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The Israeli army carried out 100 simultaneous attacks across Lebanon, including the capital Beirut, resulting in 254 people killed and more than 1,000 others injured, according to the Lebanese Civil Defense Directorate.The attacks have raised concerns about the potential impact on the US-Iran ceasefire, with the situation being closely monitored by international observers.The Israeli attacks have caused extensive damage in Beirut's Corniche El-Mazraa area, with a residential building lying in ruins and surrounding structures showing heavy damage.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

The UK's food system is heavily dependent on oil, which is used for transportation, fertilizers, and other aspects of food production. This dependency on oil has been highlighted by recent global events, including the US-Israel war on Iran and Russia's invasion of Ukraine. Experts argue that the UK needs to take a more proactive approach to food security, rather than waiting for a crisis to occur. This includes diversifying food supplies, growing more of its own food, and engaging the public in protecting itself from future shocks. The UK's food system is also vulnerable to disruptions caused by climate breakdown, ransomware attacks, and other hybrid threats. To address this, the government needs to prioritize food security and develop a more comprehensive approach to protecting the country's food supply. Some of the key recommendations for improving food security in the UK include: Regionalizing food production to reduce reliance on long-distance transportation and promote local food systems. Applying defense-strategy thinking to food security, including protecting food supply chains from disruptions and attacks. Prioritizing public engagement and education on food security, including providing guidance on nutrition and resilience. Rebuilding a regional horticulture sector to increase domestic food production and reduce reliance on imports. Addressing food inequality and ensuring that everyone has access to nutritious food. Overall, the UK's food security crisis is a wake-up call for sustainable solutions. By taking a proactive and comprehensive approach, the country can reduce its vulnerabilities and ensure a more resilient food system for the future.

Outcome arrives on Apple TV+ on April 10 as Jonah Hill’s most ambitious foray into Hollywood satire. The film casts Keanu Reeves as Reef Hawk, a globally recognized star whose public persona of kindness masks a deep‑seated narcissism and a hidden past of heroin addiction.Reef becomes the target of a mysterious extortionist who claims to possess compromising footage. His crisis lawyer, Ira—portrayed by Hill himself with a shaved head and unnerving veneers—guides him through a frantic quest to locate the blackmailer. The narrative unfolds as a “whodunnit without a body,” prompting Reef to apologize to every person he’s ever wronged while hunting the unseen threat.Supporting roles feature Cameron Diaz and Matt Bomer as Reef’s high‑school friends who reluctantly join the mission. The film also boasts cameo appearances from Laverne Cox as a women’s‑rights attorney, Drew Barrymore playing herself, and a moving turn by Martin Scorsese as a washed‑up talent manager. In a tongue‑in‑cheek detail, Ira’s office wall displays a picture of Kanye West, symbolising the industry’s obsession with redemption narratives.The satire’s core message is that wealth and fame do not guarantee happiness. Reef spends idle moments Googling his own reputation—searching “Reef Hawk bad person”—underscoring a profound loneliness beneath the glittering surface. While the script delivers frequent laughs, its climax lands on a comparatively flat note, offering personal growth rather than the expected murder or public humiliation.Overall, the performances remain consistently entertaining, and Hill’s dialogue, co‑written with Ezra Woods, captures the insider tone of Hollywood’s inner circle. Outcome serves as both a comedic critique and a reflective portrait of celebrity culture, inviting audiences to consider the cost of perpetual public scrutiny.

Federal weather data reveal that March 2026 was the hottest March ever recorded across the continental United States in a 132‑year dataset, with average temperatures soaring to 50.85 °F (10.47 °C), a staggering 9.35 °F (5.19 °C) above the 20th‑century March norm. This anomaly eclipsed the previous record of an 8.9 °F excess set in March 2012, marking the most extreme departure from average temperatures for any month in U.S. history. The month’s daytime highs were equally extreme, averaging 11.4 °F above the long‑term benchmark—almost a degree hotter than the typical April high, according to the National Oceanic and Atmospheric Administration (NOAA). Such extreme warmth is part of a broader trend: six of the ten most abnormal heat months have occurred within the last decade, and February 2026, at 6.57 °F above normal, ranked as the tenth most anomalous month on record. “The March heat wave was unprecedented across the United States,” noted Shel Winkley of Climate Central, emphasizing the sheer volume of records broken. In just two days (March 20‑21), roughly one‑third of the nation experienced temperatures that would have been virtually impossible without human‑induced climate change, according to Climate Central’s analysis. Data compiled by meteorologist Guy Walton shows that more than 19,800 daily temperature records were surpassed in March, and over 2,000 locations set new monthly heat records—a volume of record‑breaking events usually spread across entire decades. Jeff Masters of Yale Climate Connections warned that “climate change is kicking our butts,” adding that the January‑March period was the driest on record for the contiguous United States. The combination of extreme heat and historic dryness threatens water supplies, agriculture, river navigation, and overall ecosystem health. Looking ahead, both the European Copernicus climate service and NOAA project the formation of a “super” El Niño in the coming months, with the potential to amplify global temperatures into late 2026 and 2027. Meteorology professor Victor Gensini of Northern Illinois University cautioned that such an event could push the planet to new record‑high temperature thresholds.

Argentina's congress has approved a bill promoted by President Javier Milei that authorizes mining in ecologically sensitive areas of glaciers and permafrost, sparking widespread environmental protests. The bill, which was already approved by the senate in February, will make it easier to mine for metals such as copper, lithium, and silver in frozen parts of the Andes mountains.The chamber of deputies approved the amendment with 137 votes in favor, 111 against, and three abstentions after nearly 12 hours of debate. Environmentalists argue that the legislative changes will weaken protections for crucial water sources, with thousands protesting outside parliament, holding banners with slogans such as “Water is more precious than gold!” and “A glacier destroyed cannot be restored!”Seven Greenpeace activists were arrested earlier in the day after scaling a statue outside parliament and unfurling a banner urging lawmakers “not to betray the Argentine people”. The passage of the amendment is a new coup for Milei, who pushed through looser labor laws in February despite repeated street protests.Environmental activists, such as Flavia Broffoni, argue that there is no possibility of creating a 'sustainable mine' in a periglacial environment. Argentina has nearly 17,000 glaciers or rock glaciers, with glacial reserves in the north-west shrinking by 17% in the last decade due to climate change.Milei, a free-market radical who does not believe in human-made climate change, says the bill is necessary to attract large-scale mining projects. The Central Bank of Argentina estimates that the country could triple its mining exports by 2030. Supporters argue that the bill will provide legal certainty and clear definitions, while critics, such as Enrique Viale, warn that it threatens the water supply for 70% of Argentinians.

As rising temperatures push snakes and humans into closer contact, the world faces an estimated 5.5 million snakebites each year, resulting in 138,000 deaths and 400,000 lasting disabilities. In response, a Wisconsin‑based amateur scientist has taken an extreme route to help solve the crisis.For almost 20 years, Tim Friede, a former window cleaner, allowed some of the planet’s most lethal snakes to bite him, accumulating over 200 intentional bites. His goal: to provoke his own immune system into producing antibodies that could be harvested for a near‑universal antivenom.The endeavor has been perilous. Friede survived a coma after being bitten by two cobras within an hour, endured anaphylactic shocks, lost tissue in a finger, and even had to cut necrotic muscle from his leg. Yet he persisted, eventually becoming immune to the inland taipan—the world’s most venomous snake, whose single bite can kill more than 100 people.In 2019, California biotech firm Centivax hired Friede to extract his antibodies. Early laboratory work showed that his serum can neutralise toxins from 19 elapid species, including cobras, mambas, taipans, coral snakes and kraits—roughly half of all venomous snakes worldwide.The next step is a veterinary trial in Australia, slated for later this year, before any human application. If successful, the antivenom could dramatically reduce the burden of snakebite in low‑income regions across Asia and Africa, where most victims live.Climate scientists warn that warming climates will expand snake habitats and increase human exposure, as illustrated by the recent surge of rattlesnake bites in California’s Ventura County. This amplifies the urgency for scalable, affordable antivenoms, especially as international aid budgets face cuts and manufacturing capacity remains insufficient.Friede’s unconventional path underscores a broader lesson: confronting emerging health threats may require bold, unconventional science, but the potential payoff—a life‑saving treatment for millions—could be transformative.

Labour leader Ed Miliband is facing a dilemma over whether to support new oil and gas licences in the North Sea, a move that could undermine the party's commitment to renewable energy and climate action. Reform UK, led by Nigel Farage, is pushing for the licences as a way to cut fuel bills, and some trade unions are also expressing support.However, Labour's green-friendly manifesto and Miliband's long-standing commitment to combating climate change make it difficult for the party to backtrack on its opposition to fossil fuel extraction. The issue has become a battleground between Labour and Reform UK, with Farage framing it as a fight between the 'common man' and the 'elites'. The North Sea oil and gas industry is in decline, and even if new licences were granted, it would take five to seven years for the wells to become productive. Moreover, the global energy market is driven by fossil fuel prices, so extracting more oil from the North Sea would have a minimal impact on UK energy prices.Instead of succumbing to pressure from the right, Labour should focus on investing in renewable energy and breaking the energy market into clean power and fossil power. This approach would not only help combat climate change but also provide a more sustainable and resilient energy supply.The article concludes that Labour must stay committed to its green agenda and not give in to the 'nostalgic fantasy' of North Sea drilling, which would only serve to benefit Nigel Farage and Reform UK.

Oil and gas markets rallied on Thursday as investors grappled with the shaky outlook for the two‑week Iran‑Israel ceasefire. Brent crude rose more than 2% to $96.77 a barrel, while New York light crude climbed nearly 3% to $97.23, still shy of the $100 threshold that many traders watch. The previous session had seen Brent plunge 13.29% to a four‑week low of $94.75. In the gas sector, the UK month‑ahead contract rebounded 1% to 115.35p per therm after a 15% drop the day before. European natural‑gas futures also recovered, edging toward €46/MWh from a five‑week trough of €45.30. The price uptick reflects growing scepticism about the durability of the ceasefire announced a day earlier by the United States and Iran, which included a pledge to reopen the Strait of Hormuz. UAE and Kuwait reported intercepting Iranian drones, and Iran’s parliamentary speaker accused the United States and Israel of breaching several agreement points. Iran’s Revolutionary Guards warned of a “regret‑inducing response” if Israeli strikes on Lebanon continue. The latest Israeli barrage killed at least 254 people and wounded 837, prompting the Fars news agency to note that oil‑tanker traffic through the strait had been halted. Former President Donald Trump used his Truth Social platform to threaten that U.S. forces would remain in the region until a “real agreement” is fully honoured, warning that any non‑compliance would trigger “stronger than anyone has ever seen before” military action. Asian equity markets reacted negatively: Japan’s Nikkei slipped 0.7%, South Korea’s Kospi fell 1.7%, and Hong Kong’s Hang Seng edged down 0.4%. In Europe, the FTSE 100 dipped 0.1%, Germany’s DAX fell 0.6%, France’s CAC 40 dropped 0.3%, and Italy’s FTSE MIB slipped 0.2%. The pan‑European Stoxx 600 trimmed 0.1% after a near‑4% rally the day before, while U.S. futures pointed to a lower opening on Wall Street. Deutsche Bank strategist Jim Reid noted that market stress has eased compared with 24 hours earlier, as the ceasefire news generated renewed optimism and reduced fears of a stagflationary shock. On the diplomatic front, White House press secretary Karoline Leavitt announced that Vice‑President JD Vance will lead a delegation to Islamabad, with initial talks slated for Saturday morning. Jefferies chief European economist Mohit Kumar argued that, despite its fragility, the truce is likely to hold because of the “mutually assured destruction” calculus. He added that both sides now see a ceasefire as the lesser‑evil, given the escalating costs of continued conflict and the strategic challenges of securing cheap drone interceptors and a reliable Hormuz passage.