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What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

The Marine Heatwave's Persistence and ExpansionAn enormous marine heatwave off the US west coast is ringing alarm bells among ocean and atmospheric scientists as new data shows its ecological and environmental effects are intensifying. The unusual area of warm water has persisted since peaking in size during September 2025 and still stretches thousands of miles from the California coastline – more than halfway across the Pacific – affecting a vast triangle-shaped region of oceanic habitats from Hawaii to British Columbia and southward to Mexico.The Event DetailsAs recently as early April, marine scientists had hoped that the heatwave might diminish and the worst of its effects may be avoided. However, new projections released last week by the National Oceanic and Atmospheric Administration (Noaa) show it is now expected to expand and strengthen in the months to come.The Data AnalysisScientists say the effects may already be far reaching. A surge in the marine heatwave would accompany the formation of El Niño in the tropical Pacific – resulting in an atmospheric and oceanic mélange that could influence everything from record-breaking temperatures on land to disrupted marine food chains.The Impact AnalysisAdditional data acquired in recent weeks has left climate scientists gobsmacked and re-examining their assumptions of how the complex interplay between the ocean and the atmosphere could accelerate the effects of human-caused climate crisis. Climate scientists said the persistent marine heatwave has contributed to shockingly extreme temperatures downstream across most of the United States.The Prediction“There’s real concern right now that even if this marine heatwave didn’t persist, we’re heading into a bad wildfire season with poor water supply conditions,” said Larry O’Neill, an Oregon State University climatologist. “Our summer is going to be much warmer than normal.”

The Lead: Indigenous Voices Warn of a New Extraction EraIn the arid dry‑tropical forest of La Guajira, Maria Elena Aguilar Uriana points to a dried‑up watering hole and describes how mining has already devastated her community. Now she and other Wayúu leaders fear that the country’s push for wind‑energy is creating a second wave of exploitation.Coal Mining Legacy and Emerging Renewable Projects in La GuajiraFor decades the region has been dominated by Cerrejón, one of the world’s largest open‑pit coal mines, operated by UK‑listed Glencore. The mine has polluted water, spread coal dust over pastures and forced families to relocate. Today, national and corporate plans aim to replace that extractive model with large‑scale wind farms, but Wayúu representatives say the same top‑down approach is being repeated.Scale of the Cerrejón Mine and Planned Wind InfrastructureCerrejón is among the biggest open‑pit coal mines globally, covering thousands of hectares.Renewable‑energy developers are proposing dozens of wind turbines across Wayúu territory, though exact capacity figures have not been disclosed publicly.The projects are promoted as “green” solutions for Colombia’s energy transition, yet community consent processes remain limited.Health, Water Scarcity and Displacement Impacts on Wayúu CommunitiesWayúu testimonies describe chronic respiratory illness, malnutrition and the loss of livestock due to coal dust and dwindling water supplies. José Silva Duarte, president of Nación Wayúu, notes that water is already scarce, and mining consumes vast quantities, forcing families to rely on state‑provided water deliveries or travel long distances to unsafe wells. The combined stress of past mining and looming wind projects has spurred migration to urban centres and across borders, eroding cultural practices built over centuries.Outlook: Negotiating Consent and Sustainable DevelopmentWhile Glencore asserts it monitors air quality and follows Colombian law in land purchases, Wayúu leaders demand genuine participation, protection of water resources and health safeguards before any renewable infrastructure proceeds. The coming months will test whether Colombia can balance its climate ambitions with the rights and wellbeing of its largest Indigenous group.

The Economic Crisis in War-Torn LebanonBeirut, Lebanon – Mario Habib, a 51-year-old barber who opened his shop in 2006 just before war broke out between Israel and Hezbollah, is now living through another conflict. Twenty years later, his business in Furn el-Shebbak neighborhood is struggling as Lebanon's economy deteriorates under the weight of renewed war and global fuel crisis. "The price of running the generator is killing me," Habib said. "Everything has gotten more expensive, the price of petrol doubled, the supermarket is more expensive, even the products [I use for my business] got more expensive."Regional Conflict Disrupts Fuel Supplies and Economic GrowthIsrael's war on Lebanon and the broader US-Israel war on Iran are severely damaging Lebanon's fragile economy. Supply issues have particularly affected oil from the Gulf region, which has largely stopped flowing since the US and Iran blockaded the Strait of Hormuz. In Lebanon, which was already suffering from a severe economic crisis, there is less work and people are losing their jobs at an alarming rate.Despite Lebanon's government expressing optimism about the country's economy in 2025, with the World Bank recording a modest 3.5 percent GDP growth that year, the renewed conflict has erased those gains. In March 2026, inflation reached an 18-month high in Lebanon. Lebanon's Bank Audi now predicts that there will be 0 percent GDP growth in 2026 if the war continues.Economic Indicators Show Deteriorating ConditionsInflation reached an 18-month high in March 2026Bank Audi projects 0% GDP growth for 2026 if war continuesLebanon had recorded 3.5% GDP growth in 2025Reconstruction and recovery costs estimated at $11bn by World BankWar-related losses in 2026 estimated at $3bn (with more expected)Oil prices have increased approximately 65% since MarchCompounding Crises Create Perfect Economic StormLebanon's current economic crisis is not solely the result of recent conflicts. The country has been facing multiple compounding crises for years:2019: Financial mismanagement led to a banking crisis, cutting people off from their savings2020: Beirut port explosion killed 218 people and devastated infrastructure2021-2022: Worsening state services and mass emigration2023-2024: Hezbollah-Israel war displaced thousands of Lebanese2024: Israel intensified attacks, displacing more than one million people2026: Renewed Israeli attacks have displaced over 1.2 million people"This is a war that comes after a war," said Sami Zoughaib, an economist and research manager at The Policy Institute, a Beirut-based think tank. "It comes after institutional collapse. It comes after one of the worst financial crises in history."Societal Impact and Economic VulnerabilityThe economic crisis is disproportionately affecting Lebanon's most vulnerable populations. According to the World Bank, agriculture, commerce, and tourism—sectors accounting for 77 percent of economic losses—are key income sources for low-wage and informal workers now at significant risk.Remittances, which were approximately $6.6bn in 2023, are expected to drop significantly in 2026 due to rising oil prices. The 65% increase in oil prices since March particularly affects remittances from Gulf countries, which are crucial to Lebanon's economy.The displacement crisis has mostly impacted Lebanon's Shia community, from which Hezbollah draws its support. However, economists warn that the economic fallout could exacerbate societal divisions, with political elites potentially scapegoating displaced people for the country's economic problems—a pattern seen in the past with Syrians and Palestinians.Future Outlook: Economic Collapse or Recovery?Should the current pattern of conflict continue, Lebanon's economy could soon become unviable, with many investors deciding that opening or operating businesses is not worth the potential returns. The impact has been felt across the country, with no community left untouched by the economic consequences of war.While some areas have been hit harder than others, economist Sami Zoughaib warns that Lebanon may be reaching a point of no return. "That is, for me, very dangerous," Zoughaib said, referring to the potential for political elites to exploit economic divisions for their own gain.For ordinary Lebanese citizens like Mario Habib, the immediate concern is survival. Despite rising costs and reduced business, Habib refuses to raise his prices. "I always prefer that the person who comes here is comfortable," he said. "A lot of things are more expensive, but I prefer to be conservative on this. I feel like if you come to me, you want to be happy and relaxed."

The Lead: A Spring Showcase of Contrasting Pollination TacticsOn a sunny May morning along a former railway line, thousands of flowers display a startling range of pollination mechanisms—from the violent, explosive release of pollen in broom (Cytisus scoparius) to the precise, almost surgical delivery by white dead‑nettle (Lamium album) and the generous, pollinator‑free bounty of dandelions (Taraxacum officinale).Location: former railway line, May morningSpecies observed: broom, white dead‑nettle, dandelionPrimary pollinators: bumblebees, common carder beeBroom’s Explosive Pollen Release: Violence in the Keel PetalWhen a bumblebee lands on a broom flower it finds no nectar; the moment its abdomen contacts the keel petal, ten stamens and a coiled stigma burst free, slamming pollen onto the insect and delivering a “gut‑punch.” The trap is triggered in almost every flower, ensuring both pollen export and collection in a single, forceful act.Mechanism: explosive stamens and stigma releaseEffect on pollinator: brief contact, no nectar rewardOutcome: simultaneous pollen deposition and collectionWhite Dead‑Nettle’s Precise Pollen Transfer: Gentle EngineeringIn contrast, white dead‑nettle hides its stamens inside a hooded standard petal. A visiting common carder bee probes the flower’s throat for nectar; hidden stamens deposit a dab of pollen onto the bee’s thorax, which is later deposited on the next flower’s fork‑tipped stigma. The process is subtle, causing no apparent distress to the pollinator.Mechanism: concealed stamens within hooded petalPollinator interaction: gentle pollen placementResult: efficient cross‑pollination with minimal disturbanceDandelions’ Redundant Generosity: The Free Lunch for BeesDandelions produce abundant nectar and pollen but are apomictic, setting seed without fertilisation. For bumblebees the flowers are an “all‑you‑can‑eat” buffet, providing essential spring energy even though the plant does not rely on pollinators for reproduction.Reproductive strategy: apomixis (self‑seeded)Pollinator role: energy source, not required for seed setEcological benefit: supports pollinator populations during early seasonEcological Implications: Why Diverse Strategies MatterThe coexistence of violent, precise, and redundant pollination tactics illustrates the evolutionary arms race between plants and their visitors. Violent mechanisms like broom’s may deter less efficient pollinators, while gentle precision maximises pollen placement. Redundant generosity, as seen in dandelions, supports pollinator populations during scarce periods, indirectly sustaining ecosystem health.Evolutionary pressure: plant‑pollinator co‑adaptationCommunity impact: varied strategies sustain diverse pollinator assemblagesConservation insight: preserving a mix of pollination types benefits ecosystem resilienceLooking Ahead: Future Directions for Plant‑Pollinator CoevolutionAs climate change reshapes flowering phenology, the balance between these strategies could shift. Species that can both attract a wide range of pollinators and ensure successful fertilisation—whether through force, finesse, or self‑sufficiency—may gain a competitive edge, influencing future biodiversity patterns.Potential shift: altered timing of flower bloom and pollinator activityAdaptive advantage: flexible pollination mechanismsResearch focus: monitoring how climate impacts plant‑pollinator dynamics

The LeadIn a remarkable display of resilience and community spirit, a Lebanese woman displaced by war has taken it upon herself to bake 3,000 loaves of bread daily to feed her war-hit community. Her selfless act has become a beacon of hope amid the ongoing conflict that has displaced thousands and disrupted daily life across the region.Baking Through AdversityThe woman, whose identity has not been fully disclosed, has transformed her baking skills into a lifeline for those affected by the conflict. Working from a makeshift kitchen, she rises early each morning to prepare dough, bake bread, and coordinate distribution to families in need. Her operation has grown from a small effort to a community-wide initiative, supported by volunteers who help with distribution and sourcing ingredients.The Scale of GenerosityProducing 3,000 loaves daily is no small feat. This represents approximately 1,500 kilograms of flour, 750 liters of water, and countless hours of labor. The bread, typically simple flatbreads that are a staple in Lebanese cuisine, provides essential nutrition to families who may otherwise go without. The scale of this operation highlights both the severity of the food crisis and the extraordinary response from ordinary citizens.Community ImpactThe bread distribution has become more than just a food program; it's a gathering point for the community. Families line up daily, not just for sustenance, but for human connection and a moment of normalcy in otherwise chaotic circumstances. The baker has created a network of mutual support, with some recipients helping to distribute bread to those unable to travel, and others contributing what little they have to keep the operation running.Humanitarian ResponseWhile international aid organizations are present in the region, this grassroots effort fills critical gaps in the response. Large-scale aid often takes time to reach those in need, and bureaucratic hurdles can delay assistance. The woman's bakery operates on a neighborhood scale, ensuring that help reaches those most quickly and efficiently. Her work has drawn attention from larger aid groups, who are now exploring ways to support and scale her efforts.Future OutlookAs the conflict continues, the need for such community-based initiatives is likely to grow. The woman has expressed determination to continue baking as long as needed, and has begun training others to take over should she be forced to relocate again. Her story has inspired similar efforts in other displaced communities, suggesting a potential model for grassroots humanitarian response in crisis situations.

The Lead: Football's Global IconsFootball is a great leveller. Not everyone goes to a school with a rugby pitch and not everyone can afford a pony. However, from the favelas of Rio de Janeiro and the slums of Nairobi to the playgrounds of Monaco and Beverly Hills, you will see children kicking a football about.Arguments over the greatest 10 World Cup heroes have kept friends debating into the small hours for decades. Such arguments will continue for as long as football is played. But here, before the FIFA World Cup 2026, are the 10 we think have been the best:The Legends: Ranking World Cup Greats10. Zinedine ZidaneOne of the greatest and most controversial players of the game, Zidane won the 1998 World Cup for France at home, scoring twice in the final. Injuries kept him largely out of France's short-lived 2002 World Cup campaign, but he went on to be named player of the tournament at the 2006 edition – despite the infamous head butt that sent him off in the final against Italy. Thousands of fans lined the streets of Paris chanting Zidane's name when the team returned home.Having scored 31 goals in 108 matches for France, his talismanic leadership shaped the national team into something much greater than the sum of its parts. As a coach, he went on to win three Champions League titles and La Liga twice with Real Madrid.9. Jimmy GreavesNot even the great Bobby Moore, whose statue greets supporters arriving at Wembley Stadium, was as loved by English fans as Jimmy Greaves. Already a star at home, Greaves gained international recognition after rescuing a pitch-invading dog that had evaded the Brazilian greats during England's 1962 World Cup quarterfinal. Brazil's Garrincha took the dog home, and Greaves became known in Brazil as "Garrincha's dog-catcher".Greaves was part of the 1966 World Cup-winning squad, but a savage injury inflicted by France's Joseph Bonnel that required 14 stitches kept Greaves out of the final. Greaves scored six hat-tricks in an England shirt, a record that still stands. The 1966 campaign continues to be a focal point of English identity, the squad universally adored, and Greaves became a broadcaster, welcomed into the nation's living rooms for decades.8. Ferenc PuskasPuskas was captain of the Mighty Magyars, Hungary's golden team, which flourished under the influence of Jimmy Hogan's Total Football. He scored 84 goals in 85 matches for Hungary and made four appearances for Spain. Hungary were so dominant under Puskas that the 1954 World Cup final was the only game they lost in the entire decade.He scored 702 goals from 705 career games. The giant of European football was a vocal supporter of the 1956 Hungarian Revolution and defected to Spain while on tour after the Soviet army killed 2,500 of his countrymen while crushing the uprising. He returned to Hungary after the collapse of communism and remains worshipped by Hungarians.7. Lothar MatthausGermany's most-capped player, Matthaus scored 23 goals in 150 international matches. A box-to-box midfielder, he featured in five World Cups, helping West Germany win the 1990 edition. The only German to be named FIFA World Player of the Year, Matthaus holds the record for most World Cup games (25). His natural leadership gave him a commanding presence on the field, and his technical ability combined with his tactical awareness gave him an unstoppable dominance on the pitch.The bullish Diego Maradona called him the toughest opponent he ever faced.6. Miroslav KloseIt's rare that you get prizes just for being a good guy, but Germany's record goal scorer, the somersaulting Miroslav Klose, has a handful of them. With a career hallmarked by fair play and decency – he famously refused to accept a penalty awarded to him during a club match because he knew the referee was mistaken – Klose scored in four World Cups, finally lifting the trophy in 2014.A physical powerhouse of a forward, his stature belied his speed. He scored 71 goals in 137 matches in a German jersey. He also scored 16 World Cup goals. No one has ever scored more. He was prolific, and a good guy.5. Ronaldo"The Phenomenon" reinvented the role of striker while playing for Brazil in 98 matches and scoring 62 goals. He lifted the 1994 World Cup trophy at the age of just 17. Four years later, he was named Player of the Tournament after steering Brazil into the final, only to suffer a convulsive fit just hours before the game. He scored twice in the 2002 World Cup final to add to his six in the competition earlier, once more lifting the trophy.A fourth World Cup appearance saw Ronaldo score a then-record-breaking 15th World Cup goal. But it was the way in which he did it that set the world on fire: speed, control, vision, total mastery of the ball, explosive runs, juggling the ball past defenders with acrobatic flicks and tricks, and the goals.4. Franz BeckenbauerNo compilation of World Cup heroes could omit Franz Beckenbauer, one of only three men – along with Didier Deschamps and Mario Zagallo – to lift the World Cup trophy both as a player and a manager. Despite playing as a defender, Beckenbauer scored 14 goals in his 103 appearances for West Germany, captaining the 1974 winning side.After playing in the 1966 World Cup final loss to England, he got revenge four years later, scoring a searing goal to knock the English out and send West Germany to the semifinal. But three World Cup appearances weren't enough for him, and as Germany marched towards unification and a new era, Beckenbauer guided the national team as manager to win the 1990 World Cup.3. Johan CruyffThe three-time Ballon d'Or winner, one of the most influential figures in the sporting philosophy of Total Football, brought a new level of sophistication to the game. Football for Cruyff wasn't just an athletic sport but a blending of mind, body and artistry – an exercise in simplicity and beauty.A creative playmaker with a unique understanding of the geometry of players' pitch positions, he led his team like the conductor of an orchestra. The Netherlands never lost a game in which he scored. And he scored a lot – 33 goals in 48 international matches. Cruyff led the Netherlands to the final of the 1974 World Cup, scoring twice against Argentina and knocking out then-champions Brazil. It was only the defensive heroics of Franz Beckenbauer that frustrated Cruyff's efforts on goal and kept the Dutchman from lifting the trophy.2. Diego MaradonaThe drug-addled "Golden Boy" is widely regarded as one of the greatest players in the history of football. His 60-metre (66-yard) dribble past five England players in the 1986 World Cup quarterfinal led to the "goal of the century", yet its mastery followed the sport's most famous unpenalised handball – the goal that became known as "the hand of God".That game epitomised the two sides of Maradona: the raw, prodigious talent of the Argentinian captain mixed with an absolute disregard for rules, the shameless arrogance of a genius and the belief that one's innate talent sets you apart from – and above – the mere mortals around you. Argentina went on to win the 1986 World Cup, 10 years after Maradona had made his first appearance for the national side aged just 16.1. PeleHas there ever been a more successful football icon than Brazil's Pele? In 1958, when he scored his first World Cup goal – the result of a scuffed mishit that ended Wales's World Cup dreams for the following seven decades – could anyone have known the giant he was to become?With either foot, Pele could produce the sort of magic that inspired generations. Off the pitch, as one of the first truly global Black sports superstars, his outspoken support for improving the lives of the poor made him a national hero. Pele lifted the World Cup three times: 1958, 1962 and 1970. He remains Brazil's leading goal scorer with 77 goals in 92 games. He was so famous, so beloved all around the world that in 1969, both sides in Nigeria's civil war agreed to a ceasefire so they could watch Pele play in an exhibition match in Lagos.The Legacy: World Cup Impact on National IdentityPerhaps the way in which football stars have often escaped humble origins to shine in the sport allows the very best to become icons on and off the pitch and truly become heroes of nations. For many countries, World Cup success has become intertwined with national identity, with players elevated to almost mythical status for their contributions to the sport and their country's prestige on the world stage.The Evolution: Changing Standards of GreatnessAs the World Cup has evolved over decades, so too have the standards by which we measure greatness. Early World Cup heroes were often celebrated for their technical skill and leadership, while modern players are increasingly judged by their statistics, consistency across tournaments, and ability to perform under pressure. The rise of data analytics in football has added new dimensions to the debate about what constitutes greatness in the World Cup context.The Future: Who Will Join the Pantheon?As we approach the 2026 World Cup, the question remains: who will join this pantheon of greats? With players like Lionel Messi already having cemented their legacy, and emerging talents like Kylian Mbappé showing signs of greatness, the debate will continue to evolve. The World Cup has always been a stage where legends are made, and the 2026 tournament promises to be no exception.

Six-Month Contempt Sentence for LC&F; Founder Over Illegal Asset SalesFormer London Capital & Finance chief Michael Thomson was sentenced to six months in prison for contempt of court after admitting he breached a restraining order by selling luxury items, including horse saddles and a hot tub. His wife Debbie Thomson received a suspended six‑month term.Financial Scale of Breaches and Compensation PayoutsBreached SFO restraint order by receiving a £2,000 holiday refund and selling assets worth almost £5,800.Earlier breach involved a £95,000 transfer to his wife to conceal funds.SFO estimates the Thomsons dissipated over £100,000 in assets.LC&F collapsed after selling £236 million of mini‑bonds.As of February 2024, the Financial Services Compensation Scheme has paid out more than £173 million to victims (£58 million from industry funding, £115 million from government top‑up).Implications for SFO Enforcement and Investor Confidence in Mini‑Bond MarketThe case underscores the Serious Fraud Office’s aggressive stance on post‑collapse asset recovery and highlights lingering vulnerabilities in the UK mini‑bond sector, where speculative investments and opaque fund flows contributed to the 2019 failure of LC&F.Future Regulatory Scrutiny and Potential ReformsAccording to Paul Napper, head of proceeds of crime at the SFO, the inquiry will continue on behalf of thousands of investors. The sentencing may prompt tighter oversight of restraint orders and reinforce the need for robust compensation mechanisms for victims of similar schemes.

The LeadEleven weeks after the start of the Iran war, the Strait of Hormuz has remained closed to naval traffic, bleeding the global economy far beyond the Gulf. Iran's Islamic Revolutionary Guard Corps (IRGC) maintains an iron grip over this narrow, strategic waterway, while a corresponding United States naval blockade on Iranian ports has failed to reopen it.Before the war began, between 120 and 140 ships travelled through the strait each day, about half of them oil tankers carrying some 20 million barrels of oil between them. Now, only a few vessels whose owners have negotiated with the IRGC are permitted to pass.The Strategic Control of HormuzOn Wednesday, Iran said it coordinated the transit of 26 vessels through the Strait of Hormuz in 24 hours, two days after announcing the formation of the Persian Gulf Strait Authority (PGSA), a new body to provide "real-time updates" on operations in the strait.Since the announcement of a temporary ceasefire between the US and Iran in April, Iran has been working on formalising a mechanism to charge a transit fee from ships crossing the critical chokepoint, through which 20 percent of the world's oil and liquefied natural gas (LNG) are shipped during peacetime.Tehran has reportedly already charged fees as high as $2m per ship for transit since the war started. Even though countries opposing Tehran say this is illegal, it may still be less expensive than the overall cost of the closure of the strait each day.The Economic Cost of BlockadeNearly one-fifth of global oil and LNG exports were shipped by Gulf producers through the Strait of Hormuz before the US and Israel bombed Iran on February 28, triggering the Iranian closure of the waterway. The strait is the only waterway linking Gulf producers to the open ocean – there is no other route through which they can ship exports.About 20.3 million barrels per day of oil passed through the Strait of Hormuz in peacetime – nearly 27 percent of global maritime oil trade. The lion's share of that crude went to Asian markets.Global LNG trade has been similarly hard hit. On the day before the war broke out, Brent crude – the global benchmark for oil prices – closed at $72.48 per barrel. After Iran closed the waterway on March 4 and began attacks on vessels attempting to sail through, traffic came to a standstill, stranding about 2,000 ships on either side of the strait.In terms of lost oil revenues, this amounts to $114.8bn of losses per day. About 10 billion cubic feet of LNG per day also used to pass through the strait, worth a further $7.8bn.The Cost-Benefit Analysis of Transit FeesFor hundreds of ships stranded in the Gulf with thousands of sailors on board, the cost of remaining anchored is steep, including crew wages, loan repayments, repair and management, coupled with inflated war risk premiums.In turn, Iran has reportedly been charging up to $2m for authorisation to pass. Experts say many will see this as worthwhile purely in terms of monetary cost."There is no doubt that paying Iran is cheaper than a continuous blockade because a sitting tanker bleeds money," said Nader Habibi, an Iranian American economist."It makes sense from an economic point of view, but it is not politically feasible," he added. "The companies are under pressure from the US sanctions and not to make arrangements with Iran. This is not just a purely economic cost-benefit analysis, but long-term considerations that are taken into account."International Legal PerspectivesInternational law protects free transit through strategic waters such as natural straits like Hormuz, barring countries from imposing passage tolls even where the waterways fall entirely into territorial waters, like in the case of Hormuz.However, services such as security controls, inspections and insurance regimes can be charged for. Chargeable fees also partly depend on whether a waterway is a man-made passageway or a natural one.These are three different precedents in maritime traffic flow:Panama Canal: An artificial waterway connecting the Atlantic and Pacific oceans. Vessels pass through a unique system of locks that raise and lower vessels across elevated terrain. Since Panama built, maintains and operates the canal, it can charge transit fees based on vessel size, cargo capacity and booking priority. These range from several hundred thousand dollars per transit to some slots sold for millions of dollars.Suez Canal: Another artificial canal, linking the Mediterranean and Red seas. Egypt charges transit fees for the use of canal infrastructure, maintenance and traffic management services through the narrow waterway. Container ships and oil tankers pay from several hundred thousand dollars to more than one million dollars per voyage.Turkiye's Bosporus Strait and Dardanelles: These are different because they are natural straits, rather than man-made canals. Turkiye charges for navigation-related services such as lighthouse operations, rescue readiness, medical support and traffic management – and tightly controls ship scheduling and navigation.Regional Cooperation PossibilitiesIran's newly-formed PGSA published a new map of Hormuz, stretching from Kuh-e Mubarak in Iran to south of Fujairah, in the UAE, at the eastern entrance of the strait, and from the tip of Qeshm Island to Umm al-Quwain at the western entrance.Given how the Iran war has spilled over into the Gulf region – with the UAE taking the brunt of Iranian strikes – economist Mohammad Reza Farzanegan said "regional cooperation with Iran is the most realistic path to stable transit through the Strait of Hormuz."The UAE, Oman, Qatar and Iran will have to work together because their economies require it, he argued. A workable arrangement could include a joint maritime authority, shared monitoring, emergency coordination, environmental protection and service-based contributions for maintaining safe passage."This would give Iran a recognised role in the security of the waterway while giving Persian Gulf economies more predictability," Farzanegan added. "Such a framework is also more realistic than relying on external military enforcement, which has been more a source of trouble for these states."The Future OutlookWhile it may seem that the economics of the closure of the strait are currently skewed towards Iran, Aniseh Tabrizi, an associate fellow on the Middle East and North Africa Programme at think tank Chatham House, noted that "the economics by itself is not going to be the driver to change calculation or move from the current standpoint."She emphasized that Iran and the US need to reach a "diplomatic compromise, with other calculations linked in to the economic factor", before there can be an end to the energy supply crisis.Farzanegan added that if the world expects stable access to the Strait of Hormuz, then paying Iran could well be accepted as the price of keeping the vital waterway predictable. "From an economic perspective, a negotiated transit arrangement [with Iran] now makes more sense than continued closure," he concluded.