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The UK is on the brink of a medicine shortage crisis, with experts warning that the country is just weeks away from feeling the effects of the ongoing conflict in Iran. The war has already disrupted the supply of essential raw materials, including oil, gas, crop fertiliser, and helium.The pharmaceutical industry, which relies heavily on imports, is particularly vulnerable to these disruptions. India, known as the 'pharmacy of the world', produces a significant proportion of generic drugs and active pharmaceutical ingredients (APIs) used globally. However, with the Strait of Hormuz largely closed due to the conflict, the transportation of these vital supplies is becoming increasingly difficult.Medicine prices are also expected to rise as a result of the conflict. The US-Israel war on Iran has doubled air freight costs, which could make some medicines loss-making to supply to the NHS. While suppliers have long-term pricing agreements with NHS hospitals, they have more flexibility to increase prices for drugs supplied to GP practices and pharmacies.The UK's reliance on imported medicines is significant, with about half of its medicines produced domestically, a third coming from India, and another chunk from the EU. During the Covid pandemic, paracetamol and other painkillers were in short supply in Britain and elsewhere, as drugmakers in India struggled to keep up with demand.Medical distributors typically stock six to eight weeks of supplies to avoid shortfalls, but if the conflict drags on, drug shortages could emerge in only a few weeks' time. Experts warn that the overall ripple effect on the industry is significant, with the patient ultimately picking up the tab, either directly or via public health systems like the NHS.

IPO Overview Confidential Form F‑1 filed, targeting the second half of 2026. Proposed raise: $10 billion to $14 billion, equivalent to issuing roughly 2 % of existing shares. Current market cap: about $440 billion. Issuing 2 % of a $440 billion company would normally generate ~$8.8 billion; the higher $10‑14 billion range implies a modest premium, helping lift the share price toward U.S. peer multiples. Valuation Gap & Peer Comparison SK hynix trades at a discount to U.S. listed peers such as Micron despite comparable HBM capacity. Analyst notes that geography, not fundamentals, drives the gap. Cross‑listing could mirror TSMC's experience, where U.S.‑listed shares command a premium during AI‑driven demand spikes. Shareholder Structure Largest shareholder SK Square holds 20.07 % (Dec 2025), just above Korea’s 20 % holding‑company floor. The IPO design allows SK Square to retain its stake while still raising capital. Capital Deployment Plans Target net cash: $75 billion (≈100 trillion KRW) to fund AI‑era growth. Long‑term investment: $400 billion by 2050 for a semiconductor cluster in Yongin, South Korea. New facilities: $25 billion in South Korea and $3.3 billion in Indiana, USA. EUV lithography acquisition from ASML: $7.9 billion deal slated for completion by 2027 to boost HBM output. Industry Ripple Effects Investors urging Samsung Electronics to consider a similar U.S. ADR listing. Major shareholder Artisan Partners cites valuation uplift and broader U.S. retail access as benefits. Memory shortage dubbed “RAMmageddon” could persist through 2027, pressuring all AI‑focused chipmakers. Tech firms like Google are tackling the bottleneck with software solutions such as the TurboQuant memory‑compression algorithm. Strategic Implications The IPO not only provides immediate funding but also signals SK hynix’s intent to align its market valuation with global peers, potentially reshaping capital flows into the AI‑chip supply chain. If successful, the move may set a precedent for other Korean semiconductor firms seeking U.S. market exposure.

India has taken a significant step to shield its consumers from the impact of rising global energy prices, slashing fuel taxes in the face of increasing tensions between the United States, Israel, and Iran. The move aims to prevent a sharp increase in fuel prices that could have been triggered by the crisis.Petroleum Minister Hardeep Singh Puri announced on Friday that the government had decided to reduce petrol duties from 13 rupees ($0.14) per litre to 3 rupees ($0.032) per litre. Additionally, the 10-rupee (0.11) per litre duty on diesel has been completely removed, effective immediately.The decision comes as oil prices have surged past $100 per barrel following Iran's near-closure of the Strait of Hormuz after Israel and the US launched attacks on February 28. India, being the world's third-largest crude importer, relies heavily on this passageway for its crude oil supply, with about 40 percent of its crude coming through the Strait of Hormuz.Despite concerns about potential shortages, authorities have assured that there is no shortage of crude and that current reserves will cover 74 days. The government also moved to quash rumours of an impending lockdown, with Minister Puri stating that such claims are 'completely false' and that India is 'resilient.'The impact of the tax cuts on pump prices for ordinary consumers remains uncertain. Analysts suggest that oil companies previously selling at a loss are likely to benefit from the tax reductions. According to economist Madhavi Arora from Emkay Global, the annualised fiscal hit from these cuts is estimated at nearly 1.55 trillion rupees ($16.3bn).In a related move, finance authorities have reimposed export taxes on diesel and aviation fuel, raising them to 21.5 rupees ($0.23) and 29.5 ($0.31) rupees per litre respectively. This comes after the taxes were previously scrapped in 2024.

Iran has formally responded to the US's proposal to end the nearly month-long war, asserting its 'natural and legal right' over the Strait of Hormuz. The Islamic Revolutionary Guard Corps-affiliated Tasnim news agency reported that Iran had sent its official response on Wednesday night and was awaiting a response.The Iranian response appears to contradict US President Donald Trump's claim that Tehran was 'begging to make a deal'. Instead, Iran has laid out conditions that signal a continued hardening of its position, including an end to 'aggressive acts of assassination', compensation and war reparations, measures to ensure 'war does not recur', and an end to hostilities from 'all resistance groups that took part in this battle throughout the region'.US special envoy Steve Witkoff claimed on Thursday that Tehran was seeking an 'off-ramp', with signs that Iran had realised there was no alternative to negotiation. However, the source cited in Tasnim's report slammed the US proposal, claiming that Washington sought to 'deceive the world' by presenting a peaceful image while preparing for 'ground invasion'.Trump posted on Truth Social that he would pause attacks on Iran's energy infrastructure for 10 days until April 6, claiming Tehran requested the move amid 'ongoing' talks that were 'going very well'. He also claimed that Iran was 'begging to make a deal', saying 'We are absolutely obliterating Iran' and that Iranians were 'lousy fighters, but great negotiators'. The economic and humanitarian toll of the conflict continues to mount, with Iran effectively blocking the Strait of Hormuz, leading to fuel shortages worldwide.

The reintroduction of beavers in Dorset has shown promising results, with the animals building a 35-metre dam and creating a deep, wildlife-rich pool. By coppicing trees, they have allowed more light in and improved habitats for plants, insects, amphibians, birds, and bats.Trail cameras have captured footage of an otter fishing in the pond, as well as a barn owl hunting there. Volunteers have spotted birds including redpolls and water rails. The cameras also captured footage of two of the beavers mating, indicating they have settled in their new home and that there could be kits this summer.Despite some hitches, including the death of a male beaver and the relocation of a female, the western pair of beavers has been busy doing their engineering work. The National Trust, which is in charge of the project, said it was thrilled with the progress, highlighting the astonishing effect on the ecosystem in a relatively short time.Gen Crisford, the National Trust's wetlands project officer, said setbacks were inevitable but expressed hope for a 'happy ever after moment' with the western pair. The project allows for the release of 10 to 25 adult beavers, with the next release expected to take place this autumn.

The boss of Asda, the UK's second-largest fuel retailer, has warned of temporary shortages at petrol pumps due to the ongoing conflict in the Middle East. Allan Leighton, executive chair of Asda, stated that the company has been experiencing high demand from drivers as fuel prices have surged over the past four weeks.Leighton emphasized that the temporary shortages have only affected the odd pump at a small number of Asda's petrol forecourts, typically when customers arrive at a time the retailer is waiting for a fuel delivery. He added that these shortages are temporary and addressed quickly.Petrol and diesel prices have climbed significantly since the US and Israel began their campaign against Iran on 28 February. The average price of petrol in the UK rose above 150p a litre for the first time since May 2024, reaching 150.11p, according to the RAC. Diesel prices have also increased, averaging 177.68p a litre.Leighton rejected claims that fuel retailers might be 'profiteering' from the crisis by raising their prices, stating that Asda's profit margin is coming under pressure from higher fuel costs. He also noted that the government is benefiting from the situation through increased tax revenue.The global price of oil has moved higher again, climbing 2.5% to almost $111 a barrel. This increase is likely to keep petrol and diesel prices higher in the coming weeks, affecting motorists during the Easter weekend.

The US men's national team is facing a critical center-back shortage ahead of their friendlies against Belgium and Portugal, mirroring the kind of injury crisis they might encounter at the World Cup. Defenders Chris Richards and Miles Robinson are out due to injuries, leaving Pochettino with only three healthy natural center-backs: Tim Ream, Auston Trusty, and Mark McKenzie.Pochettino is considering tactical adjustments and alternative players to fill the gap. He mentioned that the absences could create an opportunity to try players at different spots, including Joe Scally, a right-back who has played as a right center-back in a three-man backline, and Tanner Tessmann, a midfielder who has filled in as a center-back for Lyon on several occasions.The team's strategy and player versatility will be put to the test as they prepare for the World Cup. Pochettino emphasized the importance of being prepared for such situations, stating, “When we talk about being right in the players that you pick … if this is happening in a World Cup, you need to see all the options that you have.”The friendlies against Belgium and Portugal will serve as a crucial test for the team's depth and adaptability, with potential implications for the World Cup roster. The USMNT will have to make the most of their current squad, as there are no reinforcements coming.

Actor Paul Dano is inviting fans to ask him questions in a special Guardian reader interview. This comes after a recent controversy sparked by Quentin Tarantino's comments on Dano's acting abilities, calling him 'weak sauce'. Tarantino's remarks, made on a podcast last year, led to a strong reaction from the film community, with George Clooney, Toni Collette, Ben Stiller, and Daniel Day-Lewis coming to Dano's defense. Dano has had a successful career with notable roles in films such as There Will Be Blood, Love & Mercy, 12 Years a Slave, and Prisoners. His versatility as an actor has been praised, particularly his ability to portray complex characters with a likable yet quietly unnerving quality. Dano is also set to appear in the upcoming political thriller The Wizard of the Kremlin, where he plays a young artist in 90s Russia who becomes an influential government official. The film, starring Jude Law as a young Vladimir Putin, is set to release in UK and Irish cinemas on April 17. Interested fans can post their questions for Dano by 6pm GMT on April 2, and his answers will be published shortly after.

The UK's physics community is reeling from a devastating blow as the government slashes funding for particle theory research. Grants from 2026 to 2030 have been cut by nearly 70%, leaving fewer than 20 postdoctoral researchers to work in the field across the country. This drastic reduction has sparked fears that some physics departments may close and that the UK's reputation as a hub for physics research could be irreparably damaged.Brian Cox, a prominent TV scientist and professor at the University of Manchester, described the impact as 'unquantifiable' and warned that it amounts to the 'destruction of the future'. The cuts have been criticized by scientists around the world, with over 600 international researchers signing an open letter in support of the UK's physics community.The Science and Technology Facilities Council (STFC) has defended the cuts, citing 'particular pressures' due to inflation and higher operating and staffing costs. However, many scientists argue that the cuts are a shortsighted move that will ultimately harm the UK's scientific progress and reputation. The UK's physics community has a rich history, with notable figures such as Stephen Hawking, Peter Higgs, and Paul Dirac making groundbreaking contributions to the field.The cuts have also sparked concerns about the impact on young researchers, who are the lifeblood of scientific progress. Prof Jeff Forshaw, also at Manchester, described the cuts as 'annihilating' a field of research that inspires young people into physics and fires up the public imagination. The situation has prompted alarm around the world, with Prof Ed Witten, considered one of the greatest physicists since Albert Einstein, expressing concern that the UK is following in the footsteps of the US, which has also made major cuts to science funding.