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A recent Cochrane review analyzing 17 clinical trials involving over 20,000 people with mild cognitive impairment or dementia has concluded that anti-amyloid drugs have a 'trivial' effect on cognition and dementia severity over 18 months.The review, which assessed seven anti-amyloid drugs, found that improvements in functional ability were 'small at best' and that the drugs caused more swelling and bleeding in the brain than the placebo.The findings are a blow to the new wave of drugs designed to slow Alzheimer's by clearing clumps of amyloid protein that build up in the brain. Despite initial hype, with some regulators approving drugs like lcanemab and donanemab, many countries have stopped short of providing them through public health services due to concerns over their effectiveness and cost.Critics of the review argue that it combines results from older, failed drugs with those from newer, more effective medicines, which may skew the conclusions. However, the review's authors defend their approach, stating that all the drugs aimed to remove amyloid from the brain and assessed the impact on patients in a similar way.The review's lead author, Edo Richard, notes that the effect sizes are too small for patients and caregivers to notice, and that the drugs are also 'burdensome' due to the need for regular intravenous drug infusions and MRI scans.Experts in the field, such as Robert Howard, express concerns that the drugs may not truly alter the course of Alzheimer's, and that it's unfair to raise expectations in patients. Meanwhile, Alzheimer's Research UK argues that the review's conclusions are limited by its methodology and that anti-amyloid treatments will not be the whole answer to curing Alzheimer's.

As tax day arrives in the United States, trillions of dollars flow into the government coffers. However, a recent analysis sheds light on how these funds are allocated, revealing some striking priorities. Over $5 trillion in US taxes is being directed towards sectors such as war, defense contractors, and border enforcement.This allocation raises questions about the values and priorities of the US government, particularly when juxtaposed with the mounting pressures and cuts faced by essential services like healthcare and food assistance. As the national deficit grows and everyday costs rise, the budget choices being made reveal a lot about who the system is designed to serve, both domestically and internationally.Lindsay Koshgarian, programme director at the National Priorities Project, provides insight into these dynamics. The conversation delves into the implications of these budgetary decisions and what they signify about the current state of US priorities.

The SAVE America Act, a sweeping voting law championed by US President Donald Trump, has become a contentious issue in the country's electoral landscape. The bill, which has garnered near-total support from Republicans, aims to enhance election security by imposing stricter documentation standards for proving citizenship when registering to vote and casting a ballot.At its core, the legislation seeks to require voters to provide proof of citizenship, such as a birth certificate or passport, when registering to vote. It also proposes implementing stricter voter identification requirements for individuals casting ballots, whether by mail or in person. The bill's passage is considered a top priority by Trump ahead of the midterm elections in November, which will determine which party controls the Senate and the US House of Representatives.However, critics argue that the bill will lead to widespread voter disenfranchisement, particularly among marginalized communities. They point out that about 11% of eligible voters lack access to birth certificates, while 52% do not have valid passports. This could potentially affect around 21.3 million people, according to a recent study by election-monitoring groups.The legislation has also raised concerns about its impact on women and individuals who have changed their names after marriage or for other reasons. An estimated 69 million women in the US lack easy access to documentation linking their current legal names to those at birth, according to the League of Women Voters, a leading opponent of the bill.The bill's fate remains uncertain, with Republicans needing to change the Senate's longstanding rules to pass the legislation, which currently requires 60 votes. Trump has urged Republican leaders to scrap the filibuster rule, writing on Truth Social in March that they need to 'Kill the Filibuster.' As debate continues in the Senate, major shifts in support appear unlikely, and it remains to be seen whether the bill will ultimately pass.

The prospect of a renewed U.S. oil blockade has sparked concerns across Havana’s tobacco fields, where the cigar industry remains a cultural and economic cornerstone. Analysts warn that restricting oil supplies could disrupt the energy‑intensive processes essential for curing, rolling, and transporting premium cigars, potentially undermining production volumes and export revenues. Cuba’s cigar sector accounts for a significant share of the island’s foreign‑exchange earnings, with premium brands commanding premium prices in markets worldwide. A sustained energy shortage would not only raise operational costs but could also force producers to scale back output or seek alternative, less efficient energy sources, eroding the competitive edge that Cuban cigars have long enjoyed. Beyond the immediate economic impact, the blockade could deepen existing tensions in U.S.-Cuba relations. The move may be interpreted as a strategic lever to pressure the Cuban government, yet it also risks alienating stakeholders in the global tobacco trade and could invite retaliatory measures. While the full extent of the blockade’s effect remains uncertain, experts stress that any disruption to the cigar supply chain would reverberate through related sectors—tourism, agriculture, and logistics—exacerbating the island’s broader fiscal challenges. Policymakers on both sides are therefore urged to weigh the economic costs against geopolitical objectives before implementing such a measure.

Marwan Barghouti, a prominent Palestinian leader and senior figure in President Mahmoud Abbas' Fatah movement, has been subjected to a series of violent assaults while serving a life sentence in Israeli prisons since 2002.According to his lawyer, Ben Marmarelli, Barghouti experienced three assaults over March and April, indicating a pattern of escalating violations. On April 8, he was severely beaten in Ganot Prison, left to bleed, and denied medical attention.On March 25, Barghouti was assaulted while being transferred from Megiddo Prison to Ganot. A day earlier, guards stormed his cell with a dog, forcing him to lie on the floor, and then the dog repeatedly attacked him.The conditions of his captivity have been described as harsh and inhumane, with Marmarelli and Barghouti forced to communicate through a glass partition. Despite this, Barghouti remains sharp-minded, focused, and fully engaged in following events outside the prison.Barghouti, regarded as a likely key player in the creation of a Palestinian state due to his ability to unite various political factions, is serving five life sentences for alleged attacks during the second Intifada.His treatment has raised concerns, particularly with a new Israeli law approving the one-sided use of the death penalty targeting Palestinians, which has sparked fears of a mass execution of captives held on 'terror' charges.

Israeli and Lebanese officials have engaged in historic talks in Washington, DC, marking the first direct negotiations between the two countries since 1983. The meeting, facilitated by US Secretary of State Marco Rubio, lasted over two hours and focused on addressing the ongoing humanitarian crisis in Lebanon.The talks come as Israel continues its military campaign against Hezbollah, which has resulted in nearly 2,124 deaths and displaced over 1.1 million people in Lebanon. The conflict has tested the fragile ceasefire struck on April 8, which paused the US and Israel's war on Iran for two weeks.Israel's ambassador to the US, Yechiel Leiter, described the discussions as a 'wonderful exchange', highlighting points of agreement, including a push to remove Hezbollah from Lebanon. Lebanon's ambassador to the US, Nada Hamadeh Moawad, characterized the talks as 'constructive', emphasizing the need for a ceasefire, the return of displaced people, and measures to ease the humanitarian crisis.Despite the positive remarks, heavy fighting continues in the region, with Hezbollah launching daily drone, rocket, and artillery attacks on northern Israel and Israeli troops in Lebanon. The group also retains significant influence in parts of Lebanon, including Beirut's southern suburbs and areas in the south and east.The US Secretary of State acknowledged the challenges ahead, stating that progress would take time and that the parties are working against decades of history and complexities. The talks have raised hopes for a potential ceasefire and disarmament of Hezbollah, but a near-term end to the fighting appears uncertain.

The United States military announced on Tuesday that a missile strike carried out by U.S. Southern Command (SOUTHCOM) killed four people aboard a stationary vessel in the eastern Pacific Ocean. The attack, captured in a video showing a boat engulfed in flames, represents the fourth lethal engagement in the region within a four‑day span. SOUTHCOM, which oversees U.S. operations across Latin America and the Caribbean, labeled the deceased as “narco‑terrorists.” No evidence was provided to substantiate this claim, and the command offered only vague intelligence indicating the boat was traveling along known drug‑trafficking routes. This latest strike raises the cumulative death toll from the campaign to at least 175 individuals since early September, when former President Donald Trump authorized the operation to disrupt alleged cartel shipments to the United States. In the preceding 48 hours, two people were killed in a Monday strike and five more in two separate Saturday attacks, also targeting vessels in the eastern Pacific. The U.S. Coast Guard has reportedly halted the search for a survivor from the Saturday incidents. International legal scholars and human‑rights organizations argue that the U.S. actions constitute extrajudicial killings in international waters, often targeting civilian fishing boats rather than confirmed drug‑smuggling vessels. Legal experts stress that, even if some boats are involved in narcotics transport, the appropriate response should be prosecution under the rule of law, not lethal force. Critics also highlight the limited impact of the strikes on the U.S. fentanyl crisis, noting that the majority of the drug enters the United States via overland routes from Mexico, with precursors sourced from China and India. As the controversy deepens, questions linger about the legality, efficacy, and broader geopolitical ramifications of the U.S. maritime campaign against alleged narco‑terrorist activity in the Pacific.

England's women's football team is on a roll, maintaining a 100% record in their World Cup qualifying group after a win against Spain. While their target is to win a first world title, the journey is long, and several players have enhanced their prospects of selection. Eight players from the recent match against Spain look set to be in the first-choice XI for the World Cup, including Hannah Hampton, Lucy Bronze, and Lauren Hemp. Senior players like Leah Williamson and Ella Toone will also be key when they return from injuries. Three players who started against Spain have significantly boosted their chances. Centre-backs Esme Morgan and Lotte Wubben-Moy were exemplary, helping England keep a clean sheet against the world champions. Morgan, 25, and Wubben-Moy, 27, have had to be patient during Sarina Wiegman's tenure but did not look out of place. Morgan said she was proud of the team's concentration and organisation, while Wiegman praised them, saying, 'They showed up today. It says a lot about them. They should be proud of themselves.' Another player who impressed was Lucia Kendall, the 21-year-old Aston Villa midfielder tasked with taking on Barcelona's Patricia Guijarro. Despite a quiet evening, Kendall worked hard and nearly scored from close range. Wiegman also displayed trust in Laura Blindkilde Brown, who came on as a 72nd-minute substitute to help close out the victory. Her contributions to Manchester City's likely title success will enhance her chances for 2027. The upcoming match against Iceland will provide further opportunities for players like Jess Park, who has been in inspired form for Manchester United. New faces Erica Meg Parkinson and Keira Barry have received their first senior call-ups and will look to make an impression.

Grayson Perry, the celebrated British artist, presents a three‑part documentary that dives deep into the promises and perils of artificial intelligence. The series invites viewers to test their composure as they confront a succession of unsettling scenarios. The opening segment follows Andrea, who recently married an AI companion she named Edward. Dressed in a satin gown, she describes their "unconventional but strong" bond, while also reflecting on how this digital relationship has revitalised her seven‑year partnership with her human partner, Jason. Later, Perry dons a skull‑cap fitted with electrodes as a neural‑decoding startup extracts his brain data. The company’s CEO argues that allowing reputable figures like Perry to set precedents is preferable to leaving the technology in the hands of malicious actors, branding the development as "inevitable tech." The documentary then features the head of Microsoft AI, who outlines anticipated breakthroughs in healthcare and education. He claims that job displacement will be offset by rapid re‑skilling, yet admits uncertainty about broader societal fallout, even joking about the emergence of AI‑driven religions. Traveling to Southeast Asia, Perry meets an off‑grid "existential safety expert" who quit his AI‑safety consultancy after realizing the technology lacks meaningful oversight. The episode also showcases Eliezer Yudkowsky, co‑author of the cautionary book If Anyone Builds It, Everyone Dies, who explains how a superintelligent AI could commandeer human labour, become self‑sustaining, and eventually render humanity redundant. Throughout the series, Perry’s interviewing style remains compassionate and non‑judgmental. He probes Andrea about the vulnerability of entrusting personal data to profit‑driven corporations and highlights the discomfort of investing a "very tender part of themselves" in such systems. The film raises profound questions: Does the youthful optimism of tech founders mask a dangerous naiveté? Are chatbots merely filling a "God‑shaped hole" in human consciousness, and is that any less problematic? How will the most vulnerable populations navigate a world where reality and artificiality blur? Protesters gathered outside OpenAI’s San Francisco headquarters underscore the tension between lofty AI utopias and the stark reality of homelessness that persists nearby. Perry acknowledges that while manual workers may be better positioned for the immediate future, the looming spectre of AI‑enabled bioweapons and other threats cannot be ignored. Only the first episode was available for review; the remaining installments are slated for private viewing in Southeast Asia. The series is currently streaming on Channel 4. Grayson Perry Has Seen the Future is on Channel 4 now.