League final last season as Arsenal delivered a shock defeat."I see a team that is more mature than last season," said Romeu. "I see a team with greater capacity to change things during the game than last season and I think we have reached a good point."Putellas described Romeu as a "complete coach", before the showdown on Saturday. "We've been working together for several seasons now and he has always tried to help me evolve as a player, which I'm very grateful for," she said. "He's the most complete coach. This season I've tried to do the best I possibly can without forgetting my own qualities in order to help the team."Romeu is relishing the master-apprentice battle in such a significant game. "I, as a coach, am super-excited to be able to face this match against a former coach of the club in Jonatan," he said. "I'm sure we'll both do everything we can to keep our teams' identities and keep doing the best we can to win."Dominate DomesticallyBarcelona secured another domestic treble on Saturday with a 3-1 Copa de la Reina final win over Atlético Madrid in their final game before travelling to Norway. Meanwhile, Lyonnes are one game away from their own domestic treble, having dispatched Nantes with an emphatic 8-0 win in the semi-final of the Premiere Ligue play-offs, with the final between the holders and Paris FC, taking place next Friday.The Lyonnes midfielder Lily Yohannes told Uefa that the club "just have so much hunger in us," after their three-year European dry spell. "We have so much fight. No matter what happens, we stick together, we rise above the challenges, and we just have such a winning mentality in the group."The 35-year-old centre-back Wendie Renard, who has been involved in each of the club's record eight Champions League wins, similarly spoke about a togetherness and desire in the team after a disappointing European run last season."If I had to sum up our journey this season: dedication," she told Uefa. "A Champions League campaign never comes easy, from one game to another. We've also had doubts and fears at times, but the squad has remained strong, and we've kept focusing on work and humility and performed well together."The Midfield BattleThe midfield battle will be key, with the impact of Melchie Dumornay, who was the difference maker in their semi-final fightback against Arsenal, critical for Lyonnes and Barcelona unsure of the readiness of the three-time Ballon d'Or winner Aitana Bonmatí, who is "feeling better every day", according to Romeu, but has not played 90 minutes for the team since November and only played 18 minutes of the Copa de la Reina final.Contrasting StylesThe Champions League final will ultimately be a contest between two different ways of playing, Barcelona's slick tiki-taka football and the more aggressive way Lyonnes play. Both cannot dominate possession in this game, one will have to cede it and find a different way to win. That is what makes it an enthralling fixture.

The Return of Janez Jansa Slovenia's parliament has voted to bring back right-wing politician Janez Jansa as prime minister, after his last stint in power ended in 2022. The Parliamentary Vote Legislators in the 90-member assembly voted 51-36 for Jansa on Friday – marking a shift for the small European Union country recently run by a liberal government. Jansa will need to return to parliament within the next 15 days for another vote to confirm his future Cabinet. His appointment concludes a post-election stalemate after the vote two months ago ended in a tie. The New Coalition Government Jansa and his populist Slovenian Democratic Party (SDS) signed a coalition agreement with several centre-right groups to form a new government, which now holds 43 seats in the assembly. The new coalition government is made up of the SDS, New Slovenia, Democrats, the Slovenian People’s Party and Focus. It also secured additional backing from the right-wing Resnica party, which will not formally join the government. Jansa's Future Goals In a speech laying out the government’s future goals, Jansa listed the economy, the fight against corruption and red tape, and decentralisation. He also promised to lower taxes for the rich and support private education and healthcare. The Impact of Jansa's Appointment Jansa is an admirer of US President Donald Trump and was also a close ally of Hungary’s former populist Prime Minister Viktor Orban. During his last term in office, Jansa faced accusations of clamping down on democratic institutions and press freedoms, leading to protests then and scrutiny from the European Union. The Future Outlook It will be the fourth time 67-year-old Jansa has been in office, having previously led the country from 2004 to 2008, 2012 to 2013 and 2020 to 2022.

The LeadFour races into the 2026 Formula One season, Mercedes arrives in Montreal with their first major technical upgrades, seeking to maintain their perfect record of four poles and four wins. As teams continue to adapt to the new regulations, the Canadian Grand Prix presents a unique challenge with its sprint format and distinctive circuit characteristics.Mercedes' Technical AdvantageMercedes has opened the season with a dominant car that has claimed all four poles and all four wins. With the new regulations offering enormous scope for improvement, the team brings their opening salvo of major parts to Quebec. While rivals like McLaren, Red Bull, and Ferrari have already implemented their first major upgrades in Miami, Mercedes' technical package could further solidify their position at the top of the grid.The Development RaceThe 2026 season is shaping up to be a fierce development fight as teams optimize their cars under the new regulations. In Miami, Red Bull and particularly McLaren made significant strides forward, with McLaren introducing a new front wing – a critical component in the aerodynamic battle. Team principal Andrea Stella estimated Mercedes still held about a tenth of a second advantage over McLaren in Miami, but with all teams continuously improving, the pecking order remains fluid.Driver DynamicsThe internal championship battle at Mercedes intensifies as 19-year-old Kimi Antonelli continues his impressive form, winning the last three races in a row to lead the world championship by 20 points over his more experienced teammate George Russell. Russell, the pre-season favorite, has faced questions about mounting pressure after managing only fourth place in Miami. The Canadian Grand Prix, a circuit where Russell has taken pole in the last two meetings and won last year, presents an opportunity for him to reassert himself in the title race.Circuit ChallengesThe Circuit Gilles Villeneuve presents a unique technical challenge with its long straights interrupted by short, stop-start chicanes and two hairpins at each end. Unlike high-speed circuits where aerodynamic developments are maximized, the Canadian track favors drivers who excel in technical precision rather than outright speed. The sprint weekend format adds another layer of complexity, with teams having only one practice session to assess and adjust around their new parts.Weather and Regulation FactorsTeams face additional challenges in Montreal, with temperatures potentially dropping to 11°C on Sunday and rain forecast – which would be the first competitive session these new cars have run in the wet. The lower temperatures and possible wet conditions could significantly impact tire performance and car handling. Meanwhile, off-track discussions continue about changing engine regulations, with manufacturers split between implementing changes for 2027 or 2028 to address driver dissatisfaction with the current power balance between combustion and electric components.

The Ongoing Battle Between Apple and Epic Games Apple is once again fighting a court's ruling in its lawsuit with Epic Games over App Store commissions. The iPhone maker has petitioned the U.S. Supreme Court to review a lower court ruling, arguing that Epic Games' beef with Apple over its fee structure shouldn't lead to an injunction that applies to all developers on the U.S. App Store. The Dispute Over App Store Rules Epic Games never brought a class action and never attempted to show that enjoining Apple's conduct against all other developers — like Microsoft or Spotify, who have nothing to do with Epic — was necessary to provide relief to Epic. Apple argues that the injunction should be specific to Epic Games and not apply to other developers. The Data Analysis: Financial Implications Apple charges fees of 27% on external payments, which led to a civil contempt order. The company has seemingly infinite money to fund its legal battles, having been fighting Epic's original 2020 lawsuit for over five years. The Impact Analysis: Industry Ramifications The dispute has significant implications for the tech industry, particularly for companies like Microsoft and Spotify, which could be affected by the injunction. Epic Games criticized Apple's latest move as 'one last Hail Mary to delay a conclusion to this case and avoid opening up the gates to payment competition for the benefit of consumers.' The Prediction: Future Outlook The Supreme Court's decision on Apple's petition will have a significant impact on the future of the App Store and its rules. If the court rules in favor of Apple, it could limit the scope of the injunction and allow the company to maintain its current fee structure. However, if the court rules against Apple, it could lead to significant changes in the way the App Store operates and potentially open up the gates to payment competition.

The Growing Rift at Roland GarrosA simmering dispute between players and the Grand Slams over revenue sharing intensified at the French Open, with Novak Djokovic warning the sport risked further fragmentation as leading players pressed for a greater voice in shaping its future. Several players limited their appearances at Friday's traditional pre-tournament media day to 15 minutes and declined additional multi-media interviews in a coordinated display of discontent.Player Demands Beyond Financial ConcernsThe tensions have been building for weeks, but the rhetoric sharpened in Paris, where players, such as Taylor Fritz, insisted that their grievances were not just about "wanting more money". "It's about just wanting what's fair," the American added. "As the tournaments make more money, we obviously want to see the revenue shared back to the players reflect that."Players have pointed to pensions, tournament expansion, scheduling and late-night finishes among the issues fuelling frustration, alongside what several described as a persistent lack of dialogue from organizers. Russian Andrey Rublev painted a picture of a widening disconnect: "When you try to communicate for so many years ... they don't hear you. They don't answer," Rublev said. "When you send the mail in, no one responds to official mail for months."The Financial Divide in TennisWhile top ATP and WTA events redistribute around 22 percent of revenues to players, the Grand Slams are estimated to return closer to 15 percent, a gap that has become a central source of tension. French Open organizers have been arguing that tournament profits fund entire national tennis ecosystems, not just prize money. They are expected to meet player agents on Friday as discussions continue over revenue sharing and player representation.Industry-Wide ImplicationsWorld number one Aryna Sabalenka cast the debate as a struggle on behalf of the sport's lesser lights rather than its leading stars. "It's not about me. It's about the players who's lower in the ranking, who is suffering," she said. "But as the world number one, I feel like I have to stand up and to fight for those players."Djokovic emphasized the broader structural issues facing tennis: "We tend to forget how little is the number of people that live from this sport." He pointed to golf and the divisions caused by the emergence of LIV Golf as a warning for tennis: "Let's learn from that. Let's try to be a bit more united and have a unifying voice into finding better structure and better future for our sport."Path Forward for Tennis GovernanceEven so, players adopted a more cautious tone over the prospect of a boycott after Sabalenka raised the possibility earlier this month in Rome. "I don't know if I want to start throwing around the 'B' word," Fritz said. "It's a really big deal, and I don't think we as players should really make big threats like that unless we're fully ready to do it."French Open tournament director Amelie Mauresmo expressed regret over the reduced media access: "It's always regrettable because media day is an important moment for the tournament, for journalists who come from all over the world and also for the fans through the media coverage," Mauresmo told reporters. "We understand that there are discussions and concerns from the players, but dialogue is always preferable."

Roberto De Zerbi defended Cristian Romero after the captain flew to Argentina to watch his boyhood club, insisting the trip was approved by Tottenham’s medical staff and would not affect the club’s fight against relegation.De Zerbi Explains Medical Approval for Romero’s Argentina TripRomero, sidelined since a knee injury against Sunderland, has been criticised for attending Belgrano’s playoff final. De Zerbi clarified that the medical department authorised the trip so the 28‑year‑old could continue rehabilitation with Argentine specialists, adding that the injury “is already an injury” and the team must accept his absence.Premier League Numbers Highlight Spurs’ precarious PositionTottenham sit 17th after 37 games with 38 points and a -10 goal difference.West Ham occupy 18th with 36 points and a -22 goal difference.A win against Everton guarantees survival; a draw would likely suffice given a 12‑point superior goal difference to West Ham.Relegation Stakes Heighten Pressure on TottenhamGlenn Hoddle labelled Romero’s decision “selfish”, but De Zerbi dismissed the criticism, emphasizing that the club’s focus must remain on the upcoming match. He highlighted the availability of Dominic Solanke after a hamstring injury and the return of Djed Spence with a protective mask, underscoring the squad’s depth.What Lies Ahead for Spurs and RomeroDe Zerbi warned that individual choices will not change the outcome on the pitch and urged his players to “play with blood, character, and spirit”. The manager’s final message: Tottenham must seize control of their fate by securing a home victory – the first since December – while Romero continues his World Cup preparation from the sidelines.

What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

The Latest Escalation in Lebanon Israeli attacks have killed at least 11 people in southern Lebanon, including several healthcare workers. The attacks occurred on Friday in the Tyre district and are the latest in a long line, questioning the durability of the shaky United States-mediated ceasefire between Israel and Lebanon. Details of the Attacks At least 11 people killed in Israeli attacks in southern Lebanon Several healthcare workers among the dead, including paramedics and a child Attacks occurred in the Tyre district, including in the municipality of Deir Qanoun en-Nahr and the town of Hannaouiyah The Humanitarian Impact More than 400 people have been killed by Israeli fire since the ceasefire came into force in mid-April. Israel insists it will continue to target the Hezbollah armed group, which opposed the Lebanese government’s agreement on the ceasefire. At least 2,896 people killed in Lebanon since Israeli attacks began More than 8,824 injured and over 1.6 million displaced – about one-fifth of the country’s population The Systematic Destruction of Health Facilities The Israeli military has repeatedly attacked health facilities and medical teams in Lebanon, accusing Hezbollah of using them to conceal weapons and fighters. The Lebanese government rejects that claim. 116 healthcare workers killed since the latest escalation in early March 16 hospitals damaged and 147 ambulances attacked The Future Outlook A ceasefire brokered by the United States came into effect in mid-April, but the violence has continued, and Hezbollah has continued to trade attacks with Israel. The US has imposed sanctions on individuals with links to Hezbollah, including Iran’s ambassador to Lebanon.

The Deadliest Day in Recent Honduran HistoryGunmen have killed at least 25 people, including six police officers, in attacks across Honduras. The attacks marked Thursday as one of the most violent days the country has seen in recent years. They came despite ongoing efforts by the government to rein in organised crime and violence.Details of the Coordinated AttacksNineteen people were killed as gunmen raided a palm plantation in the municipality of Trujillo in the north of the country. A leader of one rural group told the AFP news agency that those killed were employees of an armed group controlling a plantation. However, local media indicated that armed suspects had fired indiscriminately on labourers. They reported that the oldest victim was 61.Meanwhile, in the west near the Guatemalan border, six police officers were killed in another shooting in the municipality of Omoa. Police report that the officers had travelled to the area as part of an operation to quash gang activity. However, they were ambushed.After the two attacks, the National Police issued a statement, saying it "will proceed immediately with a direct intervention in the affected areas." "The state will act firmly to capture those responsible, protect vulnerable communities and guarantee comprehensive justice for all affected victims," it added.The Human Cost of ViolencePhotos showed bodies, some wearing thick rubber boots for work, strewn on the ground outside the plantation in Trujillo. The attacks represent a significant loss of life in a single day, highlighting the extreme danger faced by ordinary citizens and security forces alike in Honduras.The National Police has vowed to respond forcefully to the attacks, but the scale of violence suggests that the security situation in Honduras remains precarious despite government efforts to address the problem.Honduras' Ongoing Security CrisisHonduras is struggling to crack down on gang violence. Until January, many parts of the country were under a state of emergency launched in 2022. That emergency decree ended, however, with the inauguration of right-wing President Nasry "Tito" Asfura, a close ally of United States President Donald Trump, who has prioritised a hardline approach to security in Latin America.The attacks will, therefore, raise concerns over security, but also civil liberties. Laws passed earlier this week will allow authorities to designate gangs and drug cartels as terrorist groups. A new anti-organised crime unit has also been created.Root Causes: Land Conflict and Organized CrimeThe Trujillo shooting occurred near the Aguan River Valley, where armed groups, involved in narcotrafficking and palm oil extraction, have been fighting over land for decades. Trujillo police chief Carlos Rojas told local media that the groups occupy and illegally exploit several large African palm plantations, using money from the crops to obtain weapons.Local farmer groups, however, accuse transnational agribusiness corporations of sponsoring the criminal groups to carry out land occupations and prevent residents from reclaiming disputed lands. According to Reuters, more than 150 people in the area have been killed or disappeared, with environmental and land rights activists a particular target.Honduras is one of the most dangerous countries in the world for such activists. Earlier this month, police arrested several individuals, including a mayor, for plotting the assassination of a prominent environmental campaigner in 2024.Future Outlook for Security in HondurasThe recent surge in violence suggests that Honduras' security challenges are far from resolved despite the new administration's hardline stance. The combination of organized crime, land disputes, and narcotrafficking creates a complex security environment that cannot be addressed through law enforcement measures alone.International attention and cooperation, particularly with the United States, may play a crucial role in addressing the root causes of violence. However, the immediate priority for the Honduran government will be to demonstrate its ability to protect citizens and restore a sense of security in the affected regions.