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GSK has revealed promising early results for its treatment for gynaecological cancers, Mocertatug Rezetecan (Mo-Rez), as its chief executive, Luke Miels, seeks to speed up drug development at the group.The company reported that in an early-stage trial, Mo-Rez shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.GSK acquired the Mo-Rez cancer treatment, an antibody-drug conjugate (ADC), from China’s Hansoh Pharma in late 2023, and has trialled it in 224 patients around the world, including the UK, over the past year. Few patients needed to stop treatment because of side-effects, the most common being nausea. It is administered every three weeks via intravenous infusion.Combined with data from a separate, intermediate trial in China, these results give GSK the confidence to go straight to late-stage trials, with five clinical studies planned globally in the next few months, including on patients in the UK.Presenting the results at the Society of Gynecologic Oncology’s annual meeting on women’s cancer in Puerto Rico, Hesham Abdullah, GSK’s global head of cancer research and development, said: “Treatment of gynaecological cancers remains a major challenge, with a pressing need for new therapies that offer improved response rates. With Mo-Rez we now have compelling evidence of a promising clinical profile.”Endometrial cancer affects 1.6 million women globally, with 417,000 new cases each year. Ovarian cancer affects 843,000 people, with 240,000 new cases annually.Abdullah described Mo-Rez as a “key asset” in the company’s growing cancer portfolio, expected to be a blockbuster drug with peak annual sales of more than £2bn, which GSK hopes will help it achieve its 2031 sales target of £40bn.

Apple users are being warned about a nasty scam doing the rounds, impersonating the company's iCloud service. The scam emails claim that the recipient's iCloud storage is full and threaten to delete their photos and videos if they do not upgrade their storage immediately.The emails include a button to upgrade iCloud storage, but this is a malicious link designed to harvest people's bank and personal details. If clicked, it leads to a phishing website that looks genuine but aims to steal sensitive information.Criminals behind the scam may attempt to steal money or sell the details to other criminals on the 'dark web' if victims provide their bank details or make a payment.The scam emails can coincide with genuine messages from Apple saying users have run out of storage and urging them to upgrade, making it appear convincing.To avoid falling victim, users are advised to ignore and bin these emails, and not click on any links. Scam emails can be reported by forwarding them to [email protected], and emails impersonating iCloud can be sent to [email protected] and/or [email protected].

The U.S. Central Command (CENTCOM) reported that the destroyers USS Frank E. Peterson and USS Michael Murphy "transited the Strait of Hormuz and operated in the Arabian Gulf" as part of a mission to clear sea mines allegedly laid by Iran’s Islamic Revolutionary Guard Corps (IRGC).Admiral Brad Cooper hailed the operation as a turning point in the U.S.–Israeli campaign against Iran, saying the navy was establishing a "new passage" to restore safe commercial flow. Iran’s Khatam al‑Anbiya Central Headquarters immediately rejected the claim, stating that any vessel movement in the strait remains under the "Armed Forces of the Islamic Republic of Iran" and that the U.S. report is "strongly denied." The strait, a narrow chokepoint through which roughly 20% of the world’s oil and natural gas transits, has been a flashpoint since the February 28 U.S.–Israel attacks that prompted Iran to restrict passage to pre‑approved ships. The closure spiked global fuel prices and disrupted both commercial and military traffic. Analysts, such as Maria Sultan of the South Asian Strategic Stability Institute, argue that any U.S. navigation would require Tehran’s explicit permission, underscoring the strategic leverage Iran holds over the waterway. Simultaneously, senior delegations from the United States and Iran met in Islamabad for historic face‑to‑face talks—the highest‑level engagement since the 1979 Islamic Revolution. The negotiations, sparked by a preliminary ceasefire announced earlier in the week, focus on contentious issues including Iran’s nuclear program, frozen assets, and the future of Israeli operations in Lebanon. Both parties acknowledge that control of the Strait of Hormuz remains a major point of disagreement. Iran has signaled willingness to temporarily reopen the channel for commercial shipping but insists on maintaining leverage, proposing tolls to compensate for war damages. The United States, however, deems continued Iranian control a "non‑starter." U.S. President Donald Trump used his Truth Social platform to assert that Iran is "losing big" and to downplay the strait’s importance to the United States relative to its allies, claiming the mine‑clearing effort benefits nations such as China, Japan, South Korea, France, and Germany. Al Jazeera’s on‑the‑ground correspondents noted that despite a "deficit of trust," negotiators are working late into the night to bridge gaps, though fundamental disagreements over the strait’s governance persist.

Ali Majed Hamadneh, 23, was killed after Israeli settlers opened fire during a raid on the West Bank village of Deir Jarir, north‑east of Ramallah, the Palestinian Ministry of Health reported on Saturday. He was transported to the Palestine Medical Complex in critical condition and later succumbed to his gunshot wounds.The Palestinian news agency Wafa described the attack as carried out by "armed colonists, under the protection of Israeli forces," who entered the village from its western entrance and fired on residents. The Israeli military has not issued an immediate comment.This raid occurs just two days after Israel approved 34 new settlements in the occupied West Bank, a move denounced by the Palestinian Presidency, the Organisation of Islamic Cooperation and the European Union as a breach of international law.Since assuming office in 2022, Prime Minister Benjamin Netanyahu's right‑wing government has sanctioned at least 102 settlements, a marked increase compared with previous administrations. All Israeli settlements in the occupied West Bank are considered illegal under international law.Violence in the West Bank has escalated sharply since Israel's war in Gaza began in October 2023, and a further spike in deadly settler attacks has been reported since the United States‑Israel conflict with Iran started at the end of February, according to Palestinian authorities and the United Nations.While settler assaults have persisted for years, the recent surge has drawn criticism from influential rabbis, settler leaders, and Israel’s military chief Eyal Zamir, who labeled the attacks "morally and ethically unacceptable."

A violent incident unfolded at New York City's iconic Grand Central station on Saturday, when a man armed with a machete allegedly attacked and wounded three elderly individuals.Police responded swiftly to the situation, and one officer opened fire, striking the attacker. The man was taken to a local hospital in critical condition.The victims, identified as an 84-year-old man, a 70-year-old woman, and a 65-year-old man, were hospitalized in stable condition. The NYPD reported that the incident occurred at 9:40am Eastern Time (13:40 GMT).Grand Central station, a major transit hub in Midtown Manhattan, is renowned for its Beaux-Arts architecture and is one of the most visited tourist attractions globally, with an average of 750,000 travelers and visitors daily.

At least seven Palestinians have been killed and others wounded in Israeli strikes across the central and southern Gaza Strip. An Israeli drone fired two missiles close to a police post in Bureij refugee camp in central Gaza, killing and wounding several people.Medical sources confirmed the early morning attack to Al Jazeera, saying the strike hit a group of civilians in the 'Block 9' area of Bureij. Several people were killed and seriously wounded, they said.Ambulance crews faced difficult conditions as they worked to transport the bodies and those injured to nearby hospitals, the sources added. The al-Aqsa hospital in central Gaza received six bodies and seven wounded people, including four in critical condition.Separately, in the southern Gaza Strip, Nasser Medical Complex received three wounded people following an Israeli drone strike against a tent of displaced people in the town of Bani Suheila, located east of Khan Younis.Al Jazeera's correspondent on the ground also reported Israeli artillery shelling and heavy tank fire near Bani Suheila and east of Gaza City.Israel's genocidal war on Gaza has killed more than 72,300 people since it began in October 2023, according to the Gaza Ministry of Health, including at least 738 since the so-called ceasefire went into effect last October.The tally includes at least 32 deaths since the start of April alone – among them Al Jazeera journalist Mohammed Wishah, who was killed in an attack west of Gaza City earlier this week.United Nations human rights chief Volker Turk condemned Israel's recent violence in the Gaza Strip, saying that 'the unrelenting pattern of killings' reflects Israel's 'sweeping impunity'.Meanwhile, in the occupied West Bank, Israeli settlers and forces stormed homes and villages throughout the morning, continuing an escalating campaign to expand their illegal settlements.

Senior Iranian officials, including parliamentary speaker Mohammad Bagher Ghalibaf and Foreign Minister Abbas Araghchi, have arrived in Islamabad, Pakistan, for ceasefire talks with the United States. The US delegation, led by Vice President JD Vance, along with special envoy Steve Witkoff and Jared Kushner, is representing Washington in the negotiations.Ahead of the talks, Vance indicated a potential opening for diplomacy, stating that Washington is ready to “extend an open hand” if Iran negotiates in good faith. However, the situation on the ground remains volatile, with Lebanon’s Health Ministry reporting that at least 357 people were killed in Israeli attacks on Wednesday, with the death toll expected to rise.In IranIran is experiencing a near internet blackout that has passed 1,000 hours, making it one of the longest nationwide internet disruptions on record, according to the monitoring group NetBlocks.Analyst Zohreh Kharazmi noted that Iranians remain sceptical ahead of the negotiations, despite Tehran believing it holds leverage, including over the Strait of Hormuz.War DiplomacyIran’s delegation of top officials arrived in Islamabad for ceasefire talks with the US, as reported by Iranian state television on Friday.Lebanon’s presidency announced that a meeting will be held at the US Department of State on Tuesday to discuss declaring a ceasefire and the start date for negotiations between Lebanon and Israel under US auspices.Iran demands a truce in Lebanon and the release of its blocked assets as Vance warned Tehran not to “play” Washington in their talks.US President Donald Trump stated that Iran has “no cards” in upcoming talks with the US and mentioned that US warships are being reloaded with weaponry to strike Iran if the talks fail to produce a deal.In the USTrump says the Strait of Hormuz will reopen ‘fairly soon’, pledging that Washington will “open up the Gulf” amid ongoing disruption to global energy supplies.Former US ambassador Douglas Silliman noted that Trump is likely to push for a fast outcome in the talks to ease economic pressure, with the reopening of the Strait of Hormuz seen as a critical priority.US consumer prices surged to a two-year high, increasing pressure on the administration as economic concerns grow at home.In IsraelThe US has reportedly asked Israel to halt attacks on Hezbollah in Lebanon to avoid derailing negotiations, with the current US-Iran ceasefire set to expire on April 21.Israel’s military operations and expanding ground offensive in Lebanon continued, even as ceasefire negotiations were scheduled.In Gaza and JerusalemMore than 100,000 people attended the first Friday prayers at the Al-Aqsa Mosque in East Jerusalem since its reopening following the US-Iran truce, the holy site’s Islamic authority reported.An Israeli air strike killed at least six people and injured several others at the Bureij refugee camp in the central Gaza Strip, according to the Gaza Health Ministry.In LebanonHeavy toll from Israeli attacks: Lebanon’s Health Ministry reported that nearly 2,000 people have been killed by Israeli air strikes and ground operations since early March, with thousands more wounded.Lebanon is facing a food security crisis, with prices surging and supply chains disrupted amid Israel’s offensive, according to the United Nations World Food Programme (WFP).

Brazilian President Luiz Inácio Lula da Silva used his Friday social‑media post to herald a new security partnership with the United States as a breakthrough in the fight against transnational crime.The agreement links the Brazilian Federal Revenue Service with U.S. Customs and Border Protection, establishing the DESARMA programme. Under DESARMA the two agencies will exchange real‑time data, apply rigorous cargo‑tracking protocols and launch joint operations to intercept illicit shipments of arms and narcotics.Finance Minister Dario Durigan called the collaboration an “important step in strengthening international cooperation”, noting that it will integrate intelligence and joint actions to curb the flow of weapons and drugs between the two nations.The pact is part of President Donald Trump’s broader “Shield of the Americas” initiative, which seeks to enlist right‑wing governments across the Western Hemisphere in a hard‑line campaign against criminal networks.Despite the cooperation, Lula’s administration has pushed back against Washington’s attempts to label Brazilian gangs such as the Primeiro Comando da Capital (PCC) and Comando Vermelho (CV) as foreign terrorist organisations. Lula and Foreign Minister Mauro Vieira have repeatedly asserted Brazil’s sovereignty and warned against external “tutelage”.In the last twelve months Brazil reported seizing 1,168 illegally imported weapons and parts, most of which originated from the U.S. state of Florida, underscoring the scale of the smuggling problem.A statement from the Revenue Service emphasized that the deal will ensure a “continuous flow of information from U.S. authorities to their Brazilian counterparts”, enhancing operational coordination.Relations remain strained: Vieira told U.S. Secretary of State Marco Rubio that Brazil opposes the terrorist‑label designation, while the Trump administration continues aggressive actions in the region, including lethal strikes on maritime vessels and a controversial raid in Venezuela.Looking ahead, Lula is expected to travel to Washington, D.C., later this year for talks with Trump, providing a diplomatic channel to manage both cooperation and disagreement.

Chelsea FC has suspended midfielder Enzo Fernández for two games following his comments about potentially joining Real Madrid. Fernández, along with teammate Rodri, expressed interest in moving to the Spanish club during the international break.Fernández's statements, while not unusual in the football world, were deemed to have 'crossed a line' by Chelsea, leading to the suspension. The midfielder's comments included expressing admiration for Real Madrid players Luka Modric and Toni Kroos, and stating that Madrid's lifestyle is similar to his hometown of Buenos Aires.The suspension comes at a critical time for Chelsea, who are vying for a top-five finish in the Premier League and a spot in the Champions League. The team's players reportedly petitioned manager Liam Rosenior to allow Fernández to play in the upcoming match against Manchester City.The incident highlights the challenges faced by Chelsea in retaining top talent, particularly under the ambitious project led by Todd Boehly and Clearlake. The club's strategy of signing young players to long contracts with performance-based incentives may be flawed, as top players often seek better opportunities or more lucrative deals as they develop.Fernández's situation serves as a microcosm of the broader issues in football, where player loyalty and contract commitments are frequently tested by the allure of top clubs and better offers. The incident also underscores the differing approaches of Chelsea and other top clubs, such as Manchester City, which seem more tolerant of players expressing their aspirations.