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Peptides are short chains of amino acids that naturally occur in the body, acting as hormones such as insulin, oxytocin and vasopressin, or as fragments released during protein digestion.In recent years, a wave of interest has turned these molecules into purported therapeutic agents for everything from weight loss to anti‑ageing and tissue repair. Prescription drugs like semaglutide (Wegovy) and tirzepatide (Mounjaro) are synthetic peptides that have undergone rigorous clinical testing and are approved for specific medical uses.However, a large portion of the market consists of unregulated, experimental peptides sold for self‑administration. These products often bypass the strict approval processes required for medicines, raising serious safety concerns.Who is using these products? Initially confined to a niche of powerlifters and bodybuilders in the 2010s, the audience has expanded dramatically. Influential figures such as podcaster Joe Rogan have promoted combinations like the “Wolverine stack” (BPC‑157 and TB‑500) for injury recovery, while other compounds—CJC‑1295, MK‑677, ipamorelin, and GHK‑Cu—are marketed for muscle growth and anti‑ageing. Social media platforms are now flooded with instructions on purchasing and injecting these substances.Scientific backing is scant. Reviews of the literature reveal that most experimental peptides have only been tested in animal or cell models. For example, BPC‑157 shows promise for tendon and muscle repair in pre‑clinical studies, but no randomized human trials have validated these effects. Similarly, TB‑4 and its synthetic analogue TB‑500 have demonstrated limited blood‑vessel formation in laboratory settings, yet human data are absent and both are listed as prohibited substances by the World Anti‑Doping Agency.Researchers also highlight a critical knowledge gap: dosage, frequency and treatment duration remain undefined, making self‑administration a gamble.Legal landscape in the UK is clear that peptides not classified as medicines fall outside the Medicines and Healthcare products Regulatory Agency’s (MHRA) remit. If a seller makes medicinal claims, the product must hold a marketing authorisation under the Human Medicines Regulations 2012. The MHRA warns that labeling items as “research use only” does not shield vendors from enforcement when evidence shows the products are intended for human consumption.Health risks are multi‑fold. Experts caution that benefits observed in animal studies do not guarantee safety in humans. Contamination with harmful impurities or bacterial endotoxins can trigger severe reactions, including septic shock. Injecting excess natural peptides may disrupt the body’s tightly regulated hormonal balance, potentially affecting multiple physiological pathways.There is also theoretical concern that augmenting peptide levels could accelerate tumour growth, as some cancers over‑express certain peptide pathways. While no direct cases have been documented, the possibility underscores the need for caution.Additional dangers include improper injection techniques (e.g., air embolism), unknown interactions with existing medications, and the lack of systematic monitoring of long‑term effects. As one researcher put it, “If something goes wrong, users may never notice until irreversible damage has occurred.”

Mary Beth Hurt died on 28 March 2026 at the age of 79, closing a four‑decade career that blended intellectual cinema with acclaimed stage work. Born in Marshalltown, Iowa, she entered the film world with Woody Allen’s experimental drama Interiors (1978), earning a BAFTA nomination for Best Newcomer alongside Christopher Reeve.Although Interiors was a modest critical success, it proved financially profitable, grossing $10 million on a $3 million budget. Hurt’s portrayal of the directionless Joey marked the start of a career defined by thoughtful, understated performances.Her next high‑profile role came as Helen Holm, the college‑professor wife of Robin Williams’s titular character in The World According to Garp (1982). The film’s daring tonal shifts – including a shocking car‑crash scene – earned Oscar nominations for John Lithgow and Glenn Close, while giving Hurt a rare chance to play a fully sexual woman.Early setbacks included losing the lead in Joan Micklin Silver’s Head Over Heels (1979) to Jamie Lee Curtis and a troubled turn in the melodrama A Change of Seasons (1980), which suffered from production turmoil and poor box‑office returns.On stage, Hurt distinguished herself with three Tony nominations: for Pinero’s Trelawny of the ‘Wells’ (1976) opposite a debuting Meryl Streep, for a 1982 revival of Beth Henley’s Crimes of the Heart, and for Michael Frayn’s Benefactors (1986). She debuted on Broadway in 1974’s revival of William Congreve’s Love For Love opposite Glenn Close.Her personal life intersected with her professional world. She married fellow actor William Hurt in 1971, divorcing in December 1982, and later wed director Paul Schrader in August 1983. Collaborations with Schrader included Light Sleeper (1992), Affliction (1997) and The Walker (2007).Later film work featured a supporting turn in Karen Moncrieff’s feminist thriller The Dead Girl (2006), which earned her an Independent Spirit Award nomination, and a cameo in Martin Scorsese’s The Age of Innocence (1993). Her final screen appearance was in the small‑town drama Change in the Air (2018), filmed before a diagnosis of Alzheimer’s disease.Reflecting on her craft, Hurt once said, "I never felt very beautiful or incredibly smart or witty, so I was always looking for something about the role that intrigued me… more fascinating than the gold‑medal moments."She is survived by husband Paul Schrader and their two children, Molly and Sam.

Iran has released footage of US aircraft conducting a search operation for pilots who were shot down in Iranian airspace. The videos, obtained by Iranian authorities, provide a glimpse into the search efforts undertaken by the US military.The release of these videos comes amid heightened tensions between Iran and the United States, with both countries engaging in a delicate diplomatic dance. The incident highlights the complexities of military interactions between nations and the importance of transparency in such situations.

Recent drone footage has surfaced, showcasing a factory in Israel that has sustained considerable damage due to debris from an Iranian missile. The incident underscores the escalating tensions between Israel and Iran, with this event being a stark visual representation of the heightened conflict between the two nations.The footage, which has been widely circulated, provides a clear visual impact of the missile debris on the factory, indicating a significant military escalation in the region. This development comes at a time when international concerns are growing over the potential for a wider regional conflict.

More than 100 United States‑based international law scholars have signed an open letter denouncing the recent US‑Israeli strikes on Iran as a violation of the United Nations Charter and potentially amounting to war crimes. The letter, released on Thursday, asserts that the campaign – launched on February 28 – proceeded without UN Security Council authorization and without credible evidence of an imminent Iranian threat. According to the scholars, the legal basis for force against another state exists only in self‑defence against an actual or imminent armed attack, or when expressly sanctioned by the Security Council. Iran has not attacked the United States or Israel, and the Security Council did not approve the operation. The experts organize their concerns into four categories: the legality of the war decision, the conduct of hostilities, threatening rhetoric from senior officials, and what they describe as the dismantling of civilian‑protection safeguards within the US defence establishment under Secretary of Defense Pete Hegseth’s “gloves‑off” approach. Among the most alarming incidents highlighted is the strike on a primary school in Minab, Iran on the first day of the conflict, which killed at least 175 people, the majority of them children. The letter also cites attacks on hospitals, water treatment facilities, and energy infrastructure, emphasizing that schools, health facilities, and homes have been targeted. The signatories condemn public statements by senior US officials, including a mid‑March remark by former President Donald Trump that the United States might strike Iran “just for fun,” and early‑March comments from Pentagon chief Pete Hegseth dismissing “stupid rules of engagement.” They argue that such rhetoric reflects an “alarming disrespect” for international humanitarian law, which is designed to protect civilians and combatants alike. Financially, the letter notes that the war is costing US taxpayers up to $2 billion per day, underscoring the broader economic burden of the conflict. The open letter was co‑authored by prominent legal scholars such as Yale Law School’s Oona Hathaway, former State Department legal adviser Harold Koh, NYU’s Philip Alston, and former Human Rights Watch chief Kenneth Roth. While the authors focus on the United States’ conduct, they warn of a heightened risk of atrocities throughout the region. Emphasizing the need for consistent application of international law, the scholars write: “We urge US government officials to uphold the UN Charter, international humanitarian law, and human rights law at all times, and to publicly make clear US commitment to and respect for norms of international law.”

In the devastated streets of Gaza City's Tuffah neighborhood, residents are taking matters into their own hands to rebuild their homes. Mohammed al-Jadba, a 31-year-old father of 10, is using stones from the rubble of his destroyed house and mud to construct a new shelter. His home, once a four-storey building, was reduced to rubble during Israel's genocidal war on Gaza.With Israeli restrictions on imports preventing the entry of essential construction materials like cement, Gaza residents are forced to get creative. Mohammed has been collecting iron, window frames, and door frames from his old house to use in his new build. The mud, mixed with human hair collected from barbershops, is being used to stick everything together.The United Nations estimates that it will cost $70bn to fully reconstruct Gaza, with 92% of residential buildings damaged or destroyed. An urgent $20bn is needed within the first three years to initiate basic recovery and restore essential services. However, reconstruction efforts have been hindered by continued Israeli restrictions on the entry of construction materials and heavy machinery.As a result, Palestinians in Gaza have focused on partial reconstruction, using available materials to make damaged homes habitable. The United Nations Development Programme (UNDP) has worked on over 230 housing units, benefiting more than a thousand people. However, these interventions are temporary solutions, and the real solution remains elusive.Abdel Nasser al-Jalousi, a 55-year-old resident of Khan Younis, has benefited from partial rehabilitation projects. His heavily damaged home has been made habitable with tarpaulins used as substitutes for walls, doors, and room partitions. However, he stresses that these materials are not a long-term fix and will need to be replaced every season.The scale of the crisis remains severe, with over 213,000 families living in tents and widespread damage during winter storms. The situation highlights the need for political will and massive resources to rebuild Gaza and provide sustainable solutions for its residents.

The Panama Papers, a massive leak of 11.5 million documents from Panamanian law firm Mossack Fonseca, exposed a vast network of offshore shell companies used by global elites to evade taxes and scrutiny. The leak, which involved over 350 journalists from 80 countries, revealed that hundreds of people, including over 140 politicians, were linked to offshore entities.The scandal led to significant consequences, including the resignation of Iceland's Prime Minister Sigmundur Gunnlaugsson and the disqualification of Pakistan's Prime Minister Nawaz Sharif from office. Mossack Fonseca ultimately shut down in 2018 following the leak.Governments worldwide have recovered around $2 billion in taxes, penalties, and levies since 2016, with countries like the UK, Sweden, and France each recovering between $200-250 million. However, the amount of unaccounted funds remains significantly higher.The leak has also driven regulatory changes, including the Corporate Transparency Act in the US, which requires disclosure of beneficial owners of offshore entities. The United Nations is considering a Convention on Taxation to address global tax challenges.Despite progress, gaps remain in the global tax system, allowing individuals and companies to exploit loopholes and avoid taxes. Experts stress the need for a multilateral tax convention to address tax competition and treaty shopping.

Analysts say that more than two years of relentless campaigns against Gaza, the Houthis, Lebanon and now Iran have reshaped Israel’s politics, economy and social fabric.Washington, rather than Jerusalem, is likely to decide the ultimate outcome of the conflict that Israeli leaders describe as an “existential battle” with Tehran.According to the Bank of Israel, the cumulative cost of these wars has reached 352 billion shekels (about $112 bn), which translates to roughly 300 million shekels ($96 m) per day. The financial pressure is compounded by the International Court of Justice hearing credible genocide accusations and the International Criminal Court’s arrest warrants for the prime minister and a former defence minister.Domestically, Israelis endure frequent air‑raid alerts and school closures, while many families juggle work and shelter duties. Yet a poll by the Israel Democracy Institute in late March showed that 78 % of Jewish Israelis still support continuing the war, even as a majority doubt that Washington and Israeli planners have fully grasped Tehran’s capabilities.Political commentator Dahlia Scheindlin told Al Jazeera that a “graveness” has settled over the population, noting a grim determination to press on despite exhaustion.Israel’s right‑wing coalition, led by figures such as National Security Minister Itamar Ben‑Gvir and ultra‑Orthodox Finance Minister Bezalel Smotrich, has pushed through a controversial death‑penalty law targeting Palestinians and approved a record $271 bn budget. The budget allocates substantial funds to ultra‑Orthodox and settler communities, a move described by critics as an attempt to shore up Prime Minister Netanyahu’s waning support.Internationally, the United Nations, European Union and several Muslim‑majority states have condemned the new death‑penalty legislation, though Israel has so far avoided direct sanctions.Economists warn that the war’s fiscal impact extends beyond defence spending. A Le Monde analysis highlighted rising defence outlays, lost productivity from reservist mobilisation, and dampened consumer activity. While temporary tax cuts have mitigated fuel‑price spikes caused by Iran’s closure of the Strait of Hormuz, political economist Shir Hever cautions that Israel’s reliance on imported fuel means any relief is short‑lived.Hever likens the current economic trajectory to that of a “totalitarian state,” where military expenses are pursued arbitrarily, ignoring broader economic stability.Ultimately, the war’s duration may hinge more on U.S. policy than Israeli strategy. When asked by Newsmax about progress toward its goals, Prime Minister Netanyahu could only claim the effort was “halfway” achieved.

The conflict between the US and Israel against Iran has taken a devastating toll on the country's healthcare system. At least 2,076 people have been killed and 26,500 wounded in Iran since the US and Israel first launched strikes on the country on February 28.Iranian President Masoud Pezeshkian has strongly condemned the attacks, appealing to international health organizations to respond to the crisis. On Thursday, he wrote on X: “What message does attacking hospitals, pharmaceutical companies and the Pasteur Institute as a medical research center in Iran convey?”The Pasteur Institute, a key center for medical research and vaccine production in Tehran, has been targeted. The institute, founded over 100 years ago in collaboration with the Institut Pasteur in Paris, conducts research on infectious diseases, produces vaccines, and provides advanced diagnostics.According to the World Health Organization (WHO), over 20 attacks on healthcare facilities in Iran have been verified since March 1, resulting in at least nine deaths, including an infectious diseases health worker and a member of the Iranian Red Crescent Society.Some of the facilities hit include:Red Crescent warehouse in Bushehr province, which was destroyed by a drone strike on Friday morning.Tofigh Daru Research and Engineering Company, one of Iran’s largest pharmaceutical companies, which was hit on March 31.Delaram Sina Psychiatric Hospital in Tehran, which was significantly damaged on March 29.Ali Hospital in Andimeshk, which sustained damage from an explosion on March 21.Gandhi Hospital in Tehran, which was damaged during attacks on a nearby television communications tower on March 2.International humanitarian law states that health establishments and units, including hospitals, should not be attacked. The United Nations Security Council resolution 2286 was adopted unanimously in 2016, condemning attacks on healthcare and calling on nations to respect international law.The attacks on healthcare facilities are not limited to Iran. Israel has also targeted healthcare facilities in Lebanon and Gaza, resulting in significant damage and loss of life.